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Effect of cooling media on bead geometry,microstructure,and mechanical properties of wire arc additive manufactured IN718 alloy

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Advances in Manufacturing 2024年第1期12卷 124-149页

作者： parveen kumar Satish kumar sharma Ratnesh kumar Raj Singh Department of Mechanical Engineering Thapar Institute of Engineering and TechnologyPatialaPunjab147004India

This work aims to present and explore thermal management techniques for the wire arc additive manufacturing(WAAM)of IN718 *** heat can be mitigated via air or water *** this study,the material was deposited under four different heat-input conditions with air or water *** air cooling,the layer is deposited in a normal atmospheric air environment,whereas with water cooling,the material is deposited inside a water tank by varying the water *** validate the air and water cooling thermal management techniques,IN718 single-pass and multilayer linear walls were deposited using the bidirectional gas metal arc welding based WAAM setup under four different heat input *** the deposition of single layers,the temperature profiles were recorded,and the geometric and microstructural features were *** multilayer wall structures,the mechanical properties(hardness,tensile strength,and elongation)were determined and assessed using the corresponding microstructural features explored through scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),and electron backscatter diffraction(EBSD)*** microstructure observed through SEM analysis in the building direction was found to be nonhomogenous compared with that in the deposition ***,water cooling was found to govern bead characteristics,such as wall width and *** grain size and anisotropy of the mechanical properties also decreased in the water-cooled ***,water cooling is an economical and efficient method to mitigate excessive heat accumulation in WAAM-deposited IN718.

关键词： Air cooling Water cooling IN718 Bead characteristics Microstructure Electron backscatter diffraction(EBSD)

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Comparison of Sensitivity and Specificity of ZN and Fluorescent Stain Microscopy with Culture as Gold Standard

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Journal of Tuberculosis Research 2017年第2期5卷 118-128页

作者： Rekha Bansal parveen kumar sharma Subhash Chand Jaryal Puneet kumar Gupta Dinesh kumar Department of Pulmonary Medicine Dr. RP Government Medical College Kangra at Tanda (HP) India Department of Pharmacology SLBS Government Medical College Mandi at Nerchowk (HP) India Department of Microbiology SLBS Government Medical College Mandi at Nerchowk (HP) India Department of Microbiology All India Institute of Medical Sciences Rishikesh Uttarakhand India Department of Community Medicine Dr. RP Government Medical College Kangra at Tanda (HP) India

Introduction: Reports indicate that fluorescent staining of smears increases sensitivity of direct microscopy;so ZN staining is being replaced with fluorescent microscopy in RNTCP in India. Chemical processing and sputum concentration may also improve sensitivity of microscopy. Objective: To compare the sensitivity and specificity of microscopy for AFB using ZN and fluorescent stains in direct and concentrated specimen with culture as gold standard. Methods: Morning sputum specimen of patients, suspected of having pulmonary tuberculosis, over a period of 6 months was subjected to direct microscopy using fluorescent stain;the same slide was over-stained with ZN stain. Same sputum sample was concentrated by Petroff’s method and subjected to fluorescent microscopy followed by ZN microscopy and finally to culture for AFB. Results: Sensitivity of fluorescent stained concentrated sputum samples was maximum and of ZN stained unprocessed sputum samples was minimum. Specificity of three of the methods was equal at 0.96 but of ZN stained concentrated sputum smears was 0.97. Sensitivity of total fluorescent stains was 0.85 (Specificity 0.96) and sensitivity of total ZN stained smears was 0.80 (Specificity 0.96). Discussion: We used same smear for fluorescent and ZN stains, so smear related variability is decreased. Blinding for microscopy was practically complete. Conclusion: The sensitivity of sputum microscopy for AFB can be increased by concentrating the sputum and using fluorescent microscopy. The specificity remains high in all the methods.

关键词： Sensitivity and Specificity Microscopy for AFB ZN Staining Fluorescent Stain Concentration of Sputum

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Adverse Drug Reactions in Patients on Second Line Anti-Tubercular Drugs for Drug Resistant Tuberculosis in Rural Tertiary Care Hospital in North India

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Journal of Tuberculosis Research 2018年第3期6卷 207-214页

作者： Anita kumari parveen kumar sharma Dinesh Kansal Rekha Bansal Rajan Negi Department of Pharmacology Dr. YSP Government Medical College Nahan (HP) India Department of Pharmacology SLBS Government Medical College Mandi at Nerchowk (HP) India Department of Pharmacology Dr. RP Government Medical College Kangra at Tanda (HP) India Department of Pulmonary Medicine Dr. RP Government Medical College Kangra at Tanda (HP) India

Introduction: The adverse drug events (ADEs) to second-line anti-TB drugs are one of the major reasons for the patients default on treatment. A general awareness of various adverse drug events (ADE) and their management is essential for the effective management of tuberculosis. Identification of adverse drug reaction profile of patients can be useful for the early detection, management and prevention of adverse drug events. Material and methods: It was a prospective observational study conducted after approved Institutional Ethics Committee. A total of 104 drug resistant tuberculosis patients registered from 1st November 2012 to 31st October 2013 started with second line anti-tubercular drugs under PMDT-RNCP after taking written informed consent. Adverse drug reaction during treatment recorded and assessed by Hart wig and WHO scale. Results: 87% patients experienced adverse drug reactions. Total 346 ADR were reported. Most common were gastritis (65%) and arthralgia (60.6%), others were nausea (35.6%), vomiting (32.7%), hyperuricemia (30.8%), giddiness (27%), anorexia (17.3), generalized weakness (15.4), insomnia (10.6%), psychosis (8.6%), hearing impairment (6.7%), hypersensitivity reaction (5.8%), peripheral neuropathy (4.8%), visual disturbance (3.8%), nephrotoxicity (2.9%), forgetfulness (2.9%), gynaecomastia (1.9%), hypothyroidism (1%), seizure (1%), and thrombocytopenia (1%). Conclusion: Majority of patients experienced wide range adverse drug reactions. Most of patients faced the problem within 2 - 3 months of initiation of treatment and managed by symptomatic. Early identification, prompt management and standardized reporting adverse drug reactions at all the level of healthcare are needed.

关键词： Drug Resistant Tuberculosis ADR: Second line Anti-Tubercular Drugs

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Observations on Traditional Phytotherapy among the Inhabitants of Lahaul Valley through Amchi System of Medicine—A Cold Desert Area of Himachal Pradesh in North Western Himalayas, India

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Chinese Medicine 2011年第3期2卷 93-102页

作者： parveen kumar sharma Surender kumar Thakur S. Manuja R. K. Rana Pardeep kumar Sanjay sharma Jagdish Chand Ashok Singh Krishan kumar Katoch 不详

The paper highlights the Phyto-diversity and indigenous uses an ecosystem existing in Lahaul Valley of tribal district of Lahaul and Spiti in Himacjhal Pradesh, India. This is one of the most preferred tourist spot especially for foreigners. The cold desert area of India is known for its specific topography, sense climate and unique vegetation. The valley is rich in high value medicinal wealth and local inhabitants (Buddhist) practice the Tebetan Amchi System of Medicine. Keeping in view the continuous pressure on nature, this paper reflects the Phyto-diversity of Valley, with reference to medicinal and aromatic plants and conserva-tion mechanisms to protect the valuable wealth of the valley and also suggests effective ecotourisim planning of the study area.

关键词： Diversity Medicinal and Aromatic Plants Ecotourisim Lahaul Valley Indigenous Uses Tebetan Amchi System of Medicine

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Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury

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World Journal of Stem Cells 2024年第7期16卷 742-759页

作者： Prashasti sharma Dharmendra kumar Maurya Life Sciences Homi Bhabha National InstituteMumbai 400094MaharashtraIndia Radiation Biology&Health Sciences Division Bhabha Atomic Research CentreMumbai 400085MaharashtraIndia

Wharton’s jelly mesenchymal stem cells(WJ-MSCs)are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation ***-MSCs are more naïve and have a better safety profile,making them suitable for both autologous and allogeneic *** review highlights the regenerative potential of WJ-MSCs and their clinical applications in mitigating various types of radiation *** this review,we will also describe why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and ***,the most updated literature related to both preclinical and clinical usage of WJ-MSCs for their potential application in the regeneration of tissues and organs will also be compiled.

关键词： Stem cells Wharton’s jelly mesenchymal stem cells Radiotherapy Xerostomia Lung fibrosis

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Intrusion detection systems for wireless sensor networks using computational intelligence techniques

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Cybersecurity 2024年第2期7卷 81-95页

作者： Vaishnavi Sivagaminathan Manmohan sharma Santosh kumar Henge Lovely Professional University PhagwaraIndia

Network Intrusion Detection Systems(NIDS)are utilized to find hostile network *** can be accom-plished by looking at traffic network activity,but it takes a lot of *** NIDS heavily utilizes approaches for data extraction and machine learning to find *** terms of feature selection,NIDS is far more *** is accurate since anomaly identification uses a number of time-consuming *** of this,the feature selec-tion method influences how long it takes to analyze movement patterns and how clear it *** goal of the study is to provide NIDS with an attribute selection *** has been used for that *** Network Intrusion Detection System that is being developed will be able to identify any malicious activity in the network or any unusual behavior in the network,allowing the identification of the illegal activities and safeguarding the enormous amounts of confidential data belonging to the customers from being *** the research,datasets were produced utilising both a network infrastructure and a simulation *** is used to gather data packets whereas Cisco Packet Tracer is used to build a network in a simulated ***,a physical network consisting of six node MCUs connected to a laptop and a mobile hotspot,has been built and communication packets are being recorded using the Wireshark *** train several machine learning models,all the datasets that were gatheredcre-ated datasets from our own studies as well as some common datasets like NSDL and UNSW acquired from Kaggle-were ***,PsO,which is an optimization method,has been used with these ML algorithms for feature *** the research,KNN,decision trees,and ANN have all been combined with PSO for a specific case *** it was found demonstrated the classification methods PSO+ANN outperformed PSO+KNN and PSO+DT in this case study.

关键词： Network intrusion detection systems(NIDS) Cisco packet tracer Wireshark tool Machine learning PSO Cybersecurity Optimization

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Improved Energy Management Strategy for Prosumer Buildings with Renewable Energy Sources and Battery Energy Storage Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 381-392页

作者： Pavitra sharma Krishna kumar Saini Hitesh Datt Mathur Puneet Mishra Department of Electrical&Electronics Engineering Birla Institute of Technology&SciencePilaniIndia IEEE

The concept of utilizing microgrids(MGs)to convert buildings into prosumers is gaining massive popularity because of its economic and environmental *** pro-sumer buildings consist of renewable energy sources and usually install battery energy storage systems(BESSs)to deal with the uncertain nature of renewable energy ***,because of the high capital investment of BESS and the limitation of available energy,there is a need for an effective energy management strategy for prosumer buildings that maximizes the profit of building owner and increases the operating life span of *** this regard,this paper proposes an improved energy management strategy(IEMS)for the prosumer building to minimize the operating cost of MG and degradation factor of ***,to estimate the practical operating life span of BESS,this paper utilizes a non-linear battery degradation *** addition,a flexible load shifting(FLS)scheme is also developed and integrated into the proposed strategy to further improve its *** proposed strategy is tested for the real-time annual data of a grid-tied solar photovoltaic(PV)and BESS-powered AC-DC hybrid MG installed at a commercial ***,the scenario reduction technique is used to handle the uncertainty associated with generation and load *** validate the performance of the proposed strategy,the results of IEMS are compared with the well-established energy management *** simulation results verify that the proposed strategy substantially increases the profit of the building owner and operating life span of ***,FLS enhances the performance of IEMS by further improving the financial profit of MG owner and the life span of BESS,thus making the operation of prosumer building more economical and efficient.

关键词： Prosumer building battery energy storage system(BESS) battery degradation factor demand response energy management microgrid solar photovoltaic(PV)system

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Pharmacological potential of Manilkara zapota(L.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： Priyanka sharma Aakash Deep Harish kumar Nitin Bansal Sanjiv kumar Arun Davinder kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

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SHT-based public auditing protocol with error tolerance in FDL-empowered IoVs

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Digital Communications and Networks 2024年第1期10卷 142-149页

作者： Kui Zhu Yongjun Ren Jian Shen Pandi Vijayakumar Pradip kumar sharma School of Computer and Software Nanjing University of Information Science&TechnologyNanjing210044China Peng Cheng Laboratory Shenzhen518000China Department of Computer Science and Engineering University College of Engineering TindivanamTamil Nadu604001India Department of Computing Science University of AberdeenAberdeenAB243UEUK

With the intelligentization of the Internet of Vehicles(lovs),Artificial Intelligence(Al)technology is becoming more and more essential,especially deep *** Deep Learning(FDL)is a novel distributed machine learning technology and is able to address the challenges like data security,privacy risks,and huge communication overheads from big raw data ***,FDL can only guarantee data security and privacy among multiple clients during data *** the data sets stored locally in clients are corrupted,including being tampered with and lost,the training results of the FDL in intelligent IoVs must be negatively *** this paper,we are the first to design a secure data auditing protocol to guarantee the integrity and availability of data sets in FDL-empowered ***,the cuckoo filter and Reed-Solomon codes are utilized to guarantee error tolerance,including efficient corrupted data locating and *** addition,a novel data structure,Skip Hash Table(SHT)is designed to optimize data ***,we illustrate the security of the scheme with the Computational Diffie-Hellman(CDH)assumption on bilinear *** theoretical analyses and performance evaluations demonstrate the security and efficiency of our scheme for data sets in FDL-empowered IoVs.

关键词： Internet of vehicles Federated deep learning Data security Data auditing Data locating and recovery

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Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh kumar sharma Erdal Ozdemir Shuichiro Miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

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