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Trans-anal minimally invasive surgery for rectal neoplasia:Experience from single tertiary institution in China

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World Journal of Gastrointestinal Oncology 2018年第6期10卷 137-144页

作者： Nan Chen Yi-Fan peng yun-feng Yao Jin Gu Department of Gastrointestinal Center Unit Ⅲ Peking University Hospital and InstituteBeijing 100142China

AIM To evaluate the feasibility and safety of trans-anal minimally invasive surgery(TAMIS) from single institute in China. METHODS A retrospective review was conducted for patients with rectal neoplasia, who underwent TAMIS using single incision laparoscopic surgery-Port from January 2013 till January 2016 by a group of colorectal surgeons from Gastrointestinal Center Unit Ⅲ, Peking University Cancer Hospital. Patients' demographic data, surgical related information, post-operational pathology, as well as perioperative follow-up were all collected. RESULTS Twenty-five patients with rectal neoplasia were identified consequently. Complete full-thickness excision was achieved in all cases without conversion. 22(88%) cases had rectal malignancies [6 were adenocarcinomas and 16 were neuroendocrine tumors(NET)], while 3 patients had adenomas. Mean surgical duration was 61.3 min, and mean post-operative stay were 2.7 d. Post-operational examination demonstrated 5 cases had positive resection margin: 2 adenocarcinoma cases and 1 NET case with positive lateral margin, and the other 2 NET cases with positive basal margin. The curve of operation time for TAMIS cases suggested a minimum of 10 cases for a laparoscopic surgeon proficient withthis technique. CONCLUSION TAMIS was demonstrated to be reproducible and safe,with a relatively short learning process for laparoscopic surgeons in selected cases for rectal neoplasia. Longterm oncological outcome needs to be determined by further investigation.

关键词： Rectal neoplasia Resection margin Transanal minimally invasive surgery

基于OBE理念的企业项目实战课程教学改革探索

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电脑知识与技术 2021年第15期17卷 138-139,157页

作者：汪加楠郭磊刘家磊刘凌霞彭云峰安阳师范学院软件学院河南安阳455000

为培养出适合市场需求的软件工程类专业人才,在"新工科"背景下,以OBE教育理念为导向,针对传统教学中存在的问题,本课程以项目为主线,学生为中心,"做中学"的方式加强实践环节,这种课程教学改革改变了以往学生感觉软件工程课程枯燥的情况... 详细信息

为培养出适合市场需求的软件工程类专业人才,在"新工科"背景下,以OBE教育理念为导向,针对传统教学中存在的问题,本课程以项目为主线,学生为中心,"做中学"的方式加强实践环节,这种课程教学改革改变了以往学生感觉软件工程课程枯燥的情况,使学生愿意主动去学习,探究未知领域,同时,能够很好地培养和提高学生的工程实践能力和团队合作能力。

关键词：企业项目实战成果导向教育 OBE理念课程教学改革

基于OBE-CDIO模式的软件工程专业课程群教学改革

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电脑知识与技术 2020年第35期16卷 67-68,73页

作者：汪加楠郭磊刘家磊于亚芳彭云峰安阳师范学院软件学院河南安阳455000

为进一步培养和提高学生的工程实践能力,在“新工科”背景下,将CDIO教育理念和OBE教学模式应用到“软件工程专业”课程群中,以学生为导向,项目为主线,学生通过“做中学”的教学方式来学习软件工程专业课程,以加深学生对自己专业的理解,... 详细信息

为进一步培养和提高学生的工程实践能力,在“新工科”背景下,将CDIO教育理念和OBE教学模式应用到“软件工程专业”课程群中,以学生为导向,项目为主线,学生通过“做中学”的教学方式来学习软件工程专业课程,以加深学生对自己专业的理解,进而培养符合CDIO模式和产业需求的创新型软件工程人才。

关键词： OBE理念 CDIO模式软件工程课程群教学改革

短期增温对紫花针茅草原土壤微生物群落的影响

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植物生态学报 2018年第1期42卷 116-125页

作者：王军王冠钦李飞彭云峰杨贵彪郁建春周国英杨元合中国科学院植物研究所植被与环境变化国家重点实验室北京100093 中国科学院大学北京100049 中国科学院西北高原生物研究所藏药研究重点实验室西宁810008

土壤微生物是生态系统碳循环的重要参与者和调控者。全球变暖可能对土壤微生物群落产生影响,加速陆地生态系统向大气中释放碳,进而引起陆地碳循环对气候变暖的正反馈。然而,目前学术界对土壤微生物群落如何响应气候变暖等问题认识不足,... 详细信息

土壤微生物是生态系统碳循环的重要参与者和调控者。全球变暖可能对土壤微生物群落产生影响,加速陆地生态系统向大气中释放碳,进而引起陆地碳循环对气候变暖的正反馈。然而,目前学术界对土壤微生物群落如何响应气候变暖等问题认识不足,尤其是缺乏低温干旱条件下土壤微生物对增温响应的实验证据。为此,该文依托青藏高原紫花针茅(Stipa purpurea)草原建立的增温实验平台,基于磷脂脂肪酸(PLFA)方法测定了2015和2016年生长季表层(0–10 cm)土壤微生物各类群的生物量,在此基础上揭示气候变暖对紫花针茅草原土壤微生物群落结构的影响。结果显示,短期增温处理导致2015和2016年生长季(5–10月)的表层土壤温度均显著提高1.6℃,同时也导致土壤含水量显著下降了3.4%和2.4%(体积分数),但并没有显著改变土壤化学性质及归一化植被指数。增温处理下,两年生长季旺期(8月)的微生物生物量碳(MBC)含量分别为749.0和844.3 mg·kg^(–1),微生物生物量氮(MBN)含量为43.1和102.1 mg·kg^(–1),微生物生物量碳氮比分别为17.9和8.4,但实验期间MBC、MBN和微生物生物量碳氮比与对照没有差异。PLFA分析的结果显示细菌在微生物群落中占主导,而丛枝菌根真菌含量最少,增温处理并没有改变不同类群的微生物生物量以及群落结构。进一步的分析显示,土壤温度和含水量是调控土壤微生物群落变异的主要因子,并且增温导致的微生物生物量碳的变化量分别与土壤温度和含水量的变化量呈显著正相关关系。以上结果表明,由于受水分的限制,短期增温对紫花针茅草原土壤微生物群落没有显著影响。

关键词：气候变暖磷脂脂肪酸微生物群落青藏高原高寒草原

Time-resolved ESI-MS Investigation on Reduction and Alkylation in Unfolding Process of Lysozyme

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Chemical Research in Chinese Universities 2001年第4期17卷 387-393页

作者： SONG Hao-wei XU Chong-feng FU yun-lin YANG peng-yuan WANG Hong-hai Department of Chemistry State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200433P.R.China

The kinetic procedure of the unfolding of lysozyme induced by the reduction of disulfide was monitored by the time-resolved ESI-MS with a sheath liquid assistant electrospray interface. It was found that the reduction process for the eight disulfides had a less difference in the reaction time after denatured treatment. In addition, the alkylation of the reduced free thiols was much slower than the reduction procedure. An artifact peak produced by the CID fragmentation in the mass spectra was identified and the possible mechanism of the Hofmann elimination reaction was proposed.

关键词： Unfolding Lysozyme Reduction and alkylation Time-resolved ESI-MS

硅铝溶胶混合黏结剂的稳定性及其催化性能的研究

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石化技术与应用 2017年第1期35卷 28-31页

作者：张涛丁伟许鹏郑云锋左少卿高雄厚兰州交通大学化学与生物工程学院甘肃兰州730070 中国石油兰州化工研究中心甘肃兰州730060 中国石油石油化工研究院北京100083

以酸性硅溶胶、碱性硅溶胶为原材料,考察了6种不同酸碱性质的硅溶胶与铝溶胶按硅铝比(质量比)1∶1混合后的凝胶情况和稳定性,并分别以铝溶胶、酸性硅溶胶与铝溶胶、碱性硅溶胶与铝溶胶为黏结剂制备催化裂化(FCC)催化剂,对其孔结构、酸... 详细信息

以酸性硅溶胶、碱性硅溶胶为原材料,考察了6种不同酸碱性质的硅溶胶与铝溶胶按硅铝比(质量比)1∶1混合后的凝胶情况和稳定性,并分别以铝溶胶、酸性硅溶胶与铝溶胶、碱性硅溶胶与铝溶胶为黏结剂制备催化裂化(FCC)催化剂,对其孔结构、酸性及酸量进行分析,考察了引入部分硅溶胶的FCC催化剂在性能上的变化。结果表明:硅溶胶与铝溶胶混合凝胶程度及稳定性受硅铝溶胶的浓度及p H值等因素的影响。酸性硅溶胶与铝溶胶不能直接混合,但可以用蒸馏水先稀释再混合,则不发生凝胶;碱性硅溶胶不能与铝溶胶直接混合,可调节碱性硅溶胶p H值为1~7;硅、铝混合溶胶催化剂与铝溶胶催化剂比较,孔体积和B酸、L酸的酸量减小,比表面积增加。

关键词：硅溶胶铝溶胶黏结剂催化裂化催化剂

Motivic Milnor Fibre of Cyclic L∞-algebras

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Acta Mathematica Sinica,English Series 2017年第7期33卷 933-950页

作者： yun feng JIANG Department of Mathematics University of Kansas405 Snow Hall 1460 Jayhawk BlvdLawrence KS 66045USA

Abstract We define the motivic Milnor fiber of cyclic L∞-algebras of dimension three using the method of Denef and Loeser of motivic integration. It is proved by Nicaise and Sebag that the topo- logical Euler characteristic of the motivic Milnor fiber is equal to the Euler characteristic of the étale cohomology of the analytic Milnor fiber. We prove that the value of Behrend function on the germ moduli space determined by a cyclic L∞-algebra L is equal to the Euler characteristic of the analytic Milnor fiber. Thus we prove that the Behrend function depends only on the formal neighborhood of the moduli space.

关键词： L∞-algebra motivic Milnor fiber analytic Milnor fiber Donaldson Thomas invariants,the Behrend function

Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy:A prospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2048-2060页

作者： Nan Chen Chang-Long Li Yi-Fan peng yun-feng Yao Department of Gastrointestinal Surgery WardⅢKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND The role of HER2 overexpression in rectal cancer is *** To assess the role of HER2 overexpression in the long-term prognosis of rectal *** Data from patients with locally advanced rectal cancer who underwent total mesorectal excision after short-course radiotherapy at Beijing Cancer Hospital between May 2002 and October 2005 were collected.A total of 151 tissue samples of rectal cancer were obtained using rigid proctoscopy before neoadjuvant radiotherapy,followed by immunohistochemistry and fluorescence in situ hybridisation to determine the patients’HER2 expression *** and multivariate analyses of the associations between the clinicopathological factors and HER2 status were *** was estimated and compared using the Kaplan-Meier method based on HER2 expression status,and the differences between groups were verified using the log-rank *** A total of 151 patients were enrolled in this study.A total of 27(17.9%)patients were ultimately confirmed to be *** follow-up duration ranged from 9 mo to 210 mo,with a median of 134 *** metastasis and local recurrence occurred in 60(39.7%)and 24(15.9%)patients,***2 positivity was significantly associated with the pre-treatment lymph node stage(pre-N)(P=0.040),while there were no differences between HER2 status and age,sex,preoperative CEA levels(pre-CEA),T stage,and lympho-vascular *** terms of prognosis,HER2 overexpression was correlated with distant meta stasis(P=0.002)rather than local recurrence(P>0.05).The multivariate analysis demonstrated that elevated pre-CEA[P=0.002,odds ratio(OR)=3.277,97.5%confidence interval(CI):1.543-7.163],post N(+)(P=0.022,OR=2.437,97.5%CI:1.143-5.308)and HER2(+)(P=0.003,OR=4.222,97.5%CI:1.667-11.409)were risk factors for distant *** survival analysis showed that there were significant differences between rectal cancer patients in terms of disease-free survival(DFS)[hazard ra

关键词： HER2 Rectal cancer Distant metastasis Local recurrence Survival

Theoretical analysis of cross-plane lattice thermal conduction in graphite

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Chinese Physics B 2019年第6期28卷 317-323页

作者： yun-feng Gu College of Electronic and Mechanical Engineering Nanjing Forestry University

A theoretical analysis of the cross-plane lattice thermal conduction in graphite is performed by using first-principles calculations and in the single-mode relaxation time approximation. The out-of-plane phonon acoustic mode ZA and optical mode ZO have almost 80% and 20% of contributions to cross-plane heat transfer, respectively. However, these two branches have a small part of total specific heat above 300 K. Phonons in the central 16% of Brillouin zone contribute80% of cross-plane transport. If the group velocity angle with respect to the graphite layer normal is less than 30?, then the contribution is 50% at 300 K. The ZA phonons with long cross-plane mean free path are focused in the cross-plane direction, and the largest mean free path is on the order of several micrometers at room temperature. The average value of cross-plane mean free path at 300 K is 112 nm for ZA phonons with group velocity angle with respect to the layer normal being less than 15?. The average value is dropped to 15 nm when phonons of all branches in the whole Brillouin zone are taken into account, which happens because most phonons have small or even no contributions.

关键词： graphite cross-plane thermal conduction phonon mean free path layered systems