检索结果-南通市图书馆

EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2022年第4期20卷 290-300页

作者： DU Bing-Xin lin pei lin Jun School of Life Sciences and Health Engineering Jiangnan UniversityWuxi 214122China

Catechins have been proven to exert antitumor effects in different kinds of ***,the underlying mechanisms have not been completely clarified *** study aimed to assess the effects and mechanisms of(-)-epigallocatechin-3-gallate(EGCG)and(-)-epicatechin-3-gallate(ECG)on human melanoma skin A375 *** showed that EGCG and ECG inhibited the proliferation of A375 cells and ECG showed better inhibitory *** cytometry analysis had shown that EGCG and ECG induced apoptosis and led to cell cycle *** and ECG decreased Bcl-2 expression and upregulated Caspase-3 protein level,indicating the development of ***,EGCG and ECG could decreased mitochondrial membrane potential of A375 *** addition,the expression of Beclin-1,LC3 and Sirt3 were downregulated at protein levels,which known to be associated with *** autophagy was increased by rapamycin,the apoptotic trend was not change,indicating that apoptosis and autophagy are ***,EGCG and ECG treatments decreased phosphorylated-AMPK(p-AMPK)and increased the ratios of P-PI3K,p-AKT and p-mTOR in melanoma ***,EGCG and ECG induced apoptosis via mitochondrial signaling pathway,downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling *** indicated that EGCG and ECG may be utilized in human melanoma treatment.

关键词： EGCG ECG Apoptosis Autophagy PI3K/AKT/mTOR

Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2022年第12期20卷 937-947页

作者： HONG Mengsa XIAO Kun lin pei lin Jun School of Life sciences and Health Engineering Jiangnan UniversityWuxi 214122China

This study was designed to investigate the effects of five Rutaceae family ethanol extracts(FRFEE):Citrus medica linn(CML),Citrus aurantium ***(CAD),Citrus medica ***(Noot.)Swingle(CMS),Citrus sinensis ***(CSO)and Zanthoxylum bungeanum Maxim(ZBM)on retarding the progression of H_(2)O_(2) and LPS-induced HaCaT *** inflammatory injury model was established by H_(2)O_(2) and *** alleviative effects of FRFEE were evaluated by detecting the activity of superoxide dismutase(SOD),glutathione(GSH)and the generation of reactive oxygen species(ROS).The inflammatory signaling pathways of NF-κB and JAK-STAT3 were detected by Western blotting,the mRNA expression levels of inflammatory factors and skin barrier factors were detected by RT-PCR.50%ethanol extracts of five medicinal and food homologous herbs of Rutaceae family showed different levels of anti-oxidant and anti-inflammatory *** FRFEE effectively improved SOD and GSH content and decreased ROS ***,FRFEE strongly suppressed two inflammatory signaling pathways NF-κB and *** RT-PCR examination of inflammatory factors and skin barrier factor revealed significant anti-inflammatory effects of *** was worth noting that among the five extracts,Zanthoxylum bungeanum Maxim extract had the best anti-inflammatory and anti-oxidation *** addition,it could strongly inhibit the expression of psoriasis factor *** summary,these results suggested that Zanthoxylum bungeanum Maxim extract could be used as an anti-psoriatic agent in the treatment of psoriasis among FRFEE.

关键词： Rutaceae Medicinal and food homologous herbs Oxidative stress Anti-inflammation Psoriasis

Inertial focusing and rotating characteristics of elliptical and rectangular particle pairs in channel flow

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2022年第8期31卷 266-272页

作者： pei-Feng lin Xiao Hu Jian-Zhong lin Key Laboratory of Fluid Transmission Technology of Zhejiang Province Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China

The lattice Boltzmann method is used to study the inertial focusing and rotating characteristics of two-dimensional elliptical particles and rectangular particles in channel flow. The results show that both elliptical particles and rectangular particles initially located on one side and two sides of channel centerline migrate first towards the equilibrium ***, the single-line particle train with an increasing spacing and the staggered particle train with stable spacing are formed. The axial spacing of the staggered particle pair increases with aspect ratio and Reynolds number increasing. The staggered elliptical or rectangular particle pairs form perpendicular orientation angles, which will be more obvious at larger aspect ratio and lower Reynolds number. The single-line particle trains with different shapes seldom form the perpendicular orientation angle.

关键词： lattice Boltzmann method particle trains self-organization inertial migration particle shape

A soft-contact hybrid electromagnetic–triboelectric nanogenerator for self-powered water splitting towards hydrogen production

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 6567-6574页

作者： Fuxue Ma Yingjie Wu Shuge Dai pei lin Junlu Sun lin Dong Key Laboratory of Material Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450000China

The effective acquisition of hydrogen energy from the ocean offers a promising sustainable solution for increasing global energy ***,a self-powered high-efficient hydrogen generation system is proposed by integrating a triboelectric–electromagnetic hybrid nanogenerator(TEHG),power management circuit(PMC),and an electrolytic *** the wind triggering,as-fabricated TEHG can effectively convert breeze energy into electric energy,which demonstrates a high output current of 20.3 mA at a speed rotation of 700 rpm and the maximal output power of 13.8 mW at a load of 10 MΩ.Remarkably,asdesigned self-powered system can perform a steady and continuous water splitting to produce hydrogen(1.5μL·min^(−1))by adding a matching capacitor between the PMC and electrolytic *** the circuit,the capacitor can not only function as a charge compensation source for water splitting,but also stabilize the working *** other self-powered water splitting systems,the proposed system does not need catalysts or the complex electrical energy storage/release process,thus improving the hydrogen production efficiency and reducing the *** work provides an effective strategy for clean hydrogen energy production and demonstrates the huge potential of the constructed self-powered system toward carbon neutralization.

关键词： wind energy harvester hybrid nanogenerator energy conversion and management hydrogen energy production

FAULT CAUSED BY WATER PRESSURE IN THE HEAD-COVER CHAMBER

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2006年第3期18卷 280-286页

作者： pei Hai-lin QI Xue-yi LI Hui LI Jian-hui pei Ze-yu College of Fluid Power and Control Lanzhou University of Technology Lanzhou 730050 China Gansu Electrical and scientifical Institute Lanzhou 730050 China Vernon Barford School Edmonton Alberta T6J2X6 Canada

Owing to the high temperature of the thrust beating pads, the No.l unit wasn＇t performed in the upgrading test at Liujiaxia Hydropower Plant. Through the experimental and theoretical analysis, it has been confirmed that the fault unit was caused by the high water pressure in the head-cover chamber. This type of the fault is out-of-the-way. After the suitable measure wags against the fault were taken, the No. 1 unit can stably operate. The conclusions and the methodology are of the certain reference value to the fault-diagnosis of the hydroelectric unit.

关键词： hydroelectric unit perturbation vibration,fault diagnosis

Production of laccase by Coriolus versicolor and its application in decolorization of dyestuffs: (Ⅱ) Decolorization of dyes by laccase containing fermentation broth with or without self-immobilized mycelia

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2003年第1期15卷 5-8页

作者： lin Jian ping LIAN Wei XIA Li ming CEN pei lin Department of Chemical Engineering and Bioengineering Zhejiang UniversityHangzhou 310027China.

The capability of decolorization for commercial dyes by Coriolus versicolor fermentation broth containing laccase with or without immobilized mycelium was evaluated. With cell free fermentation broth containing laccase, high decolorization ratio was achieved for acid orange 7, but not for the other dyes concerned. The immobilized mycelium was proved to be more efficient than the cell free system. All the four dyestuffs studied were found being decolourized with certain extent by immobilized mycelium. The repeated batch decolorization was carried out with satisfactory results. The experimental data showed that the continuous decolorization of wastewater from a printing and dyeing industry was possible by using the self immobilized C. Versicolor.

关键词： laccase textile dyes immobilized mycelium decolorization Coriolus versicolor

同方期刊数据库

Instream coliform gradients in the Holtemme, a small headwater stream in the Elbe River Basin, Northern Germany

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2017年第3期11卷 544-553页

作者： Daniel KARTHE pei-Ying lin Katja WESTPHAL Helmholtz Centre for Environmental Research Magdeburg Germany Department of Geography Gottingen University Germany Institute of Applied Geology Central University Taiwan China

The Holtemme is a small headwater stream in North Germany＇s Elbe River Basin. According to German and European legislation, hygienic monitoring is not mandatory for such water bodies which are neither drinking water sources nor categorized as bathing waters. Consequently, relatively little is known about the occur- rence of-potentially pathogenic- bacteria and viruses in Germany＇s streams and rivers. The Holtemme was selected for a case study because it is relatively well monitored for both chemical water quality and aquatic ecology, but not for hygiene. Originating in the mountains of Harz Nature Park, the 47 km long Holtemme is characterized by a strong longitudinal gradient in chemical water quality, which is related to different land uses and the influx of treated wastewater from two urban areas （Wernigerode and Halberstadt）. Waste water loads received by the Holtemme are comparatively high when compared to similarly small streams. In 2015, total coliform concentrations between more than 200 and 77,010 bacteria per 100 mL, and fecal coliform concentrations between 5 and 24,060 bacteria per I00 mL were observed in the Holtemme＇s main channel. The highest concentrations were typically found below the outlets of the two wastewater treatment plants. The treated wastewater contained total and fecal coliform concentra- tions of up to 200,500 and 83,100 per 100 mL, respectively; however, there were significant temporal variations. While the observed concentrations are unpro- blematic from a legal perspective （because no maximum permissible limits are defined for streams in Germany）, they would exceed the tolerable limits for bathing waters in the EU, indicating moderate to critical pollution limits.

关键词： surface water stream hygine instream coli-forms

Cross-national Buddhism and Identity Construction in Ch＇oe Ch＇iwon＇s ＂Four Mountains Stele＂

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fudan Journal of the Humanities and Social Sciences 2015年第1期8卷 81-94页

作者： pei-Ying lin Research Fellow at the School of Historical Studies Tel Aviv University

This paper aims to evaluate how Chart Buddhism played a part in Buddhist discourses reflecting an increased sense of legitimacy in ninth-century East Asia. It may not surprise us that the sinicisation of Buddhism implies a process of identity construction to place China in the centre. Culture and religion joined together in this process, first in China and then in Korea. However, the location of centrality or marginality was not fixed in Buddhist ontology. Rather, innovative Buddhist intellects such as Ch＇oe Ch＇iwon （b. 857 A.D.） ventured to create a reversal of centre and margin. In Ch＇oe Ch＇iwon＇s inscriptions for four Korean Son schools （the total of nine schools are also known as nine mountains）, an attempt to supersede China through Chan Buddhism is conspicuous. It is particularly inter- esting to note that, in the context of the cross-border transmission of Buddhism, the mobility of ＂Chan patriarchs＂ was essential in maintaining the legitimacy and continuity. This characteristic of the mobility of Chan patriarchs is seen in the Korean masters depicted by Ch＇oe Ch＇iwon＇s, namely Chingam, Ranghye and Chijong.

关键词： Ch'oe Ch'iwon · Silla · Chan Buddhism · Son Buddhism ·Cultural identity

Medium optimization for enhanced production of cytosine-substituted mildiomycin analogue (MIL-C) by Streptoverticillium rimofaciens ZJU 5119

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 77-84页

作者： Dan YE Zhi-nan XU pei-lin CEN Department of Chemical and Biochemical Engineering Zhejiang University Hangzhou 310027 China

Cytosine-substituted mildiomycin analogue （MIL-C） was produced effectively by supplementing cytosine into the culture of Streptoverticillium rimofaciens. In order to improve the yield of MIL-C, statistically-based experimental designs were applied to optimize the fermentation medium for S. rimofaciens ZJU 5119. Fifteen culture conditions were examined for their significances on MIL-C production using Plackett-Burman design. The Plackett-Burrnan design and one-variable-at-a-time design indicated that glucose and rice meal as the complex carbon sources, and peanut cake meal and NH4NO3 as the complex nitrogen sources were beneficial for MIL-C production in S. rimofaciens ZJU 5119. The results of further central composition design （CCD） showed that the optimal concentration of glucose, rice meal and peanut cake meal were 18.7 g/L, 64.8 g/L and 65.1 g/L, respectively. By using this optimal fermentation medium, the MIL-C concentration was increased up to 1336.5 mg/L, an approximate 3.8-fold improvement over the previous concentration （350.0 mg/L） with un-optimized medium. This work will be very helpful to the large-scale production of MIL-C in the future.

关键词： Cytosine-substituted mildiomycin analogue (MIL-C) Plackett-Burman design Response surface methodology Streptoverticillium rimofaciens Nucleoside antibiotic