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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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A novel multi-fidelity coupled simulation method for flow systems

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Chinese Journal of Aeronautics 2013年第4期26卷 868-875页

作者： Wang peng zheng Yun Zou zhengping Qi lei Zhou Zhixiang National Key Laboratory of Science & Technology on Aero-Engine Aero-thermodynamics School of Energy and Power Engineering Beihang University Aeroengine Numerical Simulation Research Center School of Energy and Power Engineering Beihang University Chinese Aviation Powerplant Research Institute

For the numerical simulation of flow systems with various complex components, the traditional one-dimensional （1D） network method has its comparative advantage in time consuming and the CFD method has its absolute advantage in the detailed flow capturing. The proper coupling of the advantages of different dimensional methods can strike balance well between time cost and accuracy and then significantly decrease the whole design cycle for the flow systems in modern machines. A novel multi-fidelity coupled simulation method with numerical zooming is developed for flow systems. This method focuses on the integration of one-, two-and three-dimensional codes for various components. Coupled iterative process for the different dimensional simulation cycles of sub-systems is performed until the concerned flow variables of the whole system achieve convergence. Numerical zooming is employed to update boundary data of components with different dimen-sionalities. Based on this method, a highly automatic, multi-discipline computing environment with integrated zooming is developed. The numerical results of Y-Junction and the air system of a jet engine are presented to verify the solution method. They indicate that this type of multi-fidelity simulationmethod can greatly improve the prediction capability for the flow systems.

关键词： Complex flow system Coupling Jet engine Multi-fidelity Zooming

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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A Verifiable Trust-Based CP-ABE Access Control Scheme for Cloud-Assisted Renewable Energy Systems

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Computers, Materials & Continua 2025年第1期82卷 1211-1232页

作者： Jiyu Zhang Kehe Wu Ruomeng Yan zheng Tian Yizhen Sun Yuxi Wu Yaogong Guo Department of Control and Computer Engineering North China Electric Power UniversityBeijing102206China State Grid Information&Communication Company of Hunan Electric Power Corporation Changsha410118China State Grid Hunan Electric Power Corporation Chenzhou Power Supply Branch Chenzhou423000China

Renewable Energy Systems(RES)provide a sustainable solution to climate warming and environmental pollution by enhancing stability and reliability through status acquisition and analysis on cloud platforms and intelligent processing on edge servers(ES).However,securely distributing encrypted data stored in the cloud to terminals that meet decryption requirements has become a prominent research ***,managing attributes,including addition,deletion,and modification,is a crucial issue in the access control scheme for *** address these security concerns,a trust-based ciphertext-policy attribute-based encryption(CP-ABE)device access control scheme is proposed for RES(TB-CP-ABE).This scheme effectivelymanages the distribution and control of encrypted data on the cloud through robust attribute key *** introducing trust management mechanisms and outsourced decryption technology,the ES system can effectively assess and manage the trust worthiness of terminal devices,ensuring that only trusted devices can participate in data exchange and access sensitive ***,the ES system dynamically evaluates trust scores to set decryption trust thresholds,thereby regulating device data access permissions and enhancing the system’s *** validate the security of the proposed TB-CP-ABE against chosen plaintext attacks,a comprehensive formal security analysis is conducted using the widely accepted random oraclemodel under the decisional q-Bilinear Diffie-Hellman Exponent(q-BDHE)***,comparative analysis with other schemes demonstrates that the TB-CP-ABE scheme cuts energy/communication costs by 43%,and scaleswell with rising terminals,maintaining average latency below 50ms,ensuring real-time service *** proposed scheme not only provides newinsights for the secure management of RES but also lays a foundation for future secure energy solutions.

关键词： Access control renewable energy systems(RES) ciphertext-policy attribute-based encryption(CP-ABE) security

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“地理信息系统”课程开展课程思政教学探讨

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教育教学论坛 2021年第41期 129-132页

作者：吴佳妮邹丹肖汶斌雷鹏正国防科技大学气象海洋学院湖南长沙410073

“地理信息系统”是一门实践性较强的专业课程,使学生在掌握地理信息系统相关概念、原理与方法的基础上,能应用GIS软件解决地学分析实际问题。在认清“地理信息系统”课程开展“课程思政”建设必要性的基础上,针对课程特点,从强化教师... 详细信息

“地理信息系统”是一门实践性较强的专业课程,使学生在掌握地理信息系统相关概念、原理与方法的基础上,能应用GIS软件解决地学分析实际问题。在认清“地理信息系统”课程开展“课程思政”建设必要性的基础上,针对课程特点,从强化教师课程思政意识、挖掘课程的思政元素以及调整多元化教学方法三个方面,探讨了“地理信息系统”课程开展思政教学的方式方法,以期在传授专业知识的同时,逐步培养学生的家国情怀、个人品格以及科学素养,实现高校教育教学全过程和全方位育人。

关键词：地理信息系统课程思政意识思政元素教学方法

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Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING zheng JIANFENG CAI JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

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A Hybrid Features Based Detection Method for Inshore Ship Targets in SAR Imagery

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Journal of Geodesy and Geoinformation Science 2023年第1期6卷 95-107页

作者： Tong zheng peng lei Jun WANG School of Artificial Intelligence Beijing Technology and Business UniversityBeijing 100031China School of Electronic and Information Engineering Beihang UniversityBeijing 100083China

Convolutional Neural Networks(CNNs)have recently attracted much attention in the ship detection from Synthetic Aperture Radar(SAR)***,compared with optical images,SAR ones are hard to ***,due to the high similarity between the man-made targets near shore and inshore ships,the classical methods are unable to achieve effective detection of inshore *** mitigate the influence of onshore ship-like objects,this paper proposes an inshore ship detection method in SAR images by using hybrid ***,the sea-land segmentation is applied in the pre-processing to exclude obvious land regions from SAR ***,a CNN model is designed to extract deep features for identifying potential ship targets in both inshore and offshore *** this basis,the high-energy point number of amplitude spectrum is further introduced as an important and delicate feature to suppress false alarms ***,to verify the effectiveness of the proposed method,numerical and comparative studies are carried out in experiments on Sentinel-1 SAR images.

关键词： Convolutional Neural Network(CNN) Synthetic Aperture Radar(SAR) inshore ship detection hybrid features high-energy point number amplitude spectrum

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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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Science China Life Sciences 2025年

作者： Xiaonan Wang Ning Zhou Xuejiao J.Gao Zijing Zhu Minmin Sun Qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang zheng Ye Yuan Yuan Liu lei Chen Jing Jiang pengcheng Bu Lizeng Gao CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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Visible-light-driven photocatalytic inactivation of bacteriophage f2 by Cu-TiO_2 nanofibers in the presence of humic acid

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Journal of Environmental Sciences 2019年第3期31卷 383-391页

作者： Rong Cheng Mi Kang Zhi-peng Shen lei Shi Xiang zheng School of Environment & Natural Resources Renmin University of China

Pathogenic viruses in drinking water are great threats to public health. Visible-lightdriven photocatalysis is a promising technology for virus inactivation. However, the existing photocatalytic antiviral research studies have mostly been carried out in single-component systems, neglecting the effect of natural organic matter, which exists widely in actual water bodies. In this paper, electrospun Cu-TiO2 nanofibers were prepared as photocatalysts, and their photocatalytic antiviral performance in the presence of humic acid(HA) was comprehensively studied for the first time. The properties of the reaction mixture were measured during the reaction. In addition, the safety, reliability and stability of photocatalytic disinfection in the mixed system were evaluated. The results showed that the virus removal efficiency decreased with the increase of the HA concentration. The type of reaction solution, such as PBS buffer solution or water, did not affect the removal efficiency noticeably. Under acidic conditions, the electrostatic forces between photocatalysts and viruses were strengthened, leading to higher virus removal efficiency. As the reaction time went on, the pH value in the solution increased first and then tended to be stable, the conductivity remained stable, and the dissolved oxygen increased first and then decreased. The safety test showed that the concentration of Cu ions released into the solution was lower than specified by the international standards. No photoreactivation was observed, and the addition of HA significantly reduced the reutilization efficiency of the photocatalysts.

关键词： Photocatalysis Visible light Bacteriophage f2 Humic acid

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Soil type and wetting intensity control the enhancement extent of N_(2)O efflux in soil with drought and rewetting cycles

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International Soil and Water Conservation Research 2024年第1期12卷 137-144页

作者： Panpan Jiao lei Yang Zhongwu Li peng zheng Xiaodong Nie School of Geographical Sciences Hunan Normal UniversityChangsha 410081China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau The Research Center of Soil and Water Conservation and Ecological EnvironmentChinese Academy of Sciences and Ministry of EducationYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Climate change alters the intensity and frequency of drought and rewetting(D/W)events;however,the influence patterns of D/W on soil N_(2)O efflux in the water-limited area were not fully ***,the impacts of D/W cycles varying in different extent of rewetting and frequency to N_(2)O efflux in two kinds of soil on the Loess Plateau were *** incubation conditions consisted of 1)D/W treatments with four 7-day cycles from 10%water holding capacity(WHC)to 60%WHC or 90%WHC,2)constant moisture of 60%WHC and 90%*** pulse of N_(2)O efflux rate under 10-60%WHC treatment was higher than that under 10-90%WHC treatment in calcic cambisols,while opposite trend was observed in earth-cumuli-orthic ***,the pulse of N_(2)O efflux rate decreased as cycle number increased for different wetting intensities and soil *** direct N_(2)O efflux under 10-60%WHC and 10-90%WHC treatments were 5.49 and 1.89μg N_(2)O-N g^(-1)soil in calcic cambisols,with those being 1.92 and 10.85μg N_(2)O-N g^(-1)soil in earth-cumuli-orthic anthrosols,*** N loss in earth-cumuli-orthic anthrosols was approximately 5.74 times greater than that in calcic cambisols under 10-90%WHC treatment,whereas the N loss under 10-60%WHC treatment was about 2.86 times greater in calcic cambisols than that in earth-cumuli-orthic *** study suggested that extreme rainfall events can enhance the N_(2)O efflux and N loss in agricultural soils on the Loess Plateau in terms of soil type and wetting intensity,which should not be ignored in the N fertilizer management.

关键词： Drought/rewetting cycles N_(2)O efflux Wetting intensity Microbial biomass N Dissolved organic N Loess plateau

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