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国外医学（心血管疾病分册） 1991年第1期18卷 18-20页

作者： petersen p 戈戎

作者对房颤患者血栓栓塞并发症的危险因素进行了评述,主要讨论甲状腺毒性房颤、阵发性房颤(及由此转变成慢性房颤)、左房扩大、隐性脑血管栓塞和脑血流降低所起的作用。作者认为,非风湿性慢性房颤患者应予抗凝治疗。

关键词：房颤血栓栓塞并发症预防

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数值问题CRAY-1的向量FORTRAN

计算机工程与科学 1985年第1期 73-96页

作者： W.p.petersen ,何玉兰

1.前言在CRAY-1上以向量方式进行的一些计算比以标量方式进行的计算要快几个数量级。本文只讨论一些最基本的内容:向量硬件运算及CFT(Cray FORTRAN)的编译程序如何利用它们。稍微了解一下向量硬件是有用的,因为CRAY-1上的一些运算比其

关键词：向量长度数组等式向量运算 CRAY-1 FORTRAN

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用离子色谱技术分析污泥中的硫酸盐

国外农业环境保护 1992年第2期 40-41页

作者： Soren p. petersen 赵晨曦

前言硫酸盐经常存在于城市废水和工业废水中。由于各种原因,在废水的厌氧处理中,高浓度硫酸盐的存在是令人讨厌的。这是因为硫酸盐还原细菌会把硫酸盐转化为硫化物产生大量的H_2S。H_2S是一种潜在的有毒化合物,它会给厌氧过程带来麻烦... 详细信息

前言硫酸盐经常存在于城市废水和工业废水中。由于各种原因,在废水的厌氧处理中,高浓度硫酸盐的存在是令人讨厌的。这是因为硫酸盐还原细菌会把硫酸盐转化为硫化物产生大量的H_2S。H_2S是一种潜在的有毒化合物,它会给厌氧过程带来麻烦。在厌氧处理体系中,硫酸盐浓度和微生物硫酸盐还原率的测定对于控制令人讨厌的微生物活动产物H_2S,具有重要意义。

关键词：污泥硫酸盐离子色谱色谱法

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在替代的心脏移植手术中边缘心脏移植并不增加原发性移植物功能障碍发生率

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 16-17页

作者： Lima B. Rajagopal K. petersen R.p C.A. Milano 朱启明 DUMC Box 3043 Department of Surgery Duke University Medical Center Durham NC 27710 United States.Dr

背景:现代心脏移植(HT)的成功临床经验使替代心脏移植(AL HT)策略得以发展,它是指不符合标准心脏移植条件的边缘心脏移植。边缘心脏移植可能会增加原发性移植物功能障碍(pGD)的发生率,pGD是心脏移植术后早期死亡的首要原因。

关键词：心脏移植移植物功能变力性药物心室辅助装置排斥反应成人患者缺血性心肌病机械循环总死亡率

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白介素-33至白介素-13信号级联调节小鼠胃组织上皮化生

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英国医学杂志中文版 2018年第7期21卷 418-418页

作者： Christine p petersen Anne R Meyer Carlo De Salvo Eunyoung Choi Cameron Schlegel Alec petersen Amy C Engevik Nripesh prasad Shawn E Levy R Stokes peebles Theresa T pizarro James R Goldenring 李佳宁(译) 吴东(校) 不详北京协和医院消化科

目的选择性活化巨噬细胞（Alternativelyactivated macrophages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SpEM）过程相关。然而，诱导SpEM的确切机制及关键介质尚不明确。研究设计为确定这一... 详细信息

目的选择性活化巨噬细胞（Alternativelyactivated macrophages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SpEM）过程相关。然而，诱导SpEM的确切机制及关键介质尚不明确。研究设计为确定这一过程中的关键基因，分离胃部SpEM小鼠（DMp-777处理）及高级胃部SpEM小鼠（L635处理）胃体的巨噬细胞进行RNA测序。评估白介素．33、白介素-33受体（ST2）及白介素-13基因敲除小鼠，经L635处理急性壁细胞缺失后对上皮细胞化生过程的影响。结果胃部上皮化生相关性巨噬细胞中可鉴定出M2极化亚群。高级胃部SpEM小鼠巨噬细胞中自介素-33的表达显著上调。L635可在野生型小鼠胃组织中诱导上皮化生，但在白介素-33及白介素．33受体敲除鼠中未观察到这一现象。尽管在诱导上皮化生过程中不需白介素．5及白介素-9，白介素-13基因敲除小鼠无法在L635诱导下发生上皮化生。对白介素-33受体基因敲除小鼠应用白介素-13，可重新诱导急性壁细胞缺失后的上皮化生。结论壁细胞缺失后上皮化生及巨噬细胞极化过程通过白介素．33及白介素-13的细胞信号网络协调进行，将损伤应答过程中固有黏膜机制及M2浸润联系起来。

关键词： IL-13 组织变形调整老鼠串联信号胃

Role of simple biomarkers in predicting fibrosis progression in HCV infection

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World Journal of Gastroenterology 2010年第45期16卷 5710-5715页

作者： Rajasekhara R Mummadi John R petersen Ned Snyder Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Texas Medical BranchHoustonTX 77025United States Department of pathology University of Texas Medical BranchHoustonTX 77025United States Department of Gastroenterology and Hepatology Kelsey Seybold Clinic2727 W. HolcombeHoustonTX 77025United States

AIM: To examine the accuracy of the aspartate aminotransferase (AST)/platelet Ratio Index (ApRI) and FIB-4, in predicting longitudinal changes in liver histology in hepatitis C virus (HCV) ***: patients that underwent repeat liver biopsies at least 1 year apart from 1999 to 2007 were identified. Liver fibrosis was staged on needle core biopsies evaluated by a single expert liver pathologist. Only laboratory values within 3 mo of the liver biopsies were ***: Thirty-six patients met the inclusion criteria with 50% stage 1 on initial biopsy, 25% stage 2, and 22% stage 3. Nineteen of 36 (53%) had progression of fibrosis on repeat biopsies, while 16 (44%) showed no change in stage, and one (3%) showed improvement. patients that showed progression of fibrosis had significantly higher alanine aminotransferase and aspartate aminotransferase levels than the group that did not show progression. A significant correlation was seen between change in stage of fibrosis and change in ApRI (r2 = 0.39, p = 0.00001) and a change in FIB-4 (r2 = 0.31, p = 0.00004). A change in ApRI (ΔApRI) of 0.18 had 80% positive predictive value (ppV) and 67% nega- tive predictive value (NpV) for progression of fibrosis. A change in FIB-4 (ΔFIB-4) of 0.39 had 75% ppV and 75% NpV for predicting progression of fibrosis. CONCLUSION: ΔApRI and ΔFIB-4 parallel changes in fibrosis progression, and could be useful tools for clinicians in following patients with active chronic HCV infection.

关键词： Hepatitis C Liver fibrosis Liver biopsy Biomarkers

HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C

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World Journal of Gastroenterology 2002年第3期8卷 562-566页

作者： Rainer p.Woitas Uwe petersen Dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler Department of Intemal Medicine I University of Bonn53105 BonnGermany Institute of Experimental Hematology University of Bonn53105 BonnGermany Institute of Medical Microbiology and Immunology University of Bonn53105 BonnGermany

AIM:Cytokine release by macrophages critically determines the type of immune response to an ***,we studied hepatitis C virus(HCV)-specific induction of interleukins-1β,-10,-12(IL-1β,IL-10,IL-12),and tumor necrosis factor-α(TNF-α)in monocytes. METHODS:Intracallular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear calls with recombinant core,NS3,NS4,NSSa and NSSb proteins. RESULTS:patients with HCV viremia revealed greater spontaneous expression of IL-1β,TNF-α,and IL-10. Furthermore,greater than twofold higher IL-10 expression was induced by the HCV antigens in chronic hepatitis C than in the other two groups(ppreferentially. CONCLUSION:In chronic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 *** may contribute to persistent viral replication.

关键词： Adult Cytokines Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interleukin-1 Interleukin-10 Interleukin-12 Male Middle Aged Monocytes Research Support, Non-U.S. Gov't Tumor Necrosis Factor-alpha Viremia

Current and future applications of nanotechnology in plastic and reconstructive surgery

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plastic and Aesthetic Research 2014年第1期1卷 43-50页

作者： Dana K.petersen Tate M.Naylor Jon p.Ver Halen Department of Otolaryngology-Head and Neck Surgery University of Tennessee Health Science CenterMemphisTN 38163USA Department of Surgical Oncology School of MedicineUniversity of Tennessee Health Sciences CenterMemphisTN 38163USA Department of Surgical Oncology Division of PlasticReconstructive and Hand SurgeryBaptist Memorial Healthcare CorporationMemphisTN 38120USA Department of Surgical Oncology Vanderbilt Ingram Cancer CenterNashvilleTN 37232USA Department of Surgical Oncology St Jude Children’s Research HospitalMemphisTN 38105USA.

Although nanotechnology is a relatively young field,there are countless biomedical applications in use or under *** specialties have benefitted from nanoscale refinements of diagnostic and therapeutic *** and reconstructive surgery is an incredibly diverse specialty,encompassing craniofacial and hand surgery;trauma,oncologic and congenital reconstruction;burn care,and aesthetic *** in nanotechnology have significantly impacted wound management,topical skin care,implant and prosthetic design,tissue engineering,and drug delivery ***,plastic surgeons are researching the utility of nanoscale tools for bone regeneration,bone prosthetics,and drug *** will continue to build upon preceding discoveries,and its biomedical applications in the field of plastic and reconstructive surgery will expand significantly.

关键词： Bone graft burns drug delivery implants nanotechnology tissue engineering wound care

Association between dairy intake,lipids and vascular structure and function in diabetes

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World Journal of Diabetes 2017年第5期8卷 202-212页

作者： Kristina S petersen Jennifer B Keogh Natalie Lister Jacquelyn M Weir peter J Meikle peter M Clifton School of pharmacy and Medical Sciences and Sansom Institute for Health Research University of South Australia Baker IDI Heart and Diabetes Institute

AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** Serum lipid species [lysophosphatidylcholine(LpC) 14:0, LpC 15:0, LpC 16:1, phosphatidylcholine(pC) 29:0 pC 30:0, pC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; p pids was positively associated with the 3-mo change in central systolic [LpC 14:0(rho 0.30; p = 0.007), pC 30:0(rho 0.28; p = 0.010)] and diastolic blood pressure [LpC 14:0(rho 0.32; p = 0.004), LpC 15:0(rho 0.23; p = 0.04), LpC 16:1(rho 0.23; p = 0.035), pC 29:0(rho 0.28; p = 0.01), pC 30:0(rho 0.36; p = 0.001), pC 31:0(rho 0.30; p = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0(rho 0.22; p = 0.02)]. pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.

关键词： Lipids phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness pulse wave velocity Diabetes

Observational study of a new modular femoral revision system

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World Journal of Orthopedics 2020年第3期11卷 167-176页

作者： Karen Dyreborg Michael Mørk petersen Sidse Schwartz Balle Anne Grete Kjersgaard Søren Solgaard Department of Orthopaedic Surgery Herlev-Gentofte Hospital2900 HellerupDenmark Department of Orthopaedic Surgery Rigshospitalet2100 KøbenhavnDenmark Department of Diagnostic Radiology Herlev-Gentofte Hospital2900 HellerupDenmark

BACKGROUND The uncemented ArcosTM Modular Femoral Revision System(ARCOS)is a new comprehensive,press-fit revision *** modular design offers a wide range of possible combinations to accommodate different variations of anatomy and bone *** ARCOS is made by a proximal body and a distal *** probably the only ones worldwide we predominantly use a combination of body and stem which supports proximal fixation and load,since this mimics the concept of the primary total hip arthroplasty with proximal weight-bearing,leading to bone stock preservation and no stress shielding or thigh *** To evaluate the early results after femoral revision in a consecutive series of patients undergoing surgery over 3 *** We included 116 patients in the *** were operated in the period August 2011 to December 2014 and we got a clinical mean observation time of 4(0.5-6)*** and radiographical follow-up included present function of the hip assessed by Harris Hip Score,Oxford Hip Score,and EQ5D(measure of health outcome).Of the 116 patients,17 died in the interim and were consequently included only in the implant survivorship analysis;46 patients attended the follow-up *** In total 6(5%)hips were re-revised due to infection(n=3),fracture(n=2)or subsidence(n=1).No patient was re-revised due to aseptic *** 1-,2-and 5-year probability of implant survival(95%CI)were 97%(93%-100%),97%(93%-100%)and 96%(92%-99%),*** this cohort 95 patients received a combination of a proximal broach and a distal curved and slotted stem(BS),aiming for proximal fixation and load bearing;21 patients received a different *** comparing these two groups the BS-group had a 5-year implant survival probability(95%CI)of 97%(93%-100%)compared with the group of other combinations with a 5-year implant survival probability(95%CI)of 90%(78%-100%)(p=0.3).Our regression analysis showed that periprosthetic fracture as an indication for the ARCO

关键词： Hip prosthesis Arthroplasty Implantation Replacement arthroplasty Total hip replacements Modular femoral stem