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Long-term efficacy and safety of Huangqi(Radix Astragali Mongolici)-based Traditional Chinese Medicine in diabetic peripheral neuropathy:a Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2024年第2期44卷 229-242页

作者： ping jing HAO Hongzheng WU Zhenqi ZOU Meijuan LI Zuojing CHENG Gang School of Life Sciences and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110000China Department of Endocrinology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China Department of Research Administration Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110000China

OBJECTIVE:To assess the long-term effectiveness of Huangqi(Radix Astragali Mongolici,HQ)-based Traditional Chinese Medicine(TCM)in the treatment of diabetic peripheral neuropathy(DPN).METHODS:Nine databases were searched to retrieve available randomized controlled trials that compared HQbased TCM and Western Medicines in the treatment of *** methodological quality of the included studies was assessed using the Cochrane bias risk tool,and RevMan 5.4 was used for data *** effect estimates of interest were risk ratio(RR),mean difference(MD)or standardized mean difference(SMD)with 95%confidence interval(CI).RESULTS:The results from 48 available studies assessing 3759 patients demonstrated that cases administered HQ-based TCM[RR=1.30,95%CI(1.21,1.40),P<0.00001]or HQ-based TCM combined with Western Medicines[RR=1.25,95%CI(1.19,1.31),P<0.00001]exhibited higher total efficacy rates than individuals who received Western Medicine *** results showed that the HQ-based TCM group had decreased Toronto Clinical Scoring System scores[MD=-1.50,95%CI(-1.83,-1.17),P<0.00001],and reduced serum interleukin 6[SMD=-0.57,95%CI(-0.87,-0.27),P=0.0002]and tumor necrosis factors-αlevels[SMD=-0.60,95%CI(-0.95,-0.25),P=0.0009].In addition,both HQ-based TCM and HQbased TCM combined with Western Medicine increased nerve conduction velocity and decreased glycaemia compared with Western Medicine *** terms of blood lipids,oxidative stress and adverse drug reactions,there were no significant differences between the HQ-based TCM groups and the Western Medicine control ***:The current Meta-analysis revealed that HQ-based TCM yields higher efficacy and safety than Western Medicine alone for the treatment of DPN,although further well-designed RCTs are required to validate these findings.

关键词： Huangqi(Radix Astragali Mongolici) medicine Chinese traditional diabetic peripheral neuropathy Meta-analysis

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Two-dimensional conjugated coordination polymer monolayer as anode material for lithium-ion batteries:A DFT study

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Chinese Chemical Letters 2024年第6期35卷 180-184页

作者： Xin-Tong Zhao Jin-Zhi Guo Wen-Liang Li jing-ping Zhang Xing-Long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

Nowadays,lithium-ion batteries(LIBs)play a crucial role in modern society in the aspect of portable electronic devices and large-scale smart ***,the current performance of lithium-ion batteries has been unable to meet the growing expectations of society and scientific ***,we have synthetically investigated availability of 2D Ni-TABQ monolayer as anode based on DFT for LIBs *** findings have demonstrated that 2D Ni-TABQ monolayer is a semiconductor with a small band gap of 0.2 eV,which suggest that the electronic property of 2D Ni-TABQ monolayer would take place an evident shift from semiconductor property to metallic property after Li ***,we checked the stability of 2D Ni-TABQ monolayer and investigated the viability of exfoliation from bulk multilayer Ni-TABQ to form 2D Ni-TABQ monolayer in the light of exfoliation energy and binding *** continuously studied electrochemical properties of 2D Ni-TABQ monolayer with respect of theoretical specific capacity,Li-ion diffusion barriers and open-circuit *** the charging process,2D Ni-TABQ monolayer can achieve a high specific capacity of 722 m Ah/g with an open-circuit voltage range from 1.12 V to 0.22 *** aforementioned results make the 2D Ni-TABQ monolayer a promising anode for LIBs.

关键词： The first principles Density functional theory Lithium-ion battery Anode material Two-dimensional material

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Exogenous insulin autoimmune syndrome:A case report and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1691-1697页

作者： Ling-Ling Xu Jia-Xin Chen jing-ping Cheng Ni Luo Medical College School of MedicineWuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina Department of Gerontology CR&WISCO General Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina

BACKGROUND Insulin autoimmune syndrome(IAS)is a severe manifestation of spontaneous *** is characterized by elevated levels of immune-reactive insulin and highly potent insulin autoantibodies(IAAs),which are induced by endogenous insulin circulating in the *** is distinguished by recurring instances of spontaneous hypoglycemia,the presence of IAA within the body,a substantial elevation in serum insulin levels,and an absence of prior exogenous insulin ***,recent studies show that both conventional insulin and its analogs can induce IAS episodes,giving rise to the notion of nonclassical ***,more attention should be paid to these *** SUMMARY In this case report,we present a rare case of non-classical IAS in an 83-year-old male patient who present with symptoms of a psychiatric *** symptom onset,the patient exhibited Whipple's triad(including hypoglycemia,blood glucose level less than 2.8 mmol/L during onset,and rapid relief of hypoglycemic symptoms after glucose administration).Concurrently,his serum insulin level was significantly elevated,which contradicted his C-peptide *** a comprehensive examination,the patient was diagnosed with exogenous insulin autoimmune *** that the patient had type 2 diabetes mellitus and a history of exogenous insulin use before disease onset,it was presumed that non classical IAS was induced by this *** PubMed database was used to search for previous cases of IAS and non-classical IAS to analyze their characteristics and treatment *** The occurrence of non-classical IAS is associated with exogenous insulin or its analogs,as well as with sulfhydryl *** can be effectively alleviated through the discontinuation of relevant medications,administration of hormones or immunosuppressants,plasma exchange,and lifestyle adjustments.

关键词： Insulin autoimmune syndrome Type 2 diabetes Exogenous insulin Insulin autoantibodies Hypoglycemia Case report

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Challenging anticoagulation therapy for multiple primary malignant tumors combined with thrombosis:A case report and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1704-1711页

作者： Jia-Xin Chen Ling-Ling Xu jing-ping Cheng Xun-Hua Xu Department of Gerontology China Resources and Wisco General HospitalWuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina Medical College Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina Department of Gerontology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina Department of Radiology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina

BACKGROUND Venous thromboembolism significantly contributes to patient deterioration and *** of its etiology and anticoagulation treatment is intricate,necessitating a comprehensive consideration of various factors,including the bleeding risk,dosage,specific anticoagulant medications,and duration of ***,a case of lower extremity thrombosis with multiple primary malignant tumors and high risk of bleeding was reviewed to summarize the shortcomings of treatment and prudent anticoagulation *** SUMMARY An 83-year-old female patient was admitted to the hospital due to a 2-wk history of left lower extremity edema that had worsened over 2 *** her medical history and relevant post-admission investigations,it was determined that the development of left lower extremity venous thrombosis and pulmonary embolism in this case could be attributed to a combination of factors,including multiple primary malignant tumors,iliac venous compression syndrome,previous novel coronavirus infection,and inadequate treatment for prior thrombotic ***,the selection of appropriate anticoagulant medications,determination of optimal drug dosages,and establishment of an appropriate duration of anticoagulation therapy were important because of concurrent thrombocytopenia,decreased quantitative fibrinogen levels,and renal *** Anticoagulant prophylaxis should be promptly initiated in cases of high-risk *** anticoagulation therapy is required for complex thrombosis.

关键词： Venous thromboembolism Cancer-associated thrombosis Anticoagulation therapy iliac vein compression syndrome COVID-19 Thrombocytopenia Case report

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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma jing-ping Yun Judy Wai ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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当前我国未成年人保护研究的趋势及热点——以1998-2022年CNKI数据为例

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中南民族大学学报（人文社会科学版） 2024年第8期44卷 126-133,186页

作者：李静萍湖北省社会科学院社会学研究所湖北武汉430077

以1998-2022年CNKI数据库的未成年人保护研究文献为数据来源,利用CiteSpace软件分析发文量、作者及研究机构、研究热点、演进趋势及研究前沿。研究表明:近25年来我国未成年人保护研究发文量呈现震荡上行趋势,作者及研究机构之间的合作... 详细信息

以1998-2022年CNKI数据库的未成年人保护研究文献为数据来源,利用CiteSpace软件分析发文量、作者及研究机构、研究热点、演进趋势及研究前沿。研究表明:近25年来我国未成年人保护研究发文量呈现震荡上行趋势,作者及研究机构之间的合作有待加强,热点主题主要集中于未成年人家庭保护、学校保护、社会保护、网络保护、政府保护和司法保护六个方面。这一时期的研究分为起步阶段(1998-2007年)、高速发展阶段(2008-2017年)和平稳发展阶段(2018至今)。个人信息、民法典、隐私政策、收容教养、国家亲权、家事审判是研究前沿问题。

关键词：未成年人保护少年司法儿童权利家事审判

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央行担保品扩容对重污染企业转型升级的影响机理研究

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经济体制改革 2024年第2期 130-137页

作者：李静萍栗文山西财经大学金融学院山西太原030006

央行担保品扩容作为支持金融直达实体经济的重要举措之一,其微观政策效果受到广泛关注。以2018年6月中国央行将绿色资产纳入合格担保品范围为准自然实验,选取2013~2021年沪深A股上市公司样本,运用PSM-DID模型检验央行担保品扩容对重污... 详细信息

央行担保品扩容作为支持金融直达实体经济的重要举措之一,其微观政策效果受到广泛关注。以2018年6月中国央行将绿色资产纳入合格担保品范围为准自然实验,选取2013~2021年沪深A股上市公司样本,运用PSM-DID模型检验央行担保品扩容对重污染企业转型升级的影响,并重点考察其影响机理。研究表明:央行担保品扩容显著推动了重污染企业转型升级;产权异质性分析表明,相较于非国有重污染企业,国有重污染企业转型升级的提升效果更大;影响机制分析表明,央行担保品扩容可通过对技术创新的“倒逼”效应和融资成本的“激励”效应,推动重污染企业转型升级。因此,应进一步完善央行担保品框架,加强对非国有重污染企业转型升级的引导作用,疏通技术创新和融资成本的传导渠道,推动新型货币政策工具更加精准有力。

关键词：央行担保品扩容重污染企业转型升级技术创新融资成本

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科技金融对科技型中小企业“专精特新”发展的影响——基于“科技和金融结合试点”的准自然实验

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技术经济与管理研究 2024年第7期 30-36页

作者：靳晓旭常京萍太原理工大学经济管理学院山西太原030024

以2008—2021年中小板、创业板和科创板科技型企业为样本,以“科技和金融结合试点”为准自然实验,构建双重差分模型考察科技金融对科技型中小企业“专精特新”发展的影响。研究发现,科技金融对科技型中小企业“专精特新”发展具有显著... 详细信息

以2008—2021年中小板、创业板和科创板科技型企业为样本,以“科技和金融结合试点”为准自然实验,构建双重差分模型考察科技金融对科技型中小企业“专精特新”发展的影响。研究发现,科技金融对科技型中小企业“专精特新”发展具有显著的促进效果。作用机制分析表明,科技金融通过缓解企业融资约束助推科技型中小企业“专精特新”发展。异质性分析表明,科技金融对非国有企业、财务风险稳定性较高的企业和内部控制不存在缺陷的科技型中小企业的促进作用明显。研究结论为科技和金融试点政策进一步推广实施,助力科技型中小企业“专精特新”高质量发展提供决策依据。

关键词：科技金融 “专精特新” 科技型中小企业融资约束

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近代以来中文语境下的新疆坎儿井文化意象演化研究

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青海民族研究 2024年第1期35卷 205-212页

作者：张景平杨璐兰州大学甘肃兰州730000

新疆坎儿井是我国干旱区传统水利工程的杰出代表,清代开始为汉语史料所明确记载,逐步形成辨识度鲜明的文化意象。清代民国时期,坎儿井作为边疆开发“利器”的巨大效益引发了内地人士的关注,并被知识精英视为古代中原文化影响西域的活化... 详细信息

新疆坎儿井是我国干旱区传统水利工程的杰出代表,清代开始为汉语史料所明确记载,逐步形成辨识度鲜明的文化意象。清代民国时期,坎儿井作为边疆开发“利器”的巨大效益引发了内地人士的关注,并被知识精英视为古代中原文化影响西域的活化石。1949年之后,以《人民日报》为代表的中央媒体极大提升了新疆坎儿井的知名度,人民史观与民族团结视角灌注期间,虽一度在具体宣传口径方面蕴含张力,最终融合于铸牢中华民族共同体意识的有关话语中,使新疆坎儿井成为各民族共创中华的代表符号之一。民国以来逐步形成的一系列重要修辞策略促进了新疆坎儿井文化意象在中文语境中的公众接受,但其中亦存在欠严谨、缺乏学术支撑等问题,对新疆坎儿井文化意象的提升造成某些明显的负面影响,亟需加以改进。

关键词：新疆坎儿井文化意象宣传口径中华民族共同体

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新生儿重症监护室呼吸机相关性肺炎研究进展

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中华医院感染学杂志 2024年第4期34卷 628-634页

作者：刘玥张静萍中国医科大学附属第一医院院内感染管理办公室辽宁沈阳110001

呼吸机相关性肺炎(VAP)作为医院获得性肺部感染,在新生儿重症监护病房(NICU)中是重症患儿常见的并发症之一.但因新生儿VAP的定义尚无统一标准,且易与其他早产儿特有的肺部病理临床表现发生重叠,导致其诊断特异度较低,主观性较大.许多NIC... 详细信息

呼吸机相关性肺炎(VAP)作为医院获得性肺部感染,在新生儿重症监护病房(NICU)中是重症患儿常见的并发症之一.但因新生儿VAP的定义尚无统一标准,且易与其他早产儿特有的肺部病理临床表现发生重叠,导致其诊断特异度较低,主观性较大.许多NICU实施了集束化预防策略,通过手卫生、口腔护理、设备无菌操作、每日评估是否可拔管及体位管理防止胃液反流等措施来减少VAP的发生,但需进一步证据来支持束元素的有效性.本文主要对新生儿VAP的流行病学、发病机制和预防措施等方面予以讨论与评估.

关键词：新生儿新生儿重症监护室呼吸机相关性肺炎集束化预防策略

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