检索结果-南通市图书馆

MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Gastroenterology 2014年第32期20卷 11199-11209页

作者： Marion Gayral Sébastien j. Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet j.nick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail j.rome Torrisani Pierre Cordelier Cancer Research Center of Toulouse Team 10 UMR INSERM U1037Université Paul Sabatier P?le Digestif Centre Hospitalier Universitaire Toulouse

Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a maj.rity of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.

关键词： MicroRNAs Biomarkers Pancreatic cancer Therapeutic targets Precancerous lesions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轮胎部件挤出最新进展

轮胎工业 2002年第8期22卷 497-500页

作者： Gohlish H j.吴秀兰 paul Troester Maschinenfabrik

众所周知,轮胎由许多挤出和压延预制部件组成,其胶料塑炼要尽可能经济和均匀,部件成型要尽可能精确和在尽可能低的应力下进行,冷却、临时存放和再加工都不会产生进一步形变.这就要求使用兼具高度自动化和最少再加工及停机时间的低维护... 详细信息

众所周知,轮胎由许多挤出和压延预制部件组成,其胶料塑炼要尽可能经济和均匀,部件成型要尽可能精确和在尽可能低的应力下进行,冷却、临时存放和再加工都不会产生进一步形变.这就要求使用兼具高度自动化和最少再加工及停机时间的低维护量设备.

关键词：轮胎部件挤出进展销钉挤出机器件装置

在线全文

学校读者我要写书评

暂无评论

文艺活动对青少年反社会行为的影响

基础教育参考 2022年第8期13卷 21-21页

作者：刘征(编译) 邢淑芬(编译) Bone,j.K. Bu,F. Fluharty,M.E. paul,E. Sonke,j.K. Fancourt,D. 北京市海淀区上地实验小学北京100085 首都师范大学心理学院北京100048 不详

青春期被描述为个体负面行为增加的风险期,这期间的校内不良行为、反社会和犯罪行为等发生的概率大大增加。如何预防或减少青春期不良行为,不仅对青少年的健康成长有重要作用,而且对他们成年后的生活也有重要影响。研究表明,参与文化艺... 详细信息

青春期被描述为个体负面行为增加的风险期,这期间的校内不良行为、反社会和犯罪行为等发生的概率大大增加。如何预防或减少青春期不良行为,不仅对青少年的健康成长有重要作用,而且对他们成年后的生活也有重要影响。研究表明,参与文化艺术活动是减少青春期反社会行为的重要举措。以往研究多集中于探究基于文化艺术活动的干预措施如何影响改变那些已有反社会行为的青少年,英国伦敦大学的杰西卡·博恩(j.ssica ***)教授等人则另辟蹊径,调查了普通青少年参与文化艺术活动是否会影响其青春期的反社会行为,并致力于探究这种影响背后的潜在机制。

关键词：文化艺术活动反社会行为文艺活动不良行为英国伦敦大学杰西卡犯罪行为负面行为

星形胶质细胞对炎症刺激的代谢反应受核因子-κB信号传导调控

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2020年第5期15卷 F0003-F0003页

作者： j.sephine L Robb Nadia A Hammad paul GWeightman Potter j.hn K Chilton Craig Beall Kate L j.Ellacott Institute of Biomedical and Clinical Science University of Exeter Medical SchoolExeterUK

炎症和新陈代谢与引起细胞代谢变化的炎症刺激有着内在联系,代谢能力进而决定细胞水平炎症反应。尽管外周免疫细胞的特征已较为明晰,但对星形胶质细胞中这些“免疫代谢”反应的了解相对较少。本研究测试了以下假设:核因子-κB(NF-κB)... 详细信息

炎症和新陈代谢与引起细胞代谢变化的炎症刺激有着内在联系,代谢能力进而决定细胞水平炎症反应。尽管外周免疫细胞的特征已较为明晰,但对星形胶质细胞中这些“免疫代谢”反应的了解相对较少。本研究测试了以下假设:核因子-κB(NF-κB)信号驱动的星形胶质细胞炎性反应依赖于糖酵解代谢。我们用小鼠原代皮质星形胶质细胞培养物,以细胞因子ELISA和免疫印迹法来测量炎症反应,评估了星形细胞暴露于脂多糖(LPS)后细胞代谢的变化。结果表明,星形胶质细胞对促炎性刺激在时间上具有明显的代谢适应性:LPS处理3 h可增加糖酵解,但不会改变线粒体代谢;而LPS处理24 h后,我们观察到氧化磷酸化增加,糖酵解能力和葡萄糖摄取减少,部分原因是葡萄糖转运蛋白1的表达降低。用IKK-β抑制剂TPCA-1抑制NF-κB信号传导可防止LPS诱导的糖酵解和氧化磷酸化改变。此外,TPCA-1处理本身即改变了糖酵解和氧化磷酸化而与炎症刺激无关,表明NF-κB信号传导在星形胶质细胞基础代谢的调节中起作用。用2-脱氧葡萄糖抑制糖酵解可显著减弱LPS诱导的细胞因子释放和NF-κB磷酸化,表明完整的糖酵解过程是LPS诱导完全的炎症反应所必需的。总之,本研究数据表明星形胶质细胞对急性LPS的刺激产生免疫代谢反应,这可能代表了神经炎性疾病的潜在治疗靶标。

关键词：星形胶质细胞糖酵解炎症代谢核因子-κB

Genetic analysis of stilbenoid profiles in grapevine stems reveals a maj.r mQTL hotspot on chromosome 18 associated with disease-resistance motifs

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2019年第1期6卷 195-205页

作者： Soon L.Teh Bety Rostandy Mani Awale j.mes j.Luby Anne Fennell Adrian D.Hegeman Department of Horticultural Science University of MinnesotaSaint PaulMN 55108USA Agronomy Horticulture and Plant Science DepartmentSouth Dakota State UniversityBrookingsSD 57007USA Tree Fruit Research and Extension Center Department of HorticultureWashington State UniversityWenatcheeWA 98801USA Department of Mathematics and Statistics University of North CarolinaGreensboroNC 27412USA Grape and Wine Institute University of MissouriColumbiaMO 65211USA

Grapevine(Vitis spp.)contains a wealth of phytochemicals that have received considerable attention due to healthpromoting properties and biological activities as *** date,the genetic basis of the quantitative variations for these potentially beneficial compounds has been ***,metabolic quantitative trait locus(mQTL)mapping was conducted using grapevine stems of a segregating F2 *** profiling of grapevine stems was performed using liquid chromatography–high-resolution mass spectrometry(LC-HRMS),resulting in the detection of 1317 ions/*** total,19 of these features matched with literature-reported stilbenoid masses and were genetically mapped using a 1449-SNP linkage map and R/qtl software,resulting in the identification of four *** large-effect mQTLs that corresponded to a stilbenoid dimer and a trimer were mapped on chromosome 18,accounting for phenotypic variances of 29.0%and 38.4%.Functional annotations of these large-effect mQTLs on the VitisNet network database revealed a maj.r hotspot of disease-resistance motifs on chromosome *** 2.8-Mbp region contains 48 genes with R-gene motifs,including variants of TIR,NBS,and LRR,that might potentially confer resistance to powdery mildew,downy mildew,or other *** locus also encompasses genes associated with flavonoid and biosynthetic pathways that are likely involved in the production of secondary metabolites,including *** addition,haplotype dosage effects of the five mQTLs further characterized the genomic regions for differential production of stilbenoids that can be applied in resistance breeding through manipulation of stilbenoid production in planta.

关键词： dosage linkage breeding

老年人群中的结肠镜检:在无症状患者中的低风险与低检出率

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 16-17页

作者： Duncan j.E. Sweeney W.B. Trudel j.L. 张红凯 Division of Colon and Rectal Surgery Department of SurgeryUniversity of Minnesota393 Dunlap Street NorthSt.PaulMN 55104United States.Dr

PURPOSE: Current colonoscopy guidelines do not address the issue of when to stop performing screening and surveillance colonoscopy in the elderly. We reviewed our experience and results of colonoscopy in patients aged 80 years and older to assess the risks and diagnostic yield in this population. METHODS: We reviewed retrospectively the endoscopic and pathologic reports from consecutive colonoscopies performed on patients aged 80 years and older at a single, high-volume endoscopy center between August 1999 and May 2003. Patient characteristics, indications for examination, findings at colonoscopy, and complications were recorded and analyzed. RESULTS: A total of 1,199 colonoscopic examinations were performed on 1,112 patients. Average age was 83.1 (range, 80-100) years. Male∶female distribution was 1∶1.7. Leading exclusive indications for colonoscopy included: polyp surveillance, 227 (19 percent); altered bowel habits, 168 (14 percent); iron-deficiency anemia, 132 (11 percent); and cancer follow-up, 108 (9 percent). Eighty-six examinations (7 percent) were performed solely for an indication of colorectal cancer screening. Twenty-two percent of patients had more than one indication for colonoscopy. Forty-five malignancies were found (3.7 percent). No cancers were found in the screening group, and two malignancies (0.7 percent) were detected in patients undergoing colonoscopy for polyp surveillance. There were eight (0.6 percent) reported maj.r complications. CONCLUSIONS: Colonoscopy can be performed safely in patients aged 80 years and older. However, the diagnostic yield is low, particularly in patients undergoing routine screening or surveillance exam-inations. Colonoscopy should for the most part be limited to elderly patients with symptoms or specific clinical findings.

关键词：结肠镜检无症状患者内镜检查内镜中心结肠直肠癌病理学检查特殊临床表现排便习惯年龄组

使用全新机器人引导的肝脏肿瘤影像导引下微波热消融术:初步经验

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第2期 200-200页

作者： E.C.Mbalisike T.j.Vogl S.Zangos K.Eichler P.Balakrishnan j.paul 郭凌飞 Institute for Diagnostic and Interventional Radiology Klinikum Bad Salzungen Lindigalle 3 36433 Bad Salzungen Germany

摘要目的评估并比较机器人引导与手动操作方法在影像引导下行微波热消融中的程序精确性、操作时间、程序性能和影像质量的差异。方法本研究于2013年6月—2013

关键词：微波电磁波机器人人工智能

扩散火焰在聚甲基丙烯酸甲酯(PMMA)上蔓延研究:理论、试验和数值模拟(英文)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

消防科学与技术 2007年第3期26卷 248-255页

作者： j.L CONSALVI B PORTERIE M COUTIN L AUDOUIN C CASSELMAN A RANGWALA S G BUCKLEY j.L TORERO Polytech'Marseille/DME UMR/CNRS 6595 5 rue E Fermi 13453 Marseille Cedex 13France Institut de Radioprotection et de Sreté Nucléaire DPAMCadarache 13108 Saint Paul lez DuranceFrance Department of Mechanical and Aerospace Engineering University of California San Diego La JollaCA 92093-0411USA BRE/Edinburgh Centre for Fire Research The University of Edinburgh Edinburgh EH9 3JLUK

对PMMA进行数字模拟和试验,对描述自然边界层扩散火焰理论的假设进行评价。我们把流动特性(二维边界层)和表面热平衡作为评价的关键假设。试验、数字模拟和理论模型证实了对质量传递数值定义的假设是正确的,但研究也表明,有必要对流动... 详细信息

对PMMA进行数字模拟和试验,对描述自然边界层扩散火焰理论的假设进行评价。我们把流动特性(二维边界层)和表面热平衡作为评价的关键假设。试验、数字模拟和理论模型证实了对质量传递数值定义的假设是正确的,但研究也表明,有必要对流动特性进行三维模拟。

关键词：扩散火焰火灾模型数值模拟

HIV-疾病预防性疫苗接种和病毒特异性治疗

在线全文

学校读者我要写书评

暂无评论

德国医学 1998年第3期15卷 130-138页

作者： j.Denner R.Kurth 郝连杰 paul-Ehrlich-Institut Paul-Ehrlich-Str.51-59D-63225 LangenDeutschland 同济医科大学附属同济医院

尽管多方面的努力仍然还没有对AIDS有保护作用的疫苗。针对其它逆转录病毒的免疫已取得成效,并且认识到用减弱SIV、灭活的病毒、病毒蛋白和SIV与HIV肽免疫可获得部分效果,这些有可能在今后开发疫苗应用。此外,还进行了新的有希望的研究... 详细信息

尽管多方面的努力仍然还没有对AIDS有保护作用的疫苗。针对其它逆转录病毒的免疫已取得成效,并且认识到用减弱SIV、灭活的病毒、病毒蛋白和SIV与HIV肽免疫可获得部分效果,这些有可能在今后开发疫苗应用。此外,还进行了新的有希望的研究,例如基因免疫和用病毒与细菌载体免疫。应用新的化学治疗措施,逆转录酶抑制剂联合病毒蛋白酶抑制剂治疗HIV-疾病,初步发现病人的病毒负荷显著下降,出现AIDS-病例减少。然而尚不能说是已经痊愈,因为潜伏性感染的细胞内仍有复制能力的病毒形成。因多数用药的病人不能耐受或出现强烈的副作用,要求开发新的逆转录酶、蛋白酶、整合酶抑制剂以及其它的病毒复制抑制剂。基因治疗措施尚在开始实验研究阶段,未来抗病毒策略中,可抑制病毒增殖的细胞因子,可能有重要意义。

关键词：艾滋病预防疫苗接种病毒蛋白灭活蛋白