Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

作     者：Dai-Hai YU De-Pei LIU Lai-Yuan WANG Jing CHEN Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUANG Chung-Shiuan CHEN Charles GU Ji-Chun CHEN Jie CAO Shu-Feng CHEN Paul K.WHELTON Jiang HE Dong-Feng GU 

作者机构：Department of Evidence-based Medicine and Population GeneticsCardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at BeijingBeijing 100176China Department of EpidemiologyTulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of MedicineTulane University School of MedicineNew OrleansLA 70112USA National HeartLungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of MedicineSt.LouisMO 63110USA University of Texas School of Public HealthHoustonTX 77030USA Loyola University Medical CenterMaywoodIL 60153USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2010年第4卷第1期

页      面：59-66页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by research grants(Nos.U01HL072507,R01HL087263,and R01HL090682)from the National Heart,Lung Blood Institute,National Institutes of Health,Bethesda,MD.Upsher-Smith Laboratories,Maple Grove,MN,has provided Klor-Con M20 potassium tablets for the GenSalt study 

主　　题：blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3) 

摘      要：Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identified significant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P0.0001)that remained significant after adjustment for multiple *** participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between