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Comparison and development of machine learning for thalidomideinduced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population

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World Journal of Gastroenterology 2023年第24期29卷 3855-3870页

作者： Jing mao Kang Chao Fu-Lin Jiang Xiao-ping Ye Ting Yang pan Li Xia Zhu pin-Jin Hu Bai-Jun Zhou min Huang Xiang Gao Xue-Ding Wang Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial Key Laboratory of New Drug Design and Evaluation Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Pharmacy Guangdong Women and Children HospitalGuangzhou 510000Guangdong ProvinceChina

BACKGRoUND Thalidomide is an effective treatment for refractory Crohn’s disease(CD).However,thalidomide-induced peripheral neuropathy(TiPN),which has a large individual variation,is a major cause of treatment *** is rarely predictable and recognized,especially in *** is necessary to develop a risk model to predict TiPN *** To develop and compare a predictive model of TiPN using machine learning based on comprehensive clinical and genetic *** A retrospective cohort of 164 CD patients from January 2016 to June 2022 was used to establish the *** National Cancer Institute Common Toxicity Criteria Sensory Scale(version 4.0)was used to assess *** 18 clinical features and 150 genetic variables,five predictive models were established and evaluated by the confusion matrix receiver operating characteristic curve(AURoC),area under the precision-recall curve(AUPRC),specificity,sensitivity(recall rate),precision,accuracy,and F1 *** The top-ranking five risk variables associated with TiPN were interleukin-12 rs1353248[P=0.0004,odds ratio(oR):8.983,95%confidence interval(CI):2.497-30.90],dose(mg/d,P=0.002),brainderived neurotrophic factor(BDNF)rs2030324(P=0.001,oR:3.164,95%CI:1.561-6.434),BDNF rs6265(P=0.001,oR:3.150,95%CI:1.546-6.073)and BDNF rs11030104(P=0.001,oR:3.091,95%CI:1.525-5.960).In the training set,gradient boosting decision tree(GBDT),extremely random trees(ET),random forest,logistic regression and extreme gradient boosting(XGBoost)obtained AURoC values>0.90 and AUPRC>*** these models,XGBoost and GBDT obtained the first two highest AURoC(0.90 and 1),AUPRC(0.98 and 1),accuracy(0.96 and 0.98),precision(0.90 and 0.95),F1 score(0.95 and 0.98),specificity(0.94 and 0.97),and sensitivity(1).In the validation set,XGBoost algorithm exhibited the best predictive performance with the highest specificity(0.857),accuracy(0.818),AUPRC(0.86)and AURoC(0.89).ET and GBDT obtained the highest sensitivity(1)and F1 score(0.8)

关键词： Thalidomide-induced peripheral neuropathy Refractory Crohn’s disease Neurotoxicity prediction models machine learning Gene polymorphisms

SARS-CoV-2 N protein enhances the anti-apoptotic activity of mCL-1 to promote viral replication

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3055-3069页

作者： pan pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang pin Wan mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu The First Affiliated Hospital of Jinan University 510632GuangzhouChina Foshan Institute of medical microbiology 528315FoshanChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan University510632GuangzhouChina State Key Laboratory of Virology College of Life SciencesWuhan University430072WuhanChina The First People’s Hospital of Foshan 528315FoshanChina

Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe ***,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus *** how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its ***,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N *** found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’*** study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and ***,N protein specifically interacted with anti-apoptotic protein mCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of mCL-1,which stabilized this protein and promoted it to hijack Bak in ***,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a mCL-1 specific inhibitor,***,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral *** may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other *** anticipate that abrogating the N/mCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses.

关键词： apo prevention promoted

Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo pan paul K.Chu Kenneth m.C.Cheung Kelvin W.K.Yeung Department of orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of materials Science and Engineering Nankai UniversityTianjinChina School of materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate mg^2+content niche(~4.11 mm)led to superior bone regeneration,while mg^2+-free and strong mg^2+content(~16.44 mm)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free mg zone from concentrated zone in late time point,new bone formation on free mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite magnesium ion microenvironment 3D scaffold Bone tissue regeneration

Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially

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The Innovation 2021年第3期2卷 126-134页

作者： Lingxia Xie Guomin Wang Yuzheng Wu Qing Liao Shi mo Xiaoxue Ren Liping Tong Wei Zhang min Guan Haobo pan paul KChu Huaiyu Wang Center for Human Tissues and organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China

The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone ***,poly(aryl-ether-ether-ketone)(PEEK)is coated with a programmed surface,which rapidly releases interleukin-10(IL-10)in the first week and slowly delivers dexamethasone(DEX)up to 4 *** to the synergistic effects of IL-10 and DEX,an aptly weak inflammation is triggered within the first week,followed by significant m2 polarization of macrophages and upregulation of the autophagy-related *** suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration *** sequential immune-mediated process is also validated by an 8-week implementation on a rat *** is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases,which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics.

关键词： poly(aryl-ether-ether-ketone) surface modifications sequential release immune-mediated osteogenesis bone regeneration

基于光谱稳定LED光源的长光程DoAS的大气No_2探测

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光电子．激光 2015年第9期26卷 1712-1718页

作者：凌六一林攀攀黄友锐谢品华安徽理工大学电气与信息工程学院安徽淮南232001 中国科学院安徽光学精密机械研究所中国科学院环境光学与技术重点实验室安徽合肥230031 中国科学技术大学环境科学与光电技术学院安徽合肥230031

针对LED光谱容易产生漂移从而影响差分光学吸收谱(DoAS)系统的测量性能,研究了温度和驱动电流对蓝光LED(LZ1-00B205)光谱产生漂移的影响,发现LZ1-00B205中心波长随温度和电流的变化分别为+0.025nm/℃和-0.003 2nm/mA。通过对LZ1-00B205... 详细信息

针对LED光谱容易产生漂移从而影响差分光学吸收谱(DoAS)系统的测量性能,研究了温度和驱动电流对蓝光LED(LZ1-00B205)光谱产生漂移的影响,发现LZ1-00B205中心波长随温度和电流的变化分别为+0.025nm/℃和-0.003 2nm/mA。通过对LZ1-00B205进行恒温控制(误差约为±0.1℃)和恒流驱动(电流波动oAS系统光源,对大气No2进行了监测。当光程为760m时,系统的探测限为4×10-9。实验结果表明,光谱稳定后的LED适于做DoAS系统的测量光源。通过稳定LED光谱改善DoAS反演结果,这种方法不需要反复测量参考光谱,简化了DoAS系统的操作过程,同时提高了测量精度。

关键词：长光程差分光学吸收谱(DoAS)技术 LED 波长漂移大气No2监测

维普期刊数据库

Feeding Biochar to Cows:An Innovative Solution for Improving Soil Fertility and Farm Productivity

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Pedosphere 2015年第5期25卷 666-679页

作者： Stephen JoSEPH Doug PoW Kathy DAWSoN David R.G.mITCHELL Aditya RAWAL James HooK Sarasadat TAHERYmooSAVI Lukas VAN ZWIETEN Joshua RUST Scott DoNNE paul mUNRoE Ben PACE Ellen GRABER Torsten THomAS Shaun NIELSEN Jun YE Yun LIN pan Genxing LI Lianqing Zakaria m.SoLAImAN Discipline of Chemistry University of Newcastle School of materials Science and Engineering University of New South Wales Electron microscopy Center AIIMUniversity of Wollongong Institute of Resources Ecosystem and Environment of AgricultureNanjing Agricultural University marron Brook Farm Warren Catchments Council 52 Bath StManjimup 6258 (Australia) mark Wainwright Analytical Centre University of New South Wales Wollongbar Primary Industries Institute NSW Department of Primary Industries Institute of Soil Water and Environmental SciencesThe Volcani CenterAgricultural Research Organization Centre for marine Bio-Innovation School of Biotechnology and Biomolecular SciencesThe University of New South Wales Soil Biology and molecular Ecology Group School of Earth and Environment (M087)The University of Western Australia

Addition of biochar produced through thermal decomposition of biomass has been seen as a strategy to improve soils and to sequester carbon （C）, but wide scale implementation of the technology requires to devise innovative profitable solutions. To develop biochar utilisation with an integrated system approach, an innovative program was implemented in 2012 on a 53-ha farm in Western Australia to determine the costs and benefits of integrating biochar with animal husbandry and improvement of pastures. Biochar was mixed with molasses and fed directly to cows. The dung-biochar mixture was incorporated into the soft profile by dung beetles. We studied the changes in soil properties over 3 years. Biochar extracted from fresh dung and from the soil to a depth of 40 cm was characterised. A preliminary financial analysis of the costs and benefits of this integrated approach was also undertaken. The preliminary investigation results suggested that this strategy was effective in improving soil properties and increasing returns to the farmer. It was also concluded that the biochar adsorbed nutrients from the cow＇s gut and from the dung. Dung beetles could transport this nutrient-rich biochar into the soil profile. There was little evidence that the recalcitrant component of the biochar was reduced through reactions inside the gut or on/in the soil. Further research is required to quantify the long-term impact of integrating biochar and dung beetles into the rearing of cows.

关键词： animal husbandry biochar C sequestration dung beetles financial benefit pasture

维普期刊数据库

Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,mechanics & Astronomy) 2024年

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li paul o’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P. U. Fynbo Lluis Galbany Saurabh W. Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee maitra Alessio marino Itumeleng monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia ma Xuan mao Haiwu pan Xin pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu Institut d’Estudis Espacials de Catalunya (IEEC) max Planck Institute for Extraterrestrial Physics Innovation Academy for microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University National Astronomical observatories Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas Chinese Academy of Sciences South African Astronomical observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Universite' Paris Cite' CNRS Astroparticule et Cosmologie Universite' Paris Cite' CEA Paris-Saclay School of Astronomy and Space Sciences IRFU/DAp-AIm Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research University of Chinese Academy of Sciences The University of Tokyo ESA/ESTEC Noordwijk 2201 AZ The Netherlands Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics Key Laboratory of Particle Astrophysics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology Hefei School of Astronomy and Space Sciences University of Science and Technology of China Institute of High Energy Physics Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical observatory Chinese Academy of Science

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GRoND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 keV,300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for4d,followed by a steep decay till becoming undetectable10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

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Tribological mechanisms of slurry abrasive wear

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Friction 2023年第6期11卷 1079-1093页

作者： Yulong LI paul SCHREIBER Johannes SCHNEIDER Christian GREINER Institute for Applied material(IAm) Karlsruhe Institute of Technology(KIT)Karlsruhe76131Germany KIT IAm-Zm microTribology Center(μTC) Karlsruhe76131Germany

Abrasive wear mechanisms—including two-body and three-body abrasion—dominate the performance and lifespan of tribological systems in many engineering fields,even of those operating in lubricated *** steel(100Cr6)pins and discs in a flat-on-flat contact were utilized in experiments together with 5 and 13 μm Al_(2)o_(3)-based slurries as interfacial media to shed light on the acting *** results indicate that a speed-induced hydrodynamic effect occurred and significantly altered the systems'frictional behavior in tests that were performed using the 5 μm *** experiments revealed that a speed-dependent hydrodynamic effect can lead to a 14% increase in film thickness and a decrease in friction of around 2/3,accompanied by a transition from two-body abrasion to three-body abrasion and a change in wear mechanism from microcutting and microploughing to fatigue ***,no correlation could be found between the total amount of wear and the operating state of the system during the experiment;however,the wear distribution over pin and disc was observed to change *** paper studies the influence of the hydrodynamic effect on the tribological mechanism of lubricated abrasive wear and also highlights the importance to not only consider a tribological systems'global amount of wear.

关键词： abrasive wear two-body abrasion three-body abrasion hydrodynamic effect steel

A low-power,area-efficient all-digital delay-locked loop for DDR3 SDRAm controller

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Science China(Information Sciences) 2014年第12期57卷 176-183页

作者： CHEN Hongming mA Song WANG Liu ZHANG Hao pan KenYi CHENG YuHua Shanghai Research Institute of microelectronics (SHRImE) Peking University School of Electronics Engineering and Computer Science Peking University

A new low-power,area efficiency all-digital delay-locked loop(ADDLL)circuit is proposed for *** ADDLL can process the input clock frequency ranging from 333 mHz to 800 mHz(DDR3-667/800/1066/1600)by using Phase Detector(PD),Delay Control Delay Line(DCDL),Digital Loop Filter Controller(DLFC)and Delay Generator(DG).To achieve 1.6 Gb/s/pin operation,a novel DCDL scheme is *** DCDL has a small delay with a shunt capacitor based digitally controlled delay element.A splitcontrol thermometer-code generator generates the control voltages used to set a current in the current-starved *** testchip fabricated with a 40-nm CmoS process gives the ADDLL data rate of 667 mbps–1.6 *** results that show the power consumption is 1.87 m W at 1.1 V with active area is 0.0137mm2.

关键词： all-digital delay-locked loop double-data-rate digitally controlled delay line shunt capacitor thermometer code