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Early estimation of the number of hidden HIV infected subjects: An extended Kalman filter approach

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Infectious Disease Modelling 2023年第2期8卷 341-355页

作者： paolo Di Giamberardino Daniela Iacoviello Dept.of Computer Control and Management EngineeringSapienzaUniversity of RomeVia Ariosto 2500185RomeItaly

In the last decades several epidemic emergencies have been affecting the world,influencing the social relationships,the economics and the *** particular,starting in the early 080,the Acquired Immunodeficiency Syndrome,AIDS,is representing one of the most worrying sanitary emergency,that has caused up to now more than 25 million of dead *** infection is caused by the Human Immunodeficiency Virus,HIV,that may be transmitted by body fluids;therefore with wise behaviours the epidemic spread could rapidly be *** sanitary emergency is peculiar for the long incubation time:it can reach even 10 years,a long period in which the individual can unconsciously infect other *** identification of the number of infected unaware people,mandatory to define suitable containment measures,is here obtained by using the extended Kalman filter applied to a noisy model in which,reasonably,only the number of infected diagnosed patients is *** simulations and real data analysis support the effectiveness of the approach.

关键词： Epidemic modeling Infection spread HIV-AIDS Extended Kalman filter

Microstructure and Mechanical Performance of Ti-6Al-4V Lattice Structures Manufactured via Electron Beam Melting(EBM):A Review

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 183-203页

作者： Giuseppe Del Guercio Manuela Galati Abdollah Saboori paolo Fino Luca Iuliano Department of Management and Production Engineering(DIGEP) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Department of Applied Science and Technology(DISAT) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Integrated Additive Manufacturing Center(IAM)@Polito Politecnico Di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly

Electron beam melting(EBM) process is an additive manufacturing process largely used to produce complex metallic components made of high-performance materials for aerospace and medical ***,lattice structures made by Ti-6A1-4V have represented a hot topic for the industrial sectors because of having a great potential to combine lower weights and higher performances that can also be tailored by subsequent heat ***,the little knowledge about the mechanical behaviour of the lattice structures is limiting their *** present work aims to provide a comprehensive review of the studies on the mechanical behaviour of the lattice structures made of *** main steps to produce an EBM part were considered as guidelines to review the literature on the lattice performance:(1) design,(2) process and(3) post-heat ***,the correlation between the geometrical features of the lattice structure and their mechanical behaviour is *** addition,the correlation among the mechanical performance of the lattice structures and the process precision,surface roughness and working temperature are also *** investigation on the studies about the properties of heat-treated lattice structure is also conducted.

关键词： Electron beam melting(EBM) Additive manufacturing(AM) Lattice structures Ti–6Al–4V Mechanical properties Heat treatment

Stereovision system for estimating tractors and agricultural machines transit area under orchards canopy

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 1-5页

作者： Corrado Costa paolo Febbi Federico Pallottino Massimo Cecchini Simone Figorilli Francesca Antonucci paolo Menesatti Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria(CREA) Centro di ricerca Ingegneria e Trasformazioni AgroalimentariVia della Pascolare 1600015 Monterotondo scaloRomeItaly Department of Agriculture and Forestry Science Tuscia UniversityVia S.Camillo de Lellis snc01100 ViterboItaly

Managing orchards requires delicate agricultural operations being typically carried out in narrow zones where the operators usually drive machineries under stress that could result in poor *** such conditions,the use of technology would help manage the machines to reduce the hazardous work and eventual damage to the *** safely drive a tractor,the driver needs to be aware of its surroundings,thus a stereovision system can provide helpful *** imaging has proven to be an effective three-dimensional vision ***,the range(or third coordinate)information is useful to detect the obstacle *** distances,when detected during agricultural operations,could be used to assist the operator in driving the tractor at regular or variable working speeds and eventually to provide manufacturers useful indications to model the form of ROPS(roll over protection structure).This study aimed to verify the closeness of agreement between manual and stereo-image measurements,and thus to provide helpful information regarding safety and working *** system used a custom low-cost dual web-camera in combination with an image analysis algorithm in order to automatically extract the information *** independent measurements were carried out using a metric tape(sensitivity 1 cm).A regular structure was used for the analysis:four rows of ten trees each *** red and blue paper markers were placed on the hazelnut trees(two per tree)of two couples of rows for enhanced *** each couple of trees(one on the right,the other on the left),the four markers formed a trapezoid that was *** results of the analysis demonstrated that the stereo vision provided distance measurements with reasonable accuracy(error<5%)in the range of distances lower than 20 *** resolution assessed for the developed video system is suitable for obtaining distance information in real *** information could be used to assist drivers t

关键词： stereovision precision agriculture digital agriculture hazelnut canopy ROPS orchards

Potential role of the microbiome in liver injury during COVID-19: Further research is needed

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World Journal of Gastroenterology 2023年第3期29卷 503-507页

作者： Marcos Roberto Tovani-Palone paolo Pedersini Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077India IRCCS Fondazione Don Carlo Gnocchi Milan 20148Italy

Although different studies have associated coronavirus disease 2019(COVID-19)with the occurrence of liver injury,the hepatic injury route during the COVID-19 course is not yet fully *** order to better understand the mechanisms of the disease,the human gut microbiota has been the subject of extensive discussion in the context of COVID-19 ***,many questions remain,including the risks of liver injury due to COVID-19 specific *** research in this field could allow the discovery of new personalized treatment strategies aimed at improving the microbiota composition,thereby reducing COVID-19 severity and its complications in different *** this article,we discussed basic mechanisms of severe acute respiratory syndrome coronavirus 2 infection and recent evidence on the relationship between COVID-19,the gut microbiome and liver injury as well as proposed recommendations for further research.

关键词： COVID-19 Gut microbiota Coronavirus Gut microbial-host-immune axis Gut-lung axis Liver injury

44%of steep slope cropland in Europe vulnerable to drought

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Geography and Sustainability 2024年第1期5卷 89-95页

作者： Wendi Wang Eugenio Straffelini paolo Tarolli Department of Land EnvironmentAgriculture and ForestryUniversity of PadovaAgripolisViale dell'Università16LegnaroPD 35020Italy

Steep-slope cropland plays a vital role in food production,economic development,ecosystem diversity,and Eu-ropean cultural ***,these systems are susceptible to extreme weather *** 2022 summer drought significantly impacted European agriculture,but the specific effects on steep-slope crops remain *** this is essential for comprehending similar future events and for implementing effective water management strategies to ensure the sustainability of steep-slope agriculture and associated ecosystem *** study quantitatively analyzes the spatial distribution of twelve major European steep-slope(>12%)crops and assesses agricultural drought severity during the 2022 events using open-access spatial *** satellite-based Vegetation Health Index(VHI)is utilized to identify critical *** show that olive grove is the most widespread crop in steep slope agriculture(34%of total area),followed by wheat(24%),maize(16%),and vineyard(11%).Almost half of the steep-slope agriculture in Europe suffered drought during summer *** were hardest affected at 79%,primarily in northern Portugal,northern Spain,southern France,and central *** followed at 62%,mainly in Spain,central Italy,southern France,and northern *** groves ranked third at 59%,with the most impact in northern Portugal,southern and central Spain,and southern *** was also significantly affected at 54%.In this paper,we therefore highlight the need to increase steep-slope agriculture resilience by improving water management and promoting sustainable land practices.

关键词： Drought Steep slope cropland Europe Sustainability

First evidence of heteroplasmy in Grey Partridge(Perdix perdix)

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Avian Research 2020年第3期11卷 363-365页

作者： Claudia Pizzirani paolo Viola Federica Gabbianelli Anna Fagotti Francesca Simoncelli Ines Di Rosa paolo Salvi Andrea Amici Livia Lucentini Department of Chemistry Biology and Biotechnologies(DCBB)University of Perugia06100 PerugiaItaly Department of Agriculture and Forest Science(DAFNE) University of Tuscia01100 ViterboItaly Department for Innovation in Biological Agro-food and Forest Systems(DIBAF) University of Tuscia01100 ViterboItaly Parco Nazionale dei Monti Sibillini 62039 VissoMCItaly

We report for the first time the occurrence of heteroplasmy in Grey Partridge(Perdix perdix)revealed by means of two mitochondrial *** possible serious biological and management implications of this exception to unila... 详细信息

关键词： Galliformes Grey Partridge Heteroplasmy Hybridization Perdix perdix

Higher production of tumor necrosis factor alpha in hemozoin-fed human adherent monocytes is dependent on lipidic component of malarial pigment:new evidences on cytokine regulation in Plasmodium falciparum malaria

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 85-89页

作者： Prato Mauro Gallo Valentina Arese paolo Department of Genetics Biology and BiochemistryUniversity of Torino Medical School

Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial ***:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent *** selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of ***:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these ***,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by ***:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator.

关键词： Hemozoin Plasmodium falciparum Malaria Monocyte Phagocytosis Tumor necrosis factor alpha(TNFalpha) 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid(15-HETE) Matrix metalloproteinase-9(MMP-9)

Arnica montana experimental studies:confounders and biases?

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Journal of Integrative Medicine 2018年第2期16卷 72-76页

作者： Bellavite paolo Marzotto Marta Bonafini Clara Department of Medicine University of Verona

Arnica montana is a popular traditional remedy widely used in complementary and alternative medicine, in part for its wound-healing properties. The authors recently showed that this plant extract and several of its homeopathic dilutions are able to modify the expression of a series of genes involved in inflamma- tion and connective tissue regeneration. Their studies opened a debate, including criticisms to the ＂errors＂ in the methods used and the ＂confounders and biases＂. Here the authors show that the criticisms raised on methodology and statistics are not consistent and cannot be considered pertinent. The present comment also updates and reviews information concerning the action of A. montana dilutions in human macrophage cells while summarizing the major experimental advances reported on this interesting medicinal plant.

关键词： Arnica montana Gene expression Ethanol Statistics

Digital heritage construction: Testing the heritage value of construction documentation and building processes through Virtual Reality

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Frontiers of Architectural Research 2024年第5期13卷 1039-1055页

作者： Luciano Cardellicchio paolo Stracchi Anastasia Globa School of Built Environment University of New South Wales School of Architecture Design&Planning University of Sydney

This research paper examines the heritage value of construction documentation and processes via Virtual Reality(VR), with a focus on the Sydney Opera House(SOH). It underscores the importance of comprehending and documenting transient construction techniques for heritage valuation. Utilising VR, the study offers an immersive portrayal of the SOH's construction, emphasising its innovative methods, craftsmanship, and environmental *** paper draws from the Digital Heritage Construction project, showcased at the Heritage Exposition of the ICOMOS General Assembly 2023. This project featured two VR simulations,developed through analysing 200 original shop drawings, historical photographs, and site minutes and reports. The first simulation illustrates the formwork systems used for the SOH's iconic sails, while the second elucidates the assembly methods for the precast vaulted roofs,including the operation of the telescopic erection arch and the installation of concrete segments. The paper examines the novelty of this approach through a survey conducted at the Heritage Exposition. Analysis of the survey's result reveals VR's effectiveness in deepening the appreciation of architectural heritage's intangible qualities, providing new insights into the historical construction processes of the building and their cultural significance.

关键词： Digital heritage Virtual reality Construction history Cultural significance Twentieth century Intangible heritage Archival studies