Predicting flows through microfluidic circuits with fluid walls

作     者：Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R.Cook Edmond J.Walsh 

作者机构：Department of Engineering ScienceOsney Thermo-Fluids LaboratoryUniversity of OxfordOxford OX20ESUK Sir William Dunn School of PathologyUniversity of OxfordOxford OX13REUK Cold Spring Harbor LaboratoryCold Spring HarborNYUSA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2021年第7卷第6期

页      面：119-127页

核心收录：

学科分类：080704[工学-流体机械及工程] 080103[工学-流体力学] 08[工学] 0807[工学-动力工程及工程热物理] 0801[工学-力学（可授工学、理学学位）] 

基　　金：This work was supported by iotaSciences Ltd.(who provided financial support for C.D.,F.N.,and C.S.) the William H.G.FitzGerald Scholarship(N.S.‐K.) the Impact Acceleration Account of the Biotechnology and Biological Sciences Research Council(P.R.C.and E.J.W.) awards from the Medical Research Council under the Confidence in Concept scheme(MC_PC_15029 to P.R.C.and E.J.W) 

主　　题：walls flows flow 

摘      要：The aqueous phase in traditional microfluidics is usually confined by solid walls;flows through such systems are often predicted *** solid walls limit access,open systems are being developed in which the aqueous phase is partly bounded by fluid walls(interfaces with air or immiscible liquids).Such fluid walls morph during flow due to pressure gradients,so predicting flow fields remains *** recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon(FC40).Here,we find that common medium additives(fetal bovine serum,serum replacement)induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow *** experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.