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A paean to Arnie Levine on the occasion of his 80th birthday

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Journal of Molecular Cell Biology 2019年第7期11卷 544-545页

作者： philip W.Hinds Department of Developmental Molecular and Chemical BiologyTufts University School of MedicineBostonMA 02111USA

It is an honor and a privilege to have received PhD-level training in the molecular basis of tumorigenesis from Amie Levine and to have received advice and support from him as a colleague in the decades that followed.I and numerous others who have been directly and indirectly intellectually nurtured by Arnie owe much of our success in biomedical research to his selfless sharing of his keen scientific insight,and the field of cancer therapeutics is enriched overall by the contributions his lab and 'progeny' have made over the course of his career.I first met Arnie in the fall of 1985 as a first-year PhD candidate at Princeton.

关键词： honor training Princeton

Empirical Wavelet Transform Based Method for Identification and Analysis of Sub-synchronous Oscillation Modes Using PMU Data

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 34-40页

作者： Joice G.philip Jaesung Jung Ahmet Onen the Department of Energy Systems Research Ajou UniversitySuwonSouth Korea the Department of Electrical and Electronic Engineering Abdullah Gul UniversityKayseri38080Turkey the Department of Electrical and Computer Engineering College of EngineeringSultan Qaboos UniversityAl-KhoudMuscatOman

This paper proposes an empirical wavelet transform(EWT)based method for identification and analysis of sub-synchronous oscillation(SSO)modes in the power system using phasor measurement unit(PMU)*** phasors from PMUs are preprocessed to check for the presence of *** the presence is established,the signal is decomposed using EWT and the parameters of the mono-components are estimated through Yoshida *** superiority of the proposed method is tested using test signals with known parameters and simulated using actual SSO signals from the Hami Power Grid in Northwest *** show the effectiveness of the proposed EWT-Yoshida method in detecting the SSO and estimating its parameters.

关键词： Empirical wavelet transform(EWT) sub-synchronous oscillation Prony-based method Yoshida algorithm variational mode decomposition phasor measurement unit(PMU)

Trace metals in barnacles:the significance of trophic transfer

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Science China(Life Sciences) 2005年第z1期48卷 110-117页

作者： philip S. RAINBOW Department of Zoology the Natural History Museum Cromwell Road London SW7 5BD London UK

Barnacles have very high accumulated trace metal body concentrations that vary with local trace metal bioavailabilities and represent integrated measures of the supply of bioavailable metals. Pioneering work in Chinese waters in Hong Kong highlighted the potential value of barnacles (particularly Balanus amphitrite) as trace metal biomonitors in coastal waters,identifying differences in local trace metal bioavailabilities over space and time. Work in Hong Kong has also shown that although barnacles have very high rates of trace metal uptake from solution, they also have very high trace metal assimilation efficiencies from the diet. High assimilation efficiencies coupled with high ingestion rates ensure that trophic uptake is by far the dominant trace metal uptake route in barnacles, as verified for cadmium and zinc. Kinetic modelling has shown that low efflux rate constants and high uptake rates from the diet combine to bring about accumulated trace metal concentrations in barnacles that are amongst the highest known in marine invertebrates.

关键词： barnacles, trophic transfer, assimilation efficiency, trace metals.

Rapid conversion of cellulose to 5-hydroxymethylfurfural using single and combined metal chloride catalysts in ionic liquid

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燃料化学学报 2013年第2期41卷 214-222页

作者： Hussein Abou-Yousef El Barbary Hassan philip Steele Department of Forest Products Mississippi State University Cellulose & Paper Department National Research CenterDokkiCairoEgypt

Direct conversion of cellulose into 5-hydroxymethylfurfural(HMF) was performed by using single or combined metal chloride catalysts in 1-ethyl-3-methylimidazolium chloride(Cl) ionic *** study demonstrated formation of 2-furyl hydroxymethyl ketone(FHMK),and furfural(FF) simultaneously with the formation of *** reaction parameters were addressed to optimize yields of furan derivatives produced from cellulose by varying reaction temperature,time,and the type of metal chloride *** reaction by using FeCl3 resulted in 59.9% total yield of furan derivatives(HMF,FHMK,and FF) from ***3 was the most effective catalyst for selective conversion of cellulose into HMF(35.6%) with less concentrations of FHMK,and *** the yields of furans produced from cellulose could be achieved via reactions catalyzed by different combinations of two metal *** optimization was carried out to produce total furans yield 75.9% by using FeCl3/CuCl2 ***3/CuCl2 was the most selective combination to convert cellulose into HMF(39.9%) with total yield(63.8%) of furans produced from the *** temperature and time of the catalytic reaction played an important role in cellulose conversion,and the yields of *** the reaction temperature could enhance the cellulose conversion and HMF yield for short reaction time intervals(5~20 min).

关键词：化学动力学燃料化学理论 EMIM HMF

Hepatic, pancreatic and renal manifestations of a ciliopathy

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 394-395页

作者： Sreelakshmi Kotha philip Berry Department of Gastroenterology Guy’s and St Thomas’Foundation TrustLondonUK

Hepatorenal fibrocystic diseases are inherited disorders,characterized by developmental abnormalities and fibrocystic degeneration of the portobiliary system and kidneys^([1]).They are part of a larger group of disorders referred to as"ciliopathies"which affect 1 in 1000 *** kidney disease is the most common kidney manifestation,while others include nephronophthisis,glomerulocystic disease and cystic *** manifesta-tions include Caroli’s disease,congenital hepatic fibrosis and poly-cystic liver disease.

关键词： Hepatic kidney degeneration

IJABE SWAT Special Issue:Innovative modeling solutions for water resource problems

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International Journal of Agricultural and Biological Engineering 2015年第3期8卷 1-8页

作者： philip W.Gassman Wang Yingkuan Center for Agricultural and Rural Development Iowa State UniversityAmesIA50011-1070United States Chinese Academy of Agricultural Engineering Beijing100125China

The Soil and Water Assessment Tool(SWAT)ecohydrological model is used worldwide to evaluate hydrological and water quality concerns across a plethora of watershed scales and environmental *** ten studies featured in this special issue confirm the global utility of SWAT,which include applications of the model in Brazil,China,Ethiopia and the United *** range of applications reported in the special issue mirror broader trends in the extensive existing SWAT literature and provide valuable insights regarding input data sensitivity,testing,scenario analysis,software development and other important SWAT-related *** summaries of these ten studies in this SWAT special issue are provided,highlighting key procedures and findings for each application.A brief description of SWAT structure and historical development is also given including a complete listing of key documentation and enhancements for every major release of the model between the early 1990s to the present *** overview will serve as a guide to better reading and understanding of the ten research papers in this SWAT special issue of IJABE.

关键词： Soil and Water Assessment Tool(SWAT) SWAT special issue modeling solutions water resource watershed

Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection

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Protein & Cell 2010年第6期1卷 514-519页

作者： Chihiro Motozono philip Mwimanzi Takamasa Ueno Center for AIDS Research Kumamoto UniversityKumamoto 860-0811Japan

Untreated human immunodeficiency virus(HIV)infections usually lead to death from AIDS,although the rate of the disease progression varies widely among *** cytotoxic T lymphocyte(CTL)response,which is restricted by highly polymorphic MHC class I alleles,plays a central role in controlling HIV *** is now recognized that the antiviral efficacy of CTLs at the single cell level is dependent on their antigen specificity and is important in determining the quality of host response to viruses so that the individual will remain ***,because of the extreme mutational plasticity of HIV,HIV-specific CTL responses are continuously and dynamically *** order to rationally design an effective vaccine,the questions as to what constitutes an effective antiviral CTL response and what characterizes a potent antigenic peptide to induce such responses are becoming highlighted as needing to be answered.

关键词： HIV/AIDS peptide-MHC complex HLA class I cytotoxic T lymphocyte immune escape

Nonlinear Capillary-Gravity Waves Produced by a Vertically Oscillating Plate

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China Ocean Engineering 1998年第2期13卷 147-162页

作者： philip L.-F.LIU Professor Cornell UniversityIthacaNY14853U.S.A.

The nonlinear capillary-gravity wave produced by a vertically oscillating plate, in which the contact-angle model is considered, is studied by use of the Boundary Integral Equation Method (BIEM). The present numerical experiment shows that the code is robust and efficient for modeling the generation and propagation of capillary-gravity waves. It is found that the wave heights of stationary periodic nonlinear waves radiated away from the plate are dependent on the parameters involved in the contact-angle model. The effect of the contact-angle hysteresis and the nonlinearity of capillary-gravity waves on the wave profile is discussed in the paper.

关键词： Boundary Integral Equation Method nonlinear capillary-gravity wave wavemaker

MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury

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Neural Regeneration Research 2017年第11期12卷 1749-1761页

作者： Bridget Martinez philip V.Peplow Department of Molecular and Cellular Biology University of California Department of Anatomy University of Otago

Traumatic brain injury （TBI） is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days after the trauma, and provide valuable therapeutic targets to prevent further neuronal degeneration. At the present time, there is no effective treatment for TBI due, in part, to the widespread impact of numerous complex secondary biochemical and pathophysiological events occurring at different time points following the initial injury. MicroRNAs control a range of physiological and pathological functions such as develop- ment, differentiation, apoptosis and metabolism, and may serve as potential targets for progress assessment and intervention against TBI to mitigate secondary damage to the brain. This has implications regarding improving the diagnostic accuracy of brain impairment and long-term outcomes as well as potential novel treatments. Recent human studies have identified specific microRNAs in serum/plasma （miR-425-p, -21, -93, -191 and -499） and cerebro-spinal fluid （CSF）（miR-328, -362-3p, -451, -486a） as possible indicators of the diagnosis, severity, and prognosis of TBI. Experimental animal studies have examined specific microRNAs as biomarkers and therapeutic targets for moderate and mild TBI （e.g., miR-21, miR-23b）. MicroRNA profil- ing was altered by voluntary exercise. Differences in basal microRNA expression in the brain of adult and aged animals and alterations in response to TBI （e.g., miR-21） have also been reported. Further large-scale studies with TBI patients are needed to provide more information on the changes in microRNA profiles in different age groups （children, adults, and elderly）.

关键词： traumatic brain injury microRNAs diagnostic markers therapeutic targets: humans animal models