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以汽车节强化品牌定位捷豹路虎财报印证策略奏效

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商业周刊（中文版） 2024年第14期 16-17页

作者： patrick 不详

上午的小雨,使古德伍德速度节场地里更加泥泞。这个盛会起源于里士满公爵九世于1936年发起的汽车爬坡赛,经过丰富发展但在1963年停办了。1993年,十一世里士满公爵将其恢复并且发扬光大。每年一次,它是展示汽车技术和速度的盛会,更是领... 详细信息

上午的小雨,使古德伍德速度节场地里更加泥泞。这个盛会起源于里士满公爵九世于1936年发起的汽车爬坡赛,经过丰富发展但在1963年停办了。1993年,十一世里士满公爵将其恢复并且发扬光大。每年一次,它是展示汽车技术和速度的盛会,更是领略汽车历史与文化的嘉年华。与传统的车展和赛事不同,古德伍德速度节专注于汽车文化的展览、竞技、延伸和深层次的挖掘,不同年代的经典跑车、老爷车以及越野车等同台亮相,融汇了汽车文化历史发展和现实,让车迷可以尽情欣赏汽车的过去与未来,并与专业人士共同分享对汽车的热爱,堪称“全球最伟大的汽车运动盛典”,被誉为车展界中的“百科全书”。

关键词：财报文化历史发展嘉年华里士满古德伍德强化品牌历史与文化百科全书

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爱马仕飞马行空

商业周刊（中文版） 2024年第1期 86-87页

作者： patrick 不详

多年来我越来越坚信爱马仕活动的策划者们,一定是孩子,聪明的孩子,一次次地重新教我,该怎样玩耍。他们的作品让每个观众都想回到童年,再过一遭。这次在上海,是比利时导演Jaco Van Dormael、编舞家Michele Anne De Mey和Astragales舞团... 详细信息

多年来我越来越坚信爱马仕活动的策划者们,一定是孩子,聪明的孩子,一次次地重新教我,该怎样玩耍。他们的作品让每个观众都想回到童年,再过一遭。这次在上海,是比利时导演Jaco Van Dormael、编舞家Michele Anne De Mey和Astragales舞团共同编织的梦幻奇境。

关键词：爱马仕聪明的孩子策划者比利时

High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

双鸡酒庄第四代掌门人Brice de La Morandiere:来上海开几瓶酒

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商业周刊（中文版） 2024年第3期 12-13页

作者： patrick 不详

提起勃良第(Burgundy)这个法国古老的葡萄酒产区,人们通常会想起“红酒之王”罗曼尼康帝(Domaine de la Romanée-Conti)。而几乎同样没有争议的“白葡萄酒之王”里费维(Leflaive),声音也许没有那么大,却也稳健发展,经历了四代传承。由... 详细信息

提起勃良第(Burgundy)这个法国古老的葡萄酒产区,人们通常会想起“红酒之王”罗曼尼康帝(Domaine de la Romanée-Conti)。而几乎同样没有争议的“白葡萄酒之王”里费维(Leflaive),声音也许没有那么大,却也稳健发展,经历了四代传承。由于其酒标上的两只雄鸡的图样,中国消费者喜欢称它为“双鸡酒庄”。近日,笔者有幸与里费维庄园(即“双鸡酒庄”)的继承人、第四代掌门人Bricede La Morandiere对谈。

关键词：尼康酒庄稳健发展 die

百达翡丽现任总裁泰瑞·斯登:创新是我们的传统保持战略的纯粹性非常重要

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商业周刊（中文版） 2024年第14期 14-15页

作者： patrick 不详

为庆祝百达翡丽北京源邸开幕10周年,品牌倾情呈现“北京时间落邸为家”特别展览,以时间之艺致敬中国。斯登家族第四代传人、百达翡丽现任总裁泰瑞·斯登(Thierry Stern)亲临现场,与宾客共同庆贺这一具有纪念意义的周年庆典。

关键词：现任总裁纯粹性纪念意义宾客第四代

Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status

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World Journal of Clinical Oncology 2024年第4期15卷 540-547页

作者： Chen-Gu Niu Jing Zhang Aniket-Vijay Rao Utsav Joshi patrick Okolo Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Psychiatry Rainier SpringsVancouverWA 98663United States Department of Hematology and Medical Oncology Moffitt Cancer CenterTampaFL 33606United States Department of Gastroenterology Rochester General HospitalRochesterNY 14621United States

BACKGROUND Immunotherapy have demonstrated promising outcomes in patients with high microsatellite instability(MSI)(MSI-H)metastatic colorectal ***,the comparative effectiveness of Immunotherapy and chemotherapy for patients with low MSI(MSI-L),and microsatellite stable(MSS)metastatic colorectal cancer remains *** To investigate immunotherapy vs chemotherapy for treatment of MSI-L/MSS metastatic colorectal cancer,and to evaluate the success of immunotherapy against chemotherapy in managing MSI-H metastatic colorectal cancer during a follow-up of 50 *** We conducted a retrospective cohort study using the National Cancer Database(NCDB)to evaluate the overall survival(OS)of patients with metastatic colorectal cancer treated with immunotherapy or *** study population was stratified by MSI status(MSI-H,MSI-L,and MSS).Multivariable Cox proportional hazard models were used to assess the association between treatment modality and OS,adjusting for potential *** A total of 21951 patients with metastatic colorectal cancer were included in the analysis,of which 2358 were MSI-H,and 19593 were MSI-L/*** the MSI-H cohort,immunotherapy treatment(n=142)was associated with a significantly improved median OS compared to chemotherapy(n=860).After adjusting for potential confounders,immunotherapy treatment remained significantly associated with better OS in the MSI-H cohort[adjusted hazard ratio(aHR):0.57,95%confidence interval(95%CI):0.43-0.77,P<0.001].In the MSS cohort,no significant difference in median OS was observed between immunotherapy treatment and chemotherapy(aHR:0.94,95%CI:0.69-1.29,P=0.715).CONCLUSION In this population-based study using the NCDB,immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer,but not in those with MSI-L/MSS metastatic colorectal *** studies are warranted to determine the optimal therapeu

关键词： Immunotherapy Chemotherapy Metastatic colorectal cancer Microsatellite instability National cancer database

The Influence of Biomass Cokes on the Microstructure and Thermal Shock Resistance of MgO-C Refractories

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China's Refractories 2024年第3期33卷 9-14页

作者： patrick GEHRE Magzhan KAPESSOV Stefan GUHL Martin GRÄBNER Christos G.ANEZIRIS Institute of Ceramics Refractories and Composite MaterialsTU Bergakademie FreibergFreiberg 09599Germany Institute of Energy Process Engineering and Chemical Engineering TU Bergakademie FreibergFreiberg 09599Germany

In this study,biomass cokes from sunflower seed hull(SFSH)and wood pellets(WP)were added to a MgO-C batch(3 mass%C)to replace 1.1 mass%of *** hardening and carbonizing the samples,the influence of the biomass cokes on the microstructure and thermal shock resistance was *** replacement of flaky graphite by carbonized WP and SFSH reduced the bulk density and increased the apparent porosity after pressing and carbonization,but the degree was only *** was confirmed by SEM investigations,where the biomass-coke containing samples exhibited a microstructure with a higher amount of pores between the fine MgO *** thermal shock resistance of the porous wood pellet coke containing MgO-C is at the same level as the reference sample but not superior to it.

关键词： MgO-C carbon biomass microstructure thermal shock

Physicochemical and Thermal Properties of Some Key Tropical Sawdust Woods for Energy Production

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Journal of Sustainable Bioenergy Systems 2024年第1期14卷 1-22页

作者： Davy Fiwa Kaoke Yann Le Brech Emmanuel Talla Anthony Dufour patrick Mountapmbeme Kouotou Department of Chemical Engineering School of Chemical Engineering and Mineral Industries University of Ngaoundere Ngaoundere Cameroon National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon Laboratory of Reactions and Process Engineering University of Lorraine-France Nancy France Higher Institute of Agriculture Wood Water and Environment University of Ebolowa Ebolowa Cameroon

In South Saharan countries, 85% of the population uses biomass as a primary energy source. Cameroon presents one of the highest biomass energy and sawmills produce important sawdust resources which are not used and are burnt in piles leading to significant air toxic emissions. Therefore, we have to valorize industrially these available sawdusts. This study focuses on the physicochemical and thermochemical analysis of Ayous, Sapelli and Tali sawdust. The proximate and ultimate analysis, particle size, structural composition, as well as heavy metal content and calorific value were determined. In addition, the thermogravimetric mass losses were also estimated. The results showed that high water contents (24% - 41%) were recorded in the raw sawdust, and the thermal treatment reduced these contents from 78% to values in the range of 4% - 9%. The values for ash and volatile matter content were respectively between 0.25% - 0.74% and 68% - 76%. The LHV is higher in Ayous (17.5 MJ/kg) and Sapelli (16.8 MJ/kg) than that of Tali (15.7 MJ/kg). The concentration of heavy metals is very low in each species. Extractives are more present in Tali (16.06%) than in the other sawdusts. Pyrolysis of sawdust shows the typical decomposition of hemicellulose (270˚C - 325˚C), cellulose (325˚C - 400˚C) and lignin (200˚C - 550˚C) with a maximum loss of 75% at 370˚C and the melting point is 320˚C. The results of the sawdust parameters determined in the paper can be valorized to reduce pollutants emissions by developing the efficiency and effectiveness of biomass energy processes and promoting the use of biomass as a sustainable alternative to traditional fossil fuels.

关键词： Wood Sawmills Sawdust Combustion Energy

Elevated fluid and glycosaminoglycan content in the Achilles tendon contribute to higher intratendinous pressures:Implications for Achilles tendinopathy

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Journal of Sport and Health Science 2024年第6期13卷 863-871页

作者： Lauren Pringels Gert-Jan Van Valckenborgh patrick Segers Amelie Chevalier Hedwig Stepman Evi Wezenbeek Arne Burssens Luc Vanden Bossche Department of Physical and Rehabilitation Medicine Ghent University HospitalGhent 9000Belgium Department of Rehabilitation Sciences and Physiotherapy Ghent UniversityGhent 9000Belgium Department of Electronics and Information Systems Ghent UniversityGhent 9000Belgium Department of Electromechanics University of AntwerpAntwerp 2020Belgium Department of Laboratory Medicine Ghent University HospitalGhent 9000Belgium Department of Orthopedic Surgery Ghent University HospitalGhent 9000Belgium

Background:Tendinopathy alters the compositional properties of the Achilles tendon by increasing fluid and glycosaminoglycan *** has been speculated that these changes may affect intratendinous pressure,but the extent of this relationship remains ***,we aimed to investigate the impact of elevated fluid and glycosaminoglycan content on Achilles tendon intratendinous pressure and to determine whether hyaluronidase(HYAL) therapy can intervene in this potential ***:Twenty paired fresh-frozen cadaveric Achilles tendons were mounted in a tensile-testing machine and loaded up to 5% *** resting(at 0% strain) and dynamic pressure(at 5% strain) were assessed using the microcapillary infusion ***,intratendinous pressure was measured under native conditions before and after infusion of 2 mL physiological ***,80 mg of glycosaminoglycans were administered bilaterally to the paired *** right tendons were additionally treated with 1500 units of ***,both groups were retested,and the glycosaminoglycan content was ***:It was found that both elevated fluid and glycosaminoglycan content resulted in higher intratendinous resting and dynamic pressures(p <0.001).HYAL treatment induced a 2.3-fold reduction in glycosaminoglycan content(p=0.002) and restored intratendinous ***:The results of this study demonstrated that elevated fluid and glycosaminoglycan content in Achilles tendinopathy contribute to increased intratendinous re sting and dynamic pressures,which can be explained by the associated increased volume and reduced permeability of the tendon matrix,*** degrades glycosaminoglycans sufficiently to lower intratendinous pressures and may,therefore,serve as a promising treatment.

关键词： Achilles tendon Achilles tendinopathy Intratendinous pressure Glycosaminoglycans Tendon fluid