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Comparative study on microstructure evolution and failure mechanisms of ordinary and refurbished EB-PVD TBC under cyclic oxidation

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Journal of Advanced Ceramics 2023年第9期12卷 1805-1820页

作者： pan Li Xiaochao Jin pin Lu Delin Liu Rende mou Xueling Fan Xi’an Key Laboratory of Extreme Environmental Serviceability and Protection Technologies School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China AECC Beijing Institute of Aeronautical materials Beijing 100095China

Refurbishment of thermal barrier coating(TBC)has become a valuable technique to prolong the service life of high-temperature *** study investigates the effect of the refurbishment process(coating removal and recoating)on the microstructure evolution and physical properties of TBC,including oxidation characteristics,element diffusion behavior,and crack failure *** results showed that a certain amount of interdiffusion zone(IDZ)with Cr-rich would be retained in DD6 superalloy substrate after coating *** microstructure of the refurbished specimens showed equiaxedβ-NiAl phases,while the ordinary specimens have elongated grain shapes with a high aspect ***,mixed oxides in the refurbished TBC specimens were earlier observed during cyclic oxidation,with a greater thickness compared to ordinary TBC,due to the influence of BC layer phase *** growth mechanism of thermally grown oxide(TGo-Al_(2)o_(3)layer)in the refurbished TBC specimens was also different,resulting from the different mechanisms of mixed oxides ***,under cyclic oxidation with water quenching at 1100℃,the cracks in the refurbished specimen tend to occur in the mixed oxides layer,while the cracks in the ordinary specimen occur in the top coat(TC)layer,attributing to the earlier and thicker mixed oxides layer formed in refurbished specimens.

关键词： thermal barrier coating(TBC)systems coating removal refurbishment cyclic oxidation microstructure evolution failure mechanism

Human Action Recognition Based on Dense Trajectories Analysis and Random Forest

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Journal of Electronic Science and Technology 2016年第4期14卷 370-376页

作者： pin-Zhong pan Chung-Lin Huang Sonix Technology HsinChu 30265HsinChu Department of m-Commerce and multimedia Applications Asia UniversityTaichung 41354Taichung

This paper presents a human action recognition method. It analyzes the spatio-temporal grids along the dense trajectories and generates the histogram of oriented gradients （HoG） and histogram of optical flow （HoF） to describe the appearance and motion of the human object. Then, HoG combined with HoF is converted to bag-of-words （BoWs） by the vocabulary tree. Finally, it applies random forest to recognize the type of human action. In the experiments, KTH database and URADL database are tested for the performance evaluation. Comparing with the other approaches, we show that our approach has a better performance for the action videos with high inter-class and low inter-class variabilities.

关键词： Bag-of-words (BoWs) dense trajectories histogram of optical flow (HoF) histogram of oriented gradient (HoG) random forest vocabulary tree.

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基于倒装键合的高速高功率平衡光电探测器

光学学报 2024年第13期44卷 26-33页

作者：王紫赟谢小军魏超潘炜闫连山西南交通大学信息科学与技术学院

提出并制备一种高速高功率改进型单行载流子平衡光电探测器，通过引入P型掺杂牺牲层，调节漂移层电场强度，赋能光生电子近弹道输运特性，进而减少载流子的渡越时间，有效扩展器件的带宽，并在高功率条件下有效抑制器件的功率饱和现象... 详细信息

提出并制备一种高速高功率改进型单行载流子平衡光电探测器，通过引入P型掺杂牺牲层，调节漂移层电场强度，赋能光生电子近弹道输运特性，进而减少载流子的渡越时间，有效扩展器件的带宽，并在高功率条件下有效抑制器件的功率饱和现象。同时，将光电探测器芯片倒装键合在高导热系数金刚石基片上，降低光电探测器芯片核心温度，进一步提高器件射频输出功率。在-3 V偏压下器件暗电流小于200 nA。有源区直径为4、6、8μm的器件分别具有52、42、40 GHz的3 dB带宽响应。有源区直径为6μm和8μm的器件分别在50 GHz、47 GHz处达到8.0 dBm和14.0 dBm的射频输出功率。

关键词：高速光电探测器光电探测器平衡光电探测器倒装键合微波光子学

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DNP NmR reveals the hidden surface C–C bond growth mechanism over ZnAlo_(x) during syngas conversion

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Journal of Energy Chemistry 2022年第4期31卷 640-644页

作者： pan Gao Dong Xiao Zhenchao Zhao Subhradip paul Frédéric Blanc Xiuwen Han Guangjin Hou Xinhe Bao State Key Laboratory of Catalysis National Laboratory for Clean Energy2011-Collaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina DNP mAS NmR Facility Sir Peter Mansfield Imaging CentreUniversity of NottinghamNottingham NG72RDUnited Kingdom Department of Chemistry University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom Stephenson Institute for Renewable Energy University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom

Direct catalytic transformation of syngas(Co/H_(2)) into high value-added hydrocarbons has been one of the most attractive,yet challenging issues in C1 chemistry. In recent years, the concept of oxide-zeolite(oXZEo) bifunctional catalysis has emerged and spurred renewed enthusiasm in this field [1,2]. This method describes the use of selected oxide-zeolite-based composite catalysts for the direct syngas-to-hydrocarbons conversion.

关键词： zeolite hydrocarbons syngas

Adsorptive removal of antibiotics from water using magneticion exchange resin

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Journal of Environmental Sciences 2017年第2期29卷 111-117页

作者： Tianyue Wang Xun pan Weiwei Ben Jianbing Wang pin Hou Zhimin Qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China School of Chemical and Enuironmental Engineering Beijing CampusChina University of Mining and TechnologyBeijing 100083China Foreign Economic Cooperation office Ministry of Environmental ProtectionBeijing 100035China

The occurrence of antibiotics in the environment has recently raised serious concern regarding their potential threat to aquatic ecosystem and human health. In this study, the magnetic ion exchange（mIEX） resin was applied for removing three commonly-used antibiotics, sulfamethoxazole（SmX）, tetracycline（TCN） and amoxicillin（AmX） from *** results of batch experiments show that the maximum adsorption capacities on the mIEX resin for SmX, TCN and AmX were 789.32, 443.18 and 155.15 μg/m L at 25°C,respectively, which were 2–7 times that for the powdered activated carbon. The adsorption kinetics of antibiotics on the mIEX resin could be simulated by the pseudo-second-order model（R^2= 0.99）, and the adsorption isotherm data were well described by the Langmuir model（R^2= 0.97）. Solution p H exhibited a remarkable impact on the adsorption process and the absorbed concentrations of the tested antibiotics were obtained around the neutral p *** mIEX resin could be easily regenerated by 2 mol/L Na Cl solution and maintained high adsorption removal for the tested antibiotics after regeneration. Anion exchange mechanism mainly controlled the adsorption of antibiotic and the formation of hydrogen binding between the antibiotic and resin can also result in the increase of adsorption capacity. The high adsorption capacity, fast adsorption rate and prominent reusability make the mIEX resin a potential adsorbent in the application for removing antibiotics from water.

关键词： Sulfamethoxazole Tetracycline Amoxicillin Antibiotics mIEX resin Adsorption

Comparison and development of machine learning for thalidomideinduced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population

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World Journal of Gastroenterology 2023年第24期29卷 3855-3870页

作者： Jing mao Kang Chao Fu-Lin Jiang Xiao-ping Ye Ting Yang pan Li Xia Zhu pin-Jin Hu Bai-Jun Zhou min Huang Xiang Gao Xue-Ding Wang Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial Key Laboratory of New Drug Design and Evaluation Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Pharmacy Guangdong Women and Children HospitalGuangzhou 510000Guangdong ProvinceChina

BACKGRoUND Thalidomide is an effective treatment for refractory Crohn’s disease(CD).However,thalidomide-induced peripheral neuropathy(TiPN),which has a large individual variation,is a major cause of treatment *** is rarely predictable and recognized,especially in *** is necessary to develop a risk model to predict TiPN *** To develop and compare a predictive model of TiPN using machine learning based on comprehensive clinical and genetic *** A retrospective cohort of 164 CD patients from January 2016 to June 2022 was used to establish the *** National Cancer Institute Common Toxicity Criteria Sensory Scale(version 4.0)was used to assess *** 18 clinical features and 150 genetic variables,five predictive models were established and evaluated by the confusion matrix receiver operating characteristic curve(AURoC),area under the precision-recall curve(AUPRC),specificity,sensitivity(recall rate),precision,accuracy,and F1 *** The top-ranking five risk variables associated with TiPN were interleukin-12 rs1353248[P=0.0004,odds ratio(oR):8.983,95%confidence interval(CI):2.497-30.90],dose(mg/d,P=0.002),brainderived neurotrophic factor(BDNF)rs2030324(P=0.001,oR:3.164,95%CI:1.561-6.434),BDNF rs6265(P=0.001,oR:3.150,95%CI:1.546-6.073)and BDNF rs11030104(P=0.001,oR:3.091,95%CI:1.525-5.960).In the training set,gradient boosting decision tree(GBDT),extremely random trees(ET),random forest,logistic regression and extreme gradient boosting(XGBoost)obtained AURoC values>0.90 and AUPRC>*** these models,XGBoost and GBDT obtained the first two highest AURoC(0.90 and 1),AUPRC(0.98 and 1),accuracy(0.96 and 0.98),precision(0.90 and 0.95),F1 score(0.95 and 0.98),specificity(0.94 and 0.97),and sensitivity(1).In the validation set,XGBoost algorithm exhibited the best predictive performance with the highest specificity(0.857),accuracy(0.818),AUPRC(0.86)and AURoC(0.89).ET and GBDT obtained the highest sensitivity(1)and F1 score(0.8)

关键词： Thalidomide-induced peripheral neuropathy Refractory Crohn’s disease Neurotoxicity prediction models machine learning Gene polymorphisms

SARS-CoV-2 N protein enhances the anti-apoptotic activity of mCL-1 to promote viral replication

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3055-3069页

作者： pan pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang pin Wan mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu The First Affiliated Hospital of Jinan University 510632GuangzhouChina Foshan Institute of medical microbiology 528315FoshanChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan University510632GuangzhouChina State Key Laboratory of Virology College of Life SciencesWuhan University430072WuhanChina The First People’s Hospital of Foshan 528315FoshanChina

Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe ***,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus *** how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its ***,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N *** found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’*** study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and ***,N protein specifically interacted with anti-apoptotic protein mCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of mCL-1,which stabilized this protein and promoted it to hijack Bak in ***,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a mCL-1 specific inhibitor,***,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral *** may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other *** anticipate that abrogating the N/mCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses.

关键词： apo prevention promoted

Role of Endoplasmic Reticulum Stress in Silica-induced Apoptosis in RAW264.7 Cells＊

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Biomedical and Environmental Sciences 2017年第8期30卷 591-600页

作者： HU Yong Bin WU Xia QIN Xiao Feng WANG Lei pan pin Hua Department of Pathology Xiangya Basic Medical School Central South University Changsha 410013 Hunan China Department of Pathology Xiangya Hospital Central South University Changsha 410008 Hunan China Department of Pathology The Second Xiangya Hospital Central South University Changsha 410011 Hunan China Department of Respiratory medicine Xiangya Hospital Central South University Changsha 410008 Hunan China

objective We investigated the role of endoplasmic reticulum stress （ERS） in silica-induced apoptosis in alveolar macrophages in vitro. methods RAW264.7 cells were incubated with 200 μm/mL silica for different time periods. Cell viability was assayed by the mTT assay. Cell apoptosis was evaluated by DAPI staining, flow cytometry analysis, and Western blot analysis of caspase-3. morphological changes in the endoplasmic reticulum were observed by transmission electron microscopy. The expression of ERS markers binding protein （BiP） and CCAAT-enhancer-binding protein homologous protein （CHoP） was examined by Western blotting and real-time PCR. As an inhibitor of ERS, 4-phenylbutyric acid （4-PBA） was used in the experiments. Results Silica exposure induced nuclear condensation and caspase-3 expression in RAW264.7 cells. The number of apoptotic cells increased after silica exposure in a time-dependent manner. Silica treatment induced expansion of the endoplasmic reticulum. In addition, the expression of BiP and CHoP increased in silica-stimulated cells. Furthermore, 4-PBA treatment inhibited silica-induced endoplasmic reticulum expansion and the expression of BiP and CHoP. moreover, 4-PBA treatment attenuated nuclear condensation, reduced apoptotic cells, and downregulated caspase-3 expression in silica-stimulated cells. Conclusion Silica-induced ERS is involved in the apoptosis of alveolar macrophages

关键词： Silica Alveolar macrophages Endoplasmic reticulum stress Apoptosis

monolithic Covalent organic Framework Aerogels through Framework Crystallization Induced Self-assembly:Heading towards Framework materials Synthesis over All Length Scales

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Chinese Journal of Polymer Science 2019年第11期37卷 1045-1052页

作者： Wei Zhao Tian-pin Wang Jia-Li Wu Ru-ping pan Xiang-Yang Liu Xi-Kui Liu College of Polymer Science and Engineering Sichuan University

Here, through the synergism between kinetic dynamic imine-exchange control and thermodynamic control, rarely observed compressible, porous, crystalline covalent organic framework (CoF) aerogels were synthesized, the mechanism behind which is a framework crystallization induced self-assembly (FCISA) process. The prepared CoF aerogel possessed extremely high BET surface over 2000 m^2·g^-1 and high maximum equilibrium adsorption capacity toward bisphenol-A of 699 mg·g^-1 in aqueous solution.

关键词： Covalent organic framework (CoF) Aerogel Framework crystallization