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低碳源条件下利用侧流活性污泥水解技术强化生物脱氮除磷

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给水排水 2013年第1期39卷 53-57页

作者：刘智晓 Gert petersen 张伟 Alexander Grossmann 詹卫东首创爱华天津市政环境工程有限公司天津300191 EnviDan A/S 2770 KastrupDenmark Lund Institute of Technology Lund 北京首创股份有限公司北京100028

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、p浓度比值的高低,直接制约了N、p的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部... 详细信息

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、p浓度比值的高低,直接制约了N、p的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部商业碳源会导致高昂的运行费用及其他运行问题。近十年来,充分挖掘优先利用污水处理厂内碳源技术在国外得到发展和应用。介绍了回流活性污泥(rAS)进行水解补充碳源的技术优势及工艺选择,就采用rAS侧流水解发酵在国内某厂实施技术示范项目进行了介绍,以期为国内在开发活性污泥可持续性利用技术方面提供借鉴。

关键词：活性污泥污泥水解可快速降解有机物挥发性脂肪酸生物脱氮除磷内碳源

Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： Sofie Ingdam Halkjaer Bobby Lo Frederik Cold Alice Hojer Christensen Savanne Holster Julia Konig robert Jan Brummer Olga C Aroniadis perttu Lahtinen Tom Holvoet Lise Lotte Gluud Andreas Munk petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Copenhagen IBD Center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions research Centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of Clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of Clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BACKGrOUND Irritable bowel syndrome(IBS)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched Cochrane Central,MEDLINE,EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials(rCTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBS symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(rr)and corresponding 95%CI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%CI for continuous *** Cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight rCTs(484 participants)were included in the *** resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo(rr 1.19,95%CI:0.68-2.10).Adverse events were r.ported in 97 participants in the FMT group and in 45 participants in the placebo group(rr 1.17,95%CI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(rr 0.42,95%CI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBS patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%CI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis Systematic review

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Linux参考大全第2版

percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions

1999年

作者：（美）（r.彼得森）（richard petersen）希望图书创作室译

本书分六大部分26章，介绍了四个主要的Linux主题：Internet应用，Unix功能，系统管理以及编程。本书第一部分介绍Linux的安装、启动，以及Linux所包含的大量可下载的窗口管理器、工作平台的基本操作和概念。第二部分为用户在 Linux上... 详细信息

ISBN: (纸本)7900024026

本书分六大部分26章，介绍了四个主要的Linux主题：Internet应用，Unix功能，系统管理以及编程。本书第一部分介绍Linux的安装、启动，以及Linux所包含的大量可下载的窗口管理器、工作平台的基本操作和概念。第二部分为用户在 Linux上工作，教授了一套基本的Linux操作技术。第三部分详细地讨论了Linux 系统在Internet上的许多应用，介绍了如何通过Linux自动安装、使用Internet浏览器、服务器，以及诸多的Internet应用程序和Internet工具，还讨论了使用所述工具、应用程序进行网络应用。第四和第五部分介绍了Linux作为一种Unix操作系统的特点，讨论了Unix过滤器、She11编程、标准编辑器及其使用技巧。第六部分介绍了系统、网络和XWindows管理，以及Linux编程。这一部分前段特别强调了特殊系统管理工具的使用，包括如何通过Linux平台应用这些工具设置网络，配置文件、管理器、应用程序等。后段第23章以后讨论了Linux编程。本书是真正意义上的四书合一：一本Internet书、一本Unix书、一本系统管理的书和一本Linux编程的书，由此构成了本书――一本完整的Linux参考书。本书可供Linux用户以及所有微机用户使用、参考。

关键词： UNIX操作系统

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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World Journal of Gastrointestinal Endoscopy 2022年第8期14卷 487-494页

作者： Jad p AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T petersen ryan J Law Mark D Topazian Vinay Chandrasekhara Department of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States

BACKGrOUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(pD)access may be used when conventional endoscopic retrograde cholangiopancreatogr.phy(Er.p)techniques *** use of a percutaneous transluminal angioplasty balloon(pTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)pD access and to dilate high-grade pancreatic *** To describe the technique,efficacy,and safety of pTABs for EUS-guided pD *** patients who underwent EUS with use of a pTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply *** included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch *** primary outcome was technical *** outcomes included incidence of adverse events(AEs)and need for early *** A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)*** AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for.post-procedural *** patients required early *** EUS-guided use of pTABs for.pD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional Er.p cannulation fails.

关键词： Dilating balloon pancreatic duct intervention Chronic pancreatitis Anastomotic stricture

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维生素E和多奈哌齐治疗轻度认知功能障碍

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 5-6页

作者： petersen r.C. Thomas r.G. Grundman M. 郭俊 Alzheimer’ s Disease research Center Mayo Clinic College of Medicine 200 First St. SW R ochester MN 55905 United States Dr.

BACKGrOUND: Mild cognitive impairment is a transitional state between the cog nitive changes of normal aging and early Alzheimer’ s disease. METHODS: In a do uble- blind study, we evaluated subjects with the amnestic subtype of mild cogn itive impairment. Subjects were randomly assigned to receive 2000 IU of vitamin E daily, 10 mg of donepezil daily, or.placebo for three years. The primary outco me was clinically possible or.probable Alzheimer’ s disease; secondary outcomes were cognition and function. rESULTS: A total of 769 subjects were enrolled, an d possible or.probable Alzheimer’ s disease developed in 212. The overall rate of progression from mild cognitive impairment to Alzheimer’ s disease was 16 pe rcent per year. As compared with the placebo group, there were no significant di fferences in the probability of progression to Alzheimer’ s disease in the vita min E group (hazard ratio, 1.02; 95 percent confidence interval, 0.74 to 1.41; p =0.91) or the donepezil group (hazard ratio, 0.80; 95 percent confidence interva l, 0.57 to 1.13; p=0.42) during the three years of treatment. prespecified analy ses of the treatment effects at 6- month intervals showed that as compared with the placebo group, the donepezil group had a reduced likelihood of progression to Alzheimer’ s disease during the first 12 months of the study (p=0.04), a fin ding supported by the secondary outcome measures. Among carriers of one or more apolipoprotein E e 4 alleles, the benefit of donepezil was evident throughout th e three- year follow- up. There were no significant differences in the rate of progression to Alzheimer’ s disease between the vitamin E and placebo groups a t any point, either among all patients or among apolipoprotein E e 4 carriers. C ONCLUSIONS: Vitamin E had no benefit in patients with mild cognitive impairment. Although donepezil ther.py was associated with a lower rate of progression to A lzheimer’ s disease during the first 12 months of treatment, the rate of progr

关键词：多奈哌齐阿尔茨海默病认知功能进展率安慰剂载脂蛋白双盲研究携带者老化性随机分配

白介素-33至白介素-13信号级联调节小鼠胃组织上皮化生

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英国医学杂志中文版 2018年第7期21卷 418-418页

作者： Christine p petersen Anne r Meyer Carlo De Salvo Eunyoung Choi Cameron Schlegel Alec petersen Amy C Engevik Nr.pesh prasad Shawn E Levy r Stokes peebles Theresa T pizarro James r Goldenring 李佳宁(译) 吴东(校) 不详北京协和医院消化科

目的选择性活化巨噬细胞（Alternativelyactivated macr.phages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SpEM）过程相关。然而，诱导SpEM的确切机制及关键介质尚不明确。研究设计为确定这一... 详细信息

目的选择性活化巨噬细胞（Alternativelyactivated macr.phages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SpEM）过程相关。然而，诱导SpEM的确切机制及关键介质尚不明确。研究设计为确定这一过程中的关键基因，分离胃部SpEM小鼠（DMp-777处理）及高级胃部SpEM小鼠（L635处理）胃体的巨噬细胞进行rNA测序。评估白介素．33、白介素-33受体（ST2）及白介素-13基因敲除小鼠，经L635处理急性壁细胞缺失后对上皮细胞化生过程的影响。结果胃部上皮化生相关性巨噬细胞中可鉴定出M2极化亚群。高级胃部SpEM小鼠巨噬细胞中自介素-33的表达显著上调。L635可在野生型小鼠胃组织中诱导上皮化生，但在白介素-33及白介素．33受体敲除鼠中未观察到这一现象。尽管在诱导上皮化生过程中不需白介素．5及白介素-9，白介素-13基因敲除小鼠无法在L635诱导下发生上皮化生。对白介素-33受体基因敲除小鼠应用白介素-13，可重新诱导急性壁细胞缺失后的上皮化生。结论壁细胞缺失后上皮化生及巨噬细胞极化过程通过白介素．33及白介素-13的细胞信号网络协调进行，将损伤应答过程中固有黏膜机制及M2浸润联系起来。

关键词： IL-13 组织变形调整老鼠串联信号胃

冠状动脉搭桥术并非痴呆或阿尔茨海默病的危险因素

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 41-42页

作者： Knopman D.S. petersen r.C. 赵天智 Department of Neurology Mayo Clinic 200 First Street SW Rochester MN 55905 United States.Dr

Objective: To study coronary artery bypass grafting (CABG) as a risk factor for dementia and Alzheimer disease (AD) using a case-control design. Methods: The authors used the records-linkage system of the rochester Epidemiology project to ascertain incident cases of dementia in rochester, MN, for the 5-year.period 1990 to 1994. The authors defined dementia and AD using the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Each case was individually matched by age (±1 year) and sex to a person drawn randomly from the same population, and free of dementia in the index year (year of onset of dementia in the matched case). results: Among 557 dementia cases, 24 (4.3%) had undergone a CABG prior to the onset of dementia with a median lag time of 5.5 years (range = 0.1 to 15.9). Among 557 controls, 28 subjects (5.0%) had undergone a CABG prior to the index year with a median lag time 3.9 years (rang e = 0.1 to 12.3); Or = 0.85 (95%CI = 0.49 to 1.49; p = 0.57) for dementia and O r = 0.78 (95%CI = 0.39 to 1.56; p = 0.48) for AD. The findings did not change a fter adjustment for education. The perioperative courses of cases and controls w ere comparable. Analyses including only the 481 cases of dementia with presumed neurodegenerative or cerebrovascular etiology were also negative. Conclusions: T his population-based case-control study suggests that coronary artery bypass g rafting is not a major risk factor for dementia overall, or for Alzheimer diseas e.

关键词：搭桥术危险因素危险隐患阿尔茨海默病冠状动脉

Identification of p63 expression in human lung cancer: analysis by complementary DNA and tissue microarray

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Journal of Medical Colleges of pLA(China) 2004年第1期19卷 51-54页

作者：余永伟 Mitch Garber Karsten Schlüns Manuela pacyna-Gengelbach lver petersen Department of pathology Changhai Hospital Second Military Medical University Department of Genetics Stanford University Institute of pathology Charitè Medical School

Objective: To evaluate p63 expression at mrNA transcr.pts and protein levels in lung squamous cell cancer (SCC), adenocarcinoma, large cell lung cancer (LCLC) and small cell lung cancer (SCLC) and their matched metastatic tumors. The association between p63 expression and p63 locus at chromosomal 3q27 q29 was also investigated. Methods: p63 mrNA expression levels in a large series of lung cancers including SCC, adenocarcinoma, LCLC, SCLC and their matched metastatic tumors were analyzed by cDNA microarray technology. A tissue microarray from 150 primary lung cancer specimens was constructed and used for immunohistochemical detection of p63 protein expression. Chromosomal imbalances at the p63 locus in 70 primary lung cancers samples were studied by comparative genomic hybridization (CGH) technology. results: mrNA levels were 10 fold in SCC compared to LCLC, SCLC, and adenocarcinoma. Interestingly, the mrNA expression of p63 in metastatic carcinomas was significantly higher than that in their matched primary tumors ( p ry demonstrated that p63 expression was 94.64% in SCC but only 1 79% in lung adenocarcinoma and 2 of 4 LCLC were positive staining. All the results in of SCLC were negative. There was a statistically significant difference for.p63 positivity between pT1 tumors and those of higher stage ( p =0 035). The CGH results indicated that p63 locus at chromosomal 3q27 q29 was overr.presented in SCC. p63 immunopositivity correlated significantly with pronounced gains of the p63 locus at chromosomal 3q27 q29 (p=0.0001), indicating that strong expression of p63 in lung SCC correlated with increased gene amplification. Conclusion: p63 might play an important role not only in squamous differentiation of lung cancer but also in tumor development and progression.

关键词： lung cancer cDNA microarray tissue microarray p63, comparative genomic hybridization

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学校口腔健康促进项目6年效果评价

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