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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong phuong nguyen Sa Huynh nguyen Trung Kien nguyenDuy Toan nguyen Thi Thu Ha Le Ha Khoa nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam Hanoi Medical University Ha Noi 100000Vietnam Bạch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with ***:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<***,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<*** age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<***:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

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An Optimal Deep Learning Based Computer-Aided Diagnosis System for Diabetic Retinopathy

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Computers, Materials & Continua 2021年第3期66卷 2815-2830页

作者： Phong Thanh nguyen Vy Dang Bich Huynh Khoa Dang Vo phuong Thanh Phan Eunmok Yang Gyanendra Prasad Joshi Department of Project Management Ho Chi Minh City Open UniversityHo Chi Minh City7000000Vietnam Department of Learning Material Ho Chi Minh City Open UniversityHo Chi Minh City7000000Vietnam Department of Convergence Science Kongju National UniversityGongju32588South Korea Department of Computer Science and Engineering Sejong UniversitySeoul05006South Korea

Diabetic Retinopathy(DR)is a significant blinding disease that poses serious threat to human vision *** and severity grading of DR are difficult processes to ***,it depends on ophthalmoscopically-visible symptoms of growing severity,which is then ranked in a stepwise scale from no retinopathy to various levels of DR *** paper presents an ensemble of Orthogonal Learning Particle Swarm Optimization(OPSO)algorithm-based Convolutional Neural Network(CNN)Model EOPSO-CNN in order to perform DR detection and *** proposed EOPSO-CNN model involves three main processes such as preprocessing,feature extraction,and *** proposed model initially involves preprocessing stage which removes the presence of noise in the input ***,the watershed algorithm is applied to segment the preprocessed *** by,feature extraction takes place by leveraging EOPSO-CNN ***,the extracted feature vectors are provided to a Decision Tree(DT)classifier to classify the DR *** study experiments were carried out using Messidor DR Dataset and the results showed an extraordinary performance by the proposed method over compared methods in a considerable *** simulation outcome offered the maximum classification with accuracy,sensitivity,and specificity values being 98.47%,96.43%,and 99.02%respectively.

关键词： Diabetic retinopathy convolutional neural network classification image processing computer-aided diagnosis

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Shilian Dashan With the Propagation of the Caodong Sect in Cochinchina in the Seventeenth Century

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Philosophy Study 2024年第4期14卷 194-203页

作者： Ngoc phuong nguyen Guangxi University for Nationalities NanningChina

The prosperous development of the“Maritime Silk Road”in the 17th century not only brought convenience in sea transportation and promoted trade between countries,but also acted as a bridge connecting *** bridge has the function of cultural exchange between peoples,especially in introducing and promoting China’s cultural and ideological quintessence with neighboring *** this period,Linji and Caodong sects of Chinese Zen Buddhism were spread directly into Cochinchina of Dai Viet through Chinese senior monks who followed merchant ships to this *** them was the Most Venarable Shilian Dashan,a senior monk at Changshou Temple,Guangzhou,who accepted Lord nguyen Phuc Chu’s invitation to teach the Soto Dharma in Cochinchina for nearly two years(1695-1696).Based on the study of relevant historical documents and autobiographical works on this trip byMost ***,the article presents his biography and ***,this article analyzes the method of spreading Dharma,Chan ideology,as well as the significance of his Dharma propagation activities for Buddhism in Cochinchina at that time.

关键词： Shilian Dashan Buddhism in Cochinchina Caodong Chan

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Deep Learning Based Optimal Multimodal Fusion Framework for Intrusion Detection Systems for Healthcare Data

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Computers, Materials & Continua 2021年第3期66卷 2555-2571页

作者： Phong Thanh nguyen Vy Dang Bich Huynh Khoa Dang Vo phuong Thanh Phan Mohamed Elhoseny Dac-Nhuong Le Department of Project Management Ho Chi Minh City Open UniversityHo Chi Minh City700000Vietnam Department of Learning Material Ho Chi Minh City Open UniversityHo Chi Minh City700000Vietnam Faculty of Computers and Information Mansoura UniversityDakahlia Governorate35516Egypt Institute of Research and Development Duy Tan UniversityDanang550000Vietnam Faculty of Information Technology Duy Tan UniversityDanang550000Vietnam

Data fusion is a multidisciplinary research area that involves different *** is used to attain minimum detection error probability and maximum reliability with the help of data retrieved from multiple healthcare *** generation of huge quantity of data from medical devices resulted in the formation of big data during which data fusion techniques become *** medical data is a crucial issue of exponentially-pacing computing world and can be achieved by Intrusion Detection Systems(IDS).In this regard,since singularmodality is not adequate to attain high detection rate,there is a need exists to merge diverse techniques using decision-based multimodal fusion *** this view,this research article presents a new multimodal fusion-based IDS to secure the healthcare data using *** proposed model involves decision-based fusion model which has different processes such as initialization,pre-processing,Feature Selection(FS)and multimodal classification for effective detection of *** FS process,a chaotic Butterfly Optimization(BO)algorithmcalled CBOA is *** the classic BO algorithm offers effective exploration,it fails in achieving faster *** order to overcome this,i.e.,to improve the convergence rate,this research work modifies the required parameters of BO algorithm using chaos ***,to detect intrusions,multimodal classifier is applied by incorporating three Deep Learning(DL)-based classification ***,the concepts like Hadoop MapReduce and Spark were also utilized in this study to achieve faster computation of big data in parallel computation *** validate the outcome of the presented model,a series of experimentations was performed using the benchmark NSLKDDCup99 Dataset *** proposed model demonstrated its effective results on the applied dataset by offering the maximum accuracy of 99.21%,precision of 98.93%and detection rate of 99.59%.The results assured the betterm

关键词： Big data data fusion deep learning intrusion detection bio-inspired algorithm spark

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A Remark on the Topology at Infinity of a Polynomial Mapping F: Cⁿ→Cⁿ via Intersection Homology

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Advances in Pure Mathematics 2016年第13期6卷 1037-1052页

作者： nguyen Thi Bich thuy UNESP Universidade Estadual Paulista “Júlio de Mesquita Filho” S&atilde o José do Rio Preto Brazil

In [1], Guillaume and Anna Valette associate singular varieties VF to a polynomial mapping . In the case , if the set K0(F) of critical values of F is empty, then F is not proper if and only if the 2-dimensional homology or intersection homology (with any perversity) of VF is not trivial. In [2], the results of [1] are generalized in the case where n≥3, with an additional condition. In this paper, we prove that for a class of non-proper generic dominant polynomial mappings, the results in [1] and [2] hold also for the case that the set K0(F) is not empty.

关键词： Polynomial Mappings Intersection Homology Singularities

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Zen Master Yuan Shao and His Mission to Cochinchina in the Seventeenth Century

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Journal of Philosophy Study 2021年第12期11卷 932-941页

作者： Ngoc phuong nguyen Guangxi University for Nationalities GuangxiChina

When learning about the history of Buddhism in Vietnam,it is impossible not to mention the veteran bonzes of Linji School and Caodong School who traveled to Cochinchina to propagate Buddhism in the 17th century by *** Master Yuan Shao,known as one of the pioneers of Linji Chan School,laid the foundation for the formation and development of this school which still exists *** on previous studies from the perspective of Buddhist cultural exchanges between Cochinchina and China at that time,this article focuses on analyzing the social context,biography and preaching of Yuan Shao,a well-known zen master,in this area in order to present the significance of his contributions to Cochinchina *** research methodology of the article is mainly based on the analysis and comparison of historical documents,records,related *** above basic contents will be presented in an objective and systematic way as well as some raised scholarly debate is still ahead.

关键词： Yuan Shao Cochinchina Buddhism Linji Chan School

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Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： Thu Dang Kim Hai nguyen Thanh Duong nguyen thuy Loi Vu Duc Thu Vu Thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

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A Remark on Polynomial Mappings from Cⁿ to C^n-1 and an Application of the Software Maple in Research

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Applied Mathematics 2016年第15期7卷 1868-1881页

作者： Thi Bich thuy nguyen UNESP Universidade Estadual Paulista “Júlio de Mesquita Filho” S&atilde o José do Rio Preto Brasil

In [1], we construct singular varieties associated to a polynomial mapping where such that if G is a local submersion but is not a fibration, then the 2-dimensional homology and intersection homology (with total perversity) of the variety are not trivial. In [2], the authors prove that if there exists a so-called very good projection with respect to the regular value of a polynomial mapping , then this value is an atypical value of G if and only if the Euler characteristic of the fibers is not constant. This paper provides relations of the results obtained in the articles [1] and [2]. Moreover, we provide some examples to illustrate these relations, using the software Maple to complete the calculations of the examples. We provide some discussions on these relations. This paper is an example for graduate students to apply a software that they study in the graduate program in advanced researches.

关键词： Singularities Intersection Homology Polynomial Mappings Bifurcation

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Novel Time Series Bagging Based Hybrid Models for Predicting Historical Water Levels in the Mekong Delta Region, Vietnam

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1431-1449页

作者： nguyen Thanh Hoan nguyen Van Dung Ho Le Thu Hoa thuy Quynh Nadhir Al-Ansari Tran Van Phong Phan Trong Trinh Dam Duc nguyen Hiep Van Le Hanh Bich Thi nguyen Mahdis Amiri Indra Prakash Binh Thai Pham Institute of Geography Vietnam Academy of Science and TechnologyHanoi10000Viet Nam Department of Civil Environmental and Natural Resources EngineeringLulea University of TechnologyLulea97187Sweden Institute of Geological Sciences Vietnam Academy of Science and Technology(VAST)Dong DaHanoi10000Viet Nam University of Transport Technology Thanh XuanHa Noi10000Viet Nam Department of Watershed&Arid Zone Management Gorgan University of Agricultural Sciences&Natural ResourcesGorgan***Iran DDG(R)Geological Survey of India Gandhinagar382010India

Water level predictions in the river,lake and delta play an important role in flood *** year Mekong River delta of Vietnam is experiencing flood due to heavy monsoon rains and high *** subsidence may also aggravate flooding problems in this ***,accurate predictions of water levels in this region are very important to forewarn the people and authorities for taking timely adequate remedial measures to prevent losses of life and *** are so many methods available to predict the water levels based on historical data but nowadays Machine Learning(ML)methods are considered the best tool for accurate *** this study,we have used surface water level data of 18 water level measurement stations of the Mekong River delta from 2000 to 2018 to build novel time-series Bagging based hybrid ML models namely:Bagging(RF),Bagging(SOM)and Bagging(M5P)to predict historical water levels in the study *** of the Bagging-based hybrid models were compared with Reduced Error Pruning Trees(REPT),which is a benchmark ML *** data of 19 years period was divided into 70:30 ratio for the *** data of the period 1/2000 to 5/2013(which is about 70%of total data)was used for the training and for the period 5/2013 to 12/2018(which is about 30%of total data)was used for testing(validating)the *** of the models was evaluated using standard statistical measures:Coefficient of Determination(R2),Root Mean Square Error(RMSE)and Mean Absolute Error(MAE).Results show that the performance of all the developed models is good(R2>0.9)for the prediction of water levels in the study ***,the Bagging-based hybrid models are slightly better than another model such as ***,these Bagging-based hybrid time series models can be used for predicting water levels at Mekong data.

关键词： Computational techniques bagging water level time series algorithms

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Stem cell-based therapy for human diseases

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.nguyen Trang T.K.Phan Giang H.nguyen phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular Therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&Technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be *** cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative *** are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ *** are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular ***,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical *** mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment

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