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Boron delivery agents for neutron capture therapy of cancer

Cancer Communications 2018年第1期38卷 371-385页

作者： Rolf F.Barth peng mi Weilian Yang Department of Pathology The Ohio State University4132 Graves Hall333 W.10th AveColumbusOH 43210USA Department of Radiology Center for Medical ImagingState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041P.R.China Present Address:Neurosurgery and Brain and Nerve Research Laboratory The First Affiliated Hospital of Suzhou UniversitySuzhouJiangsu 215004P.R.China

Boron neutron capture therapy(BNCT)is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope,boron-10,is irradiated with neutrons to produce high energy alpha *** review will focus on tumor-targeting boron delivery agents that are an essential component of this binary *** low molecular weight boron-containing drugs currently are being used clinically,boronopheny-lalanine(BPA)and sodium borocaptate(BSH).Although they are far from being ideal,their therapeutic efficacy has been demonstrated in patients with high grade gliomas,recurrent tumors of the head and neck region,and a much smaller number with cutaneous and extra-cutaneous *** of their limitations,great effort has been expended over the past 40 years to develop new boron delivery agents that have more favorable biodistribution and uptake for clinical *** include boron-containing porphyrins,amino acids,polyamines,nucleosides,peptides,monoclonal antibodies,liposomes,nanoparticles of various types,boron cluster compounds and ***-rently,however,none of these have reached the stage where there is enough convincing data to warrant clinical biodistribution ***,at present the best way to further improve the clinical efficacy of BNCT would be to optimize the dosing paradigms and delivery of BPA and BSH,either alone or in combination,with the hope that future research will identify new and better boron delivery agents for clinical use.

关键词： Boron delivery agents Neutron capture therapy Brain tumors Head and neck cancer Melanoma

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AN IMPROVED HYBRID SEMANTIC MATCHING ALGORITHM WITH LEXICAL SImiLARITY

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Journal of Electronics(China) 2010年第6期27卷 838-847页

作者： peng Rongqun mi Zhengkun Wang Lingjiao Broadband Wireless Communication and Sensor Network Technology Key Lab of ministry of Education Nanjing University of Posts and Telecommunications Nanjing 210003 China

In this paper, we proposed an improved hybrid semantic matching algorithm combining Input/Output (I/O) semantic matching with text lexical similarity to overcome the disadvantage that the existing semantic matching algorithms were unable to distinguish those services with the same I/O by only performing I/O based service signature matching in semantic web service discovery techniques. The improved algorithm consists of two steps, the first is logic based I/O concept ontology matching, through which the candidate service set is obtained and the second is the service name matching with lexical similarity against the candidate service set, through which the final precise matching result is concluded. Using Ontology Web Language for Services (OWL-S) test collection, we tested our hybrid algorithm and compared it with OWL-S Matchmaker-X (OWLS-MX), the experimental results have shown that the proposed algorithm could pick out the most suitable advertised service corresponding to user's request from very similar ones and provide better matching precision and efficiency than OWLS-MX.

关键词： Hybrid matching algorithm Semantic matching Lexical similarity WordNet Ontology Web Language for Services (OWL-S)

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A hybrid rendering algorithm for textile objects

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Science in China(Series F) 2009年第3期52卷 490-499页

作者： ZHANG mingmin PAN ZhiGeng SHI JiaoYing WANG peng mi QingFeng State Key Laboratory of CAD & CG Zhejiang University Hangzhou 310027 China

Although realistic textile rendering has been widely used in virtual garment and try-on systems, a robust method to simulate textile with a realistic appearance and high fidelity is yet to be established. We propose to use a novel hybrid geometric- and image-based rendering （GIBR） method to achieve photo realistic representation of textile products. The image-based technique, with its radiance synthesis algorithm, enables us to recover the reflectance properties of textile in an environment photo, and thus can render the appearance of textile material. The geometry-based technique, with its traditional illumination model of assigning illumination parameters extracted from the original scene （such as radiance and chroma dispatch）, makes it possible to interactively manipulate 3D virtual objects in the ＂real＂ environment. Our realistic textile rendering method has advantages over the traditional ones in its easiness to implement and its wide range of applications.

关键词： realistic rendering image and geometry hybrid radiance synthesis

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Atomically Dispersed Metals on Nanodiamond-Derived Hybrid Materials for Heterogeneous Catalysis

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Accounts of Materials Research 2023年第3期4卷 223-236页

作者： Fei Huang mi peng Hongyang Liu Ding Ma Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016P.R.China Beijing National Laboratory for Molecular Engineering College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871P.R.China

CONSPECTUS:Supported metal catalyst,has been one of the most important systems in the field of heterogeneous *** great complexity of both the compositions and structures of such supported metal catalysts provides a great degree of freedom for tuning their catalytic properties,which has essentially triggered the explosive growth in research on design and control active metals’surface structures for *** ideal metal catalyst theoretically features maximum active sites and optimal intrinsic reactivity to facilitate a desired chemical *** by the catalytic concepts brought by natural enzymes and homogeneous catalysis,the fabrication of heterogeneous catalysts with atomically dispersed metal atoms has attracted much attention and been extensively explored in recent *** dispersed metal catalysts(ADMCs)including single-atom catalyst(SACs)and fully exposed cluster catalyst(FECCs),as shining stars in heterogeneous catalysts have recently drawn much *** advantages of ADMCs mainly include the following three aspects:(1)the fully exposed active metal atoms can realize the utmost atomic utilization efficiency and reduce the cost of catalysts;(2)the geometric and electronic structure can be effectively regulated by altering the coordination environments of metal atoms and then further tuning the catalytic performance in terms of activity,selectivity,and stability;(3)the precisely designed structures provide a promising platform for digging the structure−performance relationships of active sites with the assistance of theoretical *** to these advantages,ADMCs have been used in thermal-catalysis,electrocatalysis,photocatalysis,*** *** this Account,a summary of recent progress regarding ADMCs for heterogeneous thermal catalysis in our group will be presented from the following ***,an overview of great opportunities brought by nanodiamond and its derivatives as substrates for anchoring atomically di

关键词： catalysis catalyst dispersed

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Fully-exposed Pt clusters stabilized on Sn-decorated nanodiamond/graphene hybrid support for efficient ethylbenzene direct dehydrogenation

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Nano Research 2022年第12期15卷 10029-10036页

作者： Linlin Wang Xuetao Qin Ting Sun Xiangbin Cai mi peng Zhimin Jia Xiaowen Chen Ning Wang Jiangyong Diao Hongyang Liu Ding Ma Department of Chemistry Northeastern UniversityShenyang110819China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Beijing National Laboratory for Molecular Engineering College of Chemistry and Molecular Engineering and College of EngineeringBIC-ESATPeking UniversityBeijing100871China Department of Physics Hong Kong University of Science and TechnologyKowloonHong Kong999077China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

The pursuit of energy conservation and environmental protection has always been a hot topic in the catalytic fields,which is inseparable from the rational designing of efficient catalysts and an in-depth understanding of the catalytic reaction *** this work,fully-exposed Pt clusters were fabricated on the atomically dispersed Sn decorated nanodiamond/graphene(Sn-ND@G)hybrid support and employed for direct dehydrogenation(DDH)of ethylbenzene(EB)to styrene(ST).The detailed structural characterizations revealed the fully-exposed Pt clusters were stabilized on Sn-ND@G,assisted by the spatial separation of atomically dispersed Sn *** as-prepared Pt/Sn-ND@G catalyst showed enhanced ST yield(136.2 molEB·molpt-1·h-1 EB conversion rate and 99.7%ST selectivity)and robust long-term stability at 500℃for the EB DDH reaction,compared with the traditional ND@G supported Pt nanoparticle catalyst(Pt/ND@G).The ST prefers to desorb from the fully-exposed Pt clusters,resulting in the enhanced DDH catalytic performance of the Pt/Sn-ND@G *** present work paves a new way for designing highly dispersed and stable supported metal catalysts for DDH reactions.

关键词： Pt cluster ethylbenzene dehydrogenation fully-exposed catalyst heterogeneous catalysis

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Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference

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Nano Research 2020年第1期13卷 238-245页

作者： Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou peng mi Xiaoyuan Chen Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102China The Department of Chemical Engineering The University of MelbourneParkvilleVictoria3010Australia School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore637457Singapore State Key Laboratory of Biotherapy and Cancer Center West China HospitalCollaborative Innovation Center for BiotherapySichuan UniversityChengdu610041China Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthBethesdaMD20892USA

Endo/lysosomal escape and gene release are two critical bottlenecks in gene ***,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)*** single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer ***,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA *** nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment.

关键词： metal-organic frameworks endo/lysosomal rupture and release photo-controllable nanoswitch RNA interference cancer therapy

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Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy

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Neural Regeneration Research 2012年第30期7卷 2370-2376页

作者： Liang peng mi Liu Xiaorong Chang Zhou Yang Shouxiang Yi Jie Yan Yan peng College of Acupuncture and Tuina Hunan University of Chinese Medicine Changsha 410007 Hunan Province China

Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanfi （ST36） for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanfi, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanfi can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa.

关键词： pre-moxibustion transection of neural pathway Zusanli (ST36) gastric mucosal lesion heat shockproteins-70 ulcer index traditional Chinese medicine neural regeneration

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Effect of warm acupuncture on nitric oxide synthase and calcitonin gene-related peptide in a rat model of lumbar nerve root compression

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Neural Regeneration Research 2009年第6期4卷 449-454页

作者： Yaochi Wu Yiqun mi peng Zhang Junfeng Zhang Wei Chen Department of Acupuncture Massage and Traumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200233 China

BACKGROUND： Varying degrees of inflammatory responses occur during lumbar nerve root compression. Studies have shown that nitric oxide synthase （NOS） and calcitonin gene-related peptide （CGRP） are involved in secondary disc inflammation. OBJECTIVE： To observe the effects of warm acupuncture on the ultrastructure of inflammatory mediators in a rat model of lumbar nerve root compression, including NOS and CGRP contents. DESIGN, TIME AND SETTING： Randomized, controlled study, with molecular biological analysis, was performed at the Experimental Center, Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University, between September 2006 and April 2007. MATERIALS： Acupuncture needles and refined Moxa grains were purchased from Shanghai Taicheng Technology Development Co., Ltd., China; Mobic tablets were purchased from Shanghai Boehringer Ingelheim Pharmaceuticals Co., Ltd., China; enzyme linked immunosorbent assay （ELISA） kits for NOS and CGRP were purchased from ADL Biotechnology, Inc., USA. METHODS： A total of 50, healthy, adult Sprague-Dawley rats, were randomly divided into five groups normal, model, warm acupuncture, acupuncture, and drug, with 10 rats in each group. Rats in the four groups, excluding the normal group, were used to establish models of lumbar nerve root compression. After 3 days, Jiaji points were set using reinforcing-reducing manipulation in the warm acupuncture group. Moxa grains were burned on each needle, with 2 grains each daily. The acupuncture group was the same as the warm acupuncture group, with the exception of non-moxibustion. Mobic suspension （3.75 mg/kg） was used in the oral drug group, once a day. Treatment of each group lasted for 14 consecutive days. Modeling and medication were not performed in the normal group. MAIN OUTCOME MEASURES： The ultrastructure of damaged nerve roots was observed with transmission electron microscopy; NOS and CGRP contents were measured using ELISA. RESULTS： The changes of the radicular ultramicrostr

关键词： warm acupuncture nerve root compression model ultrastructure nitric oxide synthase calcitonin gene-related peptide

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Construction of 3D hollow NiCo-layered double hydroxide nanostructures for high-performance industrial overall seawater electrolysis

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Nano Research 2024年第11期17卷 9472-9482页

作者： Lili Wang Di Wang Linlin Zheng Xiaorong Song Ya Yan Jiahui Li Shuheng Tian Maolin Wang mi peng Zhaohui Yin Hong Wang Junqing Xu Bowen Cheng Zhen Yin Ding Ma State Key Laboratory of Separation Membranes and Membrane Processes School of Chemistry Tiangong University Tianjin 300387 China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering and College of Engineering and BIC-ESAT Peking University Beijing 100871 China College of Chemical Engineering and Materials Science Tianjin University of Science and Technology Tianjin 300457 China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and Technology Tianjin 300457 China School of Materials Science and Engineering Tiangong University Tianjin 300387 China China Tianchen Engineering Corporation Tianjin 300400 China

Green hydrogen production via seawater electrolysis holds a great promise for carbon-neutral energy production. However, the development of efficient and low-cost bifunctional electrocatalysts for seawater electrolysis at an industrial level remains a significant challenge. Herein, we report a facile approach based on one-dimensional (1D) cobalt carbonate hydroxide (CCH) nanoneedles (NNs) as skeleton and zeolitic imidazolate framework-67 (ZIF-67) as a sacrificial template to construct a self-supported NiCo layered double hydroxide (NiCo LDH) heterostructure nanocage (CCH@NiCo LDH) anchoring on the carbon felt (CF). The NiCo LDHs have hollow features, consisting of ultrathin layered hydroxide nanosheets. Benefiting from the structural advantages, unique carbon substrate and desirable composition, three-dimensional (3D) NiCo LDH nanocages exhibit superior performance as a bifunctional catalyst for overall seawater splitting at an industrial level and good corrosion resistance in alkaline media. In the alkaline seawater (1 M KOH + 0.5 M NaCl), it exhibits low overpotentials of 356 mV for hydrogen evolution reaction (HER) and 433 mV for oxygen evolution reaction (OER) at 400 mA·cm^(−2), much better than most of reported non-noble metal catalysts. Consequently, the obtained CF electrode loading of CCH@NiCo LDH exhibits outstanding performance as anodes and cathodes for overall alkaline seawater splitting, with remarkably low cell voltages of 1.56 and 1.89 V at current densities of 10 and 400 mA·cm^(−2), respectively. Moreover, the robust stability of 100 h is also demonstrated at above 200 mA·cm^(−2) in alkaline seawater. Our present work demonstrates significant potential for constructing effective cost-efficient and non-noble-metal bifunctional electrocatalyst and electrode for industrial seawater splitting.

关键词： seawater splitting bifunctional electrocatalyst NiCo layered double hydroxide(NiCo LDH) hollow nanocages carbon felt

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基于振动信号的活体禽蛋胚胎发育中的胎动检测

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农业工程学报 2010年第11期26卷 221-224页

作者：梁森梁磊米鹏青岛理工大学机械工程学院青岛266033 宝鸡文理学院机电工程系宝鸡721007

在禽蛋孵化过程中的胚胎监控对家禽行业的发展具有非常重要的意义。该文设计了一套能获取孵化期活体禽蛋胚胎胎动信号的监测系统,提出一种半侵入法测量禽蛋胚胎胎动的新方法。先在禽蛋气室的顶部用针扎一个小洞,使活体胚胎的胎动信号经... 详细信息

在禽蛋孵化过程中的胚胎监控对家禽行业的发展具有非常重要的意义。该文设计了一套能获取孵化期活体禽蛋胚胎胎动信号的监测系统,提出一种半侵入法测量禽蛋胚胎胎动的新方法。先在禽蛋气室的顶部用针扎一个小洞,使活体胚胎的胎动信号经气室放大后传出来,然后带动贴在小孔上的铝箔运动,再通过位移传感器对其进行测量。本系统在不影响胚胎发育情况下,能对禽蛋胚胎进行识别,具有操作简单、可靠性高等特点,为进一步研发禽蛋发育过程的自动监控系统奠定了基础。

关键词：监测振动信号检测禽蛋胚胎半侵入法

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