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Physician-Rated Utility of Procedure Videos for Teaching Procedures in the Emergency Department, Overall and during Emergency Department crowding

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International Journal of clinical Medicine 2012年第7期3卷 758-764页

作者： clare L. Atzema R. Alexandra Stefan Refik Saskin Greg Michlik peter c. austin Department of Emergency Services Sunnybrook Health Sciences Centre Toronto Canada Division of Emergency Medicine Department of Medicine University of Toronto Toronto Canada The Institute for clinical Evaluative Sciences Toronto Canada

Background: Real-time use of procedure videos as educational tools has not been studied. We sought to determine whether viewing a video of a medical procedure prior to procedure performance in the emergency department improves the quality of teaching of procedures, and whether videos are particularly beneficial during periods of emergency department crowding. Methods: In this single-centre, prospective, before and after study standardized data collection forms were completed by both trainees and supervising emergency physicians (EPs) at the end of each emergency department shift in the before (August 2008-March 2009) and after (August 2009-March 2010) phase. Online procedure videos were introduced on emergency department computers in the after phase. The primary outcome measure was EP rating of the quality of teaching provided (5-point Likert scale). The interaction between crowding and videos was also assessed, to determine whether videos provide a specific additional benefit during periods of emergency department crowding. Results: There were 1159 procedures performed by 192 trainees. Median procedures performed per shift was 1.0 (IQR 0 - 2.0). Mean EP rating of teaching provided was significantly higher in the group that viewed videos, at 4.2 versus 3.7 (p 0.001). In the adjusted analysis, EP ratings increased by 0.5 with a video (p 0.001), while the odds of a score of 5.0 were 2.2 times greater if a video was viewed (p = 0.03). The interaction of crowding and procedure videos was not significant (the use of videos increased the average score by 0.24 in times of crowding compared to times of non-crowding, p = 0.19). conclusions: Use of procedural videos was associated with EP perception of improved quality of teaching provided around procedures. While EPs rated the quality of their teaching as improved overall, the effect of videos on teaching quality was the same in crowded settings as it was in non-crowded setting.

关键词： Teaching Education Procedures Emergency Department Video

The Impact of Investing in Emerging Markets on Firm Performance: An Exploratory Study of Taiwan Residents Multinational Enterprises in the chinese Mainland

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china & World Economy 2003年第3期11卷 51-59页

作者： c.Janie chang Hui-MeiTsai Jasmine Yur-austin professor of Accounting Department of Accounting and FinanceCollege of BusinessSan Jose State UniversityUSA.Associate Research FellowChung-Hug Institution For Economic ResearchTaipeiTaiwanChina.Associate Professor of FinanceDepartment of FinanceReal Estate and LawCollege of Business AdministrationCalifornia State UniversityUSA

Ⅰ.IntroductionDuring the past two decades,many multinationalenterprises(MNEs)have made substantial investmentsin emerging *** factors dominate thereasoning in favor of such an investment strategy:lowlabor costs and t... 详细信息

关键词： in of An Exploratory Study of Taiwanese Multinational Enterprises in the chinese Mainland The Impact of Investing in Emerging Markets on Firm Performance on

Links between global cO_2 variability and climate anomalies of biomes

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Science china Earth Sciences 2008年第5期51卷 740-747页

作者： peter S. BAKWIN School of Earth and Environmental Sciences Queens College City University of New York New York 11367 USA

The global rate of fossil fuel combustion continues to rise, but the amount of cO2 accumulating in the atmosphere has not increased accordingly. The causes for this discrepancy are widely debated. Par- ticularly, the location and drivers for the interannual variability of atmospheric cO2 are highly uncertain. Here we examine links between global atmospheric cO2 growth rate (cGR) and the climate anomalies of biomes based on (1986―1995) global climate data of ten years and accompanying satellite data sets. Our results show that four biomes, the tropical rainforest, tropical savanna, c4 grassland and boreal forest, and their responses to climate anomalies, are the major climate-sensitive cO2 sinks/sources that control the cGR. The nature and magnitude by which these biomes respond to climate anomalies are generally not the same. However, one common influence did emerge from our analysis; the ex- tremely high cGR observed for the one extreme El Nio year was caused by the response of the tropical biomes (rainforest, savanna and c4 grassland) to temperature.

关键词： biomes carbon cycle climate anomaly NDVI El Nio

cerebellar pathology in motor neuron disease:neuroplasticity and neurodegeneration

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Neural Regeneration Research 2022年第11期17卷 2335-2341页

作者： Rangariroyashe H.chipika Grainne Mulkerrin Pierre-François Pradat Aizuri Murad Fabrice Ango cédric Raoul peter Bede computational Neuroimaging Group Biomedical Sciences InstituteTrinity College DublinDublinIreland Pitié-Salpêtrière University Hospital Sorbonne UniversityParisFrance The Neuroscience Institute of Montpellier(INM) INSERMCNRSMontpellierFrance

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system *** clinical picture is dominated by upper and lower motor neuron degeneration,but extra-motor pathology is increasingly recognized,including cerebellar ***-mortem and neuroimaging studies primarily focus on the chara cterization of supratentorial disease,des pite emerging evidence of cerebellar degeneration in amyotrophic lateral *** clinical features of amyotrophic lateral sclerosis,such as dysarthria,dysphagia,cognitive and behavioral deficits,saccade abnormalities,gait impairment,respiratory weakness and pseudobulbar affect are likely to be exacerbated by co-existing cerebellar *** review summarizes in vivo and post mortem evidence for cerebellar degeneration in amyotrophic lateral scle *** imaging studies consistently capture cerebellar grey matter volume reductions,diffusivity studies readily detect both intra-cerebellar and cerebellar peduncle white matter alte rations and functional imaging studies commonly report increased functional connectivity with supratentorial *** functional connectivity is commonly interpreted as evidence of neuro plasticity representing compensatory processes despite the lack of post-mortem *** is a scarcity of post-mortem studies focusing on cerebellar alte rations,but these detect pTDP-43 in cerebellar *** rebellar pathology is an overloo ked facet of neurodegeneration in amyotrophic lateral sclerosis despite its contribution to a multitude of clinical symptoms,wides p read connectivity to spinal and supratentorial regions and putative role in compensating for the degeneration of primary motor regions.

关键词： amyotrophic lateral sclerosis ataxia cerebellum magnetic resonance imaging motor neuron disease neuroimaging neuroplasticity pathology primary lateral sclerosis pseudobulbar affect

Laguerre expansion on the Heisenberg group and Fourier-Bessel transform on c^n Dedicated to professor Sheng GONG on the occasion of his 75th birthday

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Science china Mathematics 2006年第11期49卷 1722-1739页

作者： cHANG Der-chen GRIENER peter Department of Mathematics Georgetown University Washington DC 20057USA Department of Mathematics University of Toronto TorontoON M5S 3G3Canada

Given a principal value convolution on the Heisenberg group Hn = cn × R, we study the relation between its Laguerre expansion and the Fourier-Bessel expansion of its limit on cn. We also calculate the Dirichlet kerne... 详细信息

关键词： Heisenberg group, Fourier transform, Laguerre expansion, Bessel functions,Poisson sum, Dirichlet kernel.

Pole-Based Approximation of the Fermi-Dirac Function

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chinese Annals of Mathematics,Series B 2009年第6期30卷 729-742页

作者： Lin LIN Jianfeng LU Lexing YING Weinan E Dedicated to professor Andrew Majda on the Occasion of his 60th Birthday

Two approaches for the efficient rational approximation of the Fermi-Dirac function are discussed： one uses the contour integral representation and conformal real〉 ping, and the other is based on a version of the multipole representation of the Fermi-Dirac function that uses only simple poles. Both representations have logarithmic computational complexity. They are of great interest for electronic structure calculations.

关键词： contour integral Fermi-Dirac function Rational approximation

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo conan Juan Alec c.Bancroft Ji Hae choi chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of chemical Biology and Medicinal chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(EcM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPcs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen EcM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-creER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-creER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPcs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPcssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPc *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Enhanced apoptosis in post-liver transplant hepatitis c:Effects of virus and immunosuppressants

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World Journal of Gastroenterology 2012年第18期18卷 2172-2179页

作者： Eu Jin Lim Ruth chin peter W Angus Joseph Torresi Liver Transplant Unit Austin HospitalHeidelbergVictoria 3084Australia Department of Medicine University of MelbourneAustin HealthHeidelbergVictoria 3084Australia Department of Infectious Diseases Austin HospitalHeidelbergVictoria 3084Australia

Hepatitis c(HcV)-infected patients have a poorer survival post-liver transplantation compared to patients transplanted for other indications,since HcV recurrence post-transplant is universal and commonly follows an aggressive *** is increasing evidence that in the non-transplant setting,induction of hepatocyte apoptosis is one of the main mechanisms by which HcV drives liver inflammation and fibrosis,and that HcV proteins directly promote *** studies have shown that post-liver transplant,there is a link between high levels of HcV replication,enhanced hepatocyte apoptosis and the subsequent development of rapidly progressive liver *** the responsible mechanisms remain unclear,it is likely that immunosuppressive drugs play an important *** is well known that immunosuppressants impair immune control of HcV,thereby allowing increased viral *** there is also evidence that immunosuppressants may directly induce apoptosis and this may be facilitated by the presence of high levels of HcV *** HcV and immunosuppressants may synergistically interact to further enhance apoptosis and drive more rapid *** findings suggest that modulation of apoptosis within the liver either by changing immunosuppressive therapy or the use of apoptosis inhibitors may help prevent fibrosis progression in patients with post-transplant HcV disease.

关键词： Hepatitis c Liver transplantation Apoptosis Immunosuppressive agents transforming growth factor-β

THE IN VITRO EFFEcTS OF STEROIDS, HUMAN cHORIONIc GONADOTROPIN AND cYANOKETONE ON GERMINAL BREAKDOWN OF STRIPED MULLET (MUGIL cEPHALUS L.)OOcYTES

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Journal of Oceanology and Limnology 1987年第1期5卷 1-8页

作者：洪万树,peter Thomas Department of Oceanology Xiamen University Fujian china Marine Science Institute University of Texas at austin TX 78373 U.S.A

The in vitro effects of steroids, human chorionic gonadotropin (HcG) and cyanoketone on germinal vesicle breakdown (GVBD) of striped mullet (Mugil cephalus L.) oocytes were investigated. All concentrations of HcG (5,10,50 I.U./ml), progesterone and pregnenolone at the highest concentrations(lug/ml) were moderately effective in inducing GVBD, whereas 17B-estrodiol, cortisol, testosterone, 11B-hydroxyandrostenedione and 11-ketotestosterone did not stimulate GVBD. 17a, 20Bdihydroxy-4-pregnen-3-one (17a, 20BdiOHprog) and deoxycorticosterone (DOc) were the most potent steroids in stimulating final oocyte maturation. The results indicate that c21 hydroxylated steroids are potent inducers of final maturation in mullet. Further, co-incubations with 17B-eslradiol, cortisol and testosterone did not alter the maturation-inducing effects of HcG or 17a,200diOHprog. cyanoketone, a blocker of 3BHSD activity, was only partially effective in blocking GVBD induced by HcG. This suggests that A5 (pregnenolone derived) and

关键词： GVBD HUMAN cHORIONIc GONADOTROPIN AND cYANOKETONE ON GERMINAL BREAKDOWN OF STRIPED MULLET MUGIL cEPHALUS L OOcYTES THE IN VITRO EFFEcTS OF STEROIDS