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Frontiers of Medicine 2024年第3期18卷 565-569页

作者： Jia Jia Lili Mao Jing Lin Wenyu Li pei Yuan Lei Guo Jie Dai Caili Li Xue Bai Zhongwu Li Yu chen Jun Guo Jianming Ying Lu Si State Key Laboratory of Molecular Oncology Department of PathologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing100142China Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou350014China Department of Pathology Peking University Cancer Hospital&InstituteBeijing100142China

Dear Editor,Extramammary Paget disease(EMPD)is a rare adenocarcinoma that originates in the apocrine gland-rich skin and usually affects the perineal skin(primary EMPD)or represents the intraepithelial spread of an underlying visceral carcinoma(secondary EMPD).Approximately half of EMPD cases are confined to the epidermis,which was defined as intraepithelial EMPD.

关键词： Paget HER2 adenocarcinoma

Eigenstate properties of the disordered Bose-Hubbard chain

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Frontiers of physics 2024年第4期19卷 57-72页

作者： Jie chen Chun chen Xiaoqun Wang Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Many-body localization(MBL)of a disordered interacting boson system in one dimension is studied numerically at the filling faction *** von Neumann entanglement entropy Svn is commonly used to detect the MBL phase transition but remains challenging to be directly *** on the U(1)symmetry from the particle number conservation,Svn can be decomposed into the particle number entropy S_(n) and the configuration entropy *** light of the tendency that the eigenstate's S_(c) nears zero in the localized phase,we introduce a quantity describing the deviation of S from the ideal thermalization distribution;finite-size scaling analysis illustrates that it shares the same phase transition point with Sv but displays the better critical *** observation hints that the phase transition to MBL might largely be determined by S and its fluctuations Notably,the recent experiments[***,et al.,Science 364,256(2019);***,et al.,***.19,481(2023)]demonstrated that this deviation can potentially be measured through the Sn ***,our investigations reveal that the thermalized states primarily occupy the low-energy section of the spectrum,as indicated by measures of localization length,gap ratio,and energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,accommodating a transition from the thermalized to the localized ***,owing to the bosonic statistics,the high-energy spectrum of the model allows the formation of distinct clusters of bosons in the random potential *** analyze the resulting eigenstate properties and briefly summarize the associated *** distinguish between the phase regions at the low and high energies,a probing quantity based on the structure of S_(VN) is also *** work highlights the importance of symmetry combined with entanglement in the study of *** this regard,for the disordered Heisenberg XXZ

关键词： entanglement entropy decomposition U(1)symmetry thermalization-to-localization transition

genERALIZED JACOBI SPECTRAL GALERKIN METHOD FOR FRACTIONAL-ORDER VOLTERRA INTEGRO-DIFFERENTIAL EQUATIONS WITH WEAKLY SINGULAR KERNELS

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Journal of Computational Mathematics 2024年第2期42卷 355-371页

作者： Yanping chen Zhenrong chen Yunqing Huang School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China Hunan Key Laboratory for Computation and Simulation in Science and Engineering Xiangtan UniversityXiangtan 411105China

For fractional Volterra integro-differential equations(FVIDEs)with weakly singular kernels,this paper proposes a generalized Jacobi spectral Galerkin *** basis functions for the provided method are selected generalized Jacobi functions(GJFs),which can be utilized as natural basis functions of spectral methods for weakly singular FVIDEs when appropriately *** developed method's spectral rate of convergence is determined using the L^(∞)-norm and the weighted L^(2)-*** results indicate the usefulness of the proposed method.

关键词： generalized Jacobi spectral Galerkin method Fractional-order Volterra integ-ro-differential equations Weakly singular kernels Convergence analysis

Neural networks-based iterative learning control consensus for periodically time-varying multi-agent systems

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Science China(Technological Sciences) 2024年第2期67卷 464-474页

作者： chen JiaXi LI JunMin chen WeiSheng GAO WeiFeng School of Mathematics and Statistics Xidian UniversityXi'an 710071China School of Aerospace Science and Technology Xidian UniversityXi'an 710071China

In this paper,the problem of adaptive iterative learning based consensus control for periodically time-varying multi-agent systems is studied,in which the dynamics of each follower are driven by nonlinearly parameterized terms with periodic *** networks and Fourier base expansions are introduced to describe the periodically time-varying dynamic *** this basis,an adaptive learning parameter with a positively convergent series term is constructed,and a distributed control protocol based on local signals between agents is designed to ensure accurate consensus of the closed-loop ***,consensus algorithm is generalized to solve the formation control ***,simulation experiments are implemented through MATLAB to demonstrate the effectiveness of the method used.

关键词： multi-agent systems adaptive iterative learning control nonlinearly parameterized dynamics Fourier series expansion neural networks

Recent Advances in Nickel Catalyzed Carbonylative Reactions via the Insertion of Carbon Monoxide

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Chinese Journal of Chemistry 2024年第2期42卷 177-189页

作者： Xinzhou chen Gang chen Zhong Lian Department of Dermatology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041China

Carbonyl compounds have attracted considerable attention due to their extensive applications in drug ***,they are important synthetic intermediates for the construction of carbon-carbon and carbon-heteroatom ***-metal-catalyzed carbonylation via the insertion of co is one of the most efficient and straightforward strategies to access carbonyl ***,most of the transition-metal-catalyzed carbonylative reactions require expensive and toxic noble-metal ***,there is a growing demand for the exploration of nickel-catalyzed carbonylative reactions via the insertion of CO due to the earth abundance and low cost of *** with the well-established palladium-catalyzed carbonylative reactions,nickel-catalyzed analogous transformations have been relatively *** is primarily because CO strongly binds to nickel,often resulting in catalyst *** recent years,some research groups have focused on using CO surrogates or NN_(2) pincer nickel catalyst to circumvent the formation of Ni(CO)_(4).Nickel-catalyzed carbonylation has been applied in the construction of carbonyl-containing compounds,such as ketones,carboxylic acids,thioesters,acyl chloride and carboxamides.

关键词： Carbonylation Nickel catalysis Carbon monoxide C1 chemistry Carbonyl-containing compounds

High-Level Security Dimension Evaluation of Blockchain BaaS System and Key Technology

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China Communications 2024年第6期21卷 176-191页

作者： chen Wanfa Zheng Qing’an chen Shuzhen Fu Hongyi chen Liang Fujian Police College Fuzhou 350007China Computer Science and Information Security Management Department Fujian Police CollegeFuzhou 350007China Fujian Province Key Laboratory for Digital Network Crime Supervision and Prevention Fuzhou 350007China Beijing University of Posts and Telecommunications Beijing 100876China Fujian Provincial Prison Administration Fuzhou 350002China

In recent years,blockchain technology integration and application has gradually become an important driving force for new technological innovation and industrial *** blockchain technology and applications are developing rapidly,the emerging security risks and obstacles have gradually become *** can still find security issues in blockchain systems and conduct attacks,causing increasing losses from network attacks every *** response to the current demand for blockchain application security detection and assessment in all industries,and the insufficient coverage of existing detection technologies such as smart contract detectiontechnology,this paper proposes a blockchain core technology security assessment system model,and studies the relevant detection and assessment key technologies and systems.A security assessment scheme based on a smart contract and consensus mechanism detection scheme is *** the underlying blockchain architecture supports the traceability of detection results using super ***,the functionality and performance of the system were tested,and the test results show that the model and solutions proposed in this paper have good feasibility.

关键词： blockchain security consensus mechanis smart contract

Deformation-based longitudinal equivalent stiffness beam model for shield tunnel and its application in seismic deformation method

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Underground Space 2024年第4期17卷 280-299页

作者： Pingliang chen Ping geng Junbo chen Qi Yang Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Intelligent Geotechnics and Tunnelling Chengdu 610031China Technology Center of Sichuan Road&Bridge Group Co. LtdChengdu 610041China

In the longitudinal seismic deformation method for shield tunnels,one of the most commonly used is the longitudinal equivalent stiffness beam model(LES)for simulating the mechanical behavior of the *** this model,axial deformation and bending deformation are independent,so the equivalent stiffness is a constant ***,the actual situation is that axial deformation and bending deformation occur simultaneously,which is not considered in *** present,we are not clear about the effect on the calculation results when axial deformation and bending deformation occur ***,in this paper,we improve the traditional LES by taking the relative deformation as a load and considering the coordinated deformation of axial and bending degrees of *** improved model is called DNLES,and its neutral axis equations are an explicit ***,we propose an iterative algorithm to solve the calculation model of the DNLES-based longitudinal seismic deformation *** a calculation example,we find that the internal forces based on LES are notably underestimated than those of DNLES in the compression bending zone,while are overestimated in the tension bending *** considering the combined effect,the maximum bending moment reached 13.7 times that of the LES model,and the axial pressure and tension were about 1.14 and 0.96 times,*** analysis reveals the coordinated deformation process in the axial and bending directions of the shield tunnel,which leads to a consequent change in equivalent *** explains why,in the longitudinal seismic deformation method,the traditional LES may result in unreasonable calculation results.

关键词： Shield tunnel Longitudinal seismic deformation method Longitudinal equivalent stiffness beam Combined axial and bending deformation

Blockchain-based immunization against kleptographic attacks

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Science China(Information Sciences) 2024年第7期67卷 172-183页

作者： Changsong JIANG Chunxiang XU Jie chen Kefei chen School of Computer Science and Engineering University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Department of Mathematics Hangzhou Normal University

Adversarial implementations of cryptographic primitives called kleptographic attacks cause the leakage of secret information. Subliminal channel attacks are one of the kleptographic attacks. In such attacks, backdoors are embedded in implementations of randomized algorithms to elaborately control randomness generation, such that the secrets will be leaked from biased outputs. To thwart subliminal channel attacks, double-splitting is a feasible solution, which splits the randomness generator of a randomized algorithm into two independent generators. In this paper, we instantiate double-splitting to propose a secure randomness generation algorithm dubbed SRG using two physically independent generators: ordinary and public randomness generators. Based on public blockchains, we construct the public randomness generator,which can be verified publicly. Hashes of a sufficient number of consecutive blocks that are newly confirmed on a blockchain are used to produce public randomness. In SRG, outputs from the two generators are taken as inputs of an immunization function. SRG accomplishes immunization against subliminal channel ***, we discuss the application strategies of SRG for symmetric and public-key encryption.

关键词： kleptographic attacks subliminal channel blockchain immunization randomized algorithm

Upregulation of the glycine-rich protein-encoding gene GhGRPL enhances plant tolerance to abiotic and biotic stressors by promoting secondary cell wall development

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Journal of Integrative Agriculture 2024年第10期23卷 3311-3327页

作者： Wanting Yu Yonglu Dai Junmin chen Aimin Liang Yiping Wu Qingwei Suo Zhong chen Xingying Yan Chuannan Wang Hanyan Lai Fanlong Wang Jingyi Zhang Qinzhao Liu Yi Wang Yaohua Li Lingfang Ran Jie Xiang Zhiwu pei Yuehua Xiao Jianyan Zeng College of Agronomy and Biotechnology Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China Chongqing Key Laboratory of Crop Molecular Improvement Chongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China

Abiotic and biotic stressors adversely affect plant survival,biomass generation,and crop *** the global availability of arable land declines and the impacts of global warming intensify,such stressors may have increasingly pronounced effects on agricultural ***,researchers face the overarching challenge of comprehensively enhancing plant resilience to abiotic and biotic *** secondary cell wall plays a crucial role in bolstering the stress resistance of *** increase plant resistance to stress through genetic manipulation of the secondary cell wall,we cloned a cell wall protein designated glycine-rich protein-like(GhGRPL)from cotton fibers,and found that it is specifically expressed during the period of secondary cell wall ***,this protein differs from its Arabidopsis homolog,AtGRP,since its glycine-rich domain is deficient in glycine *** is involved in secondary cell wall *** of GhGRPL enhances lignin accumulation and,consequently,the thickness of the secondary cell walls,thereby increasing the plant’s resistance to abiotic stressors,such as drought and salinity,and biotic threats,including Verticillium dahliae ***,interference with GhGRPL expression in cotton reduces lignin accumulation and compromises that *** together,our findings elucidate the role of GhGRPL in regulating secondary cell wall development through its influence on lignin deposition,which,in turn,reinforces cell wall robustness and *** findings highlight the promising near-future prospect of adopting GhGRPL as a viable,effective approach for enhancing plant resilience to abiotic and biotic stress factors.

关键词： glycine-rich protein-like secondary cell wall abiotic stress biotic stress stress resistance

Goal-Oriented Control Systems(GOCS):From HOW to WHAT

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 816-819页

作者： Wen-Hua chen the Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershireLE113TUU.K.

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced ***-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.

关键词： automated instru system