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Energy restriction and exercise modulate angiopoietins and vascular endothelial growth factor expression in the cavernous tissue of high-fat diet-fed rats

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Asian Journal of Andrology 2012年第4期14卷 635-642页

作者： Ines Tomada Nuno Tomada henrique Almeida Delminda neves Department of Experimental Biology Faculty of MedicineUniversidade do Porto--Alameda ProfHernmai MonteiroPorto 4200-319Portugal Instituto de Biologia Molecular e Celular(IBMC) Universidade do Porto--Rua do Campo Alegre 823Porto 4150-180Portugal Department of Urology Centro Hospital S.JoaoEPE-Alameda ProfessorHernmani MonteiroPorto 4200-319Portugal

The purpose of the current study was to evaluate the effect of a high-fat （HF） diet, energy restriction and exercise on the expression of vascular endothelial growth factor （VEGF）, angiopoietin （Ang） I and 2, and their receptors in rat corpus cavernosum （CC）. Male Wistar rats were fed adlibitum with an H F diet for 8 or 16 weeks. After 8 weeks of the H F diet, a group of rats was subjected to energy restriction with or without exercise for 8 weeks. Control animals had free access to standard diet for the same period. After euthanasia, blood was collected and the penises removed for immunofluorescence assays （VEGF, VEGF receptor （VEGFR） I and 2, Angl, Ang2 and Tie2） and semiquantification of VEGF, VEGFR 1, VEGFR2, Angl, Ang2, Tie2, endothelial nitric oxide synthase （eNOS） and Aktlphospho-Akt by Western blotting. HF diet-fed rats exhibited lower high-density lipoprotein cholesterol （HDL-c） levels, higher systolic blood pressure and an increased atherogenic index. A significant increase in Ang2 expression in the CC was verified and coupled to a decrease in VEGF and VEGFRs. The Akt pathway was activated by the HF diet. Energy restriction and exercise increased eNOS expression and restored most HF diet-induced modifications except for VEGFR2 expression. These results emphasize the role of diet on vascular function regulation, demonstrating that cavernous imbalance of VEGF/VEGFRs and Angs/Tie2 systems occurs before serum lipid changes and obesity onset, antedating structural atherosclerotic features.

关键词： angiopoietins corpus cavernosum endothelial dysfunction energy restriction exercise high-fat diet VEGF

Biopolymers-based skin-interfaced triboelectric sensors

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Nano Research 2023年第9期16卷 11753-11782页

作者： Shujia Xu pedro henrique de Souza Barbosa Wenzhuo Wu School of Industrial Engineering Purdue UniversityWest LafayetteIN 47907USA Flex Laboratory Purdue UniversityWest LafayetteIN 47907USA Regenstrief Center for Healthcare Engineering Purdue UniversityWest LafayetteIN 47907USA Birck Nanotechnology Center Purdue UniversityWest LafayetteIN 47907USA The Center for Education and Research in Information Assurance and Security(CERIAS) Purdue UniversityWest LafayetteIN 47907USA

Rapid advances in artificial intelligence,robotics,and remote healthcare have increased the demand for sustainable and highperformance wearable *** devices are gaining traction due to their self-powered operation capability and potential as wearable energy ***-interfaced triboelectric sensors(SITSs)can detect various mechanical signals and monitor physiological signals in ***-based SITSs are ideal for skin-interfaced applications since they are biocompatible and *** review focuses on the recent advancements of SITS made from biocompatible polymer materials,such as plant-based,animal-based,and synthetic polymers,and highlights their potential for various applications,including human–machine interface(HMI)and physiological *** addition,the fundamentals,challenges,and prospects of SITS based on biocompatible polymers are discussed.

关键词： skin interfaced triboelectric sensors wearable devices biopolymers

Urbanization drives adaptive evolution in a Neotropical bird

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Current Zoology 2023年第5期69卷 607-619页

作者： Rilquer Mascarenhas pedro Milet Meirelles henrique Batalha-Filho National Institute of Science and Technology in Interdisciplinary and Transdisciplinary Studies in Ecology and Evolution(INCT IN-TREE) Instituto de BiologiaUniversidade Federal da Bahia40170-115 SalvadorBahiaBrazil

Urbanization has dramatic impacts on natural habitats and such changes may potentially drive local adaptation of urban *** change has been specifically shown to facilitate the fast adaptation of birds to changing environments,but few studies have investigated the genetic mechanisms of this *** investigations could provide insights into questions about both evolutionary theory and management of urban *** this study,we investigated whether local adaptation has occurred in urban populations of a Neotropical bird species,Coereba flaveola,specifically addressing whether observed behavioral adaptations are correlated to genetic signatures of natural *** answer this question,we sampled 24 individuals in urban and rural environments,and searched for selected loci through a genome-scan approach based on RADseq genomic data,generated and assembled using a reference genome for the *** recovered 46 loci as putative selection outliers,and 30 of them were identified as associated with biological processes possibly related to urban adaptation,such as the regulation of energetic metabolism,regulation of genetic expression,and changes in the immunological ***,genes involved in the development of the nervous system showed signatures of selection,suggesting a link between behavioral and genetic *** findings,in conjunction with similar results in previous studies,support the idea that cities provide a similar selective pressure on urban populations and that behavioral plasticity may be enhanced through genetic changes in urban populations.

关键词： behavioral adaptation phenotypic plasticity selection selective sweep South America

Anomalous behaviour detection using one-class support vector machine and remote sensing images: a case study of algal bloom occurrence in inland waters

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International Journal of Digital Earth 2021年第7期14卷 921-942页

作者： pedro henrique Moraes Ananias Rogério Galante Negri Graduate Program in Natural Disasters UNESP/CEMADENSão Josédos CamposSão PauloBrazil Sciences Technology Institute São Paulo State University(UNESP)São Josédos CamposSão PauloBrazil

Algal blooms are a frequent subject in scientific discussions and are the focus of many recent studies,mainly due to their adverse effect on *** the lack of ground truth data and the need to develop tools for their detection and monitoring,this research proposes a novel method to automate *** derived from multi-temporal image series processing,spectral indices and classification with Oneclass Support Vector Machine(OC-SVM)are used in this *** from multi-spectral sensors on Landsat-8 and MODIS were acquired through the Google Earth Engine API(GEE API).In order to evaluate our method,two bloom detection case studies(Lake Erie(USA)and Lake Taihu(China))were *** were made with methods based on spectral index ***,to demonstrate the performance of the OC-SVM classifier compared to other machine learning methods,the proposal was adapted to be used with a Random Forest(RF)classifier,having its results added to the *** situ measurements show that the proposed method delivers highly accurate results compared to spectral index thresholding ***,a drawback of the proposal refers to its higher computational *** application of the new method to a real-world bloom case is demonstrated.

关键词： Remote sensing spectral indices unsupervised classification anomalies algal bloom detection

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João Vitor Mahler pedro henrique Fonseca-Castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

Microstructural characterization and mechanical behavior analysis of 7075-T6 aluminum subjected to simulated lightning strikes

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Chinese Journal of Aeronautics 2021年第12期34卷 39-50页

作者： Luis henrique SANTOS Weslei Patrick Teodosio SOUSA Sara Silva Ferreira DE DAFE pedro Americo Magalhaes JUNIOR Department of Mechanical Engineering Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535-901Brazil

Aircrafts damages caused by lightning strikes have been known since the early days of ***,the physical effects on the aircraft structure are still being *** work seeks to evaluate the lightning strike effects in the aluminum alloy *** were submitted to lightning strike simulation in laboratory and the damages evaluated through characterization *** and profilometry tests have shown material loss to 0.272 mm depth in the damaged *** addition,it was detected the material accumulation occurrence in the damage vicinity of the *** the damage,it was found a region where metallurgical changes were *** tensile and microhardness tests results have shown reduction in the percentage elongation and hardness increasing in the material affected by *** results are corroborated by the X-Ray Diffraction(XRD)and Rietveld Method(red line)that indicated an increasing in dislocation density and micro-deformation in the material *** microscopy results have shown the presence of microcracks on the normal and cross-section surface of the samples *** Energy Dispersive X-Ray Spectroscopy(EDXS)and Electron Backscattered Diffraction Test(EBSD)found coarse intermetallic phases and precipitates compounds with dimensions greater than 1 lm in *** were responsible for nucleation of the microcracks that propagate along the material grain boundaries.

关键词： Aircraft structure Characterization techniques Lightning strikes Precipitates Microcracks

Decomposition and stabilization of organic matter in an old-growth tropical riparian forest:effects of soil properties and vegetation structure

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Forest Ecosystems 2021年第1期8卷 173-181页

作者： pedro henrique de Godoy Fernandes Andréa Lúcia Teixeira de Souza Marcel Okamoto Tanaka Renata Sebastiani Graduate Program in Environmental Sciences Federal University of São CarlosSão CarlosSPBrazil Department of Environmental Sciences(DCAm) Federal University of São CarlosSão CarlosSPBrazil Department of Nature Mathematicsand Education SciencesFederal University of São CarlosSão CarlosSPBrazil

Background:Nutrient cycling in tropical forests has a large importance for primary productivity,and decomposition of litterfall is a major process influencing nutrient balance in forest *** large-scale factors strongly influence decomposition patterns,small-scale factors can have major influences,especially in old-growth forests that have high structural complexity and strong plant-soil *** we evaluated the effects of forest structure and soil properties on decomposition rates and stabilization of soil organic matter using the Tea Bag Index(TBI)in an old-growth riparian forest in southeastern *** data sets were described separately using Principal Components Analysis(PCA).The main axes for each analysis,together with soil physical properties(clay content and soil moisture),were used to construct structural equations models that evaluated the different parameters of the TBI,decomposition rates and stabilization *** best model was selected using Akaike’s ***:Forest structure and soil physical and chemical properties presented large variation among plots within the studied *** content was strongly correlated with soil moisture and the first PCA axis of soil chemical properties,and model selection indicated that clay content was a better predictor than this *** rates presented a large variation among tea bags(0.009 and 0.098 g·g^(−1)·d−1)and were positively related with forest structure,as characterized by higher basal area,tree density and larger *** stabilization factor varied between 0.211–0.426 and was related to forest stratification and soil clay ***:The old-growth forest studied presented high heterogeneity in both forest structure and soil properties at small spatial scales,that influenced decomposition processes and probably contributed to small-scale variation in nutrient *** rates were only influenced by forest structure,whereas the stabilizat

关键词： Tea bag index Forest structure Carbon fixation Nutrient cycling

Ambient Backscatter Communications over NOMA Downlink Channels

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China Communications 2020年第6期17卷 80-100页

作者： Weiyu Chen Haiyang Ding Shilian Wang Daniel Benevides daCosta Fengkui Gong pedro henrique Juliano Nardelli College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China College of Information and Communication National University of Defense TechnologyXi’an 710106China Department of Computer Engineering Federal University of CearáSobral 62010-560Brazil State Key Laboratory of Integrated Service Networks Xidian UniversityXi’an 710071China School of Energy Systems Lappeenranta University of TechnologyLappeenranta 53850Finland

In this paper,we investigate the performance of commensal ambient backscatter communications(AmBC)that ride on a non-ortho go nal multiple access(NOMA)downlink transmission,in which a backscatter device(BD)splits part of its received signals from the base station(BS)for energy harvesting,and backscatters the remaining received signals to transmit information to a cellular ***,under the power consumption constraint at BD and the peak transmit power constraint at BS,we derive the optimal reflection coefficient at BD,the optimal total transmit power at BS,and the optimal power allocation at BS for each transmission block to maximize the ergodic capacity of the ambient backscatter transmission on the premise of preserving the outage performance of the NOMA downlink ***,we consider a scenario where the BS is restricted by a maximum allowed average transmit power and the reflection coefficient at BD is fixed due to BD’s low-complexity *** algorithm is developed to determine the optimal total transmit power and power allocation at BS for this ***,a low-complexity algorithm is proposed for this scenario to reduce the computational complexity and the signaling ***,the performance of the derived solutions are studied and compared via numerical simulations.

关键词： power-domain NOMA ambient backscatter communications IoT wireless-powered devices optimization

Dexamethasone intravitreal implant(Ozurdex) in diabetic macular edema: real-world data versus clinical trials outcomes

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1571-1580页

作者： pedro neves Mário Ornelas Inês Matias João Rodrigues Margarida Santos Marco DutraMedeiros David Martins Department of Ophthalmology Centro Hospitalar de SetúbalSetúbal 2910-549Portugal Department of Ophthalmology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Ophthalmology Hospital da Luz SetúbalSetúbal 2900-722Portugal Department of Ophthalmology Centro Hospitalar Lisboa CentralFaculdade de Ciências MédicasNOVA University of LisbonLisbon 1990-237Portugal

AIM: To investigate the safety and efficacy of intravitreal dexamethasone implants(Ozurdex?/DEX) in patients with diabetic macular edema(DME) either na?ve or nonna?ve to anti-VEGF therapies who switched to DEX implant independent of response to anti-vascular endothelial growth factors(anti-VEGFs).METHODS: This was an audit retrospective review of medical records of patients with DME who switched to the DEX intravitreal implant. Patients were divided into 2 groups: patients na?ve to antiangiogenic therapy and patients who were previously treated with anti-VEGFs. Data regarding demographics, changes in mean best-corrected visual acuity(BCVA), central macular thickness(CMT), and intraocular pressure(IOP) was collected over 6 mo. The demographic data mean changes in BCVA, CMT, and IOP were compared. Six-month follow-up data of 47 patients(57 eyes), who either switched to DEX implant irrespective of response to previous treatments or were treatment na?ve before receiving DEX implant, was ***: Improvement in mean BCVA was observed from 1-4 mo after injection with a decreased effect at month 6 as expected, with better outcomes in na?ve compared to non-na?ve patients. A statistically relevant decrease in mean CMT was observed during the follow-up period. An increase in mean IOP was observed in the first 2 mo after DEX therapy. The mean number of injections of the overall population during the 6 mo was 1.3. A subgroup analysis showed no relevant difference between phakic versus pseudophakic patients relative to measured outcomes. There was no cataract progression during the follow-up period and no adverse events ***: This real-life setting study shows that intravitreal DEX implant is effective and safe. The timings of greater therapeutic impact are concordant with previous studies and suggest that earlier treatment with corticosteroids may have an additional benefit in na?ve patients.

关键词： anti-VEGF therapy diabetic macular edema dexamethasone intravitreal implant na?ve eyes steroids