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Synaptic pathology in multiple sclerosis:a role for Nogo-A signaling in astrocytes?

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Neural Regeneration Research 2023年第1期18卷 127-128页

作者： Sheila Espírito-Santo Vinícius Gabriel Coutinho Flávia carvalho alcantara Gomes Laboratório de Biologia Celular e Tecidual Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRJBrazil Laboratório de Neurobiologia Celular Universidade Federal do Rio de JaneiroInstituto de Ciências BiomédicasRio de JaneiroRJBrazil

Multiple sclerosis(MS)is characterized as an inflammatory demyelinating disease that affects the central nervous system(CNS),leading to sensory,motor and cognitive ***,axonal denudation culminates in axonal lesions and *** demyelinating lesions in MS are associated with infiltration of immune cells combined with activation of the resident CNS inflammatory cells,astro-and microglia.

关键词： sclerosis impairment lesions

Competitive Intelligence： Bibliometric Research on Early Signals

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Journal of Modern Accounting and Auditing 2013年第4期9卷 547-556页

作者： patricia Viveiros de Castro Krakauer Femando carvalho de Almeida Martinho I Ribeiro de AlmeidaUniversity of Sao Paulo Sao Paulo Brazil

Considering the importance of the anticipated intelligence issue on the current scenario, this article aims at understanding the scientific production about the subject, contributing to future researchers with greater academic knowledge about the productivity in the area. Therefore, a bibliometric research was carried out on weak signals and correlated matters between 1980 and 2010 and was supported by the literature review about the subject. The suggested analysis contributes to greater academic knowledge on productivity in the field, providing a broad perspective for future researchers who catch sight of this subject as a potential for further studies.

关键词： early intelligence weak signals bibliometric research

Mesenchymal stem cell secretome and nanotechnology:Combining therapeutic strategies

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BIOCELL 2022年第8期46卷 1807-1813页

作者： ADRIANA L.FERREIRA GUSTAVO C.PARIS ALINE de A.AZEVEDO ERIKA A.C.CORTEZ SIMONE N.carvalho LAIS de carvalho ALESSANDRA A.THOLE Laboratory of Stem Cell Research Roberto Alcantara Gomes Biology InstituteRio de Janeiro State UniversityRio de Janeiro20540170Brazil

Mesenchymal stem cells(MSC)have pushed the field of stem cell-based therapies by inducing tissue regeneration,immunosuppression,and angiogenesis mainly through vesicles and soluble factors release(paracrine signaling).MSC-extracellular vesicles(MSC-EV)adaptable secretome and homing to injured sites allowed researchers to unlock a new era of cell-free based *** parallel,nanoparticles(NP)have been explored in contributing to transport and drug delivery systems,giving drugs desired physical-chemical properties to exploit cell ***,NPs can be quickly recognized by immune cells and cleared from *** this viewpoint,we explore how combining both therapeutic strategies can improve efficacy and circumvent limitations of both *** benefit from the potent MSC membrane composition,guiding chemotaxis to tumor sites,a very restricted ***-EV has low immunogenicity,high stability,long half-life and can explore tissue targeting ligands as a precise drug carry,even across biological *** properties promote enhanced targeted drug delivery that can be combined with NP,exploring biological membrane production through:*** cell therapy with NP-infused MSC;***-containing MSC-EV generated by NP-infused MSC;*** coating NP in MSC membrane(“MSC NanoGhosts”),allowing precise cargo definition without losing ***,nanotechnology combined with cell-based therapeutic resources can greatly improve targeted drug delivery,improving efficacy and opening a new venue of therapeutic possibilities.

关键词： Mesenchymal stem cells Nanoparticles Secretome Exosome Targeted drug delivery

Surface Modification of Commercial Activated Carbon (CAG) for the Adsorption of Benzene and Toluene

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American Journal of Analytical Chemistry 2015年第6期6卷 528-538页

作者： Anna Sylmara da Costa Lopes Samira Maria Leao de carvalho Davi do Socorro Barros Brasil Rosivaldo de alcantara Mendes Marcelo Oliveira Lima Universidade Federal do Para BelemBrasil Instituto Evandro Chagas AnanindeuaBrasil

In this work, we determined the surface characteristics of natural (CA-1) and HNO3 treated (CA-2) CAG. Equilibrium, kinetics and breakthrough for adsorption of benzene and toluene by CA-1 and CA-2 were studied. Concentrations of benzene and toluene (mg/L) were determined by gas chromatography with headspace extraction. The data of adsorption kinetic and equilibrium were best fitted by pseudo-second order model and Langmuir isotherm, respectively. The best results of benzene and toluene adsorption from fixed bed were obtained at volumetric flow rate (Q1 = 70 mL/min) using adsorbent CA-2. The study of inferential statistics revealed that CA-1 and CA-2 adsorbents are statistically different at a 5% significance level.

关键词： Adsorption Activated Carbon Surface Modification Benzene Toluene

Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

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World Journal of Gastroenterology 2011年第6期17卷 766-773页

作者： Patrícia Koehler-Santos patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo carvalho Contu Mario Antonello Rosito patricia Ashton-Prolla Joāo Carlos Prolla Genomic Medicine Laboratory Experimental Research CenterHospital de Clínicas de Porto Alegre Post-Graduate Program in Medical Sciences Federal University of Rio Grande do Sul National Institute for Populational Medical Genetics Medical School Federal University of Rio Grande do Sul Post-Graduate Program in Gastroenterological Sciences Federal University of Rio Grande do Sul department of Statistics Federal University of Rio Grande do Sul Post-Graduate Program in Epidemiology Federal University of Rio Grande do Sul Research and Post-Graduation Group Hospital de Clínicas de Porto Alegre Division of Coloproctology Hospital de Clínicas de Porto Alegre department of Surgery Federal University of Rio Grande do Sul Medical Genetics Service Hospital de Clínicas de Porto Alegre department of Genetics Federal University of Rio Grande do Sul Service of Pathology Hospital de Clínicas de Porto AlegrePorto Alegre-RS90035-903Brazil

AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern ***:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of *** data and pathology features of the tumor were obtained from chart ***:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary *** histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,*** percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk ***:A significant proportion of patients with CRC were at high risk for *** and training of health care professionals are essential to ensure proper management.

关键词： Colorectal cancer Family history Hereditary cancer Lynch syndrome Microsatellite instability phenotype

Serological Evidence of Human Coinfection by Brazilian Spotted Fever and Bartonellosis

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International Journal of Clinical Medicine 2016年第11期7卷 766-770页

作者： Otília Lupi Eula carvalho Tatiana Rozental Alexsandra Rodrigues de Mendonça Favacho Elba Regina Sampaio de Lemos patricia Brasil Laboratório de Doenças Febris Agudas Instituto Nacional de Infectologia Evandro Chagas (INI) Funda&ccedil&atildeo Oswaldo Cruz (FIOCRUZ) Rio de Janeiro Brazil Laboratório de Hantaviroses e Rickettsioses Instituto Oswaldo Cruz (IOC) Funda&ccedil&atildeo Oswaldo Cruz (FIOCRUZ) Rio de Janeiro Brazil

Brazilian spotted fever and bartonellosis are zoonotic, emerging and under diagnosed diseases. Pets may be co-infected by multiple pathogens and become transmissions sources to humans. The study reports the first case of active co-infection by Brazilian spotted fever and bartonellosis based on serological evidence. The authors aim to demonstrate the importance of performing systematic syndromic investigations on nonspecific febrile syndromes, guided by the epidemiological history and considering the possibility of co-infection by zoonosis sharing the same ecological niche.

关键词： Rickettsia rickettsia Bartonella henselae Brazilian Spotted Fever Bartonellosis Co-Infection

Impacts of Coffee Production in Agroforestry System for Sustainable development

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Journal of Agricultural Science and Technology(B) 2013年第8期3卷 535-544页

作者： Flavia Maria de Mello Bliska patricia Helena Nogueira Turco Antonio Bliska Jfinior Daniel carvalho Nepomuceno Agronomic Institute Coffee Centre S6o Paulo Agency of Agribusiness Technology Agriculture Secretary of Sao Paulo StateCampinas Sao Paulo 13012-970 Brazil department of decentralization of development Silo Paulo Agency of Agribusiness Technology Agriculture Secretary of SaoPaulo State Campinas Sao Paulo 13012-970 Brazil Faculty of Agricultural Engineering University of Campinas Av. Cdndido Rondon 501-Bar6o Geraldo Campinas S6o Paulo13083-875 Brazil

This study estimates the environmental and socioeconomic impacts of coffee production in the agroforestry system in the settlements of farmers located in the West of the state of Silo Paulo, Brazil, in the region known as Pontal of Paranapanema, aiming at the development of programs to support the growth of production sustainable coffee and programs to protect the coffee activity before the possible global climate change. The settlements are located in areas with sandy soils and highly degraded by human action Moreover, the region is considered marginal for the production of coffee, because it is subject to periods of high temperatures, prolonged drought and frost risk, which hinders the sustainability of farms. The environmental and socioeconomic impacts of agroforestry are analyzed through Ambitec-agro system, consisting of a set of indicators aimed at ex-post evaluation of the contribution of technological innovation to environmental, social and economic development of an agricultural activity. The system Ambitec involves：（1） general data collection about the technology; （2） application of questionnaires with adopters selected and insertion of data on impact indicators spreadsheets via platform MS-Excel and to obtain quantitative results and impacts partial indexes and aggregates the impact of technology selected; （3） analysis and interpretation of indices obtained, which vary between -15 and 15. The results indicate that agroforestry management can contribute to：（1） maintaining or increasing the sustainability of traditional coffee-growing regions in the case of sudden climate change; （2） the expansion of the coffee regions now considered unsuitable for the cultivation of coffee; （3） for sustainable regional development.

关键词： Climate changes sustainable development regional development coffee production.

Organic Coffee under Perspective of Energy Efficiency

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Journal of Agricultural Science and Technology(B) 2014年第1期4卷 15-20页

作者： patricia Helena Nogueira Turco Osmar de carvalho Bueno: Maura Seiko Tsutsui Esperancini Flavia Mariade Mello Bliska department of decentralization of development Agriculture Secretary of S6o Paulo State Sao Paulo Agency of AgribusinessTechnology Campinas 13012-970 Sao Paulo Brazil department of Economics and Rural Sociology Faculty of Agricultural Sciences of Botucatu Universidade Jfilio de MesquitaFilho Paulista State University Rua Josd Barbosa de Barros Botucatu 18603-970 Sao Paulo Brazil Agriculture Secretary of Sao Paulo State Sao Paulo Agency of Agribusiness Technology Coffee Centre Agronomic InstituteCampinas 13012-970 Sao Paulo Brazil

The energy analysis development in this study contributes to the understanding of the dynamics of the organic coffee productive system, in particular to assess the independence of this system with respect to the use of industrialized input products. Thus, it provides information about the sustainability of that production system. Technical itineraries used in this study consist of energy expenditure made with coffee cultivation, according to the type, source and form of energy inputs, agricultural machines, equipment and labor force used in that production system. The energy expenditure, converted into energy units, quantified the input energy. And the organic coffee production, measured in kilograms of processed coffee beans, was the output energy. Primary data used in this study were obtained from organic coffee producers in the Southern region of Minas Gerais State, Brazil, in 2011. Energy balance identified was positive, since the estimated output energy was 626.465 M J/ha and the energy expenditure was 112.998 M J/ha, during the useful life of the crop.

关键词： Energetic balance sustainable production coffee cultivation.

Evaluation of Some New Wine Grape Cultivars under S^o Francisco Valley Conditions

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Journal of Agricultural Science and Technology(B) 2017年第5期7卷 320-325页

作者： patricia Coelho de Souza Leao Bruna Thais Goncalves Nunes Emille Mayara carvalho de Souza Jessica Islane de Souza Rego Jose Henrique Bemardino do Nascimento Embrapa Semifrido BR 428 Km 152 Zona Rural PO Box 23 Petrolina 56302-970 Pernambuco State Brazil Universidade de Pernambuco (UPE) Petrolina 56302-970 Pernambuco State Brazil

This study aimed to evaluate the performance and characteristics of the grapes as subsidies to the recommendation of new wine grape cultivars for the S^o Francisco Valley. An experiment was carried out in Petrolina, Pernambuco state, during four seasons in 2014 and 2015 and the treatments were represented by 10 cultivars and three breeding selections： Grenache, Tempranillo, Merlot, Cabernet Sauvignon, Malbec, Petit Verdot and Syrah for red wines and Sauvignon Blanc, Chardonnay, Chenin Blanc and breeding selections 46, 14 and 47 for white wines. The experimental design was a randomized block with four replicates and two useful plants per plot. The following variables were evaluated： sprouting, bud fertility rate, Ravaz index, production, number of clusters, weight, length and width of cluster, weight and volume of 100 berries, soluble solids and titratable acidity. A better balance between production and vigour was obtained in Grenache, Merlot and Tempranillo cultivars, presenting values of 7.56, 6.50 and 5.93, respectively, for Ravaz index. Grenache, Chenin Blanc and Tempranillo were the most productive cultivars with average yields estimated at 10.4, 8.7 and 8.4 ton/ha/season. Selection 14 had longer, wider and less compact clusters, which can reduce clusters rottenness. The percentage of sprouting ranged from 38.13% in selection 14 to 77.6% in cv. Chenin Blanc. The average index of bud fertility was 0.79 cluster/bud, with no significant differences among cultivars. Greater potential for sugar accumulation was found in the selections 14, 46 and 47, while the titratable acidity ranged from 0.63% in cv. Merlot to 0.89% in selection 47. Grenache and Tempranillo have showed potential to obtain adequate yield and balanced vines, while Sauvignon Blanc, Chardonnay, Cabemet Sauvignon, Malbec and Petit Verdot presented low yield being necessary to select clones more productive and well adapted to the tropical conditions. Further information about the quality of grapes and w

关键词： Tropical viticulture wine grape yield.