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The remarkable effect of amino hydrogen on membrane permeability and organelle staining of 1,8-naphthalimide dyes

Chinese Chemical Letters 2024年第2期35卷 347-351页

作者： Zhifeng Li Qinglong Qiao Ning Xu Kai An Wenchao Jiang Yi Tao pengjun bao Yinchan Zhang Zhaochao Xu School of Chemistry Dalian University of TechnologyDalian 116024China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Membrane permeability and intracellular diffusion of fluorescent probes determine staining selectivity of intracellular ***,the relationship between the molecular structure of fluorescent probes and their membrane permeability and intracellular distribution is poorly *** this paper,we reported a series of 1,8-naphthalimide dyes and carried out cell imaging experiments,and found that the presence of amino hydrogen in these dyes played a crucial role in their cell membrane permeability and intracellular *** secondary amino group containing compounds 1-4 show excellent membrane permeability and strong fluorescence in living *** the tertiary amine containing dyes 5 and 6 can hardly permeate the cell membrane though they show extremely similar structure with compounds *** 1 can selectively image lipid droplets by selecting the wavelength of excitation *** the specificity for lysosomes,2 and 4 have been used in long-term time-lapses imaging of lysosomal dynamics and tracking the process of lysosome-lysosome interaction,fusion and *** effect of hydrogen-containing amino substituent on the cell membrane permeability of fluorescent molecules is promising for the development of better biocompatible probes.

关键词： Amino hydrogen 1,8-Naphthalimide Cell permeability Lipid droplet Lysosome

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Constructing D-π-A-π dye to obtain red-emission fluorescent probe for structured illumination microscopy imaging of lipid droplet dynamics

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Green Chemical Engineering 2023年第4期4卷 387-392页

作者： Wenchao Jiang Jie Chen Kai An pengjun bao Qinglong Qiao Xiaogang Liu Zhaochao Xu CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China Fluorescence Research Group Singapore University of Technology and Design8 Somapah RoadSingapore487372Singapore

Lipid droplets(LDs)are dynamic organelles interacting with a variety of intracellular *** intracellular LD dynamics employing synthetic small molecules is crucial for biological *** imaging in the red and near infrared(NIR)region is more suitable for biological imaging due to its low phototoxicity and high signal-to-noise ***,available LD-dyes in the red region with remarkable environmental sensitivity,selectivity for LDs staining are ***,we constructed a red-emission D-π-A-π type LDdye LD 688P with higher environmental sensitivity and suitable“calculated log P”(Clog P)for LDs dynamic *** 688P was proved to be highly selective and photostable for tracing LD fusion including multiple consecutive fusions and fusions in a centrosymmetric manner by super-resolution *** believe that the D-π-A-π skeleton would be an efficient strategy to construct red and even NIR-emission dyes.

关键词： Lipid droplets Fluorescent probe Red-emission D-π-A-π Super-resolution imaging

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Synthesis and optical properties of novel Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics for radiation detection applications

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Journal of Rare Earths 2022年第12期40卷 1927-1934,I0005页

作者： Wanli Li Zhaoyang Chen Jie Xu pengjun Zhao Yanwei Fan Chengfa He Key Laboratory of Functional Materials and Devices for Special Environments of CAS Xinjiang Key Laboratory of Electronic Information Materials and DevicesXinjiang Technical Institute of Physics&Chemistry of CASUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Laboratory of Solid-State Radiation Physics Urumqi 830011China

45 P_(2)O_(5)-15 bao-25 ZnO-15 B2O_(3)glasses doped with different concentrations(0 mol%,0.1 mol%,0.25 mol%,0.5 mol%,and 0.75 mol%)of Gd^(3+)were prepared by a melt-quenching method and treated to fabricate glass-ceramics containing BaZn_(2)(PO_(4))_(2)crystals by controllable *** structural,optical,and dosimetric properties were *** spectra indicate that the glasses are composed of[PO_(4)],[BO_(3)],and[BO_(4)]basic structural *** XRD pattern analysis indicates that the samples contain BaZn_(2)(PO_(4))_(2)*** the photoluminesce nce(PL)spectra,two emission bands are observed at 307 and 313 nm due to the^(6)P_(5/2)→^(8)S_(7/2)and^(6)P_(7/2)→^(8)S_(7/2)transitions of Gd^(3+),*** OSL dosimetric properties of glass-ceramics were studied further under beta radiation *** optimal Gd^(3+)doping concentration of 0.5 mol%was *** fading of the OSL signal shows that the CW-OSL signal of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics decays by about 58.95%within120 h,and the intensity remains stable *** thermoluminescence(TL)curve has three peaks at 164,240,and 344℃.Minimum detectable dose(MDD)of the 0.5 mol%Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics was calculated as 0.675 *** samples also exhibit good signal reusability and a broad linear dose-response range(0.3-500 Gy).Results show the excellent dosimetric properties of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics and their potential application in radiation dosimetry.

关键词： Glass-ceramics Photoluminescence Continuous wave-optically stimulated luminescence Thermoluminescence Radiation dosimetry Rare earths

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Risk factors for adult death due to 2009 pandemic influenza A(H1N1) virus infection:a 2151 severe and critical cases analysis

Risk factors for adult death due to 2009 pandemic influenza ...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病...

作者： pengjun Zhang Bin Cao Xiao-li Li Li-rong Liang Shi-gui Yang Li Gu Zhen Xu Ke Hu Hong-yuan Zhang Xi-xin Yan Wen-bao Huang Wei Chen Jing-xiao Zhang Lan-juan Li Chen Wang Department of Respiratory Medicine Second Affiliated HospitalNanchang University Institute of Respiratory Medicine Beijing Hospital Ministry of Heath Beijing Institute of Respiratory Medicine Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Institute of Infectious Diseases First Affiliated HospitalSchool of MedicineZhejiang University Disease Control and Emergency Response Office Chinese Center for Disease Control and Prevention Department of Respiratory Medicine Remin Hospital of Wuhan University Department of Respiratory Medicine First Affiliated Hospital of Anhui Medical University Department of Respiratory Medicine Second Hospital of Hebei Medical University Department of Respiratory Medicine Hangzhou No.1 People’s Hospital Department of Respiratory Medicine Shengjing Hospital of China Medical University

Background The 2009 pandemic H1N1(pH1N1) influenza showed that relatively young adults accounted for the highest rates of hospital admission and *** preparation for pandemic H1N1,

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