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中华高血压杂志 2014年第10期22卷 999-999页

作者： pascual JM Rodilla E Costa ja Garcia-Escrich M Gonzalez C Redon J 刘莉叶鹏

该研究旨在评估降压治疗过程中,尿微量白蛋白排泄随时间的变化对心血管风险是否有预测价值。方法：对平均年龄55岁、无心血管疾病的高血压患者2835例进行随访研究,其中47.0%为男性,血压138/80mm Hg（1mm Hg=0.133kPa）,19.

关键词：原发性高血压患者微量白蛋白尿降压治疗预后价值心血管风险白蛋白排泄心血管疾病预测价值

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Physical exercise in the prevention and treatment of Alzheimer’s disease

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Journal of Sport and Health Science 2020年第5期9卷 394-404页

作者： Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valenciaand CIBERFESInsitute of Health Research-INCLIVAValencia 46010Spain INRA UMR866 Muscle dynamics and metabolismUniversity of MontpellierF-34060MontpellierFrance Department of Physiotherapy Faculty of PhysiotherapyUniversity of ValenciaValencia 46010Spain Physical Education and Sports Department University of ValenciaValencia 46010Spain

Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.

关键词： Aerobic exercise Dementia Exercise training Lifestyle factors Multidomain interventions Resistance exercise

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Reversal of age-associated frailty by controlled physical exercise:The pre-clinical and clinical evidences

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Sports Medicine and Health Science 2019年第1期1卷 33-39页

作者： C.Arc-Chagnaud F.Millan A.Salvador-pascual A.G.Correas G.Olaso-Gonzalez A.De la Rosa A.Carretero M.C.Gomez-Cabrera J.Viña Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valencia and CIBERFESFundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain INRA UMR866 Dynamique Musculaire et MetabolismeUniversite de MontpellierF-34060MontpellierFrance

Demographic aging is one of the most serious challenges facing our society.Although we live longer,we do not live better because it is considered that approximately 16–20%of our life is spent in late-life morbidity.Older people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life,disability,hospitalization and even death.Frail men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same age.In this review we will address the main physiological changes in the muscular and nervous system associated to aging.More specifically we will review the changes in muscle mass,quality,and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with aging.The last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these models.We will finally address the importance of exercise training as an intervention to delay or even reverse frailty.

关键词： Sarcopenia Multicomponent exercise Disability Skeletal muscle Healthy aging

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