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Predicting flows through microfluidic circuits with fluid walls

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Microsystems & Nanoengineering 2021年第6期7卷 119-127页

作者： Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu peter r.cook Edmond J.Walsh Department of Engineering Science Osney Thermo-Fluids LaboratoryUniversity of OxfordOxford OX20ESUK Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Cold Spring Harbor Laboratory Cold Spring HarborNYUSA

The aqueous phase in traditional microfluidics is usually confined by solid walls;flows through such systems are often predicted *** solid walls limit access,open systems are being developed in which the aqueous phase is partly bounded by fluid walls(interfaces with air or immiscible liquids).Such fluid walls morph during flow due to pressure gradients,so predicting flow fields remains *** recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon(FC40).Here,we find that common medium additives(fetal bovine serum,serum replacement)induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow *** experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.

关键词： walls flows flow

Stratification of Patients with Diabetes Using Continuous Glucose Monitoring Profiles and Machine Learning

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Health Data Science 2022年第1期2022卷 144-152页

作者： Yinan Mao Kyle Xin Quan Tan Augustin Seng peter Wong Sue-Anne Toh Alex r.cook Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore Department of Statistics and Data Science National University of SingaporeSingapore NOVI Health Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Duke-NUS Medical School Singapore

*** glucose monitoring(CGM)offers an opportunity for patients with diabetes to modify their lifestyle tobetter manage their condition and for clinicians to provide personalized healthcare and lifestyle ***,analytic toolsare needed to standardize and analyze the rich data that emerge from CGM *** would allow glucotypes of patients tobe identified to aid clinical *** this paper,we develop an analysis pipeline for CGM data and applyit to 148 diabetic patients with a total of 8632 days of follow *** pipeline projects CGM data to a lower-dimensional spaceof features representing centrality,spread,size,and duration of glycemic excursions and the circadian *** then useprincipal components analysis and k-means to cluster patients’records into one of four glucotypes and analyze clustermembership using multinomial logistic *** differ in the degree of control,amount of time spent inrange,and on the presence and timing of hyper-and *** on the program had statistically significantimprovements in their glucose *** pipeline provides a fast automatic function to label raw CGM datawithout manual input.

关键词： Patients Profiles membership

CCS research Development and Deployment in a Clean Energy Future： Lessons from Australia over the Past Two Decades

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Engineering 2017年第4期3卷 477-484页

作者： peter J. cook CO2CrC Ltd.& Peter.cook Centre for Carbon Capture and Storage research The University of Melbourne Melbourne VIC 2010 Australia

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法... 详细信息

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法全部克服,但通过不断的研究、交流和规划,目前CCS技术已得到了极大丰富。我们知道如何进行相关操作,并自信能安全有效地完成相关操作;我们知道相关的成本情况,也知道目前成本正在不断降低,而且未来会继续降低。同时,我们也知道,只要各个国家、公司、团体继续将化石燃料用作能源及用于各种工业过程,则世界就会一直需要碳捕集和封存技术。我们缺少的是必要的政策驱动和技术上呈中性(不会增加二氧化碳排放)的方法,以达到及时、低成本地降低CO_2排放,并维持稳定的、安全的电力供应以保证能源密集型工业产品的生产和使用。我们以澳大利亚为例来说明过去20年内人们对碳捕集和封存技术所做的各种努力,尤其是在碳捕集和封存技术研究和示范工程以及国际合作方面所做的各种努力。在澳大利亚国内,碳捕集和封存技术的大规模推广进展非常慢。但全球最大的碳捕集和封存项目将作为Gorgon液化天然气项目的一部分,很快在澳大利亚国内投入运营,另外还有数个大规模的碳捕集和封存的旗舰级项目正在考察中。CO2CrC Otway项目是澳大利亚国内目前唯一一个运行中的二氧化碳封存项目。该项目目前正在进行一些细节方面的组织和推进工作。需要指出的是,如果要推广Otway项目,还需对地下岩石对封存CO_2的影响开展大量研究。如果要在全球范围广泛使用碳捕集和封存技术,国际能源机构和国际气候变化委员会等机构都认为我们面临很大的挑战,还有很多重大问题需要解决。要解决这些问题,全球各方必须紧密协作。

关键词：二氧化碳碳捕集和封存技术 Otway 澳大利亚

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Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene

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Nano research 2015年第8期8卷 2620-2635页

作者： Alexander J. Marsden peter Brommer James J. Mudd M. Adam Dyson robert cook Maria Asensio Jose Avila Ana Levy Jeremy Sloan David Quigley Gavin r. Bell Neil r. Wilson Department of Physics University of Warwick Coventry UK Centre for Scientific Computing University of Warwick Coventry UK Synchrotron SOLEIL L'Orme des Merisiers Saint Aubin-BP 48 91192 Gifsur Yvette Cedex France

graphene 的共有原子价 functionalization 为定制它的性质提供机会并且是一些 graphene 合成技术的不可避免的后果。然而， functionalization 导致的变化很好没被理解。由使用原子来源控制氧和氮 functionalization 的程度，我们在原... 详细信息

graphene 的共有原子价 functionalization 为定制它的性质提供机会并且是一些 graphene 合成技术的不可避免的后果。然而， functionalization 导致的变化很好没被理解。由使用原子来源控制氧和氮 functionalization 的程度，我们在原子规模在结构和性质学习了进化。虽然，原子氧 reversibly 介绍 epoxide 组，在类似的条件下面，原子氮不可逆转地创造包括的多样的功能代理， pyridinic，和 pyrrolic 氮。原子氧在迪拉克点离开费密能量(即， undoped ) ，虽然原子氮导致网做 n；然而，试验性的结果与为两是转变从的主导的电子效果一致去除到局部性的状态，和因此签名的损失 graphene 的电子结构。

关键词：电子结构环氧基团氮原子功能化石墨物理合成技术原子尺度

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H-无穷控制器的设计及仿真（英文）

大连工业大学学报 2015年第3期34卷 225-230页

作者：张木楷 Peter.cook 南京理工大学自动化学院江苏南京210094 曼彻斯特大学电子电气工程系

利用状态空间法可以有效地解析多输入多输出系统,但LQG控制器不能很好地处理系统误差。为了消除系统误差对控制器所带来的瑕疵,利用H-无穷最优控制方法有效地解决了对所有有界能量的输入命令和外干扰信号,使系统的最大能量误差极小化;... 详细信息

利用状态空间法可以有效地解析多输入多输出系统,但LQG控制器不能很好地处理系统误差。为了消除系统误差对控制器所带来的瑕疵,利用H-无穷最优控制方法有效地解决了对所有有界能量的输入命令和外干扰信号,使系统的最大能量误差极小化;对有界范数采用不确定性方法解析,使闭环系统稳定。H-无穷控制器的设计方法是通过为其设计动态补偿器,使得闭环系统对外部干扰起到一定的抑制作用。当外部无扰动时,补偿器仍旧可以使闭环系统处于渐进稳定状态。控制器的主要设计过程就是求一个稳定的反馈控制器K,使得闭环系统保持稳定。最后利用MATLAB仿真了H-无穷控制器的可行性。

关键词： H-无穷控制器设计 MATLAB仿真

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Impacts of late Quaternary environmental change on the long-tailed ground squirrel(Urocitellus undulatus)in Mongolia

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Zoological research 2018年第5期39卷 364-372页

作者： Bryan S.McLean Batsaikhan Nyamsuren ANDrey Tchabovsky Joseph A.cook University of Florida Florida Museum of Natural History Department of Biology School of Arts and Sciences National University of Mongolia Laboratory of Population Ecology A.N. Severtsov Institute of Ecology and Evolution University of New Mexico Department of Biology and Museum of Southwestern Biology

Impacts of Quaternary environmental changes on mammal faunas of central Asia remain poorly understood due to a lack of comprehensive phylogeographic sampling for most *** help address this knowledge gap,we conducted the most extensive molecular analysis to date of the long-tailed ground squirrel （Urocitellus undulatus Pallas 1778） in Mongolia,a country that comprises the southern core of this species＇ *** on material from recent collaborative field expeditions,we genotyped 128 individuals at two mitochondrial genes （cytochrome b and cytochrome oxidase Ⅰ;1797 bp total）.Phylogenetic inference supports the existence of two deeply divergent infraspecific lineages （corresponding to subspecies *** and ***）,a result in agreement with previous molecular investigations but discordant with patterns of range-wide craniometric and external phenotypic *** the widespread western eversmanni lineage,we recovered geographically-associated clades from the：（a） Khangai,（b） Mongolian Altai,and （c） Govi Altai mountain *** structure in *** is consistent with an isolation-by-distance model;however,genetic distances are significantly lower than among subspecies,and intra-clade relationships are largely *** latter patterns,as well as the relatively higher nucleotide polymorphism of populations from the Great Lakes Depression of northwestern Mongolia,suggest a history of range shifts into these lowland areas in response to Pleistocene glaciation and environmental change,followed by upslope movements and mitochondrial lineage sorting with Holocene *** study illuminates possible historical mechanisms responsible for *** genetic structure and contributes to a framework for ongoing exploration of mammalian response to past and present climate change in central Asia.

关键词： Central Asia Gobi Desert Great LakesDepression Mongolia Phylogeography

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Cross-regional drivers for CCUS deployment

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Clean Energy 2020年第3期4卷 202-232页

作者： Anthony Y.Ku peter J.cook Pingjiao Hao Xiaochun Li John P.Lemmon Toby Lockwood Niall Mac Dowell Surinder P.Singh Ning Wei Wayne Xu National Institute of Clean and Low Carbon Energy BeijingP.R.China NICE America research Mountain ViewCAUSA Centre for CCS research University of MelbourneVictoriaAustralia State Key Laboratory for Geo-mechanics and Geo-Technical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanHubei ProvinceChina IEA Clean Coal Centre LondonUK Centre for Environmental Policy Imperial College LondonUK Centre for Process Systems Engineering Imperial CollegeLondonUK

CO_(2)capture,utilization and storage(CCUS)is recognized as a uniquely important option in global efforts to control anthropogenic greenhouse-gas(GHG)*** significant progress globally in advancing the maturity of the various component technologies and their assembly into full-chain demonstrations,a gap remains on the path to widespread deployment in many *** this paper,we focus on the importance of business models adapted to the unique technical features and sociopolitical drivers in different regions as a necessary component of commercial scale-up and how lessons might be shared across *** identify three archetypes for CCUS development-resource recovery,green growth and low-carbon grids-each with different near-term issues that,if addressed,will enhance the prospect of successful commercial *** archetypes provide a framing mechanism that can help to translate experience in one region or context to other locations by clarifying the most important technical issues and policy *** forward,the archetype framework also provides guidance on how different regions can converge on the most effective use of CCUS as part of global deep-decarbonization efforts over the long term.

关键词： CCUS CO_(2) capture decarbonization regional storage utilization

Fate of enteric pathogens in different spinach cultivars cultivated in growth chamber and field systems

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Food Quality and Safety 2018年第4期2卷 221-228页

作者： Marilyn C.Erickson Jye-Yin Liao Alison S.Payton peter W.cook Henk C.Den Bakker Jesus Bautista Juan Carlos Díaz Pérez Department of Food Science and Technology Center for Food SafetyUniversity of Georgia1109 Experiment St.GriffinGA 30223-1797USA and Department of Horticulture University of Georgia2360 Rainwater Rd.TiftonGA 31793-5766USA

between enteric pathogens and plant hosts have been shown to be *** series of studies sought to expand our knowledge in this area and evaluate whether spinach cultivar selection may be used to curtail pathogen contamination and ultimately reduce microbiological risk associated with this *** a component to that assessment,potential antimicrobials that were constituents within spinach leaves were first analysed and found to be spatially non-uniform,being more concentrated on the outer edges of the leaves than in the centre of the ***,the entire foliage of a plant was sampled in subsequent studies examining the fate of Salmonella and Escherichia coli O157:H7 on seven cultivars of *** did not affect the degree of Salmonella internalized into spinach tissue(P>0.05);however,it appeared that those Salmonella that were internalized were transient residents as the percentage of plants containing this internalized pathogen dropped within 24 *** relationship existed between antimicrobial levels(total phenols or antioxidant capacity)of the spinach cultivars and the prevalence of plants exhibiting Salmonella internalization or the persistence of Salmonella or *** O157:H7 after the plants had been sprayed with the *** both growth chamber and field studies,Salmonella was more resistant than *** O157:H7 to *** affected the persistence of both *** O157:H7 and Salmonella but the ranking for each pathogen’s survival on three of those cultivars differed suggesting the difficulty in finding one cultivar that would be inhospitable to multiple pathogens.

关键词： spinach cultivars internalization survival phenols antioxidant capacity Salmonella E.coli O157:H7.

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荒原守护者

建筑实践 2014年第4期 8-15页

作者：李莹 Peter.cook

新的巨石阵游客中心最近正式对外开放,每年将吸引超过一百万游客前来观光。它座落于距离巨石阵遗址西侧2.4公里处高低起伏的索尔兹伯里平原上,是一个轻触环境的低调建筑,包含一组微妙而简单的、建造于石灰岩平台之上的围场,被一个精致... 详细信息

新的巨石阵游客中心最近正式对外开放,每年将吸引超过一百万游客前来观光。它座落于距离巨石阵遗址西侧2.4公里处高低起伏的索尔兹伯里平原上,是一个轻触环境的低调建筑,包含一组微妙而简单的、建造于石灰岩平台之上的围场,被一个精致、凿孔的起伏顶盖所遮蔽。项目内部拥有三个功能各异的空间,使用不同材料进行分区。面积最大的空间外部覆盖甜栗木,包含展示区与服务设施。以玻璃进行围合的空间面

关键词：巨石阵高低游客遗址索尔兹伯里津巴布韦钢柱荒原