Mesenchymal stem cell secretome and nanotechnology:Combining therapeutic strategies
作者机构：Laboratory of Stem Cell ResearchRoberto Alcantara Gomes Biology InstituteRio de Janeiro State UniversityRio de Janeiro20540170Brazil
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2022年第46卷第8期
页 面：1807-1813页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001 the“Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)” the“Fundação Carlos Chagas Filho de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ)”
主 题：Mesenchymal stem cells Nanoparticles Secretome Exosome Targeted drug delivery
摘 要：Mesenchymal stem cells(MSC)have pushed the field of stem cell-based therapies by inducing tissue regeneration,immunosuppression,and angiogenesis mainly through vesicles and soluble factors release(paracrine signaling).MSC-extracellular vesicles(MSC-EV)adaptable secretome and homing to injured sites allowed researchers to unlock a new era of cell-free based *** parallel,nanoparticles(NP)have been explored in contributing to transport and drug delivery systems,giving drugs desired physical-chemical properties to exploit cell ***,NPs can be quickly recognized by immune cells and cleared from *** this viewpoint,we explore how combining both therapeutic strategies can improve efficacy and circumvent limitations of both *** benefit from the potent MSC membrane composition,guiding chemotaxis to tumor sites,a very restricted ***-EV has low immunogenicity,high stability,long half-life and can explore tissue targeting ligands as a precise drug carry,even across biological *** properties promote enhanced targeted drug delivery that can be combined with NP,exploring biological membrane production through:*** cell therapy with NP-infused MSC;***-containing MSC-EV generated by NP-infused MSC;*** coating NP in MSC membrane(“MSC NanoGhosts),allowing precise cargo definition without losing ***,nanotechnology combined with cell-based therapeutic resources can greatly improve targeted drug delivery,improving efficacy and opening a new venue of therapeutic possibilities.
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