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Association between Helicobacter pylori infection and food-specific immunoglobulin G in Southwest China

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World Journal of Clinical Cases 2021年第32期9卷 9815-9824页

作者： Ying Liu ping shuai Yu-ping Liu Dong-Yu Li Health Management Center Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina Health Management Center Chinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on *** and food allergy or intolerance,and the results are ***-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between *** infection and food allergy or *** To explore the relationship between *** infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this *** infection was detected using the 13C urea breath ***-specific IgG of eggs,milk and wheat in serum was *** were grouped according to *** positivity,and the positive rates of three kinds of food-specific IgG were compared between the two *** logistic regression analysis was performed to elucidate the association between *** infection and food-specific *** The total infection rate of *** was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,*** infection rate of *** was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in *** positive rates of food-specific IgG decreased with age in both males and *** the ***-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the ***-negative *** logistic regression analysis revealed that *** infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION *** infection was found to be negati

关键词： Food-specific IgG Helicobacter pylori Adverse food reaction Food allergy Food intolerance Humoral immunity

Research on direct-path interference suppression for bistatic radar based on GNSS reflected from the ocean surface

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Science China(Technological Sciences) 2010年第11期53卷 3051-3055页

作者： ZHANG JianJun YUAN Hong shuai ping HUANG YuMin China Academy of Space Technology Beijing 100094China Academy of Opto-Electronics Chinese Academy of SciencesBeijing 100190China

The use of global navigation satellite system signals reflected by the sea surface as a remote sensing tool has received considerable attention for over a decade. However, in signal detection processing, the direct-path interference can potentially introduce a bigger obstacle to ocean surface detection than other interferences, such as clutter and radio signals. In order to improve retrieval of the ocean surface parameters, the direct-path interference signals have to be suppressed. The interference suppression based on the improved subspace projection algorithm is put forward in this paper. First of all, the interferential signal is acquired and tracked, then according to the acquired interferential signal parameter, the corresponding disturbance subspace is constructed. Finally, the interference is eliminated using the improved subspace block projection. This method can not only reduce the influence of interferential performance by the tracking error but also decrease computation greatly. It suits the changeable environment and the multi-data sample situation. The analysis of the simulated results has confirmed the validity of this method and provided a basis for the following system optimization design.

关键词： GNSS-R reflected signal direct signal cancellation subspace projection

Investigation of Induced Unbalance Magnitude on Dynamic Characteristics of High-speed Turbocharger with Floating Ring Bearings

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 99-109页

作者： Guang-Fu Bin Yuan Huang shuai-ping Guo Xue-Jun Li Gang Wang Health Maintenance for Mechanical Equipment Key Lab of Hunan Province Hunan University of Science and Technology Xiangtan 411201 China Department of Mechanical and Aerospace Engineering The University of Alabama in Huntsville AL 35899 USA

Due to operational wear and uneven carbon absorption in compressor and turbine wheels, the unbalance(me) vibration is induced and could lead to sub?synchronous vibration accidents for high?speed turbocharger(TC). There are very few research works that focus on the magnitude e ects on such induced unbalance vibration. In this paper, a finite element model(FEM) is developed to characterize a realistic automotive TC rotor with floating ring bearings(FRBs). The nonlinear dynamic responses of the TC rotor system with di erent levels of induced unbalance magni?tude in compressor and turbine wheels are calculated. From the results of waterfall and response spectral intensity plots, the bifurcation and instability phenomena depend on unbalance magnitude during the startup of TC. The sub?synchronous component 0.12× caused rotor unstable is the dominant frequency for small induced unbalance. The nonlinear e ects of induced unbalance in the turbine wheel is obvious stronger than the compressor wheel. As the unbalance magnitude increases from 0.05 gbration 1·mm to 0.2 g·mm, the vibration component changes from mainly 0.12× to synchronous vi×. When unbalance increases continuously, the rotor vibration response amplitude is rapidly growing and the 1× caused by the large unbalance excitation becomes the dominant frequency. A suitable un?balance magnitude of turbine wheel and compressor wheel for the high?speed TC rotor with FRBs is proposed: the value of induced un?balance magnitude should be kept around 0.2 g·mm.

关键词： High?speed TC with FRBs Induced unbalance magnitude Nonlinear dynamic response Sub?synchronous vibration Stability

Association of MTHFR C677T polymorphism with primary open angle glaucoma:a Meta-analysis based on 18 case-control studies

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 896-902页

作者： Yu-Mei Yang Yu-ping Liu Dong-Yu Li Man Yu Bo Gong Lin Wang ping shuai Health Management Center Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054Sichuan ProvinceChina Department of Ophthalmology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina Sichuan Provincial Key Laboratory for Human Disease Gene Study Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina

AIM:To systematically understand the genetic association between methylenetetrahydrofolate reductase(MTHFR)C677 T polymorphism and primary open angle glaucoma(POAG).METHODS:A comprehensive literature search in Google Scholar,Pub Med,Science Citation Index,Foreign Medical Literature Retrieval Service,Chinese National Knowledge Infrastructure and Wanfang Databases was performed to collect all eligible studies up to August *** selection,data abstraction and study quality evaluation were performed by two independent *** ratios(ORs)with 95%confidence intervals(CIs)were calculated to assess the ***:Eighteen case-control studies including 2156 cases and 2201 controls were *** was no significant difference in the terms of MTHFR C677 T polymorphism and POAG in the Caucasian population(for T vs C OR=1.11,95%CI:0.88 to 1.39;for TT vs CC OR=1.01,95%CI:0.76 to 1.36;for TT+TC vs CC OR=1.15,95%CI:0.84 to 1.58 and for TT vs TC+CC OR=1.02,95%CI:0.78 to 1.33).However,a significant effect was revealed in the Asian population(for T vs C OR=1.34,95%CI:1.12 to 1.59;for TT+TC vs CC OR=1.41,95%CI:1.14 to 1.76).CONCLUSION:Based on 18 eligible studies,we provide a correlation between MTHFR C677 T polymorphism and POAG among the Asians subgroup indicating that the T allele or TT+TC genotype may play a critical role in POAG development in Asians.

关键词： methylenete trahydrofolate reductase polymorphism primary open angle glaucoma Meta-analysis

Association of n3 and n6 polyunsaturated fatty acids in red blood cell membrane and plasma with severity of normal tension glaucoma

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 476-483页

作者： Man Yu Bo Chen Bo Gong ping shuai Zheng-Zheng Wu Wei Lin Department of Ophthalmology Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Sichuan Key Laboratory for Human Disease Gene Study Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Center of Health Physical Examination and Health Management Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

AIM: To determine whether red blood cell(RBC)membrane and plasma lipids, particularly long-chain polyunsaturated fatty acids such as eicosapentaenoic acid(EPA), docosahexaenoic acid(DHA), arachidonic acid(AA) are significantly correlated with severity of normal tension glaucoma(NTG).METHODS: This study included 35 patients with NTG and 12 healthy normal control subjects, matched for age and sex with the study group. The stage of glaucoma was determined according to the Hodapp-Parrish-Anderson classification. Lipids were extracted from RBC membranes and plasma, and fatty acid methyl esters prepared and analyzed by gas chromatography-mass spectrometry(GC-MS).RESULTS: When RBC lipids were analyzed, the levels of EPA, the levels of DHA and the ratio of n3 to n6 were positively associated with the Humphrey Perimetry mean Deviation(MD) score(r =0.617, P <0.001; r =0.727, P <0.001 and r =0.720, P <0.001, respectively), while the level of AA was negatively associated with the MD score(r =-0.427, P =0.001). When plasma lipids were analyzed,there was a significant positive relationship between the levels of EPA and the MD score(r =0.648, P <0.001), and the levels of AA were inversely correlated with the MD score(r =-0.638, P <0.001). CONCLUSION: The levels of n3 and n6 polyunsaturated fatty acids in RBC membrane and plasma lipids were associated with severity of NTG.

关键词： normal tension glaucoma polyunsaturated fatty acid erythrocytes plasma

An Improved Mumford-Shah Model and Its Applications to Image Processing with the Piecewise Constant Level Set Method

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自动化学报 2007年第12期33卷 1259-1262页

作者： SONG Jin-ping LI shuai-Jie Institute of Applied Mathematics College of Mathematics and Information ScienceHenan UniversityKaifeng 475004P.R.China

为快分割并且降噪，提高 penalization 学期的古典 Mumford-Shah (MS ) 模型需要，即增加 penalization 参数，它导致目标的渐渐的消失。在这份报纸，我们建议一个改进 Mumford-Shah (IMS ) 模型避免现象，并且采用 piecewise 常数水平... 详细信息

为快分割并且降噪，提高 penalization 学期的古典 Mumford-Shah (MS ) 模型需要，即增加 penalization 参数，它导致目标的渐渐的消失。在这份报纸，我们建议一个改进 Mumford-Shah (IMS ) 模型避免现象，并且采用 piecewise 常数水平集合方法(PCLSM ) 和坡度降下方法解决最小化问题。数字实验被给显示出新模型和算法的效率和优点。

关键词：分段持续水平集方法分割降噪经典MS模型最小化算法

Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1187-1193页

作者： Bo Gong Chao Qu Xiao-Fang Huang Zi-Meng Ye Ding-Ding Zhang Yi Shi Rong Chen Yu-ping Liu ping shuai Sichuan Provincial Key Laboratory for Disease Gene Study Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Department of Ophthalmology Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital Department of Ophthalmology West China HospitalSichuan University Department of Microbiology and Immunology North Sichuan Medical College Health Management Center Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital

AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis. METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in PubMed, Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed for single-nucleotide polymorphisms (SNPs) using fixed- and random - effects models according to between-study heterogeneity. Publication bias analyses were conducted by Eggers test. RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model (CC vs CG+GG, P = 0.03) and in heterozygous model (CG vsGG, P = 0.04), but not in other models. CONCLUSION: This Meta-analysis shows that COL fill rs2269336 (CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.

关键词： COL1A1 high myopia association Meta-analysis

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基于半分析式方法的全球导航星座设计

中国空间科学技术 2006年第4期26卷 11-19页

作者：帅平曲广吉中国空间技术研究院北京100094

导航星座设计涉及诸多参数的优化组合,设计目标就是寻找一组参数组合,使其构成的星座在指定覆盖区域既能获得最优的星座性能,又节省系统建设成本和星座长期维持费用。首先,提出评价导航星座性能的技术指标、可用性算法以及半分析式星座... 详细信息

导航星座设计涉及诸多参数的优化组合,设计目标就是寻找一组参数组合,使其构成的星座在指定覆盖区域既能获得最优的星座性能,又节省系统建设成本和星座长期维持费用。首先,提出评价导航星座性能的技术指标、可用性算法以及半分析式星座设计方法;然后,详细论证设计参数对导航星座性能的影响,进而综合分析得到3种全球导航星座设计方案;最后,通过对比研究3种星座方案的性能指标和导航定位仿真结果,说明导航星座设计方法和设计方案的可行性。

关键词：卫星导航性能指标星座可用性设计方案

乳腺癌组织中HER2和Topo Ⅱα的表达及其临床意义

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中南大学学报（医学版） 2016年第11期41卷 1143-1147页

作者：帅萍赣南医学院病理学教研室江西赣州341000

目的:检测人类表皮生长因子受体(human epidermal growth factor 2,HER2)和Topo IIα在乳腺癌组织中的表达情况,并分析二者的表达对蒽环类药物新辅助化学治疗(化疗)的临床意义。方法:采用荧光原位杂交(fluorescence in situ hybridizati... 详细信息

目的:检测人类表皮生长因子受体(human epidermal growth factor 2,HER2)和Topo IIα在乳腺癌组织中的表达情况,并分析二者的表达对蒽环类药物新辅助化学治疗(化疗)的临床意义。方法:采用荧光原位杂交(fluorescence in situ hybridization,FISH)和免疫组织化学(免疫组化)方法对189例临床资料完整的浸润性乳腺癌组织样本进行HER2和Topo IIα基因和蛋白表达检测,并对乳腺癌患者接受TAC新辅助化疗后的客观有效率(objective response rate,ORR)和病理完全缓解率(pathological complete rate,p CR)进行统计和分析。结果:在189例乳腺癌患者组织中,经免疫组化检测的HER2蛋白表达46例(24.3%)3+,Topo IIα蛋白表达55例(29.1%)3+;FISH检测,HER2蛋白表达阳性49例(25.9%),Topo IIα蛋白表达阳性94例(49.0%)。HER2阴性患者ORR为47.4%,p CR为20.3%;阳性患者ORR为32.7%,p CR为16.3%,两者差异均有统计学意义(均P<0.05)。Topo IIα阳性患者ORR为69.1%,p CR为36%;阴性患者ORR为28.4%,p CR为2.2%,两者差异均有统计学意义(均P<0.05)。结论:FISH和免疫组化检查HER2和Topo IIα对于乳腺癌治疗具有重要指导意义,Topo IIα基因扩增可以有效改善蒽环类药物辅助治疗效果。

关键词：乳腺癌 HER2 Topo Ⅱα 荧光原位杂交技术免疫组织化学