Elevated fluid and glycosaminoglycan content in the Achilles tendon contribute to higher intratendinous pressures:Implications for Achilles tendinopathy

作     者：Lauren Pringels Gert-Jan Van Valckenborgh Patrick Segers Amelie Chevalier Hedwig Stepman Evi Wezenbeek Arne Burssens Luc Vanden Bossche Lauren Pringels;Gert-Jan Van Valckenborgh;Patrick Segers;Amélie Chevalier;Hedwig Stepman;Evi Wezenbeek;Arne Burssens;Luc Vanden Bossche

作者机构：Department of Physical and Rehabilitation MedicineGhent University HospitalGhent 9000Belgium Department of Rehabilitation Sciences and PhysiotherapyGhent UniversityGhent 9000Belgium Department of Electronics and Information SystemsGhent UniversityGhent 9000Belgium Department of ElectromechanicsUniversity of AntwerpAntwerp 2020Belgium Department of Laboratory MedicineGhent University HospitalGhent 9000Belgium Department of Orthopedic SurgeryGhent University HospitalGhent 9000Belgium 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第6期

页      面：863-871页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：funded by Ghent University Hospital(FIKO21/TYPE2/013) 

主　　题：Achilles tendon Achilles tendinopathy Intratendinous pressure Glycosaminoglycans Tendon fluid 

摘      要：Background:Tendinopathy alters the compositional properties of the Achilles tendon by increasing fluid and glycosaminoglycan *** has been speculated that these changes may affect intratendinous pressure,but the extent of this relationship remains ***,we aimed to investigate the impact of elevated fluid and glycosaminoglycan content on Achilles tendon intratendinous pressure and to determine whether hyaluronidase(HYAL) therapy can intervene in this potential ***:Twenty paired fresh-frozen cadaveric Achilles tendons were mounted in a tensile-testing machine and loaded up to 5% *** resting(at 0% strain) and dynamic pressure(at 5% strain) were assessed using the microcapillary infusion ***,intratendinous pressure was measured under native conditions before and after infusion of 2 mL physiological ***,80 mg of glycosaminoglycans were administered bilaterally to the paired *** right tendons were additionally treated with 1500 units of ***,both groups were retested,and the glycosaminoglycan content was ***:It was found that both elevated fluid and glycosaminoglycan content resulted in higher intratendinous resting and dynamic pressures(p 0.001).HYAL treatment induced a 2.3-fold reduction in glycosaminoglycan content(p=0.002) and restored intratendinous ***:The results of this study demonstrated that elevated fluid and glycosaminoglycan content in Achilles tendinopathy contribute to increased intratendinous re sting and dynamic pressures,which can be explained by the associated increased volume and reduced permeability of the tendon matrix,*** degrades glycosaminoglycans sufficiently to lower intratendinous pressures and may,therefore,serve as a promising treatment.