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Long lasting response to second-line everolimus in kidney cancer

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World Journal of Clinical Cases 2013年第5期1卷 166-168页

作者： Antonella Virtuoso Tania Policastro Michela Izzo Piera Federico Carlo Buonerba pasquale rescigno Giuseppe Di Lorenzo Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica Università degli Studi Federico Ⅱ80131 NaplesItaly Deparment of Clinical Medicine University Federico Ⅱ of Naples80131 Naples Italy

In the case presented here, everolimus was administered after first line therapy with sunitinib in a patient with metastatic renal cell carcinoma. The safety profile was excellent. The prolonged progression-free survival(PFS) obtained with everolimus in this case is of peculiar interest, as it is a multiple of the median PFS obtained in with everolimus in the regulatory trial. Such finding suggests that a subset of patients with renal cell carcinma may particularly benefit from everolimus.

关键词： Metastatic renal cell carcinoma Everolimus(RAD001) Sunitinib Progression-free survival

Platinum drug sensitivity and resistance in testicular germ cell tumors:two sides of the same coin

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Cancer Drug Resistance 2020年第3期3卷 672-675页

作者： pasquale rescigno Margaret Ottaviano Giovannella Palmieri Division of Clinical Studies The Institute of Cancer Research and The Royal Marsden HospitalLondon SM25NGUnited Kingdom. Division of Oncology CRTR Rare Tumors Reference CenterAOU Federico IINaples 80100Italy.

Testicular germ cell tumors(TGCTs)represent the most common malignancies in young males but they also show the highest cure rate in solid tumors with more than 95%newly diagnosed TGCTs being ultimately cured[1].Singh et al.[2]recently provided precious insight into the genomic aberrations underpinning the molecular characteristics of these tumors and a clear presentation of the mechanisms underlying sensitivity/resistance to *** importantly,the authors identified pre-target,on-target and post-target factors that can explain,the two sides of the same coin:the exquisite sensitivity of these cancers to platinum-based chemotherapy and at the same time,drug resistance when these factors are lacking.

关键词： tumors resistance chemotherapy

Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports

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World Journal of Clinical Cases 2014年第6期2卷 228-231页

作者： Sabino De Placido pasquale rescigno Piera Federico Carlo Buonerba Davide Bosso Livio Puglia Michela Izzo Tania Policastro Giuseppe Di Lorenzo Genitourinary Cancer Section Medical Oncology Department of Clinical Medicine Federico Ⅱ University

Prostate cancer is the most common non-cutaneous malignancy for men. The skeleton is the most common metastatic site but, following an improvement in survival, metastases in uncommon sites are being found more frequently in clinical practice, especially brain metastases. Despite the new drugs now available for metastatic castration resistant prostate cancer, no clinical evidence exists about their effectiveness on brain metastases. We describe the clinical history of 3 patients treated with cabazitaxel plus whole brain radiotherapy. These case reports demonstrate that cabazitaxel is highly active and well tolerated in brain metastases.

关键词： Cabazitaxel Brain metastases Prostate cancer

Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

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Open Journal of Urology 2012年第2期2卷 83-86页

作者： pasquale rescigno Giuseppe Di Lorenzo Lucia Raimondo Carmine D’Aniello Elide Matano Vincenzo Damiano Lucia Nappi Livio Puglia Antonella Petremolo Piera Federico Giovannella Palmieri Genitourinary Oncology and Rare Cancer Center Federico II University Naples Italy

Primary germ cell tumors of lung are extremely rare. The prognosis is usually poor, with various symptoms seriously affecting quality of life. In this paper we describe the unique case of a patient affected by an embryonal carcinoma of lung and a testicular seminoma after ten years. We also report literature about pulmonary extragonadal germ cell tumors.

关键词： Extragonadal Germ Cell Tumors Primary Pulmonary Germ Cell Tumor Embryonal Carcinoma Testicular Seminoma

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World Journal of Clinical Oncology 2013年第2期4卷 52-57页

作者： pasquale rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology DivisionUniversity Federico II80131 NapoliItaly Department of Dermatology University Federico II of Naples80131 NapoliItaly

AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective *** some cases,the human herpes virus 8 status was assessed by *** patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were ***:Thirty-two cases were included in this *** average age at diagnosis was 70 years,with a male/female ratio of approximately 2:***-four percent of the cases had classic *** patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal *** patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic *** median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 *** multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic *** data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.

关键词： Kaposi’s sarcoma Human herpes virus 8 Paclitaxel Pegylated liposomal doxorubicin Vinblastine

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Natural gas and biofuel as feedstock for hydrogen productionon Ni catalysts

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Journal of Natural Gas Chemistry 2009年第1期18卷 9-14页

作者： pasquale Corbo Fortunato Migliardini Istituto Motori CNR Via Marconi 8-80125 Napoli Italy

In this article, the aptitude of natural gas as feedstock in steam reforming process for hydrogen production is compared with that of different liquid fuels （pure compounds and commercial fuels）, with the aim to investigate the potentialities of biofuels to overcome the CO2 emission problems deriving from fossil fuel processing. The performances of a nickel based catalyst （commercially used in steam reforming of natural gas） were evaluated in terms of feed conversion and yield to the different products as function of temperature, space velocity and water/fuel ratio. Furthermore, a preliminary evaluation of catalyst durability was effected by monitoring yield to H2 versus time on stream and measuring coke formation at the end of experimental tests. High yields to hydrogen were obtained with all fuels investigated, whereas the deactivation phenomena, which are correlated to carbon deposition on the catalyst, were observed with all tested fuels, except for methane and biofuel.

关键词： natural gas hydrogen steam reforming biofuels

A RESULT OF SUZUKI TYPE IN PARTIAL G-METRIC SPACES

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Acta Mathematica Scientia 2014年第2期34卷 274-284页

作者： Peyman SALIMI pasquale VETRO Young Researchers and Elite Club Rasht BranchIslamic Azad University Università degli Studi di Palermo Dipartimento di Matematica e Informatica

Recently, Suzuki [T. Suzuki characterizes metric completeness, Proc. A generalized Banach contractlon principle that Amer. Math. Soc. 136 （2008）, 1861-1869] proved a fixed point theorem that is a generalization of the Banach contraction principle and char- acterizes the metric completeness. Paesano and Vetro [D. Paesano and P. Vetro, Suzuki＇s type characterizations of completeness for partial metric spaces and fixed points for partially ordered metric spaces, Topology Appl., 159 （2012）, 911-920] proved an analogous fixed point result for a self-mapping on a partial metric space that characterizes the partial metric O- completeness. In this article, we introduce the notion of partial G-metric spaces and prove a result of Suzuki type in the setting of partial G-metric spaces. We deduce also a result of common fixed point.

关键词： Fixed and common fixed points Suzuki fixed point theorem partial G-metricspaces

Biofabrication of nanovesicles for brain diseases

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Neural Regeneration Research 2023年第3期18卷 525-526页

作者： pasquale Picone Domenico Nuzzo Istituto per la Ricerca e l’Innovazione Biomedica CNRDipartimento di Scienze e Tecnologie Biologiche Chimiche e FarmaceuticheUniversitàdi PalermoPalermoItaly

Background:Nanotechnologies promise to improve disease diagnosis and treatment,overcoming the limitations of conventional *** particular,extracellular vesicles(EVs)and artificial vesicles(AVs)are strongly emerging tools in nanomedicine(Leggio et al.,2020).EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane(exosomes)or shed from the plasma membrane(microvesicles).EVs are released by different brain cells(neurons,oligodendrocytes,astrocytes,and microglia)and constitute a physiological intercellular communication ***,EVs can deliver different types of molecules(nucleic acids and proteins),which often influence the phenotype of the recipient *** play a physiological role in the central nervous system(CNS),such as development,myelination,regeneration,and synaptic activity(Lai et al.,2012).Due to their content,EVs could therefore constitute an important biomarker for neurodegenerative diseases,represent candidates for therapeutic use,enclosing regulatory molecules,or be considered as vectors for brain drug delivery(Croese et al.,2018).

关键词： diseases diagnosis constitute