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Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress

World Journal of Gastroenterology 2003年第3期9卷 446-448页

作者： Claudia P.M.S.Oliveira paulo kassab Fabio P.Lopasso Heraldo P.Souza Mariano Janiszewski Francisco R.M.Laurindo Kioshi Iriya Antonio A.Laudanna Department of Gastroenterology of Medical School of University of So paulo (USP) So PauloBrazil Department of Emergency Medicine of Mcdical School of University of So paulo (USP) So PauloBrazil Heart Institute of Medical School of University of So paulo (USP) So PauloBrazil Depatment of Pathology of Medical School of University of So paulo (USP) So PauloBrazil

AIM;Oxidative stress participates in the cell carcinogenesis by inducing DNA *** aim was to assess whether ascorbic acid,an antioxidant,could have a role in preventing ROS(Reactive Oxygen Species)generation in experimental gastric carcinoma in a rat model. METHODS:Experimental gastric cancer was induced in twelve Wistar male rats(weighting 250-350 g)by profound duodeno-gastric reflux throught split *** rats were allocated to the following groups:Group Ⅰ(n=6) was the control;Group Ⅱ(n=6)which was mantained with daily intake of tape water with Vitamin C(30 mg/Kg).After 6 or 12 months,samples of gastric tumor or non tumor mucosa were taken from the anastomosis of both groups. Oxidative stress was measured by superoxide quantification through lucigenin-amplified chemiluminescence base and by staining with *** histopathologic confirmation of adenocarcinoma was made by eosin- hemathoxilin method. RESULTS:The intestinal type of gastric adenocarcinoma was microscopically identified in all animals of group Ⅰ whereas only 3 rats of group Ⅱ showed an adenocarcinoma without macroscopic evidence of *** cancers were located in the anastomosis in all *** luminescence from tumor gastric tissue generated 38.4±6.8 count per minute/mg/×10~6(mean±SD)and 14.9±4.0 count per minute/mg/×10~6,respectively,in group Ⅰ and Ⅱ animals(P kassab P Lopasso FP Souza HP Janiszewski M Laurindo FRM Iriya K Laudanna *** effect of ascorbic acid in experimental gastric cancer:reduction of oxidative *** J G

关键词： Animals Antioxidants Ascorbic Acid Male Oxidative Stress Rats Rats, Wistar Stomach Neoplasms control

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