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journal of Geriatric Cardiology 2012年第2期9卷 197-208页

作者： phillip j tully Robert A Baker Department of Surgery Flinders Medical Centre and Flinders University of South Australia 3 Flinders Drive Bedford Park SA 5042 Australia School of Psychology University of Adelaide Hughes Building North Terrace Adelaide SA 5005 Australia Discipline of Psychiatry The University of Adelaide Eleanor Harold Building Frome Road Adelaide SA 5005 Australia Heart Failure Self Management Program Ambulatory and Primary Healthcare Directorate Hampstead Rehabilitation Centre 207 Hampstead Road Northfield SA 5085 Australia

Research to date indicates that the number of coronary artery bypass graft （CABG） surgery patients affected by depression （i.e., major, minor, dysthymia） approximates between 30% and 40% of all cases. A longstanding empirical interest on psychosocial factors in CABG surgery patients highlights an association with increased risk of morbidity in the short and longer term. Recent evidence suggests that both depression and anxiety increase the risk for mortality and morbidity after CABG surgery independent of medical factors, although the behavioral and biological mechanisms are poorly understood. Though neither depression nor anxiety seem to markedly affect neuropsy- chological dysfunction, depression confers a risk for incident delirium. Following a comprehensive overview of recent literature, practical advice is described for clinicians taking into consideration possible screening aids to improve recognition of anxiety and depression among CABG surgery patients. An overview of contemporary interventions and randomized, controlled trials are described, along with suggestions for future CABG surgery research.

关键词： Depression Depressive disorder Coronary artery bypass Coronary artery disease Antidepressive agents Anxiety

The importance of depression and alcohol use in coronary artery bypass graft surgery patients：risk factors for delirium and poorer quality of life

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journal of Geriatric Cardiology 2016年第1期13卷 51-57页

作者： joanne M Humphreys Linley A Denson Robert A Baker phillip j tully School of Psychology Faculty of Health Sciences University of Adelaide Australia Cardiac Surgery Research Department of Surgery School of Medicine Flinders University of South Australia Australia University of Bordeaux Department of Neuroepidemiology Bordeaux France INSERM Department of Neuroepidemiology Bordeaux France Freemasons Foundation Centre for Men's Health Discipline of Medicine School of Medicine University of Adelaide Australia

ObjectiveToinvestigate whether depression, anxiety and stress increase the risk for delirium and poor quality of life （QOL） after co-ronary artery bypass （CABG） *** total of 180 CABG patients （mean age of 63.5 ± 10.1 years, 82.2% males） completed baseline and postoperative self-report questionnaires to assess distress and QOL. Incident delirium was diagnosed postoperatively with a structured clinical interview and patients were monitored every day post-operatively for confusion and disturbance in *** Delirium developed in 63 persons （35% of sample）. After adjustment for covariates, delirium was significantly associated with depression [odds ratio （OR）： 1.08; 95% confidence interval （CI）： 1.03-1.13,P = 0.003], anxiety （OR： 1.07; 95% CI： 1.02-1.13,P= 0.01） and stress （OR： 1.05; 95% CI： 1.00-1.09,P= 0.03）. Preoperative depression scores were associated with poorer QOL including bodily pain （β =-0.39,P = 0.013）, vitality （β=-0.32,P = 0.020）, social functioning （β=-0.51,P≤0.001）, emotional role function （β=-0.44,P = 0.003） and general health （β=-0.33,P = 0.038）. Among the covariates, harmful levels of alcohol use was consistently associated with poorer *** Depression and harmful levels of alcohol use were consistently associated with poorer QOL whereas depression, anxiety and stress were associated with delirium risk. These findings point to further research examining depression and harmful levels of alcohol use in coronary heart disease populations undergoing coronary revascularization.

关键词： Coronary artery bypass grafts Coronary heart disease Delirium Depression Quality of life

Change in quality of life after transcatheter aortic valve implantation and aortic valve replacement surgery in Australian patients aged ≥ 75 years： the effects of EuroSCORE and patient operability

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journal of Geriatric Cardiology 2015年第1期12卷 30-36页

作者： phillip j. tully Prakash Roshan Greg D Rice Ajay Sinhal jayme S Bennetts Robert A Baker Cardiac Surgery Research Department of Surgery School of Medicine Flinders University of South Australia Bedford Park 5042 Australia Freemasons Foundation Centre for Men 's Health Discipline of Medicine School of Medicine University of Adelaide North Terrace Adelaide 5005 Australia brd Park 5042 Australia Department of Cardiac and Thoracic Surgery Flinders Medical Centre Level 6 Flinders Private Hospital Bedford Park 5042 Australia

Objective To determine the extent to which differences in generic quality of life （QOL） between transcatheter aortic valve implanta- tion （TAVI） and surgical aortic valve replacement （AVR） patients explained by EuroSCORE and heart-team operability assessment. Methods A total of 146 high-risk patients with EuroSCORE 〉 6 and aged 〉 75 years underwent TAVI （n = 80） or aortic valve replacement （n = 66） between February 2010 and july 2013. A total of 75 patients also completed preoperative and six month SF-12 QOL measures. Analyses examined incident major morbidity, compared six month QOL between groups adjusted for EUroSCORE and operability, and quantified rates of clinically significant QOL improvement and deterioration. Results The AVR group required longer ventilation （〉 24 h）（TAVI 5.0% vs. AVR 20.6%, P = 0.004） and more units of red blood cells [TAVI 0 （0-1） vs. AVR 2 （0-3）, P = 0.01]. New renal failure was higher in TAVI （TAVI 5.0% vs. AVR 0%, P = 0.06）. TAVI patients reported significantly lower vitality （P = 0.01） by comparison to AVR patients, however these findings were no longer significant after adjustment for operability. In both procedures, clinically significant QOL improvement was common [range 25.0% （general health） - 62.9% （physical role）] whereas deterioration in QOL occurred less frequently [range 9.3% （physical role） - 33.3% （mental health）]. Conclusions Clinically significant improvement and deterioration in QOL was evident at six months in high risk elderly aortic valve replacement patients. Overall QOL did not differ between TAVI and AVR once operability was taken into consideration.

关键词： Aortic valve replacement Cardiac surgery EuroSCORE Transcatheter aortic valve implantation Quality of life

Absence of Na^+/sugar cotransport activity in Barrett's metaplasia

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World journal of Gastroenterology 2008年第9期14卷 1365-1369页

作者： Lisa j Murray Owen tully David S Rudolph Marysue Whitby Mary C Valenzano Giancarlo Mercogliano james j Thornton james M Mullin Lankenau Institute for Medical Research WynnewoodPAUnited States Saint Joseph's UniversityDepartment of BiologyPhiladelphiaPA 19096United States Lankenau Hospital Department of Medicine WynnewoodPA 19096United States Lankenau Hospital Department of MedicineWynnewoodPA 19096 United States Lankenau Institute for Medical Research WynnewoodPAUnited States Lankeanu Hospital Division of GastroenterologyWynnewood PA 19096United States Lankeanu Hospital Division of GastroenterologyWynnewoodPA 19096United States

AIM:To evaluate the presence of Na+-dependent, active, sugar transport in Barrett's epithelia as an intestinal biomarker, based on the well-documented, morphological intestinal phenotype of Barrett's esophagus (BE). METHODS: We examined uptake of the nonmeta- bolizable glucose analogue, alpha-methyl-D-glucoside (AMG), a substrate for the entire sodium glucose cotransporter (SGLT) family of transport proteins. During upper endoscopy, patients with BE or with uncomplicated gastroesophageal reflux disease (GERD) allowed for duodenal, gastric fundic, and esophageal mucosal biopsies to be taken. Biopsies were incubated in bicarbonate-buffered saline (KRB) containing 0.1 mmol/L 14C-AMG for 60 min at 20℃. Characterized by abundant SGLT, duodenum served as a positive control while gastric fundus and normal esophagus, known to lack SGLT, served as negative controls. RESULTS: Duodenal biopsies accumulated 249.84 ± 35.49 (SEM) picomoles AMG/μg DNA (n = 12), gastric fundus biopsies 36.20 ± 6.62 (n = 12), normal esophagus 12.10 ± 0.59 (n = 3) and Barrett's metaplasia 29.79 ± 5.77 (n = 8). There was a statistical difference (P < 0.01) between biopsies from duodenum and each other biopsy site but there was no statistically significant difference between normal esophagus and BE biopsies. 0.5 mmol/L phlorizin (PZ) inhibited AMG uptake into duodenal mucosa by over 89%, but had nosignificant effect on AMG uptake into gastric fundus, normal esophagus, or Barrett's tissue. In the absence of Na+ (all Na+ salts replaced by Li+ salts), AMG uptake in duodenum was decreased by over 90%, while uptake into gastric, esophageal or Barrett's tissue was statistically unaffected. CONCLUSION: Despite the intestinal enterocyte phenotype of BE, Na+-dependent, sugar transport activity is not present in these cells.

关键词： Barrett's esophagus Cancer Biomarker Sodium glucose cotransporters Glucose transport Alphamethyl-D-glucoside Phlorizin Esophagus Metaplasia

Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors

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World journal of Gastroenterology 2012年第22期18卷 2793-2797页

作者： Christopher Farrell Melissa Morgan Owen tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano james j Thornton Mary Carmen Valenzano james M Mullin Division of Gastroenterology Lankenau Hospital Wynnewood PA 19096 United States Lankenau Institute for Medical Research Wynnewood PA 19096 United States

AIM： To determine if the observed paracellular sucrose leak in Barrett＇s esophagus patients is due to their pro- ton pump inhibitor （PPI） use. METHODS： The in vivo sucrose permeability test was administered to healthy controls, to Barrett＇s patients and to non-Barrett＇s patients on continuous PPI thera- py. Degree of leak was tested for correlation with pres- ence of Barrett＇s, use of PPIs, and length of Barrett＇s segment and duration of PPI use. RESULTS： Barrett＇s patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was ob- served in Barrett＇s patients who ceased PPI use for 7 *** initial introduction of PPI use （in a PPI-na＇ive population） results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spon- taneous decline in leak. The sucrose leak observed in Barrett＇s patients showed no correlation to the amount of Barrett＇s tissue present in the esophagus. CONCLUSION： Although future research is needed to determine the degree of paracellular leak in actual Barrett＇s mucosa, the relatively high degree of leak ob- served with in vivo sucrose permeability measurement of Barrett＇s patients reflects their PPI use and not their Barrett＇s tissue perse.

关键词： Barrett's esophagus Sucrose Tight junc-tion Paracellular, Omeprazole Proton pump inhibitor Transepithelial

Prevalence and clinical risk factors for esophageal candidiasis in non-human immunodeficiency virus patients:A multicenter retrospective case-control study

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World journal of Gastrointestinal Endoscopy 2023年第6期15卷 480-490页

作者： Alexandra V Kimchy AkramⅠAhmad Lindsey tully Connor Lester Kavya Sanghavi joseph j jennings Department of Internal Medicine MedStar Georgetown University HospitalWashingtonDC 20007United States Department of Internal Medicine MedStar Washington Hospital CenterWashingtonDC 20007United States Department of Internal Medicine Georgetown University School of MedicineWashingtonDC 20007United States Department of Biostatistics and Biomedical Informatics MedStar Research InstituteHyattsvilleMD 20781United States Department of Gastroenterology MedStar Georgetown University HospitalWashingtonDC 20007United States

BACKGROUND Although esophageal candidiasis(EC)may manifest in immunocompetent individuals,there is a lack of consensus in the current literature about predisposing conditions that increase the risk of *** To determine the prevalence of EC in patients without human immunodeficiency virus(HIV)and identify risk factors for *** We retrospectively reviewed inpatient and outpatient encounters from 5 regional hospitals within the United States(US)from 2015 to *** Classification of Diseases,Ninth and Tenth Revisions were used to identify patients with endoscopic biopsies of the esophagus and *** with HIV were *** with EC were compared to age,gender,and encounter-matched controls without *** demographics,symptoms,diagnoses,medications,and laboratory data were obtained from chart *** in medians for continuous variables were compared using the Kruskal-Wallis test and categorical variables using chi-square *** logistic regression was used to identify independent risk factors for EC,after adjusting for potential confounding *** Of the 1969 patients who had endoscopic biopsies of the esophagus performed from 2015 to 2020,295 patients had the diagnosis of EC.177 of 1969 patients(8.99%)had pathology confirming the diagnosis of EC and were included in the study for data collection and further *** comparison to controls,patients with EC had significantly higher rates of gastroesophageal reflux disease(40.10%vs 27.50%;P=0.006),prior organ transplant(10.70%vs 2%;P<0.001),immunosuppressive medication(18.10%vs 8.10%;P=0.002),proton pump inhibitor(48%vs 30%;P<0.001),corticosteroid(35%vs 17%;P<0.001),Tylenol(25.40%vs 16.20%;P=0.019),and aspirin use(39%vs 27.50%;P=0.013).On multivariable logistic regression analysis,patients with a prior organ transplant had increased odds of EC(OR=5.81;P=0.009),as did patients taking a proton pump inhibitor(OR=1.66;P=0.03)or corticost

关键词： Candidiasis Esophagus Endoscopy Proton pump inhibitors Transplants Glucocorticoids

Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies

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journal of Sport and Health Science 2021年第3期10卷 290-295页

作者： Pinar Soysal Christopher Hurst jacopo Demurtas joseph Firth Reuben Howden Lin Yang Mark A.tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith Department of Geriatric Medicine Bezmialem Vakif UniversityIstanbul 34093Turkey Institute of Neuroscience Newcastle UniversityNewcastle upon Tyne NE17RUUK Primary Care Department Azienda Usl Toscana Sud EstGrosseto 52100Italy Division of Psychology and Mental Health University of ManchesterManchester M139PLUK College of Health&Human Services University of North Carolina at CharlotteLong BeachCA 90815USA Department of Cancer Epidemiology and Prevention Research Alberta Health ServicesHoly Cross CentreAlbertaT5J 3E4Canada School of Health Sciences Institute of Mental Health SciencesUlster UniversityNewtownabbey BT151EDUK Research and Development Unit Sant Joan de Deu Health ParkCIBER of Mental Health(CIBERSAM)Barcelona 08003Spain ICREA Pg.Lluis Companys 23Barcelona 08010Spain The Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust King’s Lynn PE304ETUK Faculty of Sport Sciences University of MurciaMurcia 30100Spain Institute for Evidence in Medicine Medical CenterUniversity of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79085Germany Neuroscience Institute Aging BranchNational Research CouncilPadua 35122Italy The Cambridge Centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridge CB11PTUK

Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbrella review of systematic reviews with meta-analyses of observational studies was *** assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess *** graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 ***,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing *** associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as *** further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.

关键词： Handgrip strength Health outcomes Meta-analysis Umbrella review

LOW ENERGY INELASTIC COLLISION PROCESSES:SURFACE REACTIONS IN SPACE

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Nuclear Science and Techniques 1990年第Z1期1卷 40-45页

作者： N.H.Tolk R.G.Albridge A.V.Barnes M.A.Albert C.N.Sun D.P.Russell j.C.tully P.Nordlander P.M.Savundararaj D.Harper j.Benit Center for Atomic and Molecular Physics at Surfaces Department of Physics and Astronomy Vanderbilt University Nashville TN. 37235 U.S.A. AT & T Bell Laboratories Murray HillN.J. Rutgers University New Brunswick N.J.

The electonic transition rates in low-energy ion-surface interaction were studied by emplaying tilted-foil and grazing incidence geometries, and the linear and circular polarizations of light emitted were observed, re... 详细信息

关键词： Desorption Electronic transition (DIET) Grazing incidence Tilted-foil nentralization

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新布伦兹维克普莱参特山的斑岩钨矿带

世界地质 1982年第1期 71-81页

作者： I.S.Parish j.V.tully 钟汉

自1967年以来,索利凡采矿集团(The Sullivan Mining Group)就已经在勘探新布伦兹维克(New Brunswick)南部普莱参特山(Mount PLe-asant)地区的矿床了,索利凡的地质学家们已经编录了长达60英里以上的钴探岩芯,填制了5英里以上的地下坑道图... 详细信息

自1967年以来,索利凡采矿集团(The Sullivan Mining Group)就已经在勘探新布伦兹维克(New Brunswick)南部普莱参特山(Mount PLe-asant)地区的矿床了,索利凡的地质学家们已经编录了长达60英里以上的钴探岩芯,填制了5英里以上的地下坑道图,并且研究了大量地表露头。已经确定了几个矿化带,并且圈定了两个品位较高的斑岩钨矿体,在这些矿体中钨锰铁矿呈浸染状的斑点和直径达1英寸半的颗粒产出,含矿岩石是一个侵入于密西西北期石英—长石斑岩中的角砾状的流纹斑岩,含矿岩石本身又被一个称为过渡岩的酸性、斑岩侵入,其下伏岩石是一个微晶花岗岩。矿化带、含矿岩石、过渡岩和微晶花岗岩被认为都是来自同一岩浆,并且代表着那个岩浆连续演化的不同部分。

关键词：斑岩接触带侵入岩层凝灰岩钨矿岩石长石架状硅酸盐矿物微晶花岗岩普莱布伦

New Insights into the Action of Gravitons in Spiral Galaxies

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journal of High Energy Physics, Gravitation and Cosmology 2023年第4期9卷 968-983页

作者： Firmin j. Oliveira East Asian Observatory James Clerk Maxwell Submillimetre Telescope Hilo USA

New details of the action of gravitons in spiral galaxies are described. The effect of the graviton energy loss is hypothesized to be coupled to the baryon mass in the galaxy. From this relation, it follows that the baryonic tully-Fisher relation is applicable to not just the final velocity of the galaxy but also to the rotational velocity at each radial position. In addition, a quadratic equation for the baryonic mass distribution is derived from the equation of motion. These results are demonstrated by making fits to galaxy rotation curves using a mass to light ratio model as well as the quadratic model for the mass distribution.

关键词： Gravitons Gravitational Redshift Graviton Coupling Coefficient Spiral Galaxies Mass to Light Ratio