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The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells

Journal of Molecular Cell Biology 2011年第4期3卷 221-229页

作者： Ning yang Xiaoxu Hong penghui yang Xiangwu Ju Yuguo Wang Jun Tang Chenggang Li Quanshui Fan Fuqiang Zhang Zhongwei Chen Li Xing Zhongpeng Zhao Xiao Gao Guoyang Liao Qihan Li Xiliang Wang Dangsheng Li Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesPeking Union Medical CollegeTsinghua UniversityChinese Academy of Medical SciencesBeijing 100005China Department of Viral Immunology Institute of Medical BiologyChinese Academy of Medicine SciencePeking Union Medical CollegeKunming 650118China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Centre for Disease Prevention and Control Cheng Du Military RegionKunming 650032China Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031China

In 2009,a novel swine-origin H1N1 influenza virus emerged in Mexico and quickly spread to other countries,including *** 2009 pandemic H1N1 can cause human respiratory disease,but its pathogenesis remains poorly ***,we studied the infection and pathogenesis of a new 2009 pandemic strain,A/Wenshan/01/2009 H1N1,in China in human airway epithelial cell lines compared with contemporary seasonal H1N1 influenza *** results showed that viral infection by the A/Wenshan H1N1 induced significant apoptotic cell death in both the human nasopharyngeal carcinoma cell line CNE-2Z and the human lung adenocarcinoma cell line *** A/Wenshan H1N1 virus enters both of these cell types more efficiently than the seasonal influenza *** entry in both cell lines was shown to be mediated by clathrin-and dynamin-dependent ***,we discovered that the 2009 pandemic H1N1 strain,A/Wenshan/01/2009,can induce apoptotic cell death in epithelial cells of the human respiratory tract,suggesting a molecular pathogenesis for the 2009 pandemic H1N1.

关键词： apoptosis respiratory S-OIV H1N1 influenza virus

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SiO_(2)气凝胶改性复合防火聚苯板的制备及性能

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建筑材料学报 2024年第9期27卷 832-836页

作者：彭月飞杨鹏辉杨晨三棵树涂料股份有限公司福建省建筑涂料企业重点实验室福建莆田351100

构建了聚苯乙烯泡沫颗粒与玻化微珠二级级配模型,得出聚苯乙烯泡沫颗粒与玻化微珠的最佳粒径比约为5∶2,体积比约为100∶7.根据级配模型配制骨料,采用模压成型工艺制备复合防火聚苯板,显微结构显示其骨料堆积紧密、有序.分析了硅酸盐胶... 详细信息

构建了聚苯乙烯泡沫颗粒与玻化微珠二级级配模型,得出聚苯乙烯泡沫颗粒与玻化微珠的最佳粒径比约为5∶2,体积比约为100∶7.根据级配模型配制骨料,采用模压成型工艺制备复合防火聚苯板,显微结构显示其骨料堆积紧密、有序.分析了硅酸盐胶凝材料、SiO_(2)气凝胶及憎水剂对复合防火聚苯板性能的影响.结果表明:复合防火聚苯板的阻燃性能及拉拔强度随着硅酸盐胶凝材料掺量的增加而增大;导热系数和拉拔强度随着SiO_(2)气凝胶掺量的增加而降低,软化系数随着SiO_(2)气凝胶掺量的增加而升高;吸水率随着憎水剂掺量的增加而降低.

关键词：复合防火聚苯板聚苯乙烯泡沫颗粒 SiO_(2)气凝胶燃烧总热值级配模型

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Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils

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Journal of Molecular Cell Biology 2018年第6期10卷 573-585页

作者： Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang penghui yang State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Chinese PLA General Hospital Beijing 100853China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology Third Military Medical UniversityChongqing 400038China Beijing 307 Hospital of PLA Affiliated with the Chinese Academy of Medical Sciences Beijing 100070China Beijing 302 Hospital of PLA Beijing 100039China

Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the *** infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully *** this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and ***2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling ***2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and *** importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected *** on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting ***,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.

关键词： influenza H1N1 virus recombinant FGF2 protein neutrophil recruitment FGFR2-PI3K-AKT-NFκB signaling therapeutic target

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Response of BALB/c mice to a monovalent influenza A （H1N1） 2009 split vaccine

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Cellular & Molecular Immunology 2010年第2期7卷 116-122页

作者： penghui yang Li Xing Chong Tang Weihong Jia Zhongpeng Zhao Kun Liu Xiao Gao Xiliang Wang Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and Biosecurity Beijing China

The novel influenza A （H1N1） 2009 virus has emerged to cause the first pandemic of the twenty-first century. Disease outbreaks caused by the influenza A （H 1N 1） virus have prompted concerns about the potential for a pandemic and have driven the development of vaccines against this subtype of influenza A. In this study, we developed a monovalent influenza A （H 1N 1） split vaccine and evaluated its effects in BALB/c mice. Mice were immunized subcutaneously with 2 doses of the vaccine containing hemagglutinin （HA） alone or HA plus an aluminum hydroxide （AI（OH）3） adjuvant. Immunization with varying doses of HA （3.75, 7.5, 15, 30, 45 or 60μg） was performed to induce the production of neutralizing antibodies. The vaccine elicited strong hemagglutination inhibition （HI） and microneutralization, and addition of the adjuvant augmented the antibody response. A preliminary safety evaluation showed that the vaccine was not toxic at large doses （0.5 ml containing 60 μg HA＋600 μg AI（OH）3 or 60 μg HA）. Moreover, the vaccine was found to be safe at a dose of 120 μg HA＋ 1200 μg AI（OH）3 or 120 μg HA in 1.0 ml in rats. In conclusion; the present study provides support for the clinical evaluation of influenza A （H1N1） vaccination as a public health intervention to mitigate a possible pandemic. Additionally, our findings support the further evaluation of the vaccine used in this study in primates or humans.

关键词： BALB/c mice influenza influenza A (H1N1) split vaccine

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Concurrent Learning-Based Adaptive Control for the Wheeled Mobile Robot with Uncertainties and Disturbances

Concurrent Learning-Based Adaptive Control for the Wheeled M...

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第43届中国控制会议

作者： Bo Qin Huaicheng Yan Kai Rao penghui yang Key Laboratory of Smart Manufacturing in Energy Chemical Process of Ministry of Education East China University of Science and Technology Hubei Key Laboratory for High-efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology

This paper focuses on the tracking problem of a perturbed wheeled mobile robot(WMR). Taking both the kinematic model and dynamic model into account, a transformed model is proposed based on the heading position. By extracting deep-root information from the lumped disturbance, the influence of the lumped disturbance can be estimated and eliminated by a simple adaptive compensation term. concurrent learning(CL) is introduced to the adaptive law to relax the persistent excitation(PE)condition. A Lyapunov-based method is used to ensure globally uniformly ultimately bounded(GUUB) stable tracking. The proposed control strategy is proven effective by a numerical simulation.

关键词： wheeled mobile robot concurrent learning adaptive control disturbances

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Response of mice and ferrets to a monovalent influenza A(H7N9) split vaccine

Response of mice and ferrets to a monovalent influenza A(H7N...

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中华医学会第十三次全国感染病学术会议

作者： penghui yang Yueqiang Duan Xiliang Wang Shaogeng Zhang 302 Military Hospital Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and Biosecurity

In early spring 2013,the emergence of the influenza A(H7N9)virus in humans in Eastern China raised concerns of a new influenza *** of a safe and effective H7N9 influenza vaccine is urgently *** this end,we first synthesized the hemagglutinin(HA)and neuraminidase(NA)genes of the influenza A(H7N9)virus A/AnHui/1/*** reverse genetics,we rescued a reassortant virus(H7N9/PR8)

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Prescribed-time distributed localization of multi-agent systems based on local bearing information

Prescribed-time distributed localization of multi-agent syst...

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第43届中国控制会议

作者： Yunkai Lv Huaicheng Yan Kai Rao penghui yang Key Laboratory of Advanced Control and Optimization for Chemical Process of Ministry of Education East China University of Science and Technology

This work considers the localizability of multi-agent systems based on local bearing measurement.A novel prescribedtime orientation estimation algorithm is first proposed to guarantee that the local reference frame of the follower agent is aligned with the global *** orientation estimation algorithm is then applied to the problem of position estimation,and a prescribedtime distributed localization estimation algorithm is *** global convergence is derived based on the cascade *** simulation results are provided to prove the effectiveness of the proposed estimation methods.

关键词： Local bearing information orientation estimation prescribed-time

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Immunization with a live attenuated H7N9 influenza vaccine protects mice against lethal challenge

Immunization with a live attenuated H7N9 influenza vaccine p...

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第十届全国免疫学学术大会

作者： Yueqiang Duan penghui yang Xiaolan yang Zhongpeng Zhao Hongjing Gu Xiliang Wang Beijing Institute of Microbiology and Epidemiology 302 hospitial

The emergence of severe cases of human influenza A(H7N9) viral infection in China in the spring of 2003 resulted in a global effort to rapidly develop an effective candidate vaccine. In this report, using reverse genetic technology, we generated a cold-adapted(ca), live attenuated monovalent reassortant influenza H7N9 virus(Ah01/AA ca) that contained hemagglutinin(HA) and neuraminidase(NA) genes from a 2013 pandemic A H7N9 isolate, A/Anhui/01/2013 virus(Ah01/H7N9);the remaining six internal gene segments came from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus(AA virus). Ah01/AA ca exhibited phenotypes of temperature sensitivity(ts), ca, and attenuation(att). Intranasal immunization of female BALB/c mice with Ah01/AA ca twice at a 2-week interval induced robust humoral, mucosal, and cellmediated immune responses in a dose-dependent manner. Furthermore, the candidate Ah01/AA ca virus was immunogenic and offered partial or complete protection of mice against a lethal challenge by the live 2013 influenza A H7N9(A/Anhui/01/2013). Protection was demonstrated by the inhibition of viral replication and the attenuation of histopathological changes in the challenged mouse lung. Taken together, these data support the evaluation of this Ah01/AA ca candidate vaccine for human use in clinical trials.

关键词： H7N9 live attenuated vaccine cold-adapted

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Oncolytic activity of a novel influenza A virus carrying GM-CSF in hepatocellular carcinoma

Oncolytic activity of a novel influenza A virus carrying GM-...

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第十三届全国免疫学学术大会

作者： penghui yang Fang Sun Jin Yan Shaogeng Zhang Xiliang Wang Beijing 302 Hospital State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and Epidemiology

Oncolytic virotherapy is a promising strategy for the treatment of *** A virus(IAV) has shown potential as an oncolytic *** this study, we generated a recombinant PR8 influenza viral vector, called delNS1-GM-CSF, with a partial deletion in NS and the granulocyte-macrophage colony-stimulating factor(GM-CSF) coding sequence inserted into the influenza nonstructural protein 1 *** morphological characteristics of delNS1-GM-CSF were *** delNS1-GM-CSF virus replicated well in various cell lines, including MDCK, A549, SMCC7721, and HepG2 ***, selective cytotoxicity of the virus was observed in various hepatocellular carcinoma(HCC) cell lines, while no effect was demonstrated in the normal liver cell line LO2, as indicated by 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide and crystal violet ***, using a model based on the growth of HepG2 cells as a xenograft in nude mice, we found that a reassortant delNS1-GM-CSF virus inhibited tumor growth significantly following intratumoral injection in a dose-dependent *** vivo results showed that the tumor inhibition efficacy of delNS1-GM-CSF was observed in HCC clinical *** together, these results are the first to demonstrate that IAVs may have potential as oncolytic virotherapeutic agents against HCC.

关键词： Hepatocellular carcinoma Oncolytic virotherapy IAV

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Angiotensin-converting enzyme 2(ACE2) mediates influenza H7N9 virus-induced acute lung injury

Angiotensin-converting enzyme 2(ACE2) mediates influenza H7N...

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第十届全国免疫学学术大会

作者： penghui yang Hongjing Gu Chengcai Lai Shaogeng Zhang Xiliang Wang Beijing302 Hospital State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and Epidemiology

Since 2013,the emergence of an avian-origin influenza A(H7N9)virus has raised concern in *** most infections resulted in respiratory illness,some severe cases resulted in acute respiratory distress syndrome(ARDS),which is a severe form of acute lung injury(ALI)that further contributes to *** date,no effective drugs that improve the clinical outcome of influenza A(H7N9)virus-infected patients have been ***-converting

关键词： H7N9 influenza ACE2 lung injury

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