Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection

作     者：Chihiro Motozono Philip Mwimanzi Takamasa Ueno 

作者机构：Center for AIDS ResearchKumamoto UniversityKumamoto 860-0811Japan 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2010年第1卷第6期

页      面：514-519页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This research was supported in part by a grant-in-aid for scientific research from the Ministry of Education Science Sports and Culture of Japan by a grant from Human Science Foundation and by a grantin-aid for AIDS research from the Ministry of Health Labor and Welfare of Japan 

主　　题：HIV/AIDS peptide-MHC complex HLA class I cytotoxic T lymphocyte immune escape 

摘      要：Untreated human immunodeficiency virus(HIV)infections usually lead to death from AIDS,although the rate of the disease progression varies widely among *** cytotoxic T lymphocyte(CTL)response,which is restricted by highly polymorphic MHC class I alleles,plays a central role in controlling HIV *** is now recognized that the antiviral efficacy of CTLs at the single cell level is dependent on their antigen specificity and is important in determining the quality of host response to viruses so that the individual will remain ***,because of the extreme mutational plasticity of HIV,HIV-specific CTL responses are continuously and dynamically *** order to rationally design an effective vaccine,the questions as to what constitutes an effective antiviral CTL response and what characterizes a potent antigenic peptide to induce such responses are becoming highlighted as needing to be answered.