The molecular profile of nerve repair: humans mirror rodents

作     者：Matthew B.Wilcox Kristjan R.Jessen Tom J.Quick James B.Phillips Matthew B.Wilcox;Kristjan R.Jessen;Tom J.Quick;James B.Phillips

作者机构：Peripheral Nerve Injury Research UnitRoyal National Orthopaedic HospitalStanmoreUK Department of PharmacologyUCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK UCL Centre for Nerve EngineeringUniversity College LondonLondonUK Department of Cell and Developmental BiologyUniversity College LondonLondonUK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第7期

页      面：1440-1441页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：funded by the Royal National Orthopaedic Hospital Charitable Trust England Golf Trust, Engineering Physical Sciences Research Council(EP/R004463/1) a UCL Graduate Research Scholarship(to MBW) 

主　　题：injuries mirror neural 

摘      要：Peripheral nerve injuries(PNI)are common following blunt or penetrating trauma and can lead to disability and chronic pain in affected individuals,with limited options available to promote regeneration and functional *** animal models,it is known that the regenerative capacity of the peripheral nervous system(PNS)is heavily dependent upon the remarkable ability of Schwann cells to undergo a phenotypic shift from a supportive/myelinating/maintaining phenotype to one that encourages neural regeneration.