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Bonding, Structure and Uses of Metals

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Journal of Metallic Material Research 2023年第1期6卷 7-15页

作者： peter F.lang Birkbeck College(University of London) Malet StreetLondonUK

This work briefly describes some of the different features of groups of *** highlights recent progress in research into *** details the structures and defects in solid *** common theories of metals including the free electron theory,band theory,the ions in a sea of electrons model and the soft sphere model are discussed and their merits are *** describes distinctions between the bonding in metals and inter-metallic *** shows the influence of bonding on the properties of metals and alloys and provides a summary of tradition and newer uses of metals.

关键词： Metals Alloys Inter-metallic compounds Bonding strucuture

Assessment of parameters for precipitation simulation of heat treatable aluminum alloys using differential scanning calorimetry

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2157-2167页

作者： Ahmad FALAHATI Jun WU peter lang Mohammad Reza AHMADI Erwin POVODEN-KARADENIZ Ernst KOZESCHNIK Institute of Materials Science and Technology Vienna University of Technology Materials Center Leoben Forschung GmbH Christian Doppler Laboratory for Early Stages of Precipitation Institute of Materials Science and TechnologyVienna University of Technology

Differential scanning calorimetry （DSC） has been used extensively to study different solid state reactions. The signals measured in DSC are associated with the growth and dissolution of different precipitates during a specific heat cycle. The time-temperature dependence of heat cycles and the corresponding heat flow evolution measured in the sample by DSC provide valuable experimental information about the phase evolution and the precipitation kinetics in the material. The thermo-kinetic computer simulation was used to predict the DSC signals of samples taken from 6xxx and 2xxx alloys. In the model, the evolution of different metastable and stable phases and the role and influence of excess quenched-in vacancies in the early stage of precipitation were taken into account. Transmission electron microscopy （TEM） and high-resolution TEM were used to verify the existence of precipitates, their size and number density at specific points of the DSC curves.

关键词： differential scanning calorimetry aluminum alloys precipitation kinetics simulation vacancy MatCalc

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德国铁路摆式列车的倾摆技术及其运用经验

国外内燃机车 2003年第6期 37-43,46页

作者： Hans peter lang 吴雅丽德

摆式列车是铁路运输的一种生产资料。它在运用和维护中的可靠性和经济性 ,是其长期有效运用的决定性的前提。本文从这些边界条件出发 ,结合实际运用经验 ,介绍了对摆式动车的主要要求 ,阐述了动车快速通过曲线时对铁路轨道及可靠性技术... 详细信息

摆式列车是铁路运输的一种生产资料。它在运用和维护中的可靠性和经济性 ,是其长期有效运用的决定性的前提。本文从这些边界条件出发 ,结合实际运用经验 ,介绍了对摆式动车的主要要求 ,阐述了动车快速通过曲线时对铁路轨道及可靠性技术的要求 ;同时 ,结合德国铁路在倾摆技术方面进一步发展的趋势。

关键词：内燃动车摆式列车倾摆装置可靠性经济性发展趋势

一位药物性牙龈增生患者的诊断、治疗和长期疗效

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中国口腔医学继续教育杂志 2009年第3期12卷 27-34页

作者： Wah Ching Tan Lure Peng lim Niklaus peter lang 乔敏（译）徐莉审不详北京大学口腔医学院牙周科北京海淀区中关村南大街22号100081

本文报告了1例服用环孢素和硝苯地平相关牙龈增生（肥大）患者的诊断、治疗和长期疗效。该患者在未更换全身用药情况下对牙龈增生进行了成功治疗。治疗的主要目的是降低牙龈增生的程度，进而恢复牙齿的健康、功能和美观。治疗过程是先... 详细信息

本文报告了1例服用环孢素和硝苯地平相关牙龈增生（肥大）患者的诊断、治疗和长期疗效。该患者在未更换全身用药情况下对牙龈增生进行了成功治疗。治疗的主要目的是降低牙龈增生的程度，进而恢复牙齿的健康、功能和美观。治疗过程是先行牙周基础治疗，后行牙周手术治疗，术后观察2年．牙龈增生未见复发。

关键词：环孢菌素牙龈肥大维护治疗硝苯地平

Targeted therapies in cholangiocarcinoma:light at the end of the tunnel?

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 631-633页

作者： Iakovos Amygdalos Ulf peter Neumann Sven Arke lang Department of General Visceral and Transplantation SurgeryUniversity Hospital RWTH AachenAachenGermany

The genetic landscape of cholangiocarcinoma(CCA)remains largely *** is one of the deadliest cancers(1),with the gold standard treatment for all anatomical forms(intrahepatic-iCCA,perihilar-pCCA and distal-dCCA)being surgical resection(with adjuvant capecitabine also recommended in the newest guidelines)(2,3).The importance of genetic markers in terms of postoperative and oncological outcomes is being increasingly recognized,but few actionable mutations have been identified so far(2,4).This is particularly pertinent for patients with advanced/irresectable disease,who rely on systemic *** outcomes are poor in these patients[5-year survival up to 10%-(5)]and they would profit the most from novel,targeted therapies.

关键词： Cholangiocarcinoma(CCA) targeted therapy biomarkers

Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

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Neural Regeneration Research 2017年第12期12卷 2025-2034页

作者： Jun-mei Wang Ze-qiang Qu Jin-lang Wu peter Chung Yuan-shan Zeng Department of Histology and Embryology Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Department of Electron Microscope Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Shanghai Ninth People's Hospital Shanghai liao Tong University School of Medicine Shanghai China Institute of Spinal Cord In)ury Sun Yat-sen University Guangzhou Guangdong Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China

In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata（RCE） improved spatial cognition in a rat model of Alzheimer＇s disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer＇s disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer＇s disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease intracerebroventricular injection streptozotocin neuronal apoptosis neuroprotection cytochrome c oxidase adenosine triphosphate caspase-3 NeuN neural regeneration

Coordination-driven self-assembly of dibenzo-18-crown-6 functionalized Pt(Ⅱ) metallacycles

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Chinese Chemical Letters 2023年第2期34卷 158-160页

作者： Zibin Zhang Yu Yao lang He Tao Hong Shijun Li Feihe Huang peter J.Stang College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular ScienceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry University of UtahSalt Lake CityUT 84112United States

Coordination-driven self-assembly was used to construct two metallacycles of a dicarboxylatefunctionalized dibenzo-18-crown-6 in combination with either a 0° anthracene-based clip-type acceptor or a 60° phenanthrene-based acceptor. The angularities of these moieties make them suitable for the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization and host-guest chemistry of two metallacycles were described and supported by31P{1H},1H NMR spectra and electrospray mass spectrometry.

关键词： Crown ethers Metallacycles Cation receptors Self-assembly

Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1632-1647页

作者： Katharina Joechle Jessica Guenzle Claus Hellerbrand Pavel Strnad Thorsten Cramer Ulf peter Neumann Sven Arke lang Visceral and Transplantation Surgery University Hospital Rheinisch-Westfalisch Technische Hochschule AachenAachen 52074Germany Department of General and Visceral Surgery Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Biochemistry Friedrich-Alexander University Erlangen-NurnbergErlangen 91054Germany Department of Internal Medicine Ⅲ University Hospital Rheinisch-Westfalisch Technische Hochschule AachenAachen 52074Germany

The mammalian target of rapamycin(mTOR)acts in two structurally and functionally distinct protein complexes,mTOR complex 1(mTORC1)and mTOR complex 2(mTORC2).Upon deregulation,activated mTOR signaling is associated with multiple processes involved in tumor growth and *** with mTORC1,much less is known about mTORC2 in cancer,mainly because of the unavailability of a selective ***,existing data suggest that mTORC2 with its two distinct subunits Rictor and mSin1 might play a more important role than assumed so *** is one of the key effectors of the PI3K/AKT/mTOR pathway and stimulates cell growth,cell survival,metabolism,and cytoskeletal *** is not only implicated in tumor progression,metastasis,and the tumor microenvironment but also in resistance to ***,the central subunit of mTORC2,was found to be upregulated in different kinds of cancers and is associated with advanced tumor stages and a bad ***,AKT,the main downstream regulator of mTORC2/Rictor,is one of the most highly activated proteins in *** and secondary liver cancer are major problems for current cancer therapy due to the lack of specific medical treatment,emphasizing the need for further therapeutic *** review,therefore,summarizes the role of mTORC2/Rictor in cancer,with special focus on primary liver cancer but also on liver metastases.

关键词： Mammalian target of rapamycin Mammalian target of rapamycin complex 2 Rictor Liver cancer Liver metastases Hepatocellular carcinoma Cholangiocellular carcinoma

Microvascular invasion of hepatocellular carcinoma predicts microvascular invasion of its recurrence: potential implications for salvage liver transplantation?

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 183-191页

作者： Stefan Heinrich Jens Mittler Juliane Theurer Dirk ARidder Jens UMarquardt Arndt Weinmann Uwe Scheuermann Gerd Otto peter RGalle Beate KStraub Hauke lang General Visceral and Transplantation SurgeryUniversity Hospital of MainzMainzGermany Institute of Pathology University Hospital of MainzMainzGermany Department of Medicine I University Medical Center Schleswig-HolsteinCampus LübeckGermany Department of Medicine I University Hospital of MainzMainzGermany Visceral TransplantationThoracic and Vascular SurgeryUniversity Hospital LeipzigLeipzigGermany

Background:Microvascular invasion(MVI)can only be assessed on a full surgical *** aimed at evaluating,whether the histology of the primary tumor is predictive of MVI in a hepatocellular carcinoma(HCC)***:Patients,who underwent liver resection or orthotopic liver transplantation(OLT)for recurrent HCC from January 2001 until June 2018 were eligible for this retrospective *** specimens were evaluated for HCC subtype/morphology,vessels encapsulating tumor clusters(VETC)-pattern and *** parameters were analyzed using χ^(2)-test andϕ-values,with P values<0.05 being considered ***:Of 230 HCC recurrences,37(16.1%)underwent repeated liver resection(n=22)or OLT(n=15).Of these,67.6%initially exceeded the Milan *** correlated Milan criteria(P=0.005),tumor size(P=0.015)and VETC-pattern(P=0.034)in the primary *** recurrences shared many features of the primary HCC such as tumor grade(P=0.002),VETC-pattern(P=0.035),and MVI(P=0.046).In recurrences,however,only the concordance with the Milan criteria correlated with MVI(P=0.018).No patient without MVI in the primary HCC revealed MVI on early recurrence(<2 years)(P=0.035).Conclusions:HCC recurrences share many biological features of the primary ***,early recurrences of MVI-negative HCC never revealed *** finding offers novel concepts,e.g.,patient selection for salvage OLT.

关键词： Microvascular invasion(MVI) resection selection vessels encapsulating tumor clusters(VETC) angioinvasion salvage transplantation