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The effects of industrial policymaking on the economics of low-emission technologies: the TRANSid model

Energy Storage and Saving 2023年第3期2卷 513-521页

作者： Timo Gerres José Pablo Chaves pedro linares Institute for Research in Technology(IIT) ICAI School of EngineeringComillas Pontifical UniversityMadrid28015Spain

Basic materials such as steel,cement,aluminium,and(petro)chemicals are the building blocks of industrialised ***,their production is extremely energy and emission intensive,and these industries need to decarbonise their emissions over the next decades to keep global warming at least below 2°***-emission industrial-scale production processes are not commercially available for any of these basic materials and require policy support to ensure their large-scale diffusion over the upcoming *** novel transition to industry decarbonisation(TRANSid)model analyses the framework conditions that enable large-scale investment decisions in climate-friendly basic material *** present a simplified case study of the cement sector to demonstrate the process by which the model optimises investment and operational costs in carbon capture technology by ***,we demonstrate that extending the model to other sectors allows for the analysis of industry-and sector-specific policy options.

关键词： Deep decarbonisation Industrial policy Basic material sector Industry transition Emission pricing Carbon capture

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Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 137-146页

作者： Huascar Ramos pedro linares Ester Badia Isabel Martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García Pilar Conde Begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo Mónica Vásquez Diana Joao Marina de Benito Lourdes Ruiz Felipe Jiménez Federico Sáez-Royuela 无 Department of Gastroenterology and Hepatology Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial Universitario de León Department of Gastroenterology and Hepatology Hospital Universitario de Salamanca Department of Hepatology Hospital Universitario Rio Hortega CIBERehd IBIOMED Fundación Burgos por la Investigación de la Salud Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial de Palencia Department of Gastroenterology and Hepatology Complejo Asistencial de Zamora Department of Gastroenterology and Hepatology Hospital El Bierzo Department of Gastroenterology and Hepatology Hospital Clínico Universitario de Valladolid Department of Gastroenterology and Hepatology Hospital Santos Reyes Asociación Castellano y Leonesa de Hepatología(ACyLHE)

AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized.

关键词： Hepatitis C virus infection Genotype 1-4 Real world treatment Direct-acting antiviral agents

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Robust flat filtering DSP based control of the boost converter

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Control Theory and Technology 2016年第3期14卷 224-236页

作者： Hebertt SIRA-RAMIREZ Arturo HERNANDEZ-MENDEZ Jesus linares-FLORES Alberto LUVIANO-JUAREZ Department of Hectrical Engineering Mechatronics Section ClNVESTAV-IPN Av. IPN No. 2508 Col. San Pedro Zacatenco 07360 D.F. Mexico Mexico Universidad Tecnologica de la Mixteca Carretera a Acatlima Kin. 2.5 Huajuapan de Leon Oaxaca Mexico UPIITA-IPN D.F. Mexico Mexico

The article deals with the design and implementation of a flat filter tracking digital controller for a boost DC-DC power converter. A highly perturbed switched boost converter circuit is shown to be efficiently controlled, in a trajectory tracking task for its non-minimum phase output, by means of a suitable linear filter, here addressed as a flat filter. Flat filtering is a natural robust version of generalized proportional integral control （GPIC） by which the effects of arbitrary time varying exogenous disturbances, unknown endogenous nonlinearities and un-modeled dynamics can be jointly attenuated in a conceptually similar fashion to observer-based active disturbance rejection control （ADRC） and algebraic identification based model free control （MFC） but： a） without using extended state observers and b） respecting the original system order in a time-varying simplified model while avoiding algebraic estimation techniques. The proposed control technique based on the TMS320F28335 digital signal processor chip is tested by means of realistic simulations and experimental setup.

关键词： Flat filter DSP-implementation boost converter

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