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A low-cost bromine-fixed additive enables a high capacity retention zinc-bromine batteries

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Journal of Energy Chemistry 2022年第2期31卷 89-93页

作者： pengcheng xu Tianyu Li Qiong Zheng Huamin Zhang Yanbin Yin Xianfeng Li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

In recent years,more and more efforts are devoting to clean energy,renewable energies in particular to achieving net zero carbon dioxide emissions[1].However,renewable energies,like solar power and wind power,are generally intermittent and random,hindering their wide application[2,3].To address this problem,there is an urgent need in effective and reliable energy storage device.

关键词： Zinc-bromine battery Bromine-fixed additive Capacity retention Tetraethylammonium bromide

An injectable curcumin-releasing organohydrogel with non-drying property and high mechanical stability at low-temperature for expe dite d skin wound care

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Journal of Materials Science & Technology 2023年第2期133卷 123-134页

作者： Kang Wu Qiang Yang Lin Zhang pengcheng xu Xiexing Wu Huilin Yang Huan Zhou Xiao Lin Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteDepartment of Orthopaedic SurgeryThe First Affiliated HospitalSoochow UniversitySuzhou 215031China Center for Health Sciences and Engineering(CHSE) School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Department of Minimally Invasive Spine Surgery Tianjin HospitalTianjin 300211China

Although hydrogels have demonstrated great potential as new wound dressing materials,their instability in shape and/or mechanical characteristics due to water loss or freezing remains a shortcoming for wound care application.Herein,a novel injectable organohydrogel(IOH)of physically crosslinked polyvinyl alco-hol/glycerol that possesses non-drying capability and high stability at low temperature was developed for wound care.IOH has a skin-like stiffness(G’,∼280 Pa),high injectability,self-healing capability,high water-vapor transmission rate,and bacterial inhibitory effect.IOH exhibits high shape and mechanical stabilities after curing at 37°C and 50%relative humidity for 7 days or after curing at-20°C for 1 day.In addition,glycerol in IOH enabled an efficient loading and release of water-insoluble curcumin,a well-known anti-bacterial and anti-inflammation drug.The curcumin-releasing IOH(Cur-IOH)demonstrated significantly enhanced anti-bacterial performance compared to IOH or curcumin-loading polyvinyl alco-hol hydrogel.More importantly,Cur-IOH could accelerate wound healing in a murine full-thickness skin defect wound model,revealing improved wound contraction,collagen deposition,angiogenesis,and epi-dermis formation.This study demonstrates the great potential of organohydrogel for the reparation of severe wounds and Cur-IOH as a new type of injectable wound healing material.

关键词： Wound dressing Organohydrogel Non-drying Stability Curcumin

Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 853-866页

作者： Jiewei Yin pengcheng xu Kang Wu Huan Zhou Xiao Lin Lili Tan Huilin Yang Ke Yang Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopedic InstituteSoochow UniversitySuzhou215006China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215006China Center for Health Science and Engineering(CHSE) School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin300130China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable problem.In this study,new macroporous and antibacterial gelatin/alginate(SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel matrix.The addition of Mg-Cu particles decreased the storage modulus of SAG,maintained its mechanical resilience and enhanced its water-absorbing capability.Moreover,the water vapor transmission rate of SAG added with 2 wt.%Mg-Cu(SAG-2 MC)was 124%of that of medical gauze and 804%of commercial Tegaderm^(TM)film dressing.The bacterial inhibition rates of SAG-2 MC against S.aureus.E.coli and P.aeruginosa reached 99.9%±0.1%,98.7%±1.2%and 98.0%±0.7%,respectively,significantly greater than those of the SAG hydrogel and Mg particle-modified hydrogels.In addition,SAG-2 MC hydrogel was biocompatible and promoted cell migration.In vivo experiment results indicated that SAG-2 MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness,more collagen deposition and enhanced angiogenesis compared with SAG-OMC,SAG-2 M and TegadermTM film.In summary,Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG hydrogels.Mg-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions.

关键词： Mg-Cu alloy Wound repair Macroporous Hydrogel Bacterial inhibition

Mechanisms of ultraviolet disinfection and chlorination of Escherichia coli： Culturability, membrane permeability,metabolism, and genetic damage

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Journal of Environmental Sciences 2018年第3期30卷 356-366页

作者： Limei xu Chongmiao Zhang pengcheng xu Xiaochang C.Wang International Science and Technology Cooperation Center for Urban Alternative Water Resources Development China Key Laboratory of Northwest Water Resource Environment and Ecology MOE China Engineering Technology Research Center for Wastewater Treatment and Reuse Shaanxi Province China School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology Xi'an 710055 China

Traditional culture methods may underestimate the tolerance of microorganisms to disinfectants because of the existence of viable but nonculturable or sublethally injured cells after disinfection.The selection of a strict method is crucial for the evaluation of disinfection performance.The actions of 2 typical disinfectants–ultraviolet（UV）and chlorine–on the fecal indicator Escherichia coli were investigated by the detection of culturability,membrane permeability,metabolic activity,deoxyribonucleic acid（DNA）,and messenger ribonucleic acid（m RNA）.During UV disinfection,the irreversible damages in the cell membrane and cellular adenosine triphosphate（ATP）were negligible at low UV doses（80 m J/cm^2）.However,membrane permeability was damaged at low doses of chlorine（5 mg/L）,leading to leakage of cellular ATP.Our study showed that a slight lesion in DNA was detected even at high doses of UV（400 m J/cm^2）and chlorine（5 mg/L）treatments.The decay of m RNA was more rapid than that of DNA.The degradation level of m RNA depended on the choice of target genes.After exposure to 50 m J/cm^2UV dose or 5 mg/L chlorine for30 min,the DNA damage repair function（Rec A m RNA）was inhibited.The m RNA involved in the DNA damage repair function can be a potential indicator of bacterial viability.

关键词： UV Chlorination Membrane damage Adenosine triphosphate DNA mRNA

Thermodynamic Analysis of the Gasification of Municipal Solid Waste

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Engineering 2017年第3期3卷 416-422页

作者： pengcheng xu Yong Jin Yi Cheng Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University Beijing 100084 China

This work aims to understand the gasification performance of municipal solid waste (MSW) by means of thermodynamic analysis. Thermodynamic analysis is based on the assumption that the gasification reactions take place at the thermodynamic equilibrium condition, without regard to the reactor and process characteristics. First, model components of MSW including food, green wastes, paper, textiles, rubber, chlorine-free plastic, and polyvinyl chloride were chosen as the feedstock of a steam gasification process, with the steam temperature ranging from 973 K to 2273 K and the steam-to-MSW ratio (STMR) ranging from 1 to 5. It was found that the effect of the STMR on the gasification performance was almost the same as that of the steam temperature. All the differences among the seven types of MSW were caused by the variation of their compositions. Next, the gasification of actual MSW was analyzed using this thermodynamic equilibrium model. It was possible to count the inorganic components of actual MSW as silicon dioxide or aluminum oxide for the purpose of simplification, due to the fact that the inorganic components mainly affected the reactor temperature. A detailed comparison was made of the composition of the gaseous products obtained using steam, hydrogen, and air gasifying agents to provide basic knowledge regarding the appropriate choice of gasifying agent in MSW treatment upon demand.

关键词： Gasification Waste treatment Municipal solid waste Thermodynamic analysis Gasifying agents

Machine learning for perovskite materials design and discovery

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npj Computational Materials 2021年第1期7卷 171-188页

作者： Qiuling Tao pengcheng xu Minjie Li Wencong Lu Department of Chemistry College of SciencesShanghai UniversityShanghaiChina Materials Genome Institute Shanghai UniversityShanghaiChina

The development of materials is one of the driving forces to accelerate modern scientific progress and technological innovation.Machine learning(ML)technology is rapidly developed in many fields and opening blueprints for the discovery and rational design of materials.In this review,we retrospected the latest applications of ML in assisting perovskites discovery.First,the development tendency of ML in perovskite materials publications in recent years was organized and analyzed.Second,the workflow of ML in perovskites discovery was introduced.Then the applications of ML in various properties of inorganic perovskites,hybrid organic–inorganic perovskites and double perovskites were briefly reviewed.In the end,we put forward suggestions on the future development prospects of ML in the field of perovskite materials.

关键词： materials perovskite inorganic

Correlation of aquaporin-4 expression to blood-brain barrier permeability in rats with focal cerebral ischemia

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Neural Regeneration Research 2008年第6期3卷 629-633页

作者： pengcheng xu Haorong Feng Jinbu xu Yongping Wu Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical College Xuzhou 221002 Jiangsu Province China Department of Anesthesiology the 98 Hospital of Chinese PLA Huzhou 313000 Zhejiang Province China

BACKGROUND： Ischemic cerebrovascular disease causes injury to the blood-brain barrier. The occurrence of brain edema is associated with aquaporin expression following cerebral ischemia/reperfusion. OBJECTIVE： To analyze the correlation of aquaporin-4 expression to brain edema and blood-brain barrier permeability in brain tissues of rat models of ischemia/reperfusion. DESIGN, TIME AND SETTING： The randomized control experiment was performed at the Jiangsu Province Key Laboratory of Anesthesiology, xuzhou Medical College, China from December 2006 to October 2007. MATERIALS： A total of 112 adult, male, Sprague-Dawley rats, weighing 220-250 g, were used to establish rat models of middle cerebral artery occlusion and reperfusion by the suture method. Rabbit anti-aquaporin-4 （Santa Cruz, USA） and Evans blue （Sigma, USA） were used to analyze the tissue. METHODS： The rats were randomized into sham-operated （n = 16） and ischemia/reperfusion （n = 96） groups. There were 6 time points in the ischemia/reperfusion group, comprising 4, 6, 12, 24, 48, and 72 hours after reperfusion, with 16 rats for each time point. Rat models in the sham-operated group at 4 hours after surgery and rat models in the ischemia/reperfusion group at different time points were equally and randomly assigned into 4 different subgroups. MAIN OUTCOME MEASURES： Brain water content on the ischemic side and the control side was measured using the dry-wet weight method. Blood-brain barrier function was determined by Evans Blue. Aquaporin-4 expression surrounding the ischemic focus, as well as the correlation of aquaporin-4 expression with brain water content and Evans blue staining, were measured using immunohistochemistry and Western blot analysis. RESULTS： Brain water content on the ischemic side significantly increased at 12 hours after reperfusion, reached a peak at 48 hours, and was still high at 72 hours. Brain water content was greater on the ischemic hemispheres, compared with the control hemispheres at 6, 12, 24, 48, and 72 hours after reperfusion,

关键词： aquaporin-4 blood-brain barrier Evans blue brain edema

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

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Cellular & Molecular Immunology 2023年第12期20卷 1413-1427页

作者： Jingjing Cao Lili Ji Yanxia Zhan Xia Shao pengcheng xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng Department of Hematology Zhongshan HospitalFudan UniversityShanghai200032China Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghai201508China Department of Transfusion Medicine Zhongshan HospitalFudan UniversityShanghai200032China Department of Laboratory Medicine Zhongshan HospitalFudan UniversityShanghai200032China Department of Hematology Zhongshan Hospital Qingpu BranchFudan UniversityShanghai201700China Department of Thoracic Surgery Zhongshan-Xuhui HospitalFudan UniversityShanghai200031China State Key Laboratory of Genetic Engineering Zhongshan HospitalSchool of Life SciencesFudan UniversityShanghai200438China Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai200032China

Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of inflammation.Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive.The expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were determined.Macrophage phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying mechanisms.The expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone treatment.The expression of the MST4 gene was significantly elevated in THP-1-derived M1 macrophages.Silencing of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of MST4.In a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of thrombocytopenia.Downregulation of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of macrophages.Our study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP.

关键词： Primary immune thrombocytopenia Mammalian sterile-20-like kinase 4(MST4) Macrophages M1 polarization Signal transducer and activator of transcription-1(STAT1)

Protective Effect of Silent Mating Type Information Regulation 2 Homolog 1 on TGF-β1 Pathway via mTOR in Diabetic Nephropathy

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Journal of Biosciences and Medicines 2023年第2期11卷 194-207页

作者： Yanting Gu Dechun Jiang pengcheng xu Yanchun Wang Pharmacy China Aerospace Science & Industry Corporation 731 Hospital Beijing China Pharmacy Beijing Shijitan Hospital Affiliated to Capital Medical University Beijing China Ear Institute School of Medicine Shanghai Jiao Tong University Shanghai China Pharmacy Aviation General Hospital Beijing China

Objective: To demonstrate whether the expression of silent mating type information regulation 2 homolog 1 (SIRT1) affects the level of TGF-β1 and Smad3 in HEK293 cells through regulating mTOR. Methods: First, recombinant plasmids DNA (rSIRT1) and siRNA targeting SIRT1 were constructed which were transfected into Human Embryonic Kidney 293 cell (HEK293) cells, respectively. Then, the generation of intracellular ROS in cells was examined by flow cytometry using the oxidation-sensitive probe. Last, the expressions of TGF-β1, smad3, P53, mTOR, p-mTOR, LC3-I and LC3-II in cells were detected to observe the effect of SIRT1 on TGF-β1 Pathway by western blot analysis. Results: We demonstrated that overexpressing of SIRT1 may decrease TGF-β1 and Smad3 expression in HEK293 cells through regulating mTOR. In addition, the result is the opposite when SIRT1 was silent in HEK293 cells. Conclusions: SIRT1 is closely related to TGF-β1/Smad3 pathway that correlates with the regulation of mTOR and ROS generation and causes diabetic nephropathy. The available evidence implies that SIRT1 has great potential as a clinical target for the prevention and treatment of renal fibrosis in the development of DN.

关键词： Silent Mating Type Information Regulation 2 Homolog 1 mTOR Diabetic Nephropathy Autophagy Oxidative Stress