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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu Ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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弹性宽刃精车刀与细长轴的加工

机械研究与应用 2005年第5期18卷 65-66页

作者：裴仕明李金官江苏众想集团有限公司江苏盐城224005

介绍了自制弹性宽刃精车刀对细长轴进行加工,以及加工工艺和加工中要注意的若干问题。

关键词：弹性宽刃车刀细长轴工艺

Controllability of heterogeneous interdependent group systems under undirected and directed topology

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Chinese Physics B 2018年第10期27卷 642-651页

作者： Hui-Qin pei shi-ming Chen School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang 330013China

The controllability problem of heterogeneous interdependent group systems with undirected and directed topology is investigated in this paper. First, the interdependent model of the heterogeneous system is set up according to the difference of individual characteristics. An extended distributed protocol with the external sliding-mode control is designed, under which it is shown that a heterogeneous interdependent group system is controllable when the corresponding communication topology is controllable. Then, using the network eigenvalue method, the driving individuals are determined for a heterogeneous system with undirected topology. Under directed topology, the maximum match method is utilized to confirm the driving individuals. Some sufficient and necessary conditions are presented to assure that the heterogeneous interdependent group system is structurally controllable. Via theoretical analysis, the controllability of heterogeneous interdependent systems is related to the interdependent manner and the structure of the heterogeneous system. Numerical simulations are provided to demonstrate the effectiveness of the theoretical results.

关键词： controllability heterogeneous group systems interdependent model sliding-mode control

Fabrication of N,S co-doped carbon immobilized high-density Co single atoms toward electro-oxidation of organic sulfides with water as feedstock

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Nano Research 2023年第5期16卷 6593-6600页

作者： pei Zhu Wen-Xiong shi Ying Wang Zhi-ming Zhang Lina Li Changhua An Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion Tianjin Key Laboratory of Advanced Functional Porous MaterialsInstitute for New Energy Materials&Low-Carbon TechnologiesTianjin University of TechnologyTianjin 300384China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Development of high-density single atoms site(SAs)electrocatalysts is highly desirable due to their extraordinary catalytic ***,their synthesis is still challenging and their anticorrosion capacities in electrolyte(particularly in acidic electrolyte)are ***,we have constructed N,S co-doped carbon to anchor~10 wt.%Co SAs(Co-SAs/NSC)via a novel polymerization–sulfurization–pyrolysis strategy toward selective electro-oxidation of thioethers in acidic *** asobtained Co SAs has a coordination geometry of Co-S_(2)N_(4),exhibiting excellent electrocatalytic activity and robust *** a low potential of 1.40 V *** hydrogen electrode(RHE),the conversion rate of thioethers over Co-SAs/NSC reaches 99.7%with 100%selectivity and 100%Faraday efficiency(FE)for producing sulfoxide,which is higher than the commercial Pt electrode and the reported state-of-the-art *** calculations and experiments reveal that the Co-S_(2)N_(4)structure endows the outstanding electro-oxidation activity of Co SAs through significantly promoting desorption of the *** work presents a convenient strategy to build high-performance SAs catalysts for the resourceful use of sulfur-containing pollutants.

关键词： single-atom cobalt high density selective oxidation electrocatalysis

Elliptical inclusion in an anisotropic plane:non-uniform interface effects

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Applied Mathematics and Mechanics(English Edition) 2022年第5期43卷 667-688页

作者： Pengyu pei ming DAI School of Electrical and Mechanical Engineering Jinling Institute of TechnologyNanjing 211169China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

We study the plane deformation of an elastic composite system made up of an anisotropic elliptical inclusion and an anisotropic foreign matrix surrounding the *** order to capture the influence of interface energy on the local elastic field as the size of the inclusion approaches the nanoscale,we refer to the Gurtin-Murdoch model of interface elasticity to describe the inclusion-matrix interface as an imaginary and extremely stiff but zero-thickness layer of a finite stretching *** opposed to isotropic cases in which the effects of interface elasticity are usually assumed to be uniform(described by a constant interface stretching modulus for the entire interface),the anisotropic case considered here necessitates non-uniform effects of interface elasticity(described by a non-constant interface stretching modulus),because the bulk surrounding the interface is *** this end,we treat the interface stretching modulus of the anisotropic composite system as a variable on the interface curve depending on the specific tangential direction of the *** then devise a unified analytic procedure to determine the full stress field in the inclusion and matrix,which is applicable to the arbitrary orientation and aspect ratio of the inclusion,an arbitrarily variable interface modulus,and an arbitrary uniform external loading applied *** non-uniform interface effects on the external loading-induced stress distribution near the interface are explored via a group of numerical *** is demonstrated that whether the nonuniformity of the interface effects has a significant effect on the stress field around the inclusion mainly depends on the direction of the external loading and the aspect ratio of the inclusion.

关键词： elliptical inclusion anisotropic material interface stress Gurtin-Murdoch model membrane-type interface

Homologous Comparisons of Photosynthetic System I Genes among Cyanobacteria and Chloroplasts

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Journal of Integrative Plant Biology 2008年第8期50卷 929-940页

作者： Jie Yu pei-Jun Ma Ding-Ji shi shi-ming Li Chang-Lu Wang School of Matin Science & Engineering Tianjin University of Science & Technology Tianjin 300457 China Institute of Botany the Chinese Academy of Sciences Beijing 100093 China

It has now believed that chloroplasts arose from cyanobacteria, however, during endosymbiosis, the photosynthetic genes in chloroplasts have been reduced. How these changes occurred during plant evolution was the focus of the present study. Beginning with photosystem I （PSI） genes, a homologous comparison of amino acid sequences of 18 subunits of PSI from 10 species of cyanobacteria, chloroplasts in 12 species of eucaryotic algae, and 28 species of plants （including bryophytes, pteridophytes, gymnospermae, dicotyledon and monocotyledon） was undertaken. The data showed that 18 genes of PSI can be divided into two groups： Part Ⅰ including seven genes （psaA, psaB, psaC, psal, psaJ, ycf3 and ycf4） shared both by cyanobacteria and plant chloroplasts; Part Ⅱ containing another 11 genes （psaD, psaE, psaF, psaK, psaL, psaM, btpA, ycf37, psaG, psaH and psaN） appeared to have diversified in different plant groups. Among Part Ⅰ genes, psaC, psaA and psaB had higher homology in all species of cyanobacteria and chloroplasts. Among Part Ⅱ genes, only psaG, psaH and psaN emerged in seed plants.

关键词： chloroplast cyanobacteria homologous comparison photosynthesis evolution PSI (photosystem I) genes

Correlation Between CO_2 Efflux and Net Nitrogen Mineralization and Its Response to External C or N Supply in an Alpine Meadow Soil

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Pedosphere 2011年第5期21卷 666-675页

作者： SONG ming-Hua JIANG Jing XU Xing-Liang shi pei-Li Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 (China) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) Graduate University of Chinese Academy of Sciences Beijing 100049 (China)

In nutrient-limited alpine meadows,nitrogen(N) mineralization is prior to soil microbial immobilization;therefore,increased mineral N supply would be most likely immobilized by soil microbes due to nutrient shortage in alpine *** addition,low temperature in alpine meadows might be one of the primary factors limiting soil organic matter decomposition and thus N mineralization.A laboratory incubation experiment was performed using an alpine meadow soil from the Tibetan *** levels of NH4NO3(N) or glucose(C) were added,with a blank without addition of C or N as the control,before incubation at 5,15,or 25 ℃ for 28 ***2 efflux was measured during the 28-d incubation,and the mineral N was measured at the beginning and end of the incubation,in order to test two hypotheses:1) net N mineralization is negatively correlated with CO2 efflux for the control and 2) the external labile N or C supply will shift the negative correlation to *** results showed a negative correlation between CO2 efflux and net N immobilization in the *** inorganic N supply did not change the negative *** external labile C supply shifted the linear correlation from negative to positive under the low C addition ***,under the high C level,no correlation was *** suggested that the correlation of CO2 efflux to net N mineralization strongly depend on soil labile C and C:N ratio regardless of *** research should focus on the effects of the types and the amount of litter components on interactions of C and N during soil organic matter decomposition.

关键词： C:N ratio inorganic N labile C organic matter temperature

Microstructure, Interface, and Properties of Multilayered CrN/Cr_2O_3 Coatings Prepared by Arc Ion Plating

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Journal of Materials Science & Technology 2014年第12期30卷 1193-1201页

作者： Chang-ming shi Tie-Gang Wang Zhi-Liang pei Jun Gong Chao Sun State Key Laboratory for Corrosion and Protection (SKLCP) Institute of Metal Research Chinese Academy of Sciences

There has been much interest in developing multilayered or nanolayered physical vapor deposition（PVD） coatings identified as a group of promising protective coatings for their excellent mechanical properties and corrosion resistance. In this study, the multilayered Cr N/Cr2O3 coatings with different bilayer periods（L） were synthesized on the polished high speed steel substrates from a Cr target with the alternative atmosphere of pure nitrogen and pure oxygen by arc ion plating（AIP） technique. The results revealed that the microstructure,morphologies and properties of the multilayered coatings were strongly influenced by the bilayer period（L）.There were two kinds of interfaces in the multilayered Cr N/Cr2O3coatings： the sharp ones and the blurry ones. With reducing the value of L, the macro-particles densities decreased gradually, whereas the coating microhardness, adhesive strength and wear resistance first increased, and then decreased slightly or remained stable as the bilayer period L 〈 590 nm. The multilayered Cr N/Cr2O3 coating with the bilayer period L of 590 nm possessed the best comprehensive properties, namely the highest microhardness, the strongest adhesion, and the lowest wear rate.

关键词： Cr2O3/CrN Multilayered coating Arc ion plating Interface Mechanical properties Wear

Effects of the Thickness Ratio of CrN vs Cr_2O_3 Layer on the Properties of Double-layered CrN/Cr_2O_3 Coatings Deposited by Arc Ion Plating

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Journal of Materials Science & Technology 2014年第5期30卷 473-479页

作者： Chang-ming shi Tie-Gang Wang Zhi-Liang pei Jun Gong Chao Sun State Key Laboratory for Corrosion and Protection Institute of Metal ResearchChinese Academy of Sciences

In this study, CrN/Cr2O3 double-layered coatings with various thickness ratios of CrN vs Cr2O3 layer were prepared by arc ion plating technology. The influences of the thickness ratio of CrN vs Cr2O3 layer on the microstructural characteristics as well as the mechanical and tribological properties of the CrN/Cr2O3 doublelayered coatings were investigated. The corresponding mechanisms were also discussed. The results indicated that the insertion of CrN layer between the Cr2O3 layer and substrate can effectively decrease the internal stress level of the coating. With increasing the thickness ratio of CrN vs Cr2O3 layer, the surface roughness of double-layered coatings decreased gradually, which had a certain influence on the friction coefficient. In addition, the microhardness also declined gradually, the adhesive strength almost increased linearly, whereas the wear rate declined firstly and then increased slightly. As the thickness ratio was 2：1, the double-layered coating exhibited the best wear resistance.

关键词： Cr2O3/CrN Double-layered coating Thickness ratio Arc ion plating Mechanical property Wear