冠状动脉搭桥术并非痴呆或阿尔茨海默病的危险因素

作     者：Knopman D.S. Petersen R.C. 赵天智 

作者机构：Department of Neurology Mayo Clinic 200 First Street SW Rochester MN 55905 United States.Dr 

出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)

年 卷 期：2006年第2期

页      面：41-42页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：搭桥术 危险因素 危险隐患 阿尔茨海默病 冠状动脉 

摘      要：Objective: To study coronary artery bypass grafting (CABG) as a risk factor for dementia and Alzheimer disease (AD) using a case-control design. Methods: The authors used the records-linkage system of the Rochester Epidemiology Project to ascertain incident cases of dementia in Rochester, MN, for the 5-year period 1990 to 1994. The authors defined dementia and AD using the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Each case was individually matched by age (±1 year) and sex to a person drawn randomly from the same population, and free of dementia in the index year (year of onset of dementia in the matched case). Results: Among 557 dementia cases, 24 (4.3%) had undergone a CABG prior to the onset of dementia with a median lag time of 5.5 years (range = 0.1 to 15.9). Among 557 controls, 28 subjects (5.0%) had undergone a CABG prior to the index year with a median lag time 3.9 years (rang e = 0.1 to 12.3); OR = 0.85 (95%CI = 0.49 to 1.49; p = 0.57) for dementia and O R = 0.78 (95%CI = 0.39 to 1.56; p = 0.48) for AD. The findings did not change a fter adjustment for education. The perioperative courses of cases and controls w ere comparable. Analyses including only the 481 cases of dementia with presumed neurodegenerative or cerebrovascular etiology were also negative. Conclusions: T his population-based case-control study suggests that coronary artery bypass g rafting is not a major risk factor for dementia overall, or for Alzheimer diseas e.