检索结果-南通市图书馆

Obeticholic acid for severe bile acid diarrhea with intestinal failure:A case report and review of the literature

World Journal of Gastroenterology 2018年第21期24卷 2320-2326页

作者： Christian Lodberg Hvas peter Ott peter Paine Simon Lal Soren peter Jorgensen Jens Frederik Dahlerup Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus C 8000Denmark Department of Gastroenterology Salford Royal NHS Foundation TrustSalfordManchester M6 8HDUnited Kingdom

Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum. The main therapies include bile acid sequestrants, such as colestyramine and colesevelam, which may be given in combination with the opioid receptor agonist loperamide. Some patients are refractory to conventional treatments. We report the use of the farnesoid X receptor agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure. A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue. The diarrhea resulted in hypokalemia and sodium depletion that made her dependent on twice weekly intravenous fluid and electrolyte infusions. Conventional therapies with colestyramine, colesevelam, and loperamide had no effect. Second-line antisecretory therapies with pantoprazole, liraglutide, and octreotide also failed. Third-line treatment with obeticholic acid reduced the number of stools from an average of 13 to an average of 7 per 24h and improved the patient's quality of life. The fluid and electrolyte balances normalized. The effect was sustained during follow-up for 6 mo with treatment at a daily dosage of 25 mg. The diarrhea worsened shortly after cessation of obeticholic acid. This case report supports the initial report that obeticholic acid may reduce bile acid production and improve symptoms in patients with bile acid diarrhea.

关键词： Bile acid malabsorption Diarrhea Farnesoid X-activated receptor Crohn’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Guardians of the eye:new tales about retinal microglia and other ocular macrophages

引用

Neural Regeneration Research 2022年第6期17卷 1275-1277页

作者： Dennis-Dominik Rosmus peter Wieghofer Institute of Anatomy Leipzig UniversityLeipzigGermany

Macrophages are highly versatile and plastic immune cells that are localized in nearly all organs of the body and contribute to a plethora of physiological and pathological processes in *** their roles as major players in the“first line of defense”under inflammatory conditions,macrophages are known to participate in tissue homeostasis maintenance.

关键词： organs homeostasis ocular

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isolated Bell's palsy-An unusual presentation of dengue infection

引用

Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 82-84页

作者： Soumia peter Malhotra N peter P Sood R Department of Medicine Christian Medical College & Hospital Department of Radiodiagnosis Christian Medical College & Hospital

Dengue fever is a very common arthropod-borne infection in tropical *** complications in dengue fever are relatively uncommon and among these,isolated cranial neuropathies have been reported only very *** present an unusual neurological complication of Bell’s palsy(lower motor neuron 7 th nerve palsy) associated with dengue *** the best of our knowledge,there have been very few documented cases of Flavivirus causing isolated Bell’s palsy.

关键词： Dengue infection Bell’s palsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simulation and calibration of granules using the discrete element method

引用

Particuology 2014年第1期12卷 40-43页

作者： peter Müller Jürgen Tomas Institute of Process Engineering Mechanical Process EngineeringOtto-von-Guericke University MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The discrete element method （DEM）, developed by Cundall and 5track to solve geomecnamcai problems, is used to simulate the mechanical behavior of granules. According to the DEM, an individ ual granule can be modeled as a realistic mechanical system consisting of primary particles bonded by interaction forces. Cranulometric properties of the model material, zeolite 4A, have been measured to determine their macro properties. To investigate the compression behavior, a compression test was performed using a strength tester on single granules between two pistons. A modeled granule consisting of more than 22,000 primary particles was generated. The micro properties of the modeled granule have been precisely set to allow its macro properties to be equivalent to the macro properties of zeolite 4A granules. To calibrate the mechanical properties, diametrical compression was simulated using two rigid walls stressed at a constant stressing velocity, The force-displacement curve of the modeled granule at compression has been calibrated by the experimental curve of zeolite 4A.

关键词： Discrete element method Material behavior Granulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrogenic Donor in a Spherical Quantum Dot with Different Confinements

引用

Chinese Physics Letters 2009年第8期26卷 309-312页

作者： A. John peter K. Navaneethakrishnan Govt. Arts College Melur-625 106 Madurad India Madurai Kamaraj-University Madurai-625 021 India

Binding energies of a hydrogenic donor in a spherical GaAs quantum dot surrounded by Ga1-xA4xAs matrix are calculated. The results are presented for realistie barrier heights corresponding to different values of x （x 〈 0.4）. The calculations are performed under two different conditions：（i） a spherical dot with square well confinement and （ii） a dot with parabolic potential well confinement. The results show that （i） the donor ionization energies are always higher under parabolic confinement as compared to a dot of the same radius under square well confinement and （ii） the oscillator strengths coupling ground state with excited states are two orders larger under parabolic confinement. Our results are in agreement with the results of other researchers.

关键词： ELECTRON donor-acceptor complexes QUANTUM dots BINDING energy OSCILLATOR strengths PLASMA confinement QUANTUM wells GALLIUM arsenide semiconductors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photo-Induced Electron Spin Polarization in a Narrow Band Gap Semiconductor Nanostructure

引用

Chinese Physics Letters 2012年第11期29卷 186-190页

作者： A.John peter Chang Woo Lee Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University1 SeochunGihungYonginGyeonggi 446-701S.Korea

Photo-induced spin dependent electron transmission through a narrow gap InSb/InGa_(x)Sb_(1-x) semiconductor symmetric well is theoretically studied using transfer matrix *** transparency of electron transmission is calculated as a function of electron energy for different concentrations of *** spin-polarized photon assisted resonant tunnelling in the heterostructure due to Dresselhaus and Rashba spin-orbit coupling induced splitting of the resonant level and compressed spin-polarization are *** results show that Dresselhaus spin-orbit coupling is dominant for the photon effect and the computed polarization efficiency increases with the photon effect and the gallium concentration.

关键词： polarization resonant photon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Linear and angular momenta in tightly focused vortex segmented beams of light(Invited Paper)

引用

Chinese Optics Letters 2017年第3期15卷 7-11页

作者： Martin Neugebauer Andrea Aiello peter Banzer Max Planck Institute for the Science of Light Staudtstr. 2 Erlangen D-91058 Germany Institute of Optics Information and Photonics University Erlangen-Nuremberg Staudtstr. 7/B2 Erlangen D-91058 Germany

We investigate the linear momentum density of light, which can be decomposed into spin and orbital parts, in the complex three-dimensional field distributions of tightly focused vortex segmented beams. The chosen angular spectrum exhibits two spatially separated vortices of opposite charge and orthogonal circular polarization to generate phase vortices in a meridional plane of observation. In the vicinity of those vortices, regions of negative orbital linear momentum occur. Besides these phase vortices, the occurrence of transverse orbital angular momentum manifests in a vortex charge-dependent relative shift of the energy density and linear momentum density.

关键词： Invited Paper VSB Linear and angular momenta in tightly focused vortex segmented beams of light

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Upper bounds of Schubert polynomials

引用

Science China Mathematics 2022年第6期65卷 1319-1330页

作者： Neil Jiuyu Fan peter Long Guo Department of Mathematics Sichuan UniversityChengdu 610064China Center for Combinatorics LPMCNankai UniversityTianjin 300071China

Let w be a permutation of{1,2,...,n},and let D(w)be the Rothe diagram of *** Schubert polynomial■w_(x)can be realized as the dual character of the flagged Weyl module associated with D(w).This implies the following coefficient-wise inequality:Min_(x)≤■_(w)(x)≤Max_(w)xwhere both Min_(w)(x)and Max_(w)(x)are polynomials determined by D(w).Fink et al.(2018)found that■w_(x)equals the lower bound Min_(w)(x)if and only if w avoids twelve permutation *** this paper,we show that■w_(x)reaches the upper bound Max_(w)(x)if and only if w avoids two permutation patterns 1432 and ***,for any given compositionα∈Z^(n)≥0,one can define a lower bound Min_(α)(x)and an upper bound Max_(α)(x)for the key polynomialκ_(α)(x).Hodges and Yong(2020)established thatκ_(α)(x)equals Min_(α)(x)if and only ifαavoids five composition *** show thatκ_(α)(x)equals Max_(α)(x)if and only ifαavoids a single composition pattern(0,2).As an application,we obtain that whenαavoids(0,2),the key polynomialκ_(α)(x)is Lorentzian,partially verifying a conjecture of Huh et al.(2019).

关键词： Schubert polynomial key polynomial flagged Weyl module upper bound Lorentzian polynomial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy Gap Dependence on Mn Content in a Diluted Magnetic Quantum Dot

引用

Chinese Physics Letters 2011年第4期28卷 201-204页

作者： P.Nalini A.John peter Department of Physics Yadava College Govindarajan CampusThiruppalaiMadurai-625014India Department of Physics Govt.Arts and Science CollegeMelur-625106MaduraiIndia

Positively charged donor exciton binding energy is computed as a function of quantum-dot size within the single band effective mass approximation for different Mn contents in Cd_(1)−x_(𝑥in)Mn_(x𝑥in)Te/Cd_(1−xout)𝑥outMn_(xout)𝑥*** exciton bound polaron is computed for 0≤x𝑥≤0.08,on the Mn mole *** determine the energy gap using the mean field approximation and incorporate the exchange interaction between the carrier and the magnetic *** interband emission energy is studied with the height and radius of the cylindrical quantum ***-band anisotropy is included in our theoretical model using different hole masses in different spatial *** polaronic shifts as functions of quantum-dot radius and Mn concentration are estimated using the mean field *** is found that(i)the energy gap depends on the Mn mole fraction,(ii)it increases linearly with an increase in Mn content,and(iii)the effect is more pronounced for a narrow dot,showing the quantum size *** results are in good agreement with other recently published reports.

关键词： theory quantum radius

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of degree of interlock on confined strength of jointed hard rock masses

引用

Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1152-1170页

作者： Navid Bahrani peter K.Kaiser a Department of Civil and Resource Engineering Dalhousie UniversityHalifaxNova ScotiaCanada b Bharti School of Engineering Laurentian UniversitySudburyOntarioCanada

The strength of jointed rock mass is strongly controlled by the degree of interlock between its constituent rock *** degree of interlock constrains the kinematic freedom of individual rock blocks to rotate and slide along the block forming *** HoekeBrown(HB)failure criterion and the geological strength index(GSI)were developed based on experiences from mine slopes and tunneling projects in moderately to poorly interlocked jointed rock *** has since then been demonstrated that the approach to estimate the HB strength parameters based on the GSI strength scaling equations(called the‘GSI strength equations’)tends to underestimate the confined peak strength of highly interlocked jointed rock masses(***>65),where the rock mass is often non-persistently jointed,and the intact rock blocks are strong and *** estimation of the confined strength of such rock masses is relevant when designing mine pillars and abutments at great depths,where the confining pressure is high enough to prevent block rotation and free sliding on block *** this article,a grain-based distinct element modeling approach is used to simulate jointed rock masses of various degrees of interlock and to investigate the influences of block shape,joint persistence and joint surface condition on the confined peak *** focus is on non-persistently jointed and blocky(persistently jointed)rock masses,consisting of hard and homogeneous rock blocks devoid of any strength degrading defects such as *** results from this investigation confirm that the GSI strength equations underestimate the confined strength of highly interlocked and non-persistently jointed rock ***,the GSI strength equations are found to be valid to estimate the confined strength of persistently jointed rock masses with smooth and non-dilatant joint surfaces.

关键词： Rock mass strength Degree of interlock Non-persistently jointed rock mass Blocky rock mass Geological strength index(GSI) GSI strength equations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：