检索结果-南通市图书馆

Assessment of parameters for precipitation simulation of heat treatable aluminum alloys using differential scanning calorimetry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2157-2167页

作者： Ahmad FALAHATI Jun WU peter lang Mohammad Reza AHMADI Erwin POVODEN-KARADENIZ Ernst KOZESCHNIK Institute of Materials Science and Technology Vienna University of Technology Materials Center Leoben Forschung GmbH Christian Doppler Laboratory for Early Stages of Precipitation Institute of Materials Science and TechnologyVienna University of Technology

Differential scanning calorimetry （DSC） has been used extensively to study different solid state reactions. The signals measured in DSC are associated with the growth and dissolution of different precipitates during a specific heat cycle. The time-temperature dependence of heat cycles and the corresponding heat flow evolution measured in the sample by DSC provide valuable experimental information about the phase evolution and the precipitation kinetics in the material. The thermo-kinetic computer simulation was used to predict the DSC signals of samples taken from 6xxx and 2xxx alloys. In the model, the evolution of different metastable and stable phases and the role and influence of excess quenched-in vacancies in the early stage of precipitation were taken into account. Transmission electron microscopy （TEM） and high-resolution TEM were used to verify the existence of precipitates, their size and number density at specific points of the DSC curves.

关键词： differential scanning calorimetry aluminum alloys precipitation kinetics simulation vacancy MatCalc

在线全文

学校读者我要写书评

暂无评论

德国铁路摆式列车的倾摆技术及其运用经验

国外内燃机车 2003年第6期 37-43,46页

作者： Hans peter lang 吴雅丽德

摆式列车是铁路运输的一种生产资料。它在运用和维护中的可靠性和经济性 ,是其长期有效运用的决定性的前提。本文从这些边界条件出发 ,结合实际运用经验 ,介绍了对摆式动车的主要要求 ,阐述了动车快速通过曲线时对铁路轨道及可靠性技术... 详细信息

摆式列车是铁路运输的一种生产资料。它在运用和维护中的可靠性和经济性 ,是其长期有效运用的决定性的前提。本文从这些边界条件出发 ,结合实际运用经验 ,介绍了对摆式动车的主要要求 ,阐述了动车快速通过曲线时对铁路轨道及可靠性技术的要求 ;同时 ,结合德国铁路在倾摆技术方面进一步发展的趋势。

关键词：内燃动车摆式列车倾摆装置可靠性经济性发展趋势

Bonding, Structure and Uses of Metals

在线全文

学校读者我要写书评

暂无评论

Journal of Metallic Material Research 2023年第1期6卷 7-15页

作者： peter F.lang Birkbeck College(University of London) Malet StreetLondonUK

This work briefly describes some of the different features of groups of *** highlights recent progress in research into *** details the structures and defects in solid *** common theories of metals including the free electron theory,band theory,the ions in a sea of electrons model and the soft sphere model are discussed and their merits are *** describes distinctions between the bonding in metals and inter-metallic *** shows the influence of bonding on the properties of metals and alloys and provides a summary of tradition and newer uses of metals.

关键词： Metals Alloys Inter-metallic compounds Bonding strucuture

一位药物性牙龈增生患者的诊断、治疗和长期疗效

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国口腔医学继续教育杂志 2009年第3期12卷 27-34页

作者： Wah Ching Tan Lure Peng lim Niklaus peter lang 乔敏（译）徐莉审不详北京大学口腔医学院牙周科北京海淀区中关村南大街22号100081

本文报告了1例服用环孢素和硝苯地平相关牙龈增生（肥大）患者的诊断、治疗和长期疗效。该患者在未更换全身用药情况下对牙龈增生进行了成功治疗。治疗的主要目的是降低牙龈增生的程度，进而恢复牙齿的健康、功能和美观。治疗过程是先... 详细信息

本文报告了1例服用环孢素和硝苯地平相关牙龈增生（肥大）患者的诊断、治疗和长期疗效。该患者在未更换全身用药情况下对牙龈增生进行了成功治疗。治疗的主要目的是降低牙龈增生的程度，进而恢复牙齿的健康、功能和美观。治疗过程是先行牙周基础治疗，后行牙周手术治疗，术后观察2年．牙龈增生未见复发。

关键词：环孢菌素牙龈肥大维护治疗硝苯地平

Multidisciplinary management of gastric and gastroesophageal cancers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第24期14卷 3773-3780页

作者： Markus Moehler Orestis Lyros Ines Gockel peter R Galle Hauke lang First Department of Internal Medicine of Johannes Gutenberg University of Mainz Institute of Surgery of Johannes Gutenberg University of Mainz

Carcinomas of the stomach and gastroesophageal junction are among the five top leading cancer types worldwide. In spite of radical surgical R0 resections being the basis of cure of gastric cancer, surgery alone provides long-term survival in only 30% of patients with advanced International Union Against Cancer （UICC） stages in Western countries because of the high risk of recurrence and metachronous metastases. However, recent large phase-Ⅲ studies improved the diagnostic and therapeutic options in gastric cancers, indicating a more multidisciplinary management of the disease. Multimodal strategies combining different neoadjuvant and/or adjuvant protocols have clearly improved the gastric cancer prognosis when combined with surgery with curative intention. In particular, the perioperative （neoadjuvant, adjuvant） chemotherapy is now a well-established new standard of care for advanced tumors. Adjuvant therapy alone should be carefully discussed after surgical resection, mainly in individual patients with large lymph node positive tumors when neoadjuvant therapy could not be done. The palliative treatment options have also been remarkably improved with new chemotherapeutic agents and will further be enhanced with targeted therapies such as different monoclonal antibodies. This article reviews the most relevant literature on the multidisciplinary management of gastric and gastroesophageal cancer, and discusses future strategies toimprove Iocoregional failures.

关键词： Gastric cancer Chemotherapy Chemoradiation Adjuvant Neoadjuvant

Targeted therapies in cholangiocarcinoma:light at the end of the tunnel?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第4期12卷 631-633页

作者： Iakovos Amygdalos Ulf peter Neumann Sven Arke lang Department of General Visceral and Transplantation SurgeryUniversity Hospital RWTH AachenAachenGermany

The genetic landscape of cholangiocarcinoma(CCA)remains largely *** is one of the deadliest cancers(1),with the gold standard treatment for all anatomical forms(intrahepatic-iCCA,perihilar-pCCA and distal-dCCA)being surgical resection(with adjuvant capecitabine also recommended in the newest guidelines)(2,3).The importance of genetic markers in terms of postoperative and oncological outcomes is being increasingly recognized,but few actionable mutations have been identified so far(2,4).This is particularly pertinent for patients with advanced/irresectable disease,who rely on systemic *** outcomes are poor in these patients[5-year survival up to 10%-(5)]and they would profit the most from novel,targeted therapies.

关键词： Cholangiocarcinoma(CCA) targeted therapy biomarkers

Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第12期12卷 2025-2034页

作者： Jun-mei Wang Ze-qiang Qu Jin-lang Wu peter Chung Yuan-shan Zeng Department of Histology and Embryology Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Department of Electron Microscope Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Shanghai Ninth People's Hospital Shanghai liao Tong University School of Medicine Shanghai China Institute of Spinal Cord In)ury Sun Yat-sen University Guangzhou Guangdong Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China

In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata（RCE） improved spatial cognition in a rat model of Alzheimer＇s disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer＇s disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer＇s disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease intracerebroventricular injection streptozotocin neuronal apoptosis neuroprotection cytochrome c oxidase adenosine triphosphate caspase-3 NeuN neural regeneration

Coordination-driven self-assembly of dibenzo-18-crown-6 functionalized Pt(Ⅱ) metallacycles

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 158-160页

作者： Zibin Zhang Yu Yao lang He Tao Hong Shijun Li Feihe Huang peter J.Stang College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular ScienceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry University of UtahSalt Lake CityUT 84112United States

Coordination-driven self-assembly was used to construct two metallacycles of a dicarboxylatefunctionalized dibenzo-18-crown-6 in combination with either a 0° anthracene-based clip-type acceptor or a 60° phenanthrene-based acceptor. The angularities of these moieties make them suitable for the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization and host-guest chemistry of two metallacycles were described and supported by31P{1H},1H NMR spectra and electrospray mass spectrometry.

关键词： Crown ethers Metallacycles Cation receptors Self-assembly

High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第17期15卷 2089-2096页

作者： Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke lang peter R Galle Markus Moehler Ines Gockel First Department of Internal Medicine Johannes Gutenberg University of Mainz 55131 Mainz Germany Unit of Toxicology and Chemotherapy GermanCancer Research Centre 69120 Heidelberg Germany Department of General and Abdominal Surgery Johannes Gutenberg University of Mainz 55131 Mainz Germany

AIM： To analyze the relevance of the microRNA miR-196a for colorectal ***： The impact of miR-196a on the restriction targets HoxA7, HoxBS, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction（RT-PCR） after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectalcancer samples, mucosa samples and diverse cancercell lines was quantified by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in ***： HoxA7, HoxB8, HoxC8 and HoxD8 wererestricted by miR-196a in a dose-dependent andgene-specific manner. High levels of miR-196aactivated the AKT signaling pathway as indicated byincreased phosphorylation of AKT. In addition, highlevels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towardsplatin derivatives but did not impact on proliferationor apoptosis. Furthermore, miR-196a increased thedevelopment of lung metastases in mice after tail veininjection.

关键词： Micro-RNA Cancer Colorectal miR-196a Migration Homeobox