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J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery

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Chinese Chemical Letters 2024年第1期35卷 271-274页

作者： Yun Qu Wenjuan Jin Yichen Wan zhichao pei Yuxin pei College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China

Drug loading capacity is very important in the construction of targeted drug delivery systems(TDDSs)for the improvement of drug delivery ***,the drug-loading capacity of most nanomaterials is non-idealistic,and developing the high drug-loading TDDSs is still a critical *** this work,an ultrahigh loading system(denoted as HMPB_(2))was prepared via J-aggregation of an aza-boron dipyrromethene derivative(Bod)by using hollow MnO_(2)modified with glucosamine pillar[5]arene as a carrier,which was demonstrated to have typical J-aggregate absorption of Bod,specific cancer cells targeting ability,negligible dark cytotoxicity,and potent *** work provides a successful example to construct an ultrahigh drug-loading system via J-aggregation for targeted delivery.

关键词： J-aggregate Ultrahigh drug-loading Aza-BODIPY Hollow MnO_(2) Phototherapy Pillar[n]arene

Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin pei zhichao pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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翻板闸门水闸闸墙水磨石贴面安装技术应用

浙江水利科技 2024年第1期52卷 79-83页

作者：杨齐家裴志超高文佳中国水利水电第六工程局有限公司辽宁沈阳110000

水磨石贴面用在翻板闸门水闸闸墙中,作为闸门启闭滑落轨道时,由于长期外露,且闸门水封与水磨石贴面幕墙紧密贴合,经潮涨潮落、风浪冲刷及运行过程中受外力挤压碰撞,极易造成水磨石面板破碎脱落,从而影响闸门启闭,导致运行故障。针对水... 详细信息

水磨石贴面用在翻板闸门水闸闸墙中,作为闸门启闭滑落轨道时,由于长期外露,且闸门水封与水磨石贴面幕墙紧密贴合,经潮涨潮落、风浪冲刷及运行过程中受外力挤压碰撞,极易造成水磨石面板破碎脱落,从而影响闸门启闭,导致运行故障。针对水闸闸墙采用水磨石贴面施工时,通过采用型钢短槽式石材干挂结构系统,将饰面板材固定在建筑物上,形成石材饰面幕墙,再进行石材背侧高强无收缩材料灌浆,密实填充幕墙与闸墙间空隙产生了明显效果,有效避免上述问题的发生,保证工程施工安全和质量。

关键词：翻板闸水磨石干挂灌浆

pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group

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Chinese Chemical Letters 2022年第10期33卷 4563-4566页

作者： Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao Yuxin pei zhichao pei Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China

Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug ***,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced ***,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery ***,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic *** amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug *** experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor *** experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer *** present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.

关键词： Pillararene Sodium xanthate Host-guest interaction pH-and H_(2)O_(2)-dual responsive Controllable drug delivery

小剂量高黏度骨水泥经皮椎体成形术对老年OTF患者伤椎高度恢复、椎体功能、疼痛程度、骨水泥渗漏的影响

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宁夏医学杂志 2024年第6期46卷 488-491页

作者：裴志超李俊辰孔维邦刘耀文河南宏力医院骨科河南新乡453400 河南省驻马店市第一人民医院骨科河南驻马店463000

目的探讨小剂量高黏度骨水泥经皮椎体成形术(PVP)对老年骨质疏松性胸腰椎骨折(OTF)患者伤椎高度恢复、椎体功能、疼痛程度、骨水泥渗漏的影响。方法选取104例老年OTF患者,分为小剂量组和大剂量组,各52例。2组患者均进行PVP术,小剂量... 详细信息

目的探讨小剂量高黏度骨水泥经皮椎体成形术(PVP)对老年骨质疏松性胸腰椎骨折(OTF)患者伤椎高度恢复、椎体功能、疼痛程度、骨水泥渗漏的影响。方法选取104例老年OTF患者,分为小剂量组和大剂量组,各52例。2组患者均进行PVP术,小剂量组采用小剂量(≤3 mL)高黏度骨水泥填充,大剂量组采用大剂量(>3 mL)高黏度骨水泥填充。对比2组患者骨水泥渗漏率、手术前后伤椎高度恢复情况[Cobb角、伤椎前缘高度(AVH)]、椎体功能[Oswestry功能障碍指数(ODI)]、疼痛程度[疼痛数字评分(NRS)]。结果小剂量组骨水泥总渗漏率明显低于大剂量组(P<0.05);术后3个月,小剂量组Cobb角小于大剂量组,AVH高于大剂量组(P<0.05);术后3个月,小剂量组ODI、NRS评分均低于大剂量组(P<0.05)。结论与大剂量高黏度骨水泥比较,小剂量高黏度骨水泥应用于PVP治疗老年OTF患者可降低骨水泥渗漏风险,促进恢复伤椎AVH、Cobb角,改善椎体功能,减轻疼痛感。

关键词：骨质疏松性胸腰椎骨折经皮椎体成形术高黏度骨水泥小剂量大剂量

茎段和穴盘大小对北方叶用甘薯越冬育苗的影响

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中国农学通报 2024年第21期40卷 45-51页

作者：毛思帅裴志超李仁崑孙丹曹跃杨立国北京市农业技术推广站北京100029

为探索北方叶用甘薯越冬穴盘育苗,设置4个茎段大小(4、6、8、10 cm,用D1、D2、D3、D4表示)和5种穴盘规格(32、50、72、105、128孔),搭配14个处理,研究不同搭配对种苗成活率、幼苗长势(茎粗、株高等)和鲜重等指标的影响。结果表明:相同... 详细信息

为探索北方叶用甘薯越冬穴盘育苗,设置4个茎段大小(4、6、8、10 cm,用D1、D2、D3、D4表示)和5种穴盘规格(32、50、72、105、128孔),搭配14个处理,研究不同搭配对种苗成活率、幼苗长势(茎粗、株高等)和鲜重等指标的影响。结果表明:相同穴盘下,随着茎段增长,幼苗的成活率、叶片数、基部茎粗和株高呈现增加的趋势,进而地上部鲜重和整株鲜重也随之增加,以D4处理最高。相同茎段下,随着穴盘孔数增加,幼苗的叶片数、基部茎粗、株高、地上部鲜重和全株鲜重减少,源于穴盘对地下部的影响,以32孔处理最高。不同茎段和穴盘搭配下,D4-32处理的生长情况最好,3月中旬,对于地上部鲜重而言,D2-72处理(9.79 g)可达到与D4-32处理相同的效果(两者间无显著性差异),其叶片数、基部茎粗和株高等指标满足移栽水平;对于整株鲜重而言,D2-105处理(10.21 g)可达到与D4-32处理相同的效果,且可节省228.1%的育苗面积,参考其重量,1月中旬,D3-72处理下的地上部和整株鲜重接近上述两个处理的水平,可节省125.0%的育苗面积。综合秧苗生长情况与经济效益,3月中旬移栽时,推荐D2-105,即含2个腋芽茎段与105孔穴盘的搭配,如有生产条件在1月中旬移栽,推荐D3-72,即含3个腋芽茎段与72孔穴盘的搭配。

关键词：叶用甘薯北方越冬育苗茎段大小穴盘大小

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新型冠状病毒感染合并横纹肌溶解症1例

皮肤科学通报 2024年第2期41卷 214-216页

作者：裴志超朱函坪孙一晟姚苹苹徐芳沈鑫浙江省疾病预防控制中心微生物所浙江杭州310051 宿迁市第一人民医院医学检验科江苏宿迁223800

患者男,30岁,长期进行高强度训练运动,新型冠状病毒感染后出现全身肌肉酸痛、乏力等症状持续半月余,体力不能支撑体育运动。3个月后患者自觉身体恢复开始进行适应性训练,1周后出现胸闷、肌肉剧烈疼痛、乏力、尿液呈茶色等症状。入院查体... 详细信息

患者男,30岁,长期进行高强度训练运动,新型冠状病毒感染后出现全身肌肉酸痛、乏力等症状持续半月余,体力不能支撑体育运动。3个月后患者自觉身体恢复开始进行适应性训练,1周后出现胸闷、肌肉剧烈疼痛、乏力、尿液呈茶色等症状。入院查体:双上肢肌肉压痛,四肢活动正常,未见明显水肿;实验室检查:血浆中肌酸激酶31 007 U/L,血清肌酸激酶同工酶153 U/L,肌红蛋白2170 ng/mL。诊断:横纹肌溶解症。经过补液、碱化尿液等治疗后,患者肝肾功能、心肌酶谱各项指标均下降至正常范围内,遂出院。

关键词：新型冠状病毒横纹肌溶解症肌酸激酶

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北方叶用甘薯越冬保苗扩繁方式探索

中国种业 2024年第1期 99-102,107页

作者：毛思帅李仁崑裴志超侯爽王琦崔永恒杨立国北京市农业技术推广站北京100029 北京市通州区农业(种植)技术推广中心北京101101

为探索北方叶用甘薯越冬保苗扩繁方式,设置日光温室越冬保苗+土栽扩繁、日光温室越冬保苗+基质扩繁、专业育苗温室基质育苗等3种方式,研究不同方式对叶用甘薯种苗成活率、繁殖系数、种苗质量和繁育成本等指标的影响。结果表明:日光温室... 详细信息

为探索北方叶用甘薯越冬保苗扩繁方式,设置日光温室越冬保苗+土栽扩繁、日光温室越冬保苗+基质扩繁、专业育苗温室基质育苗等3种方式,研究不同方式对叶用甘薯种苗成活率、繁殖系数、种苗质量和繁育成本等指标的影响。结果表明:日光温室越冬期间间歇性出现低于10℃的天数比可加温的专业育苗温室多,对叶用甘薯越冬成活影响相对较多;3种方式下繁育的种苗质量均能达到壮苗指标要求,专业育苗温室基质育苗成本0.309元/株,移栽无缓苗期,但对温室条件要求及管理相对较高,定植时需苗量大;日光温室越冬保苗后早春扦插扩繁仍需配套1个多月的温室,但操作相对方便,越冬保苗后基质扦插扩繁系数为12.4、成本0.212元/株,土栽扦插扩繁系数为10.2、成本0.225元/株,未来可考虑冬前定植加大密度,进一步提升扩繁量,降低育苗成本。为争取叶用甘薯生产主动性,可结合生产实际(定植时间和生产条件),选择适宜的育苗方式。

关键词：叶用甘薯日光温室越冬保苗扩繁育苗方式

Virtual special issue:Supramolecular/macrocyclic chemistry

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Chinese Chemical Letters 2018年第12期29卷 1703-1705页

作者： Xiaoyu Hu zhichao pei School of Materials Science and Technology Nanjing University of Aeronautics and Astronautics College of Chemistry & Pharmacy Northwest A&F University

Welcome to this virtual special issue, which focuses on supramolecular/macrocyclic Chemistry. The beginnings of supramolecular chemistry can be traced back to 1967 with the identification of crown ethers by Pedersen [1], and being acknowledgement by the 1987 Nobel Prize to Lehn, Cram, and Pedersen for their leading discoveries in the host-guest systems [2]. Since these

关键词： Virtual special issue:Supramolecular/macrocyclic chemistry CB