Association between Helicobacter pylori infection and food-specific immunoglobulin G in Southwest China

作     者：Ying Liu Ping Shuai Yu-Ping Liu Dong-Yu Li 

作者机构：Health Management CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina Health Management CenterChinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengdu 610072Sichuan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第32期

页      面：9815-9824页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：by Key Research and Development Projects of the Ministry of Science and Technology China No.2017YFC0113901 

主　　题：Food-specific IgG Helicobacter pylori Adverse food reaction Food allergy Food intolerance Humoral immunity 

摘      要：BACKGROUND Helicobacter pylori(***)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on *** and food allergy or intolerance,and the results are ***-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between *** infection and food allergy or *** To explore the relationship between *** infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this *** infection was detected using the 13C urea breath ***-specific IgG of eggs,milk and wheat in serum was *** were grouped according to *** positivity,and the positive rates of three kinds of food-specific IgG were compared between the two *** logistic regression analysis was performed to elucidate the association between *** infection and food-specific *** The total infection rate of *** was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,*** infection rate of *** was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in *** positive rates of food-specific IgG decreased with age in both males and *** the ***-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the ***-negative *** logistic regression analysis revealed that *** infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION *** infection was found to be negati