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Tracer Experimental Study of the Main Conveying Conduits of CCl_4 Pollutant in the Qiligou Water Supply Resource

Journal of China University of Mining and Technology 2007年第2期17卷 184-187页

作者： PEI Zong-ping HAN Bao-ping liu Han-hu LIANG Zhi ZHOU Dong-lai ZHU Xue-qiang School of Environment and Spatial Informatics China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The Ordovician karst groundwater in the Qiligou basin is an important water supply source. This groundwater has been seriously contaminated in recent years by Cfl4 from a pesticide plant located in the recharge area. The highest concentration of CCl4 in the groundwater is 3909.2μg/L. Large scale tracer experiments were carried out to study the conveying conduits for Cfl4 in the basin on May 1-6, 2005. Nontoxic, edible glucose was used as a tracer and it was detected by spectrophotometric techniques. Well area of the basin, was employed for injecting the tracer X-61, located near the pesticide plant in the southern recharge Ten wells widely located in the groundwater runoff area were used as observing and sampling wells. The results show that the migration of the pollutants is controlled by the water hydrodynamic field and by the development of karst conduits. The tracer did not enter the up-drainage wells, X-49 and X-47, near the injection point because the water levels at these wells are higher than at the injection point. The adjacent well X-62 is close to the injection site, but the tracer reached the well after eleven hours. Wells X-43, X-59, X-58, YY-1 and X-57, located in the syncline axis runoff area, are respectively 2.5, 3.5, 4.33, 4.38 and 5.44 kilometers from the in- jection site. The time for initial appearance of tracer was 4, 4, 2, 6 and 4 hours, respectively. The maximum runoff velocity （well X-58） is over two kilometers per hour, indicating that the karst conduits are well developed along the syncline basin axis. These conduits are the main conveying conduits for groundwater and Cfl4. Closer wells were not necessarily the first to receive tracer. This shows the inhomogeneity in karst development which causes complex runoff, and pollutant migration, patterns.

关键词： tracer experiment tracer karst groundwater CC14 contamination conveying conduit

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Causes associated with recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography: A large sample sized retrospective study

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World Journal of Clinical Cases 2019年第9期7卷 1028-1037页

作者： Feng Deng Mi Zhou ping-ping liu Jun-Bo Hong Guo-Hua Li Xiao-Jiang Zhou You-Xiang Chen The First Affiliated Hospital of Nanchang University Medical College of Nanchang University Department of Gastroenterology The Affiliated Ganzhou Hospital of Nanchang University Department of Gastroenterology The First Affiliated Hospital of Nanchang University

BACKGROUND Recurrence of primary choledocholithiasis commonly occurs after complete removal of stones by therapeutic endoscopic retrograde cholangiopancreatography(ERCP). The potential causes of the recurrence of choledocholithiasis after ERCP are *** To analyze the potential causes of the recurrence of choledocholithiasis after *** The ERCP database of our medical center for the period between January 2007 and January 2016 was retrospectively reviewed, and information regarding eligible patients who had choledocholithiasis recurrence was collected. A 1:1 case-control study was performed for this investigation. Data including general characteristics of the patients, past medical history, ERCP-related factors,common bile duct(CBD)-related factors, laboratory indicators, and treatment was analyzed by univariate and multivariate logistic regression analysis and KaplanMeier *** First recurrence of choledocholithiasis occurred in 477 patients; among these patients, the second and several instance(≥ 3 times) recurrence rates were 19.5%and 44.07%, respectively. The average time to first choledocholithiasis recurrence was 21.65 mo. A total of 477 patients who did not have recurrence were selected as a control group. Multivariate logistic regression analysis showed that age > 65 years(odds ratio [OR] = 1.556; P = 0.018), combined history of choledocholithotomy(OR = 2.458; P < 0.01), endoscopic papillary balloon dilation(OR = 5.679; P = 0.000), endoscopic sphincterotomy(OR = 3.463; P = 0.000), CBD stent implantation(OR = 5.780; P = 0.000), multiple ERCP procedures(≥2; OR =2.75; P = 0.000), stones in the intrahepatic bile duct(OR = 2.308; P = 0.000),periampullary diverticula(OR = 1.627; P < 0.01), choledocholithiasis diameter ≥10 mm(OR = 1.599; P < 0.01), bile duct-duodenal fistula(OR = 2.69; P < 0.05),combined biliary tract infections(OR = 1.057; P < 0.01), and no preoperative antibiotic use(OR = 0.528; P < 0.01) were independent risk factors f

关键词： Choledocholithiasis Endoscopic retrograde cholangiopancreatography Recurrence Common bile duct

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Single stage dorsal inlay buccal mucosal graft with tubularized incised urethral plate technique for hypospadias reoperations

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Asian Journal of Andrology 2008年第4期10卷 682-686页

作者： Wei-Jing Ye ping ping Yi-Dong liu Zheng Li Yi-Ran Huang Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Aim： To report the experience with single stage dorsal inlay buccal mucosal grafts using the Snodgrass technique for complex redo cases. Methods： From May 2004 to December 2005, a total of 53 patients aged from 3 to 34 years old （average 11.62 ± 7.18 years） with failed previous hypospadias surgery were included in the present study. Indications included urethral strictures and repair breakdown. The unhealthy urethra was unroofed from the meatus in the ventral midline, a buccal mucosal graft was inlayed between the incised urethral plate and fixed to the corpora cavernosa. The neourethra was tubularized, and covered with subcutaneous （dartos） tissue and penile skin. Glanuloplasty was also performed in all cases. Outcome analysis included clinical follow-up, and endoscopy in 2 selected cases. Results： The buccal mucosal graft was 3.0-7.5 cm in length and 0.7-2.0 cm in width. All patients required glanuloplasty, with buccal mucosal grafts extended to the tip of the glans. After a follow-up of 14-30 months （mean 22.6 months）, the total complication rate was 15.1%, with five cases of fistula and three cases of stricture. Conclusion： Inlaying dorsal buccal mucosal grafts applying the Snodgrass technique is a reliable method for creating a substitute urethral plate for tubularization. The recurrent rate of urethral stricture and fistula is at an acceptable level for redo cases. This approach represents an effective, simple and safe option for reoperations.

关键词： hypospadias buccal mucosal graft urethroplasty

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Microstructure,hardening and deuterium retention in CVD tungsten irradiated with neutrons at temperatures of defect recovery stagesⅡandⅢ

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Tungsten 2022年第3期4卷 248-260页

作者： Xiao-Ou Yi Tatsuya Kuwabara Vladimir KhAlimov Yu-Feng Du Wen-Tuo Han ping-ping liu Bin-You Yan Jiu-Peng Song Kenta Yoshida Takeshi Toyama Fa-Rong Wan Somei Ohnuki Yuji Hatano Yasuyoshi Nagai School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Graduate School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya464-8063Japan Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of SciencesMoscow119071Russia Institute for Materials Research Tohoku UniversityNarita-cho 2145-2OaraiIbaraki311-1313Japan Xiamen Tungsten Co.Ltd. Xiamen361021China School of Materials Science and Engineering Xihua UniversityChengdu610039China Hydrogen Isotope Research Center University of ToyamaToyama930-8555Japan

Samples of ultra-high-purity tungsten prepared using chemical vapour deposition(CVD)technique were irradiated with neutrons at temperatures T_(irr)=373-483 K(stage Ⅱ of defect recovery)and T_(irr)=573-673 K(stage Ⅲ)up to 0.15 displacements per atom(dpa)in the Belgian reactor(BR2).The study of the microstructure of neutron-damaged samples using transmission electron microscopy(TEM)revealed visible defects with a predominance of dislocation *** an increase in the neutron irradiation temperature,the spatial distribution of the loops acquired pronounced inhomogeneity,and their average size moderately *** and voids were not ***-induced hardening was found and a linear correlation was obtained between Vickers microhardness and nanohardness for undamaged and neutron-irradiated CVD-W *** of tungsten with neutrons led to a significant increase in the retention of deuterium,which accumulated mainly in vacancy-type ***,the influence of the columnar grain structure in low-dose neutron-irradiated tungsten seemed to be non-trivial upon deuterium retention.

关键词： CVD-W Neutron irradiation Microstructure Hardening Deuterium retention

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Study of OCDs Reliability Estimation System Based on Bio-Immunology

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Journal of Bionic Engineering 2009年第3期6卷 306-310页

作者： Dan-e Wu~1 Qiu-zhan Zhou~1 ping-ping liu~2 He-bin Zhang1.College of Communication Engineering,Jilin University,Changehun 130022,P.R.China2.Department of Computer Science and Technology,Jilin University,Changchun 130012,P.R.China [a]College of Communication Engineering Jilin University Changchun 130022 P. R. China [b]Department of Computer Science and Technology Jilin University Changchun 130012 P. R. China

We introduce the relationship between excess noise in Optoelectronic Coupled Devices (OCDs) and their interior defects and explain how low-fiequency noise can be used to estimate their *** concepts from the biological immune system and its process of identifying invaders,we present a system for estimation of the reliability of *** system has expressions for the antigen (excess noise),lymphocyte (criterion) and the role of the lymphocyte eliminating unreliable devices. A genetic algorithm was used to estimate the components parameters of the noise spectrum for estimating the reliability of *** experimental results demonstrated that this method is reliable,adaptable and practical.

关键词： low-frequency noise artificial immunity genetic algonthm device reliability

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Assessment of 188Re marked anti MHC class II antibody by peripheral blood mononuclear cells stimulated by donor alloantigen

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Chinese Medical Journal 2011年第16期124卷 2512-2516页

作者： DING Guo-ping CAO Li-ping liu Jie liu Da-ren QUE Ri-sheng ZHU Lin-hua ZHOU Yi-ming MAO Ke-jie HU Jun-an Department of Surgery Second Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou Zhejiang 310009China

Background Previous studies showed that anti MHC-II monoclone antibody （MAb） only had partial inhibiting effect of alloreactive mixed lymphocyte reaction （MLR） in vitro and it was unsteady and non-persistent. The aim of this research was to determine whether radioactive isotope 188Re marked MHC-II antibody could benefit the allograft acceptance in transplantation as compared to normal MHC-II antibody. Methods 188Re was incorporated to 2E9/13F（ab＇）2 which is against swine MHC class II antigen （MAb-~88Re）. Porcine peripheral blood mononuclear （PBMC） cells were examined for proliferation and cytokine mRNA expression after stimulation with MHC-II MAb or MAb-188Re. Results The proliferative response of recipient PBMCs in mixed lymphocyte reaction （MLR） to donor alloantigen showed that the stimulation index of MAb-188Re group was significantly lower than the MHC-II MAb group and control （P 〈0.05）. mRNA expression of interleukin 2, interferon y and tumor necrosis factor a （type 1 cytokines） was lower in MAb-188Re group than the MHC-II MAb group, while interleukin 10 （type 2 cytokines） was higher in MAb-~aSRe group in the first 24 hours. Conclusion MAb-188Re could help the graft acceptance by inhibiting T cell proliferation, lowering the expression of type 1 cytokines and elevating the type 2 cytokines produced by PBMC.

关键词： MHC class H antibody dendritic cells cytokine 188Re, acute rejection

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Clinical application of BVS5000 left ventricular assist device in heart failure patients

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Chinese Medical Journal 2008年第10期121卷 877-880页

作者： LUO Xin-jin HU Sheng-shou SUN Han-song XU Jian-ping liu ping ZHENG Zhe MA Wei-guo ZHANG Yan Department of Cardiovascular Surgery Fu Wai Hospital PekingUnion Medical College Beijing 100037 China

Background Mechanical ventricular assistance is an important therapeutic method for severe heart failure patients. A variety of ventricular assist devices have been designed for use, The purpose of this report was to describe the experience of using Abiomed BVS5000 as a means of left ventricular support as a clinical treatment for heart failure patients. Methods From February 2004 to April 2006, 12 male patients were supported with Abiomed BVS5000 left ventricular assist device （LVAD） at Fu Wai Hospital. The average age was （55.2±9.6） years （range 39 to 68 years）. The mean body surface area was （1.76±0.1） m^2 （range 1.6 to 1.9 m^2 ）. Devices were inserted for post-cardiotomy shock after coronary artery bypass graft in 11 patients （92%） and in 1 dilated cardiomyopathy patient for acute cardiogenic shock. Modified cannulation methods by inserting the arterial cannulae in femoral artery and inserting the venous cannula in left atrium through a segment of bovine jugular vein were used in 7 patients. In this way, the device could be taken off without re-sternotomy when support was finished. A comparison was made between the modified method and routine left atrium-to-ascending aorta cannulating method. Results The median duration of support was 5 （3-43） days, with support flow rate of 3.8-4.5 L/min. There were 9 （75%） patients weaned from support and 8 （67%） patients discharged from the hospital. Four （33%） patients were dead. The most common morbidity was adverse neurological events. There is no statistical difference between modified and routine method on average in BVS5000 support duration, in assisted flow rate, in mechanical ventilation duration, in the intensive care unit stay and thoracic drainage. Conclusions The Abiomed BVS5000 is valuable to support patients with acute cardiogenic shock for short-term use. By the modified cannulating method, the weaning procedure can be effectively simplified. Optimization of inserting indication remains challenging and attr

关键词： heart failure surgical treatment left ventricular assist devices

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Clinically applicable Gleason grading(GD)system for prostate cancer based on deep learning

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Chinese Medical Journal 2021年第7期134卷 859-861页

作者： Yun Niu Can-Cheng liu Bing-Lin Zhang Zhi-Gang Song Huang Chen ping-ping liu Jing-Si Chen Shu-Hao Wang Huai-Yin Shi Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China R&D Thorough ImagesBeijing 100102China Institute for Interdisciplinary Information Sciences Tsinghua UniversityBeijing 100084China Department of Pathology Chinese People’s Liberation Army General HospitalBeijing 100853China.

To the Editor:Prostate cancer is one of the most common malignant tumors of the male genital system,with approximately 1.1 million new cases in 2012.[1]The accurate diagnosis of prostate cancer leads to a better chance of successful treatment when it is still confined to the prostate *** Gleason grading(GD)system was first established by Donald Gleason during 1966 to 1974.[2,3]The Gleason pattern ranges from 1 to 5.A higher score corresponds to poorer differentiation,which indicates a worse prognosis and higher metastasis *** total score is calculated with the first half of the dominant Gleason pattern and the second half based on the non-dominant one.

关键词： cancer diagnosis pattern

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康柏西普治疗湿性年龄相关性黄斑变性后黄斑区视网膜结构的变化

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国际眼科杂志 2020年第2期20卷 346-349页

作者：刘萍萍朱振流丁鲁娜王倩中国山东省潍坊市中医院眼科

目的:采用光学相干断层扫描(OCT)观察康柏西普治疗湿性年龄相关性黄斑变性(wARMD)后黄斑区视网膜结构的变化。方法:选取2018-05/10本院收治的wARMD患者21例23眼为研究对象,均进行连续3mo、每月1次玻璃体内注射康柏西普治疗。末次注射后... 详细信息

目的:采用光学相干断层扫描(OCT)观察康柏西普治疗湿性年龄相关性黄斑变性(wARMD)后黄斑区视网膜结构的变化。方法:选取2018-05/10本院收治的wARMD患者21例23眼为研究对象,均进行连续3mo、每月1次玻璃体内注射康柏西普治疗。末次注射后随访6mo,观察最佳矫正视力(BCVA)和眼压的变化,并采用OCT检查观察黄斑中心凹视网膜厚度(CFT)、黄斑中心凹旁视网膜厚度(PMT)和脉络膜新生血管(CNV)面积。结果:治疗后6mo,本组患者治疗有效21眼(91%),稳定2眼(9%)。治疗后1、3、6mo,本组患者BCVA较治疗前明显改善,CFT、PMT和CNV面积较治疗前明显下降(均P0.05)。随访期间仅2眼(9%)出现短暂视物模糊、1眼(4%)眼压升高(>21mmHg)、1眼(4%)球结膜下出血,均于末次注射康柏西普后7d内恢复。结论:康柏西普治疗wARMD能显著改善视力及黄斑区视网膜结构,治疗效果佳,且副作用少,安全性高。

关键词：光学相干断层扫描年龄相关性黄斑变性黄斑康柏西普

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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