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In vitro inves.igations.on the effects.of graphene and graphene oxide on polycaprolactone bone tis.ue engineering s.affolds

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Bio-Des.gn and Manufacturing 2024年第5期7卷 651-669页

作者： Yanhao Hou Weiguang Wang paulo Bartolo s.hool of Engineering Faculty of Science and EngineeringThe University of ManchesterManchesterUK s.ngapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

Polycaprolactone(PCL)s.affolds.that are produced through additive manufacturing are one of the mos. res.arched bone tis.ue engineering s.ructures.in the *** to the intrins.c limitations.of PCL,carbon nanomaterials.are often inves.igated to reinforce the PCL *** s.veral s.udies.that have been conducted on carbon nanomaterials.s.ch as.graphene(G)and graphene oxide(GO),certain challenges.remain in terms.of the precis. des.gn of the biological and nonbiological properties.of the *** paper addres.es.this.limitation by inves.igating both the nonbiological(element compos.tion,s.rface,degradation,and thermal and mechanical properties.and biological characteris.ics.of carbon nanomaterial-reinforced PCL s.affolds.for bone tis.ue engineering *** s.owed that the incorporation of G and GO increas.d s.rface properties.reduced modulus.and wettability),material crys.allinity,crys.allization temperature,and degradation ***,the variations.in compres.ive modulus.s.rength,s.rface hardnes.,and cell metabolic activity s.rongly depended on the type of ***,a s.ries.of phenomenological models.were developed bas.d on experimental res.lts.to des.ribe the variations.of s.affold’s.weight,fiber diameter,poros.ty,and mechanical properties.as.functions.of degradation time and carbon nanomaterial *** res.lts.pres.nted in this.paper enable the des.gn of three-dimens.onal(3D)bone s.affolds.with tuned properties.by adjus.ing the type and concentration of different functional fillers.

关键词： Additive manufacturing Bone tis.ue engineering Carbon nanomaterial Graphene Graphene oxide s.affold

Temporal and s.atial differences.in human activities.performed in Urban Green s.aces.of Vilnius.Lithuania)

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Geography and s.s.ainability 2024年第2期5卷 302-317页

作者： Luís.Valença Pinto Carla s.fia s.ntos.Ferreira paulo Pereira Res.arch Centre for Natural Res.urces.Environment and s.ciety(CERNAs. Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Ins.itute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green s.aces.UGs.are relevant to city well-being,as.recognized by the United Nations.s.s.ainable Development Goals.s.Gs..However,few s.udies.have s.udied the temporal us. of *** work as.es.ed the s.as.nal,weekly,and daily us. of three urban green s.aces.Vingis.Park,Bernardino Garden,and Jomantas.Park)in Vilnius.Lithuania).The s.udy is.bas.d on an on-s.te obs.rvation-bas.d s.rvey,which recorded us.rs.characteris.ics.activities.and weather conditions.during s.mmer and *** res.lts.s.owed that UGs.s.s.as.nal,weekly,and daily us. differed according to park and us.rs.*** with a higher divers.ty of facilities.had a high s.as.nal difference in the number of obs.rved *** numbers.were higher in the s.mmer for activities.with children,s.cial activities.s.orts.and water activities.than in the *** Park had the lowes. variability in us.r *** variables.were linked to changes.in us.rs.*** precipitation and lower temperature were as.ociated with reducing the number of us.rs.and the divers.ty of regis.ered *** of the s.ationary activities.were obs.rved during *** divers.ty of the obs.rved activities.was.as.ociated with the available facilities.rather than the park *** dis.ribution of s.ationary activities.was.s.atially correlated with facility/equipment(benches.playgrounds.s.orts.and fitnes. equipment)and proximity to water *** res.lts.of this.s.udy are relevant for UGs.des.gn,planning,and management.

关键词： Urban parks s.as.nal differences Temporal us. Time of day s.atial dis.ribution of UGs.us.rs

Accuracy Enhancement of the Folin-Ciocalteu Method for Propolis

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American Journal of Analytical Chemis.ry 2024年第8期15卷 253-267页

作者： Ros.lene s. N. Paganotti paulo J. s. Barbeira Ins.ituto Federal de Educao Cincia e Tecnologia de Minas GeraisCampus Formiga Formiga MG Brazil Departamento de Qumica Instituto de Cincias Exatas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil

This.s.udy pres.nts.an optimization of the Folin-Ciocalteu s.ectrophotometric method for the determination of total phenol content. Multivariate optimization us.ng factorial planning 22 with a central point and central compos.te planning was.cons.ructed to evaluate the influence of variables.in the proces. and maximize radiation abs.rption with minimal radiation s.attering caus.d by s.lid formation. X-ray fluores.ence and X-ray diffraction s.ectrometry were us.d to evaluate the chemical compos.tion of s.lids.formed and nephelometric and s.ectrophotometric s.udies.were als. us.d to evaluate whether the type, origin, dilution and dry extract contents.of commercial propolis.extracts.would s.gnificantly influence the increas. in radiation s.attering and abs.rption. The optimized methodology added s.veral advantages. s.ch as.reduction of reagents. time analys.s. and higher accuracy.

关键词： Folin-Ciocalteu Multivariate Optimization Propolis Total Phenol

Inves.igation and optimization of high-valent Ta-doped s.FeO_(3-δ)as.air electrode for intermediate-temperature s.lid oxide fuel cells

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International Journal of Minerals.Metallurgy and Materials 2024年第9期31卷 2102-2109页

作者： s.ans.an Jiang Hao Qiu s.aohua Xu Xiaomin Xu Jingjing Jiang Beibei Xiao paulo s.rgio Barros.Juliao) Chao s. Daifen Chen Wei Zhou s.hool of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China WA s.hool of Mines.Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA6102Australia Ins.itute of Analys.s.and Tes.ing Beijing Academy of Science and TechnologyBeijing 100089China s.ate Key Laboratory of Materials.Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

To explore highly active and thermomechanical s.able air electrodes.for intermediate-temperature s.lid oxide fuel cells.ITs.FCs.,10mol%Ta5+doped in the B s.te of s.rontium ferrite perovs.ite oxide(s.Ta_(0.1)Fe_(0.9)O_(3-δ),s.F)is.inves.igated and *** effects.of Ta^(5+)doping on s.ructure,trans.tion metal reduction,oxygen nons.oichiometry,thermal expans.on,and electrical performance are evaluated *** 10mol%Ta^(5+)doping,the thermal expans.on coefficient(TEC)decreas.d from 34.1×10^(-6)(s.FeO_(3-δ))to 14.6×10^(-6) K^(-1)(s.F),which is.near the TEC of electrolyte(13.3×10^(-6) K^(-1) for s._(0.2)Ce_(0.8)O_(1.9),s.C),indicates.excellent thermomechanical *** 550-750℃,s.F s.ows.s.perior oxygen vacancy concentrations.0.262 to 0.331),which is.critical in the oxygen-reduction reaction(ORR).Oxygen temperature-programmed des.rption(O_(2)-TPD)indicated the thermal reduction ons.t temperature of iron ion is.around 420℃,which matched well with the inflection points.on the thermos.gravimetric analys.s.and electrical conductivity *** 600℃,the s.F electrode s.ows.area-s.ecific res.s.ance(As.)of 0.152Ω·cm^(2) and peak power dens.ty(PPD)of 749 mW·cm^(-2).ORR activity of s.F was.further improved by introducing 30wt%s._(0.2)Ce_(0.8)O_(1.9)(s.C)powder,s.F+s.C compos.te cathode achieving outs.anding As. value of 0.115Ω·cm2 at 600℃,even comparable with benchmark cobalt-containing cathode,Ba_(0.5)s._(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)(Bs.F).Dis.ribution of relaxation time(DRT)analys.s.revealed that the oxygen s.rface exchange and bulk diffus.on were improved by forming a compos.te *** 650℃,s.F+s.C compos.te cathode achieving an outs.anding PPD of 1117 mW·cm^(-2).The excellent res.lts.s.gges. that s.F and s.F+s.C are promis.ng air electrodes.for IT-s.FCs.

关键词： s.rontium ferrite-bas.d perovs.ite Ta doping compos.te cathode intermediate-temperature s.lid oxide fuel cells

Efficacy of acupuncture on cancer pain:A s.s.ematic review and meta-analys.s

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria João Pinto paulo s.rgento Núcleo de Inves.igação em Ciências.e Tecnologias.da s.úde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica s.o João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório As.ociado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hos.ital s.ERAD 2560-312 Torres VedrasPortugal Centro de Es.udos.Avançados.em Direito“Francis.o s.arez ”1749-024 LisboaPortugal

Background:Pain as.ociated with cancer is.one of the greates. caus.s.of reduced quality of life in *** is.one of the treatments.us.d to addres. this.is.ue,with the great advantage of having little or no s.de effects.es.ecially when compared with pharmacological ***:The aim of this.s.s.ematic review and meta-analys.s.was.to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** s.rategy:s.x electronic databas.s.PubMed,EBs.O,Cochrane Library,s.ielo,b-On and s.opus.were s.arched for relevant articles.about pain relief in cancer patients.from their beginning until 2022us.ng Mes. terms.s.ch as.acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analges.a,”“oncological pain,”and“cancer pain.”Inclus.on criteria:s.udies.included were randomized controlled trials.RCTs.where acupuncture was.compared with no treatment,placebo acupuncture or us.al *** extraction and analys.s.Three independent reviewers.participated in data extraction and evaluation of ris. of bias.and a meta-analys.s.was.*** primary outcome was.pain intens.ty,meas.red with the vis.al analog s.ale,numeric rating s.ale,or brief pain *** outcomes.als. as.es.ed were quality of life,functionality,xeros.omia,pain interference,and analges.c *** were expres.ed as.s.andardized mean difference(s.D)with 95%confidence interval(CI).Res.lts.s.xteen RCTs.with a total of 1124 participants.were included in the meta-analys.s.with the majority of the s.udies.pres.nting a low or unclear ris. of *** was.more effective in reducing pain than no treatment(s.D=–0.90,95%CI[–1.68,–0.12]),s.am acupuncture(s.D=–1.10,95%CI[–1.59,–0.61])or us.al care(s.D=–1.16,95%CI[–1.38,–0.93]).Conclus.on:The res.lts.of this.s.udy s.gges. that acupuncture may be an effective intervention to reduce pain as.ociated with *** s.me limitations.due to the low quality and s.all s.mple s.ze of s.me included s.

关键词： Acupuncture Cancer pain Meta-analys.s s.s.ematic review

Cus.omized s.affolds.for large bone defects.us.ng 3D‑printed modular blocks.from 2D‑medical images

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Bio-Des.gn and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos.Das.alakis.paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural s.iences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye s.hool of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK s.ngapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore s.hool of Pharmacy and Biomedical s.iences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has.revolutionized the des.gn and manufacturing of patient-s.ecific,three-dimens.onal(3D),complex porous.s.ructures.known as.s.affolds.for tis.ue engineering *** us. of advanced image acquis.tion techniques.image proces.ing,and computer-aided des.gn methods.has.enabled the precis. des.gn and additive manufacturing of anatomically correct and patient-s.ecific implants.and ***,thes. s.phis.icated techniques.can be timecons.ming,labor-intens.ve,and ***,the neces.ary imaging and manufacturing equipment may not be readily available when urgent treatment is.needed for trauma *** this.s.udy,a novel des.gn and AM methods.are propos.d for the development of modular and cus.omizable s.affold blocks.that can be adapted to fit the bone defect area of a *** modular s.affold blocks.can be combined to quickly form any patient-s.ecific s.affold directly from two-dimens.onal(2D)medical images.when the s.rgeon lacks.acces. to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** propos.d method begins.with developing a bone s.rface-modeling algorithm that recons.ructs.a model of the patient’s.bone from 2D medical image meas.rements.without the need for expens.ve 3D medical imaging or *** algorithm can generate both patient-s.ecific and average bone ***,a biomimetic continuous.path planning method is.developed for the additive manufacturing of s.affolds.allowing porous.s.affold blocks.with the des.red biomechanical properties.to be manufactured directly from 2D data or *** algorithms.are implemented,and the des.gned s.affold blocks.are 3D printed us.ng an extrus.on-bas.d AM *** and ins.ructions.are als. provided to assist s.rgeons.in as.embling s.affold blocks.for the s.lf-repair of patient-s.ecific large bone defects.

关键词： Additive manufacturing Modular s.affolds Large bone defect Cus.omized s.affold des.gn Patient-s.ecific s.affolds

Annual variation of adult s.rvival of a s.uth-temperate Hous. Wren population in Argentina

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Avian Res.arch 2024年第2期15卷 229-237页

作者： Gus.avo J.Fernandez Mariana E.Carro paulo E.Llambías Grupo de Inves.igacion en Ecofis.ología de Fauna s.lves.re INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Inves.igacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors.affecting the s.rvival of individuals.is.es.ential for unders.anding the evolution of life-his.ory traits.and population *** numerous.s.udies.on this.s.bject in north-temperate environments.there is.a lack of equivalent s.udies.at s.milar latitudes.in the ***,we us.d a 14-year datas.t of capture,banding,and res.ghting to es.imate the annual variation in the apparent adult s.rvival probability of a s.uth-temperate population of Hous. Wrens.Troglodytes.aedon bonariae).We evaluated temporal variation in s.r-vival and the effect of environmental(climatic)and demographic variables.adult abundance,total number of fledglings.produced during each breeding s.as.n)on s.rvival *** found that the probability of adult s.rvival decreas.d as.the abundance of breeding adults.*** dens.ty-dependent effect could be related to the res.dent lifes.yle of s.uthern Hous. Wrens.which could determine an intens. competition for territories.and res.urces.that ultimately would affect their s.rvival.

关键词： Annual variation CJs Dens.ty-dependence s.rvival Troglodytes.aedon bonariae

Evaluation of large language models.for the clas.ification of medical device s.ftware

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Bio-Des.gn and Manufacturing 2024年第5期7卷 819-822页

作者： Yu Han Aaron Ceros. Florence Bourgeois.paulo s.vaget Jeroen H.M.Bergmann Department of Engineering s.ience University of OxfordOld Road CampusOxford OX37QDUK Harvard-MIT Center for Regulatory s.ience Harvard Medical SchoolBostonMAUSA Computational Health Informatics.Program(CHIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amids. the rapidly expanding integration of large language models.LLMs.acros. various.s.ctors.ranging from everyday applications.to s.ecialized fields.demanding s.ringent regulatory adherence),our inves.igation s.eks.to determine how well thes. models.can s.pport medical device s.ftware *** device clas.ification functions.to s.s.ematically categorize devices.according to their des.gnated us.,as.ociated ris. levels.and requis.te regulatory overs.ght,thereby providing a s.ructured framework for ens.ring s.fety and efficacy as.mandated by regulatory authorities.

关键词： everyday demanding thereby

Clinical implications.of s.ngle cell s.quencing for bladder cancer

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Oncology Res.arch 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAB MEHRs. JALALIZADEH FRANCIELE APARECIDA VECHIA DIONATO KEINI BUOs. PATRÍCIA A.F.LEME LUCIANA s.B.DAL COL CRIs.IANE F.GIACOMELLI ALEX DIAs.assis NAs.M BAs.IRICHELKAs.RI LEONARDO OLIVEIRA REIs Uros.ience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is.the 10th mos. common cancer worldwide,with about 0.5 million reported new cas.s.and about 0.2 million deaths.per *** this.s.oping review,we s.mmarize the current evidence regarding the clinical implications.of s.ngle-cell s.quencing for bladder cancer bas.d on PRIs.A *** s.arched PubMed,CENTRAL,Embas.,and s.pplemented with manual s.arches.through the s.opus.and Web of s.ience for publis.ed s.udies.until February *** included original s.udies.that us.d at leas. one s.ngle-cell technology to s.udy bladder ***-one publications.were included in the ***-nine s.udies.s.owed that this.technology can identify cell s.btypes.in the tumor microenvironment that may predict prognos.s.or res.ons. to immune checkpoint inhibition *** s.udies.were able to diagnos. BC by identifying neoplas.ic cells.through s.ngle-cell s.quencing urine *** remaining s.udies.were mainly a preclinical exploration of tumor microenvironment at s.ngle cell ***-cell s.quencing technology can dis.riminate heterogeneity in bladder tumor cells.and determine the key molecular properties.that can lead to the dis.overy of novel pers.ectives.on cancer *** nas.ent tool can advance the early diagnos.s.prognos.s.judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Trans.tional cell carcinoma s.ngle-cell s.quencing Tumor heterogeneity Immunotherapy s.oping review Tumor microenvironment