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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly j Rivenbark Timothy D phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

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肾小球样血管瘤提示POEMS综合征的诊断

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 59-60页

作者： phillips j.a. Dixon j.E. Richardson j.B 潘敏

POEMS is an acronym for polyneuropathy, organomegaly, endocrinopathy,monoclonal protein, and skin changes. It is a poorly understood paraneoplastic syndrome that stems from an underlying plasma cell dyscrasia. Of the skin changes, the glomeruloid hemangioma is considered to be a specific marker of POEMS syndrome. We describe a 68-year-old man who presented to his dermatologist with multiple hemangiomas, whose biopsy diagnosis of glomeruloid hemangioma resulted in further revaluation and an eventual diagnosis of POEMS.

关键词： POEMS综合征多发性血管瘤肾小球样诊断 POEMS综合症多发性神经病变皮肤改变内分泌病变

Saturation in wavelength-division multiplexing free-space optical communication systems

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Frontiers of Optoelectronics 2019年第2期12卷 197-207页

作者： jeremiah O. BANDELE Malcolm WOOLFSON Andrew j. phillips Department of Electrical Electronics and Computer Engineering College of EngineeringAfe Babalola UniversityAdo-EkitiEkiti StateP.M.B 5454Nigeria Department of Electrical and Electronic Engineering Faculty of EngineeringUniversity of Nottingham University ParkNottinghamNG7 2RDUK

The performance of a wavelength-division multiplexing (WDM) free-space optical (FSO) commu-nication system in a turbulent atmosphere employing optical amplifiers to improve capacity is investigated, in the presence of amplified spontaneous emission noise, scintillation, beam spreading, atmospheric attenuation and interchannel crosstalk. Using on-off keying modulation, Monte Carlo simulation techniques are used to obtain the average bit error rate and system capability due to scintillation and the effect of introducing a power control algorithm (PCA) to the system is investigated. The PCA ensures that at any receiving instant, the same turbulence- free powers are received by all the receiving lenses. The performance of various WDM FSO communication system configurations such as non-amplified systems with an adaptive decision threshold (NOAADT), non- amplified systems with a non-adaptive decision threshold, fixed gain amplified systems with an adaptive decision threshold, fixed gain amplified systems with a non- adaptive decision threshold and saturated gain amplified systems with a non-adaptive decision threshold (SOA- NADT) are investigated. Results obtained show that the SOANADT is superior to the NOAADT and the PCA is only beneficial in amplified systems.

关键词： wavelength-division multiplexing (WDM) free-space optical (FSO) communication crosstalk optical amplifier (OA) gain saturation decision threshold

Decreased bioavailability of aminomethylphosphonic acid(AMPA)in genetically modified corn with activated carbon or calcium montmorillonite clay inclusion in soil

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journal of Environmental Sciences 2021年第2期33卷 131-143页

作者： Sara E.Hearon Meichen Wang Thomas j.McDonald Timothy D.phillips Veterinary Integrative Biosciences Department College of Veterinary Medicine and Biomedical Sciences Texas A&M Uniuersity College StationTx 77845USA Department of Environmental and Occupational Health School of Public Health Texas A&M UniversityCollege Station400 Bizzell St College StationTX 77843USA

The widespread use of pesticides has resulted in detectable residues throughout the environment,sometimes at concentrations well above regulatory ***,the development of safe,effective,field-practical,and economically feasible strategies to mitigate the effects of pesticides is *** is an organophosphorus herbicide that is degraded to aminomethylphosphonic acid(AMPA),a toxic and persistent metabolite that can accumulate in soil and sediment and translocate to *** this study,we investigated the binding efficacy of activated carbon(AC)and calcium montmorillonite(CM)clay to decrease AMPA bioavailability from soil and AMPA translocation to *** isotherms and thermodynamic studies on AC and CM were conducted and showed tight binding(enthalpy values>-20 k j/mol)for AMPA with high capacities(0.25 mol/kg and 0.38 mol/kg,respectively),based on derivations from the Langmuir model.A hydra assay was utilized to indicate toxicity of AMPA and the inclusion of 1%AC and CM both resulted in 90%protection of the hydra(**p≤0.01).Further studies in glyphosate-contaminated soil showed that AC and CM significantly reduced AMPA bioavailability by 53%and 44%,*** in genetically modified(GM)corn showed a conversion of glyphosate to AMPA in roots and sprouts over a 10-day exposure *** of AC and CM reduced AMPA residues in roots and sprouts by 47%-61%.These studies collectively indicate that AC and CM are effective sorbents for AMPA and could be used to reduce AMPA bioavailability from soil and AMPA residues in GM corn plants.

关键词： Glyphosate AMPA Activated carbon Calcium montmorillonite Sorbent

Thin liquid film morphology driven by electro-static field

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Applied Mathematics and Mechanics(English Edition) 2011年第8期32卷 1039-1046页

作者： E.M.TIAN T.P.SVOBODNY j.D.phillips Department of Mathematics and Statistics Wright State University

The development of stationary patterns on a thin polymer surface subject to an electric field is studied by means of the hexagonal-planform weakly nonlinear stability analysis and numerical simulations. The time evolution of the interface between the air and the polymer film on the unbounded spatial domain is described by a thin film equation, incorporating the electric driving force and the surface *** nonlinear interfacial growth includes the amplitude equations and superposition of one-dimensional structures at regular orientations. The pattern selection is driven by the subcritical instability mechanism in which the relative thickness of the polymer film plays a critical role.

关键词： thin film pattern formation electrohydrodynamic instability

Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner

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World journal of Gastroenterology 2012年第26期18卷 3389-3399页

作者： Renee j phillips Karla j Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard School of Molecular and Biomedical Science The University of Adelaide5000 AdelaideAustralia Centre for Cancer Biology SA Pathology 5000 AdelaideAustralia Drug Health Services Royal Prince Alfred Hospital2050 CamperdownAustralia

AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain *** variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell *** expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in ***-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour *** of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and ***:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B *** variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver *** of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture *** of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine *** the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative *** expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative ***:This study demonstrates that OPN plays a significant role in the proliferation of HCC thro

关键词： Osteopontin Hepatocellular carcinoma CD44 antigen Nude mice Xenograft

Progress in TILLING as a tool for functional genomics and improvement of crops

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journal of Integrative Plant Biology 2014年第5期56卷 425-443页

作者： Liang Chen Liugen Hao Martin A. j. Parry Andrew L. phillips Yin-Gang Hu State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy Northwest A&F University Department of Plant Biology and Crop Science Rothamsted Research Institute of Water Saving Agriculture in Arid Regions of China Northwest A&F University

Food security is a global concern and substantial yield increases in crops are required to feed the growing world population. Mutagenesis is an important tool in crop improvement and is free of the regulatory restrictions imposed on genetically modified organisms. Targeting Induced Local Lesions in Genomes（TILLING）, which combines traditional chemical mutagenesis with high‐throughput genome‐wide screening for point mutations in desired genes, offers a powerful way to create novel mutant alleles for both functional genomics and improvement of crops. TILLING is generally applicable to genomes whether small or large, diploid or evenallohexaploid, and shows great potential to address the major challenge of linking sequence information to the function of genes and to modulate key traits for plant breeding. TILLING has been successfully applied in many crop species and recent progress in TILLING is summarized below, especially on the developments in mutation detection technology, application of TILLING in gene functional studies and crop breeding. The potential of TILLING/EcoTILLING for functional genetics and crop improvement is also discussed. Furthermore, a small‐scale forward strategy including backcross and selfing was conducted to release the potential mutant phenotypes masked in M2（or M3） plants.

关键词： Crop breeding functional genomics mutation detection TILLING

The complex of Diplodia species associated with Fraxinus and some other woody hosts in Italy and Portugal

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Fungal Diversity 2014年第4期67卷 143-156页

作者： A.Alves B.T.Linaldeddu A.Deidda B.Scanu A.j.L.phillips Departamento de Biologia CESAMUniversidade de Aveiro3810-193 AveiroPortugal Dipartimento di Agraria Sezione di Patologia vegetale ed EntomologiaUniversitàdegli Studi di Sassarivia E.De Nicola 107100 SassariItaly Centro de Recursos Microbiológicos Departamento de Ciencias da VidaFaculdade de Ciencias e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

Studies on the taxonomy and phylogeny of Diplodia have been hampered by the lack of an ex-type culture linked to the holotype of ***,which is the type of the *** this study a large collection of Diplodia strains,obtained from ash and other woody hosts showing V-shaped cankers and branch dieback,were identified based on morphological characters and DNA sequence data from ITS and EF1-α *** of combined morphological and phylogenetic analyses showed that the Fraxinus isolates from Italy,the Netherlands,Portugal and Spain belong to three distinct species namely Diplodia fraxini,Diplodia mutila and Diplodia subglobosa *** epitype was designated for Diplodia mutila,with associated ex-epitype *** name *** is re-instated and a neotype *** species,Diplodia seriata and Diplodia pseudoseriata were reported for the first time on Fraxinus spp.

关键词： Botryosphaeriaceae Epitype Neotype Phylogeny Systematics Taxonomy

Families in Botryosphaeriales:aphylogenetic,morphological and evolutionary perspective

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Fungal Diversity 2019年第1期94卷 1-22页

作者： Alan j.L.phillips Kevin D.Hyde Artur Alves j.a.-Kui(jack)Liu Faculdade de Ciencias Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Departamento de Biologia CESAMUniversidade de Aveiro3810-193 AveiroPortugal Guizhou Institute of Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China

Botryosphaeriales was introduced in 2006 for a single family *** then the number of families has increased as a result of the transfer of one family(Planistromellaceae)into the order,re-instatement of another(Phyllostictaceae),while others resulted from raising genera to family status(Aplosporellaceae,Endomelanconiopsisaceae,Melanopsaceae,Pseudofusicoccumaceae,Saccharataceae and Septorioideaceae).All these decisions were based solely on phylogenetic analyses of several different *** has been no consensus on which loci are suitable markers at this taxonomic level and in some cases the datasets used to construct the phylogenies were *** this paper,the families of Botryosphaeriales were re-assessed in terms of morphology of the sexual morphs,phylogenetic relationships based on ITS and LSU sequence data,and evolutionary divergence times of lineages in relation to major events in the evolution of their hosts on a geological *** main lineages were resolved in the phylogenetic analyses and these correspond to six groups as defined on morphology of the sexual *** lineages evolved during the Late epoch of the Cretaceous period and survived the catastrophic event that led to the mass extinction of non-avian dinosaurs and a great loss of plant diversity at the end of the Cretaceous *** then diversified during the Paleocene and Eocene epochs of the Paleogene *** six lineages are considered to represent families in ***,six families(Aplosporellaceae,Botryosphaeriaceae,Melanopsaceae,Phyllostictaceae,Planistromellaceae and Saccharataceae)are accepted in Botryosphaeriales,while three(Endomelanconiopsisaceae,Pseudofusicoccumaceae and Septorioideaceae)are reduced to synonymy under existing families.

关键词： Classification Dothideomycetes Evolutionary divergence times Morphology

The molecular profile of nerve repair: humans mirror rodents

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Neural Regeneration Research 2021年第7期16卷 1440-1441页

作者： Matthew B.Wilcox Kristjan R.jessen Tom j.Quick james B.phillips Peripheral Nerve Injury Research Unit Royal National Orthopaedic HospitalStanmoreUK Department of Pharmacology UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK UCL Centre for Nerve Engineering University College LondonLondonUK Department of Cell and Developmental Biology University College LondonLondonUK

Peripheral nerve injuries(PNI)are common following blunt or penetrating trauma and can lead to disability and chronic pain in affected individuals,with limited options available to promote regeneration and functional *** animal models,it is known that the regenerative capacity of the peripheral nervous system(PNS)is heavily dependent upon the remarkable ability of Schwann cells to undergo a phenotypic shift from a supportive/myelinating/maintaining phenotype to one that encourages neural regeneration.

关键词： injuries mirror neural