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The Metabolic Syndrome and Sexual Dysfunction in a State of Inflammation

Advances in Sexual Medicine 2017年第2期7卷 82-96页

作者： Huseini Alidu W. K. B. A. Owiredu Nafiu Amidu peter paul mwinsanga dapare Ahmed Tijani Bawah Christian Kofi Gyasi-Sarpong Christian Obirikorang Department of Medical Laboratory Science University of Health and Allied Sciences Ho Ghana Department of Molecular Medicine Kwame Nkrumah University of Science & Technology Kumasi Ghana Department of Biomedical Laboratory Science University for Development Studies Tamale Ghana Department of Surgery (Urology Unit) Komfo Anokye Teaching Hospital Kumasi Ghana

Background: Diabetes is amongst the most researched diseases worldwide due to its debilitating effects on patients. Diabetics have a higher risk of developing erectile dysfunction. Evidence has linked erectile dysfunction severity to increased age, duration of diabetes, the metabolic syndrome and hypogonadism. However, the role of inflammatory markers in the pathogenesis of SD is still unclear. The contributions of hormonal parameters and adipokines to both macro and micro vascular complications are still poorly understood. This study was conducted to provide some evidence of an association between SD, the metabolic syndrome and inflammatory hormones. Method: A total of 130 diabetic males participated in this study. All participants were at least 18 years and were actively engaged in a stable heterosexual relationship for a minimum of two years before they were recruited for this study. The Diabetic men were evaluated using the Golombok Rust Inventory of Sexual Satisfaction for males (GRISS-M). The NCEP-ATP III, IDF and WHO criteria were used to assess the metabolic syndrome. Blood samples were taken for biochemical and hormonal assays. Results: Participants with raised Triglyceride levels showed significantly higher leptin levels for NCEP-ATP III and IDF criteria. Participants with impotence showed significantly lower leptin/adiponectin ratio (p = 0.0184) whilst participant with non-sensuality showed significantly higher values of leptin/adiponectin ratio (p = 0.0103). A significantly higher levels of insulin (p = 0.0265) was recorded in participants with Dissatisfaction problems. Participants with Non communication problems showed significantly higher levels of insulin (p = 0.0419) and lower levels of adiponectin (p = 0.0438) whilst participants with infrequency showed significantly lower levels of adiponectin (p = 0.0042). Conclusion: The relative balance between pro inflammatory and anti-inflammatory mediators of endothelial dysfunction could possibly be essenti

关键词： Golombuk-Rust Inventory for Sexual Satisfaction-Male Metabolic Syndrome Sexual Dysfunction

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Alcohol Consumption Is Associated with Hypogonadism and Decreased Sexual Function in Ghanaian Diabetics

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Advances in Sexual Medicine 2017年第3期7卷 121-130页

作者： Huseini Alidu William K. B. A. Owiredu Nafiu Amidu Christian Kofi Gyasi-Sarpong peter paul mwinsanga dapare Ahmed Tijani Bawah Arnold Togiwe Luuse Emmanuel Barima Agyemang Prempeh Department of Medical Laboratory Science University of Health and Allied Sciences Ho Ghana Department of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Biomedical Laboratory Science University for Development Studies Tamale Ghana Department of Surgery (Urology) Komfo Anokye Teaching Hospital/SMS-KNUST Kumasi Ghana Department of Academic Affairs University of Health and Allied Sciences Ho Ghana

Introduction: Alcohol usage has largely been seen as a risk factor for the development of sexual dysfunction as well as erectile dysfunction. Others have reported that prolonged alcohol usage and abuse is compatible with normal sexual function in the absence of endocrinological problems as well as hepatic dysfunction. About seventy five (75) percent of alcoholics have various sexual difficulties with improvements in sexual functions occurring after treatment of alcoholism and psychosexual therapy. It is evident from the various reports over the years that mild and occasional alcohol usage is not as much implicated in the causation of SD and its other forms as heavy, addictive or dependent alcohol usage. Alcohol usage has also long been linked to hypogonadism, testicular atrophy as well as leydig cell toxicity. Alcohol induced hypogonadism has been reported to resolve after withdrawal of alcohol use. Since both diabetes and alcohol usage have been strongly associated with both hypogonadism and sexual dysfunction, it is logical to expect that diabetics who frequently consume alcohol will have a worsened hypogonadal state and sexual function. This research therefore seeks to provide evidence of an association between alcohol consumption in diabetics and a worsened sexual dysfunction in comparison to diabetics who did not consume alcohol. Methods: Type II diabetic patients attending the Diabetic Clinic at the Maamobi General Hospital between the periods of January 2010 and March 2011 were consecutively recruited for this study. Diabetics with other known endocrinological diseases and physical disabilities were excluded from the study. Sexual function was assessed using the GRISS-M. Early morning fasting samples were used in lipid and testosterone profile assays. Results: Study participants who consumed alcohol recorded higher levels of triglycerides and LDL-Cholesterol. They also recorded significantly lower levels of bioavailable testosterone. Furthermore they also rec

关键词： Hypogonadism Sexual Dysfunction Erectile Dysfunction Libido Alcohol Abuse

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Effect of Varicocelectomy on Gonadal Function among Patients Reporting with Sexual Dysfunction in Ghana

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Open Journal of Urology 2022年第6期12卷 305-330页

作者： Yussif Adams Akisibadek Alekz Afoko Nafiu Amidu Lawrence Quaye Simon Bannison Bani peter paul M. dapare Vivian Afoko Department of Biomedical Laboratory Science School of Allied Health Sciences University for Development Studies Tamale Ghana Department of Surgery School of Medicine University for Development Studies Tamale Ghana Urology Unit Tamale Teaching Hospital Tamale Ghana Department of Paediatric Nursing School of Nursing and Midwifery University for Development Studies Tamale Ghana

Background: Long-standing varicocele is often associated with testicular hypoxia and that might worsen Leydig cell function, a significant risk factor for hypogonadism. This may affect both the secretory and endocrine functions of the testis. This study aims to determine the effect of microsurgical sub-inguinal varicocelectomy on gonadal function among men reporting sexual dysfunction in Ghana. Methods: This was an intervention study conducted at the Tamale Teaching Hospital from September 2017 to August 2021. A total of 103 participants were randomized into two groups;the surgery group (n = 52) and the observed group (n = 51). Venous blood samples were collected at baseline, varicocelectomy was performed for the surgery group, and no intervention was given to the other. Blood samples were subsequently collected at 12-, 24-, 36-, and 48-month intervals for assay of serum total testosterone, FSH, and LH. The data were analyzed in GraphPad Prism (v8.0) at an alpha value of 0.05. Results: All the participants had varicocele and were aged between 55.0 to 69.0 years old. At the baseline of the study, all participants presented with sexual dysfunction but a significant improvement (p Conclusions: Microsurgical sub-inguinal varicocelectomy improved gonadal function among varicocele patients reporting sexual dysfunction. It is recommended to use this choice for similar patients;however, these findings should be verified by a multi-institutional study to provide more evidence for this choice.

关键词： Varicocele Sub-Inguinal Varicocelectomy Gonadal Function Sexual Dysfunction

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