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中华高血压杂志 2012年第2期20卷 198-198页

作者： May e.Montasser Lawrence C.Shimmin Charles Gu Tanika N.kelly Cashell e.Jaquish Treva Rice Dabeeru C.Rao paul k.whelton.james e.hixson.罗冬梅叶鹏

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体... 详细信息

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体力活动将3142名入选者进行分组（体力活动组与非体力活动组），应用广义估计方程分析收缩压和舒张压与血压调控通路中24个基因表型改变的关系[包括196单核苷酸多态性（single-nucleotide polymorphisms，SNP）]。

关键词：体力活动血压动态相互作用基因变异中国农村非遗传因素单核苷酸多态性广义估计方程

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Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

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Frontiers of Medicine 2010年第1期4卷 59-66页

作者： Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHeN Cashell e.JAQUISH Dabeeru C.RAO james e.hixson.Jian-Feng HUANG Chung-Shiuan CHeN Charles GU Ji-Chun CHeN Jie CAO Shu-Feng CHeN paul k.whelton Jiang He Dong-Feng GU Department of evidence-based Medicine and Population Genetics Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at Beijing Beijing 100176China Department of epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA National Heart Lungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of Medicine St.LouisMO 63110USA University of Texas School of Public Health HoustonTX 77030USA Loyola University Medical Center MaywoodIL 60153USA

Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identiﬁed signiﬁcant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all Pemained signiﬁcant after adjustment for multiple *** participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between

关键词： blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3)

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