Physical exercise in the prevention and treatment of Alzheimer’s disease

作     者：Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera Adrian De la Rosa;Gloria Olaso-Gonzalez;Coralie Arc-Chagnaud;Fernando Millan;Andrea Salvador-Pascual;Consolacion García-Lucerga;Cristina Blasco-Lafarga;Esther Garcia-Dominguez;Aitor Carretero;Angela G.Correas;Jose Vi?a;Mari Carmen Gomez-Cabrera

作者机构：Freshage Research GroupDepartment of PhysiologyFaculty of MedicineUniversity of Valenciaand CIBERFESInsitute of Health Research-INCLIVAValencia 46010Spain INRAUMR866 Muscle dynamics and metabolismUniversity of MontpellierF-34060MontpellierFrance Department of PhysiotherapyFaculty of PhysiotherapyUniversity of ValenciaValencia 46010Spain Physical Education and Sports DepartmentUniversity of ValenciaValencia 46010Spain 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2020年第9卷第5期

页      面：394-404页

核心收录：

学科分类：0403[教育学-体育学] 04[教育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100203[医学-老年医学] 10[医学] 

基　　金：TagedPThis work was supported by the following grants:Instituto de Salud Carlos III and co-funded by FEDER(Grant number PIE15/00013) SAF2016-75508-R from the Spanish Ministry of Education and Science(MEC) CB16/10/00435(CIBERFES) PROMETEOII2014/056 from Conselleria,de Sanitat de la Generalitat Valenciana and EU Funded CM1001 and FRAILOMICHEALTH.2012.2.1.1-2 ADVANTAGE-724099 Join Action(HP-JA)3rd EU Health Programme and DIALBFRAIL-LATAM(825546 H2020-SC1-BHC). 

主　　题：Aerobic exercise Dementia Exercise training Lifestyle factors Multidomain interventions Resistance exercise 

摘      要：Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.