检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hepatorenal syndrome

World journal of Gastroenterology 2007年第30期13卷 4046-4055页

作者： Sharon Turban paul j Thuluvath Mohamed G Atta Department of Medicine Division of Nephrology Johns Hopkins School of Medicine and the Johns Hopkins Hospital Baltimore Maryland United States Department of Medicine Division of Gastroenterology Johns Hopkins School of Medicine and the Johns Hopkins Hospital Baltimore Maryland United States

Hepatorenal syndrome (HRS) is a "functional" and reversible form of renal failure that occurs in patients with advanced chronic liver disease. The distinctive hallmark feature of HRS is the intense renal vasoconstriction caused by interactions between systemic and portal hemodynamics. This results in activation of vasoconstrictors and suppression of vasodilators in the renal circulation. Epidemiology, pathophysiology, as well as current and emerging therapies of HRS are discussed in this review.

关键词： Acute renal failure End stage liver disease Hepatorenal syndrome Transjugular intrahepatic portosysternic shunts Dialysis Liver transplantation

Outcomes of patients with cirrhosis undergoing non-hepatic surgery:Risk assessment and management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2007年第30期13卷 4056-4063页

作者： Farida Millwala Geoffrey C Nguyen paul j Thuluvath Hepatology Section The Johns Hopkins University School of Medicine Baltimore MD 2105 United States

The reported mortality rates in patients with cirrhosis undergoing various non-transplant surgical procedures range from 8.3% to 25%. This wide range of mortality rates is related to severity of liver disease, type of surgery, demographics of patient population, expertise of the surgical, anesthesia and intensive care unit team and finally, reporting bias. In this article, we will review the pathophysiology, morbidity and mortality associated with non-hepatic surgery in patients with cirrhosis, and then recommend an algorithm for risk assessment and evidence based management strategy to optimize post-surgical outcomes.

关键词： Pre-operative risk assessment Risk stratification Cirrhosis Model for end-stage liver disease Non-transplant surgery Outcomes

Gastrointestinal manifestations of systemic mastocytosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2008年第45期14卷 7005-7008页

作者： jason K Lee scott j Whittaker Robert A Enns Peter Zetler Internal Medicine University of British Columbia St. paul's Hospital Division of Gastroenterology University of British Columbia St. paul's Hospital Division of Pathology University of British Columbia

Systemic mastocytosis (SM) is a rare disease with abnormal proliferation and infiltration of mast cells in the skin, bone marrow, and viscera including the mucosal surfaces of the digestive tract. Gastrointestinal (GI) symptoms occur in 14%-85% of patients with systemic mastocytosis. The GI symptoms may be as frequent as the better known pruritis, urticaria pigmentosa, and flushing. In fact most recent studies show that the GI symptoms are especially important clinically due to the severity and chronicity of the effects that they produce. GI symptoms may include abdominal pain, diarrhea, nausea, vomiting, and bloating. A case of predominantly GI systemic mastocytosis with unique endoscopic images and pathologic confirmation is herein presented, as well as a current review of the GI manifestations of this disease including endoscopic appearances. Issues such as treatment and prognosis will not be discussed for the purposes of this paper.

关键词： Systemic mastocytosis Idiopathic diarrhea Gastrointestinal manifestations

Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2014年第31期20卷 10729-10739页

作者： Lawrence M Knab paul j Grippo David j Bentrem Department of Surgery Northwestern University Feinberg School of Medicine Robert H Lurie Comprehensive Cancer Center Northwestern University jesse Brown VA Medical Center

The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo. The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.

关键词： Arachidonic acid Eicosanoid Cyclooxygenase-2 5-lipoxygenase Pancreatic cancer Inflammation

Telehealth in the management of diabetes mellitus in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical journal 2012年第23期125卷 4307-4311页

作者： ZHU Bin LIU Mai-lan XU Shu-qiang jun Chen Collet jean-paul Collet scott A Lear LI Ping Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing 100029 China Child and Family Research Institute Vancouver Canada Acupuncture and Tuina College Chengdu University of Traditional Chinese Medicine Chengdu Sichuan 610072 China Infection Prevention and Control Service Provincial Health Service Authority British Columbia Canada UBC Department of Pediatrics Child and Family Research Institute Vancouver Canada Faculty of Health Sciences Simon Fraser University Harbour Centre Campus Vancouver Canada

Telehealth was defined as the use of information, computers and telecommunication technologies to provide health related services when health professionals and patients are separated by a distance This new medical model involves video-conference, transmission of images, e-health portals, remote monitoring of vital signs, and continuing medical education as a whole to help patients to improve health care. It should consist of three parts, including the patient client, the specialist and the connector （platform and intemet）.

关键词： telehealth diabetes mellitus management of diabetes

The Specimen Data Refinery:A Canonical Workflow Framework and FAIR Digital Object Approach to Speeding up Digital Mobilisation of Natural History Collections

在线全文

学校读者我要写书评

暂无评论

Data Intelligence 2022年第2期4卷 320-341页

作者： Alex Hardisty paul Brack Carole Goble Laurence Livermore Ben scott Quentin Groom Stuart Owen Stian Soiland-Reyes School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAUK The Department of Computer Science The University of ManchesterManchester M139PLUK The Natural History Museum London SW75BDUK Meise Botanic Garden 1860 MeiseBelgium Informatics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

A key limiting factor in organising and using information from physical specimens curated in natural science collections is making that information computable,with institutional digitization tending to focus more on imaging the specimens themselves than on efficiently capturing computable data about *** data are traditionally manually transcribed today with high cost and low throughput,rendering such a task constrained for many collection-holding institutions at current funding *** show how computer vision,optical character recognition,handwriting recognition,named entity recognition and language translation technologies can be implemented into canonical workflow component libraries with findable,accessible,interoperable,and reusable(FAIR)*** libraries are being developed in a cloudbased workflow plaform-the Specimen Data Refinery'(SDR)-founded on Galaxy workflow engine,Common Workflow Language,Research Object Crates(RO-Crate)and WorkflowHub *** SDR can be applied to specimens'labels and other artefacts,offering the prospect of greatly accelerated and more accurate data capture in computable *** kinds of FAIR Digital Objects(FDO)are created by packaging outputs of SDR workflows and workflow components as digital objects with metadata,a persistent identifier,and a specific type *** first kind of FDO are computable Digital Specimen(DS)objects that can be consumed/produced by workflows,and other applications.A single DS is the input data structure submitted to a workflow that is modified by each workflow component in turn to produce a refined DS at the *** Specimen Data Refinery provides a library of such components that can be used individually,or in *** cofunction,each library component describes the fields it requires from the DS and the fields it will in turn populate or *** second kind of FDO,RO-Crates gather and archive the diverse set of digital and real-world resources,configurations,a

关键词： Digital Specimen Workflow FAIR Digital Object RO-Crate

Influences of Biochar and Biochar-Mineral Complex on Mycorrhizal Colonisation and Nutrition of Wheat and Sorghum

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2015年第5期25卷 686-695页

作者： paul BLACKWELL Stephen jOSEPH paul MUNROE Hossain M.ANAWAR paul STORER Robert j.GILKES Zakaria M.SOLAIMAN Department of Agriculture and Food Western Australia Geraldton Regional Office School of Materials Science and Engineering University of New South WalesSydney Discipline of Chemistry University of Newcastle University of Wollongong School of Earth and Environment and UWA Institute of Agriculture The University of Western Australia Australian Mineral Fertilisers Pty Ltd. Soil Biology and Molecular Ecology Group School of Earth and Environment and UWA Institute of AgricultureThe University of Western Australia

The high price of synthetic fertilisers and the price barrier for biochar as a soil amendment have encouraged the exploration of using biochar in fertiliser replacement formulations. Biochars coupled with fertilisers can be applied at lower application rates to achieve benefits in plant growth and nutrition, as well as soil biological fertility. It is necessary to evaluate the use of biochar as a fertiliser substitute. Therefore, this study investigated the comparative influences of biochars, including Acacia saligna （AS）, Simcoa jarrah （S j） and Wundowie jarrah （W j）, mineral fertiliser with microbes （MF ＋ M）, biochar-mineral complex （BMC） and their combination on mycorrhizal colonisation, growth and nutrition of wheat in a glasshouse experiment and sorghum in field conditions. BMC ＋ MF ＋ M treatment produced higher mycorrhizal colonisation than MF ＋ M alone, indicating that BMC had a significant role in increasing mycorrhizal colonisation. Sj （treated with acetic acid） and MF ＋ M treatments, as well as AS ＋ MF ＋ M application, showed similar effects on mycorrhizal colonisation, but lower colonisation than the BMC ＋ MF ＋ M treatment. Ovcrall~ the BMC ＋ MF ＋ M treatment supported the maximum shoot, root and total plant dry weight followed by AS ＋ MF ＋ M and Wj ＋ MF ＋ M. The MF ＋ M treatment had the maximum shoot N and K concentrations, while BMC ＋ MF ＋ M application had the maximum shoot P concentration. AS ＋ MF -4- M and Wj ＋ MF ＋ M treatments supported the maximum N uptake by wheat shoots, while BMC ＋ MF ＋ M supported the maximum P uptake. The results showed that biochars and BMCs could increase mycorrhizal colonisation, plant growth and nutrient uptake of wheat, particularly N, P, K, S and Zn. The field experiment confirmed that BMC application at a rate of 300 kg ha-1 could increase the yield of irrigated sorghum on a loam soil and provide better applied P use efficiency compared to a water-soluble fertiliser alone. These results indicated that biochar-based fer

关键词： carbon sequestration nutrient uptake P use efficiency soil biological fertility wheat production

Development of starch-based films reinforced with cellulosic nanocrystals and essential oil to extend the shelf life of red grapes

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第3期47卷 403-412页

作者： Sneh Punia Bangar William scott Whiteside Fatih Ozogul Kyle D.Dunno George Armstrong Cavender paul Dawson Department of Food Nutrition and Packaging SciencesClemson UniversitySC 29634USA Department of Seafood Processing Technology Faculty of FisheriesCukurova UniversityBalcaliAdana01330Turkey Department of Packaging Science Rochester Institute of TechnologyRochesterNYUSA

Packaging material has an important role in extending the shelf-life of *** study investigated the effectiveness of cellulose nanocrystals(CNCs)derived from Kudzu(Pueraria montana)vine to reinforce to starch-based *** addition,the essential oil was incorporated into these nanocomposite films to evaluate further improvement in film properties and *** packaging materials,including the pearl millet starch(PMS),PMS reinforced with Kudzu CNCs,and PMS reinforced with Kudzu CNCs stabilized pickering emulsion containing clove bud oil(CBO),was used to develop biodegradable nanocomposite *** films were investigated for their thermal,morphological,mechanical,and barrier *** addition,the films were used as packaging material to improve the shelf life of the grapes for 15 days at 5℃.PMS films reinforced with Kudzu CNCs stabilized pickering emulsion of CBO were most effective in extending the shelf life of red grapes up to 15 days at 5℃ by maintaining the weight,firmness,and soluble solids in grapes for a longer duration during *** study suggests that PMS+Kudzu CNCs+EO films have the potential for commercial packaging of fruits during short storage periods without adversely affecting their quality and sensory attributes.

关键词： Packaging material Nanocomposites Cellulose nanocrystals Red grapes Shelf life

The role of exosomes in peripheral nerve regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第5期10卷 743-747页

作者： Rosanna C.Ching paul j.Kingham Department of Integrative Medical Biology Umea University Department of Surgical & Perioperative Sciences Umea University

Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address these difficulties include autologous nerve grafts （which are currently the gold standard treatment） and synthetic conduits, with the latter option being able to be im- pregnated with Schwann cells or stem cells which provide an appropriate micro-environment for neuronal regeneration to occur. Transplanting stem cells, however, infers additional risk of malignant transformation as well as manufacturing difficulties and ethical concerns, and the use of autologous nerve grafts and Schwann ceils requires the sacrifice of a functioning nerve. A new approach utilizing exosomes, secreted extracellular vesicles, could avoid these complications. In this review, we summarize the current literature on exosomes, and suggest how they could help to improve axonal regeneration following peripheral nerve injury.

关键词： axonal regeneration exosome extracellular vesicle microRNA microvesicle nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell