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Preternatural Hexagonal High-Entropy Alloys: A Review

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Acta Metallurgica Sinica(English Letters) 2020年第8期33卷 1033-1045页

作者： Rui-Xuan Li Jun-Wei Qiao peter k. Liaw Yong Zhang Beijing Advanced Innovation center of Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology Beijing30 Xueyuan RoadBeijing 100083China Research center for High-Entropy Alloys College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

Recently,various topics on high-entropy alloys have been reported and great amounts of excellent properties have been investigated,including high strength,great corrosion resistance,great thermal stability,good fatigue and fracture properties,*** all these research activities,high-entropy alloys tend to form face-centered-cubic(Fcc)or body-centeredcubic(Bcc)solid solutions due to their high-entropy stabilization effect,while the hexagonal structures are rarely *** to now,the reported hexagonal high-entropy alloys are mainly composed of rare-earth elements and transitional *** phase transformation and magnetic properties have also aroused wide *** study summarizes the above results and provides the forecast to the future.

关键词： High-entropy alloys Hexagonal close-packed structure Phase formation rules Rare-earth elements Multiple-based-element(MBE)alloys

System Dynamic Modelling of Patient Flow and Transferral Problem in a Mixed Public-Private Healthcare System:A case Study of Hong kong SAR

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Journal of Systems Science and Systems Engineering 2020年第5期29卷 590-608页

作者： c.k.M.LEE W.c.TAI kam k.H.NG Department of Industrial and Systems Engineering The Hon g Kong Polytechnic UniversityHung HornHong Kong SARChina School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The current healthcare system in Hong kong is experiencing pressure due to constrained resources,with dramatic increases in inpatient services queue lengths,dissatisfaction with the working environment,unacceptable workforce arrangements and high turnover rate of hospital *** maintain the robustness of the healthcare system and a sustainable inpatients flow,the Food and Health Bureau launched a public-private partnership programme to utilise the resources of the public and private *** research investigates the potential for extension of the programme and further enhancing the sustainability of the long-term inpatient services under a mixed public-private healthcare policy via system dynamic *** findings show that an increase of human resources in public hospitals does not substantially improve inpatient flow rate ***,the results from the system dynamic approach provide insights into the expansion of the service areas of the programme and suggest increasing the number of referrals to private hospitals.

关键词： System dynamic models scenario analysis inpatient transferral mixed public-private healthcare system

NEcAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NEcAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NEcAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NEcAB2 interacts with predominantly striatal G-protein-coupled receptors, while NEcAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NEcAB proteins exhibit distinct subcellular localizations: NEcAB1 is found in the nucleus and cytosol, NEcAB2 resides in endosomes and the plasma membrane, and NEcAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NEcAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NEcAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Discovery of new MAX-phase-like layered ternary carbide V_(8)P_(6)c:crystal structure,thermal expansion,and elastic properties

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Journal of Materials Science & Technology 2024年第7期174卷 55-62页

作者： H.X.chen L.Sheng Z.L.Zhang X.c.Wen D.L.Yang X.Y.Ye P.Q.Dai School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Fujian Provincial key Laboratory of Advanced Materials Processing and Application Fuzhou 350118China State key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Due to the laminated structure,MAX phases and MAX-phase-like compounds possess outstanding dam-age tolerance capability with good thermal/electrical conductivity and other charming functional prop-erties,showing a bright future for structural-functional ***,a new MAX-phase-like ternary car-bide V_(8)P_(6)c with layered characteristics was *** to the alternate stacking of hexagonal-arranged M/A/X atom layers in MAX phases,V_(8)P_(6)c has a layered structure formed by a repeated stacking of the slabs consisting of V_(6)c-octahedrons and VP 6-distorted-octahedrons in three-atomic layers *** thermal expansion anisotropy was revealed,with the thermal expansion coefficients(TEcs)along a-axis,c-axis,and the average value,equal toα_(a)=8.55(5)μk^(−1),α_(c)=10.23(5)μk^(−1),andα_(L)=9.14(5)μk^(−1),*** dilation along the c-axis was mainly dominated by out-plane V-P bonds be-tween layered *** to the pressure-dependent lattice parameters,the polycrystalline bulk modulus(B_(0)=185(9)GPa)and high compressibility anisotropy factor(B_(a)/B_(c)=1.64)was ***-while,the second-order elastic constants were calculated,and the elastic moduli,E=303 GPa,B=198 GPa,G=122 GPa,andν=0.246,were *** the weak connection between layer slabs by out-plane V1-P bond was revealed by the bond stiffness model,with a bond stiffness close to the M-A bond in MAX ***,good damage tolerance capability was predicted according to Paugh’s ratio(G/B=0.616)and cauchy pressure(P_(a)=0 GPa,P_(c)=-7.5 GPa),even better than those of typical MAX *** discovery of V_(8)P_(6)c provides a new member of MAX-phase-like damage-tolerant ceramic with relatively low density,moderate thermal expansion,and anisotropic compressibility,and the unique lay-ered structure is inspiring for exploring new layered ternary ceramics.

关键词： New ternary carbide MAX phase Thermal expansion Elastic constants Anisotropy

An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

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Science china chemistry 2007年第2期50卷 249-252页

作者： ZHU peter c WANG Der-Haw MANI Neelakandha Advanced Sterilization Products Johnson & Johnson33 Technology DriveIrvineCA 92618USA Pharmaceutical Research and Development La Jolla Johnson & Johnson3210 Merryfield RowSan DiegoCA 92121USA

Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis(dibromomethyl) benzenes with fuming sulfuric acid,followed by hydrolysis. The yields were signifi-cantly improved by intr... 详细信息

关键词： aromatic aldehyde 1 2-bis(dibromomethyl) arene hydrolysis oxidation sodium bicarbonate fuming sulfuric acid

Recent progress in the treatment of women with diminished ovarian reserve

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Gynecology and Obstetrics clinical Medicine 2021年第4期1卷 186-189页

作者： Jingwen Yin Hsun-Ming chang Rong Li peter c.k.Leung center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalChina National clinical Research center for Obstetrics and Gynecology(Peking University Third Hospital) China key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationChina Beijing key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology China Department of Obstetrics and Gynelogy University of British ColumbiaAnd BC Children's Hospital Research InstituteVancouverBritish ColumbiaV5Z 4H4Canada

Diminished ovarian reserve(DOR)refers to a decrease in the number and/or quality of oocytes in the ovary,accompanied by a decline in reproductive potential,which is generally related to advanced age or ovarian *** in vitro fertilization(IVF)clinical practice,managing patients with DOR remains one of the most challenging *** recent years,increased research on improving ovarian function has provided us with new insights into treating patients with *** therapeutic options have been proposed to improve the ovarian function of patients with DOR,yet they are not widely utilized in clinical practice because of limited evidence of safety and *** this review,we focus on the mechanisms from animal models and clinical trials that have been applied to the treatment of DOR in recent years,intending to improve IVF outcomes in patients with ***,new insights and perspectives on the molecular and cellular regulation of follicular development and ovarian reserve are emphasized to provide more clues for research on the treatment of DOR.

关键词： Diminished ovarian reserve Infertility In vitro fertilization Ovarian function Oocyte quality Embryo quality

Reactions induced by 30 MeV 3He beam on 9Be:cluster transfer reactions

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chinese Physics c 2024年第1期48卷 61-70页

作者： B.A.Urazbekov T.Issatayev S.M.Lukyanov A.Azhibekov A.S.Denikin k.Mendibayev D.M.Janseitov Yu E.Penionzhkevich k.A.kuterbekov T.k.Zholdybayev Gumiliyev Eurasian National University 2 Satpayev StrAstanaKazakhstan Institute of Nuclear Physics 1 Ibragimov StrAlmatyKazakhstan Bogolubov Laboratory of Theoretical Physics JINR20 Joliot Curie StrDubnaRussia Flerov Laboratory of Nuclear Reactions JINR20 Joliot Curie StrDubnaRussia korkyt-ata State University 29A Aiteke-Byi StrKyzylordaKazakhstan Dubna State University 19 Universitetskaya StrDubnaRussia Al-Farabi kazakh National University AlmatyKazakhstan

An experiment was conducted for studying the cluster structure of Be induced by He ions at an energy of 30 *** results of the nuclear reaction^(3)He+^(9)Be,the differential cross sections for the exit channels–elastic,inelastic,α+^(8)Be,^(6)He+^(6)Be,^(6)Li+^(6)Li,and^(7)Be+^(5)He–were *** and inelastic scattering data were treated within both the optical model and coupled channel method.A new set of optical potentials was considered for the elastic *** deformation parameter was established for the transition 3/2→5/*** transfer reactions were analyzed via the coupled reaction channel *** nuclear reactions with the exit channels^(6)He+^(6)Be,^(6)Li+^(6)Li,and^(7)Be+^(5)He were complemented by two-step transfer *** contribution of each reaction mechanism were shown and compared with the findings of other authors.

关键词： cluster transfer reaction mechanisms coupled equations

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao changshun Ruan Haobo Pan Paul k.chu kenneth M.c.cheung kelvin W.k.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State key Laboratory of High Performance ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina cixi center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration

Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration

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Bioactive Materials 2021年第8期6卷 2315-2330页

作者： Zhengjie Lin Danni Shen Weixiao Zhou Yufeng Zheng Tiantian kong Xuanyong Liu Shuilin Wu Paul k.chu Ying Zhao Jun Wu kenneth M.c.cheung kelvin W.k.Yeung college of chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital1 Haiyuan 1st RoadFutian DistrictShenzhenChina Guangdong key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical EngineeringSchool of MedicineShenzhen UniversityShenzhen518060China State key Laboratory of High Performance ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin300072China Department of Physics Department of Materials Science and EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina centre for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China State key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

The design of orthopedic biomaterials has gradually shifted from“immune-friendly”to“immunomodulatory,”in which the biomaterials are able to modulate the inflammatory response via macrophage polarization in a local immune microenvironment that favors osteogenesis and implant-to-bone *** the well-known effects of bioactive metallic ions on osteogenesis,how extracellular metallic ions manipulate immune cells in bone tissue microenvironments toward osteogenesis and subsequent bone formation has rarely been ***,we investigate the osteoimmunomodulatory effect of an extracellular bioactive cation(Mg^(2+))in the bone tissue microenvironment using custom-made poly lactic-co-glycolic acid(PLGA)/MgO-alendronate microspheres that endow controllable release of magnesium *** results suggest that the Mg^(2+)-controlled tissue microenvironment can effectively induce macrophage polarization from the M0 to M2 phenotype via the enhancement of anti-inflammatory(IL-10)and pro-osteogenic(BMP-2 and TGF-β1)cytokines *** also generates a favorable osteoimmune microenvironment that facilitates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem *** in vivo results further verify that a large amount of bony tissue,with comparable bone mineral density and mechanical properties,has been generated at an early post-surgical stage in rat intramedullary bone defect *** study demonstrates that the concept of in situ immunomodulated osteogenesis can be realized in a controlled magnesium tissue microenvironment.

关键词： Bone regeneration Osteoimmunomodulatory property Osteoimmune environment Macrophage polarization Magnesium ions